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Protein

Cytokine receptor common subunit beta

Gene

Csf2rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • regulation of cell growth Source: MGI

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-5683826 Surfactant metabolism
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cytokine receptor common subunit beta
Alternative name(s):
GM-CSF/IL-3/IL-5 receptor common beta subunit
CD_antigen: CD131
Gene namesi
Name:Csf2rb
Synonyms:Aic2b, Csf2rb1, Il3rb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1339759 Csf2rb

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 441ExtracellularSequence analysisAdd BLAST419
Transmembranei442 – 463HelicalSequence analysisAdd BLAST22
Topological domaini464 – 896CytoplasmicSequence analysisAdd BLAST433

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001086323 – 896Cytokine receptor common subunit betaAdd BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 49By similarity
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 99By similarity
Disulfide bondi88 ↔ 94By similarity
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 263By similarity
Disulfide bondi292 ↔ 310By similarity
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei752PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei765PhosphotyrosineCombined sources1

Post-translational modificationi

May be phosphorylated by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP26955
PaxDbiP26955
PRIDEiP26955

PTM databases

iPTMnetiP26955
PhosphoSitePlusiP26955

Expressioni

Gene expression databases

BgeeiENSMUSG00000071713 Expressed in 148 organ(s), highest expression level in mesenteric lymph node
GenevisibleiP26955 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits. Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2 (By similarity). Interacts with FCER1G; this interaction is direct (PubMed:19098920). Interacts with LYN.By similarity2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi198932, 2 interactors
CORUMiP26955
DIPiDIP-46527N
IntActiP26955, 3 interactors
STRINGi10090.ENSMUSP00000094082

Structurei

3D structure databases

ProteinModelPortaliP26955
SMRiP26955
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 243Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST108
Domaini343 – 439Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi428 – 432WSXWS motif5
Motifi477 – 485Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGEX Eukaryota
ENOG4112BQP LUCA
GeneTreeiENSGT00510000048963
HOGENOMiHOG000113049
HOVERGENiHBG052113
InParanoidiP26955
KOiK04738
OMAiGFDFNGP
OrthoDBiEOG091G05K0
TreeFamiTF337996

