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Entry version 171 (22 Apr 2020)
Sequence version 2 (27 Jul 2011)
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Protein

Cytokine receptor common subunit beta

Gene

Csf2rb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-5683826 Surfactant metabolism
R-MMU-912526 Interleukin receptor SHC signaling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytokine receptor common subunit beta
Alternative name(s):
GM-CSF/IL-3/IL-5 receptor common beta subunit
CD_antigen: CD131
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Csf2rb
Synonyms:Aic2b, Csf2rb1, Il3rb1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1339759 Csf2rb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 441ExtracellularSequence analysisAdd BLAST419
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei442 – 463HelicalSequence analysisAdd BLAST22
Topological domaini464 – 896CytoplasmicSequence analysisAdd BLAST433

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001086323 – 896Cytokine receptor common subunit betaAdd BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 49By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 99By similarity
Disulfide bondi88 ↔ 94By similarity
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 263By similarity
Disulfide bondi292 ↔ 310By similarity
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei752PhosphoserineCombined sources1
Modified residuei754PhosphoserineCombined sources1
Modified residuei765PhosphotyrosineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

May be phosphorylated by LYN.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P26955

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26955

PRoteomics IDEntifications database

More...
PRIDEi
P26955

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26955

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26955

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071713 Expressed in mesenteric lymph node and 147 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P26955 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26955 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit. The beta subunit is common to the IL3, IL5 and GM-CSF receptors. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits.

Interacts with TMEM102; this interaction occurs preferentially in the absence of CSF2 (By similarity).

Interacts with FCER1G; this interaction is direct (PubMed:19098920).

Interacts with LYN.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198932, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P26955

Database of interacting proteins

More...
DIPi
DIP-46527N

Protein interaction database and analysis system

More...
IntActi
P26955, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000094082

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P26955 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26955

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini136 – 243Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST108
Domaini343 – 439Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi428 – 432WSXWS motif5
Motifi477 – 485Box 1 motif9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGEX Eukaryota
ENOG4112BQP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000048963

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015884_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26955

KEGG Orthology (KO)

More...
KOi
K04738

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFDFNGP

Database of Orthologous Groups

More...
OrthoDBi
263501at2759

TreeFam database of animal gene trees

More...
TreeFami
TF337996

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR011365 IL3_rcpt_beta
IPR015373 Interferon/interleukin_rcp_dom
IPR015321 TypeI_recpt_CBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09240 IL6Ra-bind, 1 hit
PF09294 Interfer-bind, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001956 IL3R_beta_c, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 2 hits
PS01355 HEMATOPO_REC_S_F1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P26955-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQQMALTWG LCYMALVALC WGHGVTEAEE TVPLKTLQCY NDYTNHIICS
60 70 80 90 100
WADTEDAQGL INMTLYHQLE KKQPVSCELS EELMWSECPS SHRCVPRRCV
110 120 130 140 150
IPYTRFSITN EDYYSFRPDS DLGIQLMVPL AQNVQPPLPK NVSISSSEDR
160 170 180 190 200
FLLEWSVSLG DAQVSWLSSK DIEFEVAYKR LQDSWEDAYS LHTSKFQVNF
210 220 230 240 250
EPKLFLPNSI YAARVRTRLS PGSSLSGRPS RWSPEVHWDS QPGDKAQPQN
260 270 280 290 300
LQCFFDGIQS LHCSWEVWTQ TTGSVSFGLF YRPSPVAPEE KCSPVVKEPP
310 320 330 340 350
GASVYTRYHC SLPVPEPSAH SQYTVSVKHL EQGKFIMSYN HIQMEPPTLN
360 370 380 390 400
LTKNRDSYSL HWETQKMAYS FIEHTFQVQY KKKSDSWEDS KTENLDRAHS
410 420 430 440 450
MDLSQLEPDT SYCARVRVKP ISNYDGIWSK WSEEYTWKTD WVMPTLWIVL
460 470 480 490 500
ILVFLILTLL LILRFGCVSV YRTYRKWKEK IPNPSKSLLF QDGGKGLWPP
510 520 530 540 550
GSMAAFATKN PALQGPQSRL LAEQQGESYA HLEDNNVSPL TIEDPNIIRV
560 570 580 590 600
PPSGPDTTPA ASSESTEQLP NVQVEGPTPN RPRKQLPSFD FNGPYLGPPQ
610 620 630 640 650
SHSLPDLPDQ LGSPQVGGSL KPALPGSLEY MCLPPGGQAQ LVPLSQVMGQ
660 670 680 690 700
GQAMDVQCGS SLETSGSPSV EPKENPPVEL SMEEQEARDN PVTLPISSGG
710 720 730 740 750
PEGSMMASDY VTPGDPVLTL PTGPLSTSLG PSLGLPSAQS PSLCLKLPRV
760 770 780 790 800
PSGSPALGPP GFEDYVELPP SVSQAAKSPP GHPAPPVASS PTVIPGEPRE
810 820 830 840 850
EVGPASPHPE GLLVLQQVGD YCFLPGLGPG SLSPHSKPPS PSLCSETEDL
860 870 880 890
VQDLSVKKFP YQPMPQAPAI QFFKSLKHQD YLSLPPWDNS QSGKVC
Length:896
Mass (Da):99,036
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8E30ECB42C67F89A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8VK01A0A2R8VK01_MOUSE
Cytokine receptor common subunit be...
Csf2rb
541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VHF2A0A2R8VHF2_MOUSE
Cytokine receptor common subunit be...
Csf2rb
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A338P6R9A0A338P6R9_MOUSE
Cytokine receptor common subunit be...
Csf2rb
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82E → K in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti213A → P in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti220S → Y in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti236V → A in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti634P → A in AAA37204 (PubMed:1695379).Curated1
Sequence conflicti639A → V in AAA37204 (PubMed:1695379).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M34397 mRNA Translation: AAA37204.1
AK152608 mRNA Translation: BAE31354.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27612.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A35782

