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Entry version 131 (08 May 2019)
Sequence version 2 (16 Nov 2001)
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Protein

F1 capsule-anchoring protein

Gene

caf1A

Organism
Yersinia pestis
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A probable role in capsular biogenesis. It is likely that the caf1A molecule binds F1 antigen subunits during the extracellular secretion process.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • fimbrial usher porin activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.B.11.3.8 the outer membrane fimbrial usher porin (fup) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
F1 capsule-anchoring protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:caf1A
Ordered Locus Names:YPMT1.83, Y1099, YP_pMT083
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlasmid pMT1 (pMT-1)4 Publications
Plasmid pFra1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiYersinia pestis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri632 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesYersiniaceaeYersinia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000815 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Plasmid pMT1 (pMT-1)
  • UP000001019 Componenti: Plasmid pMT1
  • UP000002490 Componenti: Plasmid pMT-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000930026 – 833F1 capsule-anchoring proteinAdd BLAST808

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi807 ↔ 829Sequence analysis

Keywords - PTMi

Disulfide bond

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P26949

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59979N

Protein interaction database and analysis system

More...
IntActi
P26949, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1833
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XETX-ray1.60A/B745-833[»]
3FCGX-ray2.85A/B253-341[»]
4B0EX-ray2.00A/B/C/D23-158[»]
4B0MX-ray1.80A23-158[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26949

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26949

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fimbrial export usher family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108D1K Bacteria
COG3188 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000261382

KEGG Orthology (KO)

More...
KOi
K07347

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000015 Fimb_usher
IPR018030 Fimbrial_membr_usher_CS
IPR025949 PapC-like_C
IPR025885 PapC_N
IPR037224 PapC_N_sf

The PANTHER Classification System

More...
PANTHERi
PTHR30451 PTHR30451, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13953 PapC_C, 1 hit
PF13954 PapC_N, 1 hit
PF00577 Usher, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141729 SSF141729, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01151 FIMBRIAL_USHER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P26949-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRYSKLFLCA GLTLATLPCW GRAYTFDSTM LDTNSGESID VSLFNQGLQL
60 70 80 90 100
PGNYFVNVFV NGRKVDSGNI DFRLEKHNGK ELLWPCLSSL QLTKYGIDID
110 120 130 140 150
KYPDLIKSGT EQCVDLLAIP HSDVQFYFNQ QKLSLIVPPQ ALLPRFDGIM
160 170 180 190 200
PMQLWDDGIP ALFMNYNTNM QTRKFREGGK SLDSYYAQLQ PGLNIGAWRF
210 220 230 240 250
RSSTSWWKQQ GWQRSYIYAE RGLNTIKSRL TLGETYSDSS IFDSIPIKGI
260 270 280 290 300
KIASDESMVP YYQWNFAPVV RGIARTQARV EVLRDGYTVS NELVPSGPFE
310 320 330 340 350
LANLPLGGGS GELKVIIHES DGTKQVFTVP YDTPAVALRK GYFEYSMMGG
360 370 380 390 400
EYRPANDLTQ TSYVGALGMK YGLPRNLTLY GGLQGSQNYH AAALGIGAML
410 420 430 440 450
GDFGAISTDV TQADSQKNKQ KKESGQRWRV RYNKYLQSGT SLNIASEEYA
460 470 480 490 500
TEGFNKLADT LNTYCKPNTR NDCRFDYAKP KNKVQFNLSQ SIPGSGTLNF
510 520 530 540 550
SGYRKNYWRD SRSTTSFSVG YNHFFRNGMS LTLNLSKTQN INKYGEKTSE
560 570 580 590 600
LLSNIWLSFP LSRWLGNNSI NSNYQMTSDS HGNTTHEVGV YGEAFDRQLY
610 620 630 640 650
WDVRERFNEK GRKYTSNALN LNYRGTYGEI SGNYSYDQTQ SQLGIGVNGN
660 670 680 690 700
MVITQYGITA GQKTGDTIAL VQAPDISGAS VGYWPGMKTD FRGYTNYGYL
710 720 730 740 750
TPYRENKVEI NPVTLPNDAE ITNNIVSVIP TKGAVVLAKF NARIGGRLFL
760 770 780 790 800
HLKRSDNKPV PFGSIVTIEG QSSSSGIVGD NSGVYLTGLP KKSKILVKWG
810 820 830
RDKNQSCSSN VVLPEKTDIS GAYRLSTTCI LNN
Length:833
Mass (Da):93,003
Last modified:November 16, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i48F409F4E28F37BE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366 – 367AL → VF in CAA43968 (PubMed:1551441).Curated2
Sequence conflicti377L → F in CAA43968 (PubMed:1551441).Curated1
Sequence conflicti392A → E in CAA43968 (PubMed:1551441).Curated1
Sequence conflicti706N → Y in CAA43968 (PubMed:1551441).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X61996 Genomic DNA Translation: CAA43968.1
AF074611 Genomic DNA Translation: AAC82757.1
AF053947 Genomic DNA Translation: AAC13219.1
AL117211 Genomic DNA Translation: CAB55265.1
AE017045 Genomic DNA Translation: AAS58715.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S20387
T14703