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR011365 IL3_rcpt_beta
IPR015373 Interferon/interleukin_rcp_dom
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
PF09294 Interfer-bind, 1 hit
PIRSFiPIRSF001956 IL3R_beta_c, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01355 HEMATOPO_REC_S_F1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P26955-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQQMALTWG LCYMALVALC WGHGVTEAEE TVPLKTLQCY NDYTNHIICS
60 70 80 90 100
WADTEDAQGL INMTLYHQLE KKQPVSCELS EELMWSECPS SHRCVPRRCV
110 120 130 140 150
IPYTRFSITN EDYYSFRPDS DLGIQLMVPL AQNVQPPLPK NVSISSSEDR
160 170 180 190 200
FLLEWSVSLG DAQVSWLSSK DIEFEVAYKR LQDSWEDAYS LHTSKFQVNF
210 220 230 240 250
EPKLFLPNSI YAARVRTRLS PGSSLSGRPS RWSPEVHWDS QPGDKAQPQN
260 270 280 290 300
LQCFFDGIQS LHCSWEVWTQ TTGSVSFGLF YRPSPVAPEE KCSPVVKEPP
310 320 330 340 350
GASVYTRYHC SLPVPEPSAH SQYTVSVKHL EQGKFIMSYN HIQMEPPTLN
360 370 380 390 400
LTKNRDSYSL HWETQKMAYS FIEHTFQVQY KKKSDSWEDS KTENLDRAHS
410 420 430 440 450
MDLSQLEPDT SYCARVRVKP ISNYDGIWSK WSEEYTWKTD WVMPTLWIVL
460 470 480 490 500
ILVFLILTLL LILRFGCVSV YRTYRKWKEK IPNPSKSLLF QDGGKGLWPP
510 520 530 540 550
GSMAAFATKN PALQGPQSRL LAEQQGESYA HLEDNNVSPL TIEDPNIIRV
560 570 580 590 600
PPSGPDTTPA ASSESTEQLP NVQVEGPTPN RPRKQLPSFD FNGPYLGPPQ
610 620 630 640 650
SHSLPDLPDQ LGSPQVGGSL KPALPGSLEY MCLPPGGQAQ LVPLSQVMGQ
660 670 680 690 700
GQAMDVQCGS SLETSGSPSV EPKENPPVEL SMEEQEARDN PVTLPISSGG
710 720 730 740 750
PEGSMMASDY VTPGDPVLTL PTGPLSTSLG PSLGLPSAQS PSLCLKLPRV
760 770 780 790 800
PSGSPALGPP GFEDYVELPP SVSQAAKSPP GHPAPPVASS PTVIPGEPRE
810 820 830 840 850
EVGPASPHPE GLLVLQQVGD YCFLPGLGPG SLSPHSKPPS PSLCSETEDL
860 870 880 890
VQDLSVKKFP YQPMPQAPAI QFFKSLKHQD YLSLPPWDNS QSGKVC
Length:896
Mass (Da):99,036
Last modified:July 27, 2011 - v2
Checksum:i8E30ECB42C67F89A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK01A0A2R8VK01_MOUSE
Cytokine receptor common subunit be...
Csf2rb
541Annotation score:
A0A2R8VHF2A0A2R8VHF2_MOUSE
Cytokine receptor common subunit be...
Csf2rb
46Annotation score:
A0A338P6R9A0A338P6R9_MOUSE
Cytokine receptor common subunit be...
Csf2rb
66Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti82E → K in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti213A → P in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti220S → Y in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti236V → A in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti634P → A in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti639A → V in AAA37204 (PubMed:1695379).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34397 mRNA Translation: AAA37204.1
AK152608 mRNA Translation: BAE31354.1
CCDSiCCDS27612.1
PIRiA35782
RefSeqiNP_031806.3, NM_007780.4
XP_006520450.1, XM_006520387.3
UniGeneiMm.235324

Genome annotation databases

EnsembliENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713
ENSMUST00000230264; ENSMUSP00000154836; ENSMUSG00000071713
GeneIDi12983
KEGGimmu:12983
UCSCiuc007woz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34397 mRNA Translation: AAA37204.1
AK152608 mRNA Translation: BAE31354.1
CCDSiCCDS27612.1
PIRiA35782
RefSeqiNP_031806.3, NM_007780.4
XP_006520450.1, XM_006520387.3
UniGeneiMm.235324

3D structure databases

ProteinModelPortaliP26955
SMRiP26955
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198932, 2 interactors
CORUMiP26955
DIPiDIP-46527N
IntActiP26955, 3 interactors
STRINGi10090.ENSMUSP00000094082

PTM databases

iPTMnetiP26955
PhosphoSitePlusiP26955

Proteomic databases

MaxQBiP26955
PaxDbiP26955
PRIDEiP26955

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713
ENSMUST00000230264; ENSMUSP00000154836; ENSMUSG00000071713
GeneIDi12983
KEGGimmu:12983
UCSCiuc007woz.2 mouse

Organism-specific databases

CTDi1439
MGIiMGI:1339759 Csf2rb

Phylogenomic databases

eggNOGiENOG410IGEX Eukaryota
ENOG4112BQP LUCA
GeneTreeiENSGT00510000048963
HOGENOMiHOG000113049
HOVERGENiHBG052113
InParanoidiP26955
KOiK04738
OMAiGFDFNGP
OrthoDBiEOG091G05K0
TreeFamiTF337996

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-5683826 Surfactant metabolism
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

PROiPR:P26955
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071713 Expressed in 148 organ(s), highest expression level in mesenteric lymph node
GenevisibleiP26955 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR011365 IL3_rcpt_beta
IPR015373 Interferon/interleukin_rcp_dom
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
PF09294 Interfer-bind, 1 hit
PIRSFiPIRSF001956 IL3R_beta_c, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01355 HEMATOPO_REC_S_F1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL3RB_MOUSE
AccessioniPrimary (citable) accession number: P26955
Secondary accession number(s): Q3U7L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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