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Protein

Ciliary neurotrophic factor receptor subunit alpha

Gene

CNTFR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to CNTF. The alpha subunit provides the receptor specificity.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor activity Source: ProtInc
  • cytokine binding Source: HGNC
  • signaling receptor binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiP26992
SIGNORiP26992

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor receptor subunit alpha
Short name:
CNTF receptor subunit alpha
Short name:
CNTFR-alpha
Gene namesi
Name:CNTFR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000122756.14
HGNCiHGNC:2170 CNTFR
MIMi118946 gene
neXtProtiNX_P26992

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1271
OpenTargetsiENSG00000122756
PharmGKBiPA26684

Polymorphism and mutation databases

BioMutaiCNTFR
DMDMi1352099

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001099123 – 342Ciliary neurotrophic factor receptor subunit alphaAdd BLAST320
PropeptideiPRO_0000010992343 – 372Removed in mature formSequence analysisAdd BLAST30

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 89PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi342GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP26992
PaxDbiP26992
PeptideAtlasiP26992
PRIDEiP26992
ProteomicsDBi54371

Expressioni

Tissue specificityi

Nervous system and skeletal muscle.

Gene expression databases

BgeeiENSG00000122756
CleanExiHS_CNTFR
ExpressionAtlasiP26992 baseline and differential
GenevisibleiP26992 HS

Organism-specific databases

HPAiCAB025310

Interactioni

Subunit structurei

Heterotrimer of the alpha subunit, LIFR and IL6ST.

Binary interactionsi

WithEntry#Exp.IntActNotes
CNTFP2644112EBI-743758,EBI-1050897

GO - Molecular functioni

  • cytokine binding Source: HGNC
  • signaling receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107671, 8 interactors
CORUMiP26992
DIPiDIP-5777N
IntActiP26992, 10 interactors
MINTiP26992
STRINGi9606.ENSP00000242338

Structurei

Secondary structure

1372
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi208 – 214Combined sources7
Beta strandi222 – 227Combined sources6
Turni235 – 239Combined sources5
Beta strandi242 – 251Combined sources10
Beta strandi257 – 261Combined sources5
Beta strandi263 – 267Combined sources5
Beta strandi272 – 274Combined sources3
Beta strandi276 – 281Combined sources6
Beta strandi284 – 287Combined sources4
Beta strandi295 – 299Combined sources5

3D structure databases

ProteinModelPortaliP26992
SMRiP26992
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26992

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 104Ig-like C2-typeAdd BLAST78
Domaini108 – 205Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST98
Domaini206 – 306Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 294WSXWS motif5

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IH2U Eukaryota
ENOG4110HUW LUCA
GeneTreeiENSGT00530000063103
HOGENOMiHOG000171060
HOVERGENiHBG051048
InParanoidiP26992
KOiK05059
OMAiQETPHVQ
OrthoDBiEOG091G0B8P
PhylomeDBiP26992
TreeFamiTF331210

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003530 Hematopoietin_rcpt_L_F3_CS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01354 HEMATOPO_REC_L_F3, 1 hit
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26992-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN
60 70 80 90 100
WDAAVTWRVN GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ
110 120 130 140 150
VLLHVGLPPR EPVLSCRSNT YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK
160 170 180 190 200
IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS ISVSNALGHN ATAITFDEFT
210 220 230 240 250
IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL KFFLRYRPLI
260 270 280 290 300
LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT
310 320 330 340 350
PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF
360 370
LVSVPITLAL AAAAATASSL LI
Length:372
Mass (Da):40,633
Last modified:February 1, 1996 - v2
Checksum:iB2F3F73DE8F8750E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73238 mRNA Translation: AAA35707.1
L38025
, L38022, L38023, L38024 Genomic DNA Translation: AAA91337.1
BT019824 mRNA Translation: AAV38627.1
AL160270 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58445.1
CH471071 Genomic DNA Translation: EAW58446.1
CH471071 Genomic DNA Translation: EAW58447.1
CH471071 Genomic DNA Translation: EAW58448.1
BC001492 mRNA Translation: AAH01492.1
CCDSiCCDS6558.1
PIRiA40854 UHHUCN
RefSeqiNP_001193940.1, NM_001207011.1
NP_001833.1, NM_001842.4
NP_671693.1, NM_147164.2
XP_016869752.1, XM_017014263.1
XP_016869753.1, XM_017014264.1
XP_016869754.1, XM_017014265.1
UniGeneiHs.129966

Genome annotation databases

EnsembliENST00000351266; ENSP00000242338; ENSG00000122756
ENST00000378980; ENSP00000368265; ENSG00000122756
ENST00000610543; ENSP00000480451; ENSG00000122756
GeneIDi1271
KEGGihsa:1271
UCSCiuc003zup.2 human

Similar proteinsi

Entry informationi

Entry nameiCNTFR_HUMAN
AccessioniPrimary (citable) accession number: P26992
Secondary accession number(s): Q5U050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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