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Protein

Guanine nucleotide-binding protein alpha-1 subunit

Gene

GPA1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53MagnesiumBy similarity1
Metal bindingi194MagnesiumBy similarity1
Binding sitei356GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 53GTPBy similarity8
Nucleotide bindingi188 – 194GTPBy similarity7
Nucleotide bindingi219 – 223GTPBy similarity5
Nucleotide bindingi288 – 291GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransducer
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein alpha-1 subunit
Short name:
GP-alpha-1
Gene namesi
Name:GPA1
Synonyms:GA1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002036212 – 384Guanine nucleotide-binding protein alpha-1 subunitAdd BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Lipidationi5S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDbiP26981

Expressioni

Gene expression databases

ExpressionAtlasiP26981 baseline and differential

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4081.Solyc08g061220.2.1

Structurei

3D structure databases

ProteinModelPortaliP26981
SMRiP26981
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The helical domain (69-189) is required for self-activation.By similarity

Sequence similaritiesi

Belongs to the G-alpha family.Curated

Phylogenomic databases

eggNOGiKOG0082 Eukaryota
ENOG410XNVQ LUCA
InParanoidiP26981
KOiK19729

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
IPR002976 Plant_Gprotein_alpha
PANTHERiPTHR10218 PTHR10218, 1 hit
PTHR10218:SF224 PTHR10218:SF224, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR01242 GPROTEINAPLT
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26981-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSLCSRNKH YSQADDEENT QTAEIERRIE QETKAEKHIQ KLLLLGAGDS
60 70 80 90 100
GKSTIFKQIK LLFQTGFDEE ELKNYIPVIH ANVYQTTKIL HDGSKELAQN
110 120 130 140 150
ELEASKYLLS AENKEIGEKL SEIGGRLDYP HLTKDLVQDI EALWKDPAIQ
160 170 180 190 200
ETLLRGNELQ VPDCAHYFME NLERFSDVHY IPTKEDVLFA RIRTTGVVEI
210 220 230 240 250
QFSPVGENKK SGEVYRLFDV GGQRNERRKW IHLFEGVTAV IFCAAISEYD
260 270 280 290 300
QTLFEDERKN RMMETKELFE WVLKQPCFEK TSFMLFLNKF DIFEQKVPKV
310 320 330 340 350
PLNACEWFKD YQSVSTGKQE IEHAYEFVKK KFEESYFQCT APDRVDRVFK
360 370 380
IYRTTALDQK LVKKTFKLVD ETLRRRNLFE AGLL
Length:384
Mass (Da):44,903
Last modified:August 1, 1992 - v1
Checksum:i5C95ED74EFC01A0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74419 mRNA Translation: AAA34167.1
PIRiJH0514 RGTOOA
RefSeqiNP_001292984.1, NM_001306055.1
UniGeneiLes.3670

Genome annotation databases

GeneIDi543985
KEGGisly:543985

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74419 mRNA Translation: AAA34167.1
PIRiJH0514 RGTOOA
RefSeqiNP_001292984.1, NM_001306055.1
UniGeneiLes.3670

3D structure databases

ProteinModelPortaliP26981
SMRiP26981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc08g061220.2.1

Proteomic databases

PaxDbiP26981

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi543985
KEGGisly:543985

Phylogenomic databases

eggNOGiKOG0082 Eukaryota
ENOG410XNVQ LUCA
InParanoidiP26981
KOiK19729

Gene expression databases

ExpressionAtlasiP26981 baseline and differential

Family and domain databases

CDDicd00066 G-alpha, 1 hit
Gene3Di1.10.400.10, 1 hit
InterProiView protein in InterPro
IPR001019 Gprotein_alpha_su
IPR011025 GproteinA_insert
IPR027417 P-loop_NTPase
IPR002976 Plant_Gprotein_alpha
PANTHERiPTHR10218 PTHR10218, 1 hit
PTHR10218:SF224 PTHR10218:SF224, 1 hit
PfamiView protein in Pfam
PF00503 G-alpha, 1 hit
PRINTSiPR00318 GPROTEINA
PR01242 GPROTEINAPLT
SMARTiView protein in SMART
SM00275 G_alpha, 1 hit
SUPFAMiSSF47895 SSF47895, 1 hit
SSF52540 SSF52540, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPA1_SOLLC
AccessioniPrimary (citable) accession number: P26981
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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