NCBI Reference Sequences

More...
RefSeqi
NP_395429.1, NC_003134.1
NP_857693.1, NC_004835.1
WP_002211763.1, NZ_UHIZ01000001.1
YP_093953.1, NC_006323.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC82757; AAC82757; AAC82757
AAS58715; AAS58715; YP_pMT083

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1149093
1172838
3077339

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ype:YPMT1.83
ypk:caf1A.pl
ypm:YP_pMT083

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|214092.21.peg.211

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61996 Genomic DNA Translation: CAA43968.1
AF074611 Genomic DNA Translation: AAC82757.1
AF053947 Genomic DNA Translation: AAC13219.1
AL117211 Genomic DNA Translation: CAB55265.1
AE017045 Genomic DNA Translation: AAS58715.1
PIRiS20387
T14703
RefSeqiNP_395429.1, NC_003134.1
NP_857693.1, NC_004835.1
WP_002211763.1, NZ_UHIZ01000001.1
YP_093953.1, NC_006323.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XETX-ray1.60A/B745-833[»]
3FCGX-ray2.85A/B253-341[»]
4B0EX-ray2.00A/B/C/D23-158[»]
4B0MX-ray1.80A23-158[»]
SMRiP26949
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59979N
IntActiP26949, 1 interactor

Protein family/group databases

TCDBi1.B.11.3.8 the outer membrane fimbrial usher porin (fup) family

Proteomic databases

PRIDEiP26949

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1149243
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC82757; AAC82757; AAC82757
AAS58715; AAS58715; YP_pMT083
GeneIDi1149093
1172838
3077339
KEGGiype:YPMT1.83
ypk:caf1A.pl
ypm:YP_pMT083
PATRICifig|214092.21.peg.211

Phylogenomic databases

eggNOGiENOG4108D1K Bacteria
COG3188 LUCA
HOGENOMiHOG000261382
KOiK07347

Miscellaneous databases

EvolutionaryTraceiP26949

Family and domain databases

InterProiView protein in InterPro
IPR000015 Fimb_usher
IPR018030 Fimbrial_membr_usher_CS
IPR025949 PapC-like_C
IPR025885 PapC_N
IPR037224 PapC_N_sf
PANTHERiPTHR30451 PTHR30451, 1 hit
PfamiView protein in Pfam
PF13953 PapC_C, 1 hit
PF13954 PapC_N, 1 hit
PF00577 Usher, 1 hit
SUPFAMiSSF141729 SSF141729, 1 hit
PROSITEiView protein in PROSITE
PS01151 FIMBRIAL_USHER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAF1A_YERPE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26949
Secondary accession number(s): O68773
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 16, 2001
Last modified: May 8, 2019
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Plasmid, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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