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Protein

Aliphatic amidase expression-regulating protein

Gene

amiC

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates the expression of the aliphatic amidase operon. AmiC functions by inhibiting the action of AmiR at the protein level. It exhibits protein kinase activity.

GO - Molecular functioni

  • amide binding Source: PseudoCAP
  • kinase activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Repressor, Transferase

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3428-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Aliphatic amidase expression-regulating protein
Gene namesi
Name:amiC
Ordered Locus Names:PA3364
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3364

Pathology & Biotechi

Chemistry databases

DrugBankiDB02736 Acetamide
DB02121 Butyramide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000645812 – 385Aliphatic amidase expression-regulating proteinAdd BLAST384

Proteomic databases

PaxDbiP27017
PRIDEiP27017

Interactioni

Subunit structurei

Homodimer. Forms a complex with AmiR.

Protein-protein interaction databases

IntActiP27017, 1 interactor
STRINGi208964.PA3364

Structurei

Secondary structure

1385
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP27017
SMRiP27017
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP27017

Family & Domainsi

Domaini

Consists of two beta-alpha-beta domains with a central cleft in which the amide binds.

Phylogenomic databases

eggNOGiENOG4107TSX Bacteria
ENOG410Y0Z1 LUCA
HOGENOMiHOG000202643
InParanoidiP27017
KOiK01999
OMAiYPYESNR
PhylomeDBiP27017

Family and domain databases

InterProiView protein in InterPro
IPR000709 Leu_Ile_Val-bd
IPR028082 Peripla_BP_I
PRINTSiPR00337 LEUILEVALBP
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P27017-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSHQERPLI GLLFSETGVT ADIERSQRYG ALLAVEQLNR EGGVGGRPIE
60 70 80 90 100
TLSQDPGGDP DRYRLCAEDF IRNRGVRFLV GCYMSHTRKA VMPVVERADA
110 120 130 140 150
LLCYPTPYEG FEYSPNIVYG GPAPNQNSAP LAAYLIRHYG ERVVFIGSDY
160 170 180 190 200
IYPRESNHVM RHLYRQHGGT VLEEIYIPLY PSDDDVQRAV ERIYQARADV
210 220 230 240 250
VFSTVVGTGT AELYRAIARR YGDGRRPPIA SLTTSEAEVA KMESDVAEGQ
260 270 280 290 300
VVVAPYFSSI DTAASRAFVQ ACHGFFPENA TITAWAEAAY WQTLLLGRAA
310 320 330 340 350
QAAGSWRVED VQRHLYDICI DAPQGPVRVE RQNNHSRLSS RIAEIDARGV
360 370 380
FQVRWQSPEP IRPDPYVVVH NLDDWSASMG GGALP
Length:385
Mass (Da):42,807
Last modified:January 23, 2007 - v5
Checksum:i33924B6C36017B79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27 – 28QR → HA in CAA32024 (PubMed:1907262).Curated2
Sequence conflicti186V → L in CAA32024 (PubMed:1907262).Curated1
Sequence conflicti263A → P in CAA32024 (PubMed:1907262).Curated1
Sequence conflicti305S → N in CAA32024 (PubMed:1907262).Curated1
Sequence conflicti319C → D in CAA32024 (PubMed:1907262).Curated1
Sequence conflicti383A → P in CAA32024 (PubMed:1907262).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti106T → N in strain: PAC181; butyramide inducible phenotype. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13776 Genomic DNA Translation: CAA32024.1
AE004091 Genomic DNA Translation: AAG06752.1
PIRiA40359
C83226
RefSeqiNP_252054.1, NC_002516.2
WP_003091751.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06752; AAG06752; PA3364
GeneIDi877798
KEGGipae:PA3364
PATRICifig|208964.12.peg.3523

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13776 Genomic DNA Translation: CAA32024.1
AE004091 Genomic DNA Translation: AAG06752.1
PIRiA40359
C83226
RefSeqiNP_252054.1, NC_002516.2
WP_003091751.1, NC_002516.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PEAX-ray2.10A1-385[»]
1QNLX-ray2.70A1-375[»]
1QO0X-ray2.25A/B1-380[»]
ProteinModelPortaliP27017
SMRiP27017
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP27017, 1 interactor
STRINGi208964.PA3364

Chemistry databases

DrugBankiDB02736 Acetamide
DB02121 Butyramide

Proteomic databases

PaxDbiP27017
PRIDEiP27017

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06752; AAG06752; PA3364
GeneIDi877798
KEGGipae:PA3364
PATRICifig|208964.12.peg.3523

Organism-specific databases

PseudoCAPiPA3364

Phylogenomic databases

eggNOGiENOG4107TSX Bacteria
ENOG410Y0Z1 LUCA
HOGENOMiHOG000202643
InParanoidiP27017
KOiK01999
OMAiYPYESNR
PhylomeDBiP27017

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3428-MONOMER

Miscellaneous databases

EvolutionaryTraceiP27017

Family and domain databases

InterProiView protein in InterPro
IPR000709 Leu_Ile_Val-bd
IPR028082 Peripla_BP_I
PRINTSiPR00337 LEUILEVALBP
SUPFAMiSSF53822 SSF53822, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAMIC_PSEAE
AccessioniPrimary (citable) accession number: P27017
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 114 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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