NCBI Reference Sequences

More...
RefSeqi
NP_031806.3, NM_007780.4
XP_006520450.1, XM_006520387.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713
ENSMUST00000230264; ENSMUSP00000154836; ENSMUSG00000071713

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12983

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12983

UCSC genome browser

More...
UCSCi
uc007woz.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34397 mRNA Translation: AAA37204.1
AK152608 mRNA Translation: BAE31354.1
CCDSiCCDS27612.1
PIRiA35782
RefSeqiNP_031806.3, NM_007780.4
XP_006520450.1, XM_006520387.3

3D structure databases

SMRiP26955
ModBaseiSearch...

Protein-protein interaction databases

BioGridi198932, 2 interactors
CORUMiP26955
DIPiDIP-46527N
IntActiP26955, 3 interactors
STRINGi10090.ENSMUSP00000094082

PTM databases

iPTMnetiP26955
PhosphoSitePlusiP26955

Proteomic databases

MaxQBiP26955
PaxDbiP26955
PRIDEiP26955

Genome annotation databases

EnsembliENSMUST00000096355; ENSMUSP00000094082; ENSMUSG00000071713
ENSMUST00000230264; ENSMUSP00000154836; ENSMUSG00000071713
GeneIDi12983
KEGGimmu:12983
UCSCiuc007woz.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1439
MGIiMGI:1339759 Csf2rb

Phylogenomic databases

eggNOGiENOG410IGEX Eukaryota
ENOG4112BQP LUCA
GeneTreeiENSGT00510000048963
HOGENOMiCLU_015884_0_0_1
InParanoidiP26955
KOiK04738
OMAiGFDFNGP
OrthoDBi263501at2759
TreeFamiTF337996

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-5683826 Surfactant metabolism
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

Protein Ontology

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PROi
PR:P26955
RNActiP26955 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000071713 Expressed in mesenteric lymph node and 147 other tissues
ExpressionAtlasiP26955 baseline and differential
GenevisibleiP26955 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR003531 Hempt_rcpt_S_F1_CS
IPR013783 Ig-like_fold
IPR011365 IL3_rcpt_beta
IPR015373 Interferon/interleukin_rcp_dom
IPR015321 TypeI_recpt_CBD
PfamiView protein in Pfam
PF09240 IL6Ra-bind, 1 hit
PF09294 Interfer-bind, 1 hit
PIRSFiPIRSF001956 IL3R_beta_c, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS01355 HEMATOPO_REC_S_F1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL3RB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26955
Secondary accession number(s): Q3U7L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: April 22, 2020
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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