UniProtKB - P26992 (CNTFR_HUMAN)
Ciliary neurotrophic factor receptor subunit alpha
CNTFR
Functioni
Binds to CNTF. The alpha subunit provides the receptor specificity. Receptor for heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303).
Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and IL27RA/WSX1 (PubMed:19386761).
2 PublicationsGO - Molecular functioni
- ciliary neurotrophic factor receptor activity Source: ProtInc
- cytokine binding Source: HGNC-UCL
- cytokine receptor activity Source: GO_Central
- signaling receptor binding Source: BHF-UCL
GO - Biological processi
- brainstem development Source: Ensembl
- ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
- cytokine-mediated signaling pathway Source: GO_Central
- negative regulation of neuron apoptotic process Source: UniProtKB
- nervous system development Source: ProtInc
- positive regulation of cell population proliferation Source: Ensembl
- sex differentiation Source: Ensembl
- signal transduction Source: ProtInc
- skeletal muscle organ development Source: Ensembl
- suckling behavior Source: Ensembl
Keywordsi
Molecular function | Receptor |
Enzyme and pathway databases
PathwayCommonsi | P26992 |
Reactomei | R-HSA-6788467, IL-6-type cytokine receptor ligand interactions |
SignaLinki | P26992 |
SIGNORi | P26992 |
Names & Taxonomyi
Protein namesi | Recommended name: Ciliary neurotrophic factor receptor subunit alphaShort name: CNTF receptor subunit alpha Short name: CNTFR-alpha |
Gene namesi | Name:CNTFR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2170, CNTFR |
MIMi | 118946, gene |
neXtProti | NX_P26992 |
VEuPathDBi | HostDB:ENSG00000122756 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- CNTFR-CLCF1 complex Source: BHF-UCL
Plasma Membrane
- apical plasma membrane Source: CACAO
- ciliary neurotrophic factor receptor complex Source: BHF-UCL
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- anchored component of membrane Source: UniProtKB-KW
- extrinsic component of membrane Source: ProtInc
- receptor complex Source: GO_Central
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1271 |
OpenTargetsi | ENSG00000122756 |
PharmGKBi | PA26684 |
Miscellaneous databases
Pharosi | P26992, Tbio |
Genetic variation databases
BioMutai | CNTFR |
DMDMi | 1352099 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000010991 | 23 – 342 | Ciliary neurotrophic factor receptor subunit alphaAdd BLAST | 320 | |
PropeptideiPRO_0000010992 | 343 – 372 | Removed in mature formSequence analysisAdd BLAST | 30 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 46 ↔ 89 | PROSITE-ProRule annotation | ||
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 142 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 190 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 342 | GPI-anchor amidated serineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
EPDi | P26992 |
jPOSTi | P26992 |
MassIVEi | P26992 |
PaxDbi | P26992 |
PeptideAtlasi | P26992 |
PRIDEi | P26992 |
ProteomicsDBi | 54371 |
PTM databases
GlyGeni | P26992, 4 sites |
PhosphoSitePlusi | P26992 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000122756, Expressed in ventricular zone and 130 other tissues |
ExpressionAtlasi | P26992, baseline and differential |
Genevisiblei | P26992, HS |
Organism-specific databases
HPAi | ENSG00000122756, Tissue enhanced (brain, skeletal muscle) |
Interactioni
Subunit structurei
Forms a heterotrimer with LIFR and IL6ST.
Interacts with heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1 (PubMed:26858303). Either alone or in complex with the heterodimer CLCF1-CRLF1 interacts with SORL1; this interaction may promote internalization and lysosomal degradation (PubMed:26858303).
Component of a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR which interacts with the neuroprotective peptide humanin (PubMed:19386761).
2 PublicationsBinary interactionsi
P26992
With | #Exp. | IntAct |
---|---|---|
Cardiotrophin-like cytokine factor 1 (PRO_0000015616) | 3 | EBI-743758,EBI-25298664 |
CNTF [P26441] | 13 | EBI-743758,EBI-1050897 |
SORL1 [Q92673] | 7 | EBI-743758,EBI-1171329 |
GO - Molecular functioni
- cytokine binding Source: HGNC-UCL
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 107671, 16 interactors |
CORUMi | P26992 |
DIPi | DIP-5777N |
IntActi | P26992, 14 interactors |
MINTi | P26992 |
STRINGi | 9606.ENSP00000368265 |
Miscellaneous databases
RNActi | P26992, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P26992 |
BMRBi | P26992 |
SMRi | P26992 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P26992 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 104 | Ig-like C2-typeAdd BLAST | 78 | |
Domaini | 108 – 205 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 98 | |
Domaini | 206 – 306 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 101 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 301 – 340 | DisorderedSequence analysisAdd BLAST | 40 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 290 – 294 | WSXWS motif | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 312 – 330 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502QUDK, Eukaryota |
GeneTreei | ENSGT00940000158864 |
InParanoidi | P26992 |
OMAi | KICDTGE |
OrthoDBi | 741136at2759 |
PhylomeDBi | P26992 |
TreeFami | TF331210 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003530, Hematopoietin_rcpt_L_F3_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01354, HEMATOPO_REC_L_F3, 1 hit PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK
160 170 180 190 200
IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF
360 370
LVSVPITLAL AAAAATASSL LI
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5T8H6 | Q5T8H6_HUMAN | Ciliary neurotrophic factor recepto... | CNTFR | 256 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73238 mRNA Translation: AAA35707.1 L38025 , L38022, L38023, L38024 Genomic DNA Translation: AAA91337.1 BT019824 mRNA Translation: AAV38627.1 AL160270 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58445.1 CH471071 Genomic DNA Translation: EAW58446.1 CH471071 Genomic DNA Translation: EAW58447.1 CH471071 Genomic DNA Translation: EAW58448.1 BC001492 mRNA Translation: AAH01492.1 |
CCDSi | CCDS6558.1 |
PIRi | A40854, UHHUCN |
RefSeqi | NP_001193940.1, NM_001207011.1 NP_001833.1, NM_001842.4 NP_671693.1, NM_147164.2 XP_016869752.1, XM_017014263.1 XP_016869753.1, XM_017014264.1 XP_016869754.1, XM_017014265.1 |
Genome annotation databases
Ensembli | ENST00000351266.8; ENSP00000242338.4; ENSG00000122756.15 ENST00000378980.8; ENSP00000368265.3; ENSG00000122756.15 ENST00000610543.4; ENSP00000480451.1; ENSG00000122756.15 |
GeneIDi | 1271 |
KEGGi | hsa:1271 |
MANE-Selecti | ENST00000378980.8; ENSP00000368265.3; NM_147164.3; NP_671693.1 |
UCSCi | uc003zup.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M73238 mRNA Translation: AAA35707.1 L38025 , L38022, L38023, L38024 Genomic DNA Translation: AAA91337.1 BT019824 mRNA Translation: AAV38627.1 AL160270 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58445.1 CH471071 Genomic DNA Translation: EAW58446.1 CH471071 Genomic DNA Translation: EAW58447.1 CH471071 Genomic DNA Translation: EAW58448.1 BC001492 mRNA Translation: AAH01492.1 |
CCDSi | CCDS6558.1 |
PIRi | A40854, UHHUCN |
RefSeqi | NP_001193940.1, NM_001207011.1 NP_001833.1, NM_001842.4 NP_671693.1, NM_147164.2 XP_016869752.1, XM_017014263.1 XP_016869753.1, XM_017014264.1 XP_016869754.1, XM_017014265.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1UC6 | NMR | - | A | 202-305 | [»] | |
AlphaFoldDBi | P26992 | |||||
BMRBi | P26992 | |||||
SMRi | P26992 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107671, 16 interactors |
CORUMi | P26992 |
DIPi | DIP-5777N |
IntActi | P26992, 14 interactors |
MINTi | P26992 |
STRINGi | 9606.ENSP00000368265 |
PTM databases
GlyGeni | P26992, 4 sites |
PhosphoSitePlusi | P26992 |
Genetic variation databases
BioMutai | CNTFR |
DMDMi | 1352099 |
Proteomic databases
EPDi | P26992 |
jPOSTi | P26992 |
MassIVEi | P26992 |
PaxDbi | P26992 |
PeptideAtlasi | P26992 |
PRIDEi | P26992 |
ProteomicsDBi | 54371 |
Protocols and materials databases
Antibodypediai | 25488, 332 antibodies from 39 providers |
DNASUi | 1271 |
Genome annotation databases
Ensembli | ENST00000351266.8; ENSP00000242338.4; ENSG00000122756.15 ENST00000378980.8; ENSP00000368265.3; ENSG00000122756.15 ENST00000610543.4; ENSP00000480451.1; ENSG00000122756.15 |
GeneIDi | 1271 |
KEGGi | hsa:1271 |
MANE-Selecti | ENST00000378980.8; ENSP00000368265.3; NM_147164.3; NP_671693.1 |
UCSCi | uc003zup.2, human |
Organism-specific databases
CTDi | 1271 |
DisGeNETi | 1271 |
GeneCardsi | CNTFR |
HGNCi | HGNC:2170, CNTFR |
HPAi | ENSG00000122756, Tissue enhanced (brain, skeletal muscle) |
MIMi | 118946, gene |
neXtProti | NX_P26992 |
OpenTargetsi | ENSG00000122756 |
PharmGKBi | PA26684 |
VEuPathDBi | HostDB:ENSG00000122756 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUDK, Eukaryota |
GeneTreei | ENSGT00940000158864 |
InParanoidi | P26992 |
OMAi | KICDTGE |
OrthoDBi | 741136at2759 |
PhylomeDBi | P26992 |
TreeFami | TF331210 |
Enzyme and pathway databases
PathwayCommonsi | P26992 |
Reactomei | R-HSA-6788467, IL-6-type cytokine receptor ligand interactions |
SignaLinki | P26992 |
SIGNORi | P26992 |
Miscellaneous databases
BioGRID-ORCSi | 1271, 7 hits in 1061 CRISPR screens |
ChiTaRSi | CNTFR, human |
EvolutionaryTracei | P26992 |
GenomeRNAii | 1271 |
Pharosi | P26992, Tbio |
PROi | PR:P26992 |
RNActi | P26992, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122756, Expressed in ventricular zone and 130 other tissues |
ExpressionAtlasi | P26992, baseline and differential |
Genevisiblei | P26992, HS |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR003530, Hematopoietin_rcpt_L_F3_CS IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF00041, fn3, 1 hit |
SMARTi | View protein in SMART SM00060, FN3, 1 hit SM00409, IG, 1 hit SM00408, IGc2, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF49265, SSF49265, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS01354, HEMATOPO_REC_L_F3, 1 hit PS50835, IG_LIKE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CNTFR_HUMAN | |
Accessioni | P26992Primary (citable) accession number: P26992 Secondary accession number(s): Q5U050 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 195 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families