UniProtKB - P26927 (HGFL_HUMAN)

BLAST

>sp|P26927|HGFL_HUMAN Hepatocyte growth factor-like protein OS=Homo sapiens OX=9606 GN=MST1 PE=1 SV=2
MGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRC
GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRG
TMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGGPWCYTTDPAVRFQS
CGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYC
RNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTA
GVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRR
CTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCR
NPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRS
KLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGT
LFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYVVPPGT
KCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVGACEGD
YGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMRLG

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History
Entry version 185 (07 Nov 2018)
Sequence version 2 (15 May 2007)
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Protein

Hepatocyte growth factor-like protein

Gene

MST1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Caution

Although related to peptidase S1 family, the active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack protease activity.Curated

GO - Molecular functionⁱ

receptor tyrosine kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22087277
serine-type endopeptidase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hepatocyte growth factor receptor signaling pathway Source: Reactome
negative regulation of gluconeogenesis
Source: UniProtKB
Inferred from direct assayⁱ
- 19720831
positive regulation of mammary gland epithelial cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cAMP-dependent protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19720831
regulation of macrophage chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Serine protease homolog

Molecular function

Serine protease homolog

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8852405 Signaling by MST1
SignaLinkⁱ	P26927
SIGNORⁱ	P26927

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	S01.975

MEROPSⁱ

S01.975

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte growth factor-like protein Alternative name(s): Macrophage stimulatory protein Macrophage-stimulating protein Short name: MSP Cleaved into the following 2 chains: Hepatocyte growth factor-like protein alpha chain Hepatocyte growth factor-like protein beta chain
Gene namesⁱ	Name:MST1 Synonyms:D3F15S2, DNF15S2, HGFL
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7380 MST1
MIMⁱ	142408 gene
neXtProtⁱ	NX_P26927

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD.2 Publications

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4485
MalaCards human disease database More...MalaCardsⁱ	MST1
Orphanetⁱ	171 Primary sclerosing cholangitis
PharmGKBⁱ	PA31185

Chemistry databases

ChEMBLⁱ	CHEMBL6042

ChEMBLⁱ

CHEMBL6042

Polymorphism and mutation databases

BioMutaⁱ	MST1
DMDMⁱ	147744563

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST	18
ChainⁱPRO_0000028085	19 – 711	Hepatocyte growth factor-like proteinAdd BLAST	693
ChainⁱPRO_0000028086	19 – 483	Hepatocyte growth factor-like protein alpha chainCuratedAdd BLAST	465
ChainⁱPRO_0000028087	484 – 711	Hepatocyte growth factor-like protein beta chainCuratedAdd BLAST	228

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	56 ↔ 78	By similarity
Disulfide bondⁱ	60 ↔ 66	By similarity
Glycosylationⁱ	72	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	110 ↔ 186	By similarity
Disulfide bondⁱ	131 ↔ 169	By similarity
Disulfide bondⁱ	157 ↔ 181	By similarity
Disulfide bondⁱ	191 ↔ 268	By similarity
Disulfide bondⁱ	194 ↔ 324	By similarity
Disulfide bondⁱ	212 ↔ 251	By similarity
Disulfide bondⁱ	240 ↔ 263	By similarity
Disulfide bondⁱ	283 ↔ 361	By similarity
Glycosylationⁱ	296	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	304 ↔ 343	By similarity
Disulfide bondⁱ	332 ↔ 355	By similarity
Disulfide bondⁱ	370 ↔ 448	By similarity
Disulfide bondⁱ	391 ↔ 431	By similarity
Disulfide bondⁱ	419 ↔ 443	By similarity
Disulfide bondⁱ	468 ↔ 588	Interchain (between alpha and beta chains)
Disulfide bondⁱ	507 ↔ 523	By similarity
Disulfide bondⁱ	602 ↔ 667	By similarity
Glycosylationⁱ	615	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	632 ↔ 646	By similarity
Disulfide bondⁱ	657 ↔ 685	By similarity

Post-translational modificationⁱ

Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P26927
PaxDbⁱ	P26927
PeptideAtlas More...PeptideAtlasⁱ	P26927
PRIDEⁱ	P26927
ProteomicsDBⁱ	54368

PTM databases

GlyConnectⁱ	1310
iPTMnetⁱ	P26927
PhosphoSitePlusⁱ	P26927

Miscellaneous databases

PMAP-CutDBⁱ	P26927

PMAP-CutDBⁱ

P26927

Expressionⁱ

Gene expression databases

CleanExⁱ	HS_MST1

CleanExⁱ

HS_MST1

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA024036

HPAⁱ

HPA024036

Interactionⁱ

Subunit structureⁱ

Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts (via beta chain) with MST1R (via SEMA domain).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MST1R	Q04912	5	EBI-6929133,EBI-2637518
STK11	Q15831	2	EBI-6929133,EBI-306838

GO - Molecular functionⁱ

receptor tyrosine kinase binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22087277

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110591, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-6028N
IntActⁱ	P26927, 8 interactors
Molecular INTeraction database More...MINTⁱ	P26927
STRINGⁱ	9606.ENSP00000414287

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	475 – 479	Combined sources	5
Beta strandⁱ	495 – 499	Combined sources	5
Beta strandⁱ	505 – 513	Combined sources	9
Beta strandⁱ	516 – 520	Combined sources	5
Helixⁱ	521 – 523	Combined sources	3
Beta strandⁱ	535 – 539	Combined sources	5
Beta strandⁱ	541 – 544	Combined sources	4
Beta strandⁱ	553 – 562	Combined sources	10
Beta strandⁱ	569 – 576	Combined sources	8
Beta strandⁱ	581 – 584	Combined sources	4
Beta strandⁱ	601 – 608	Combined sources	8
Beta strandⁱ	620 – 627	Combined sources	8
Helixⁱ	629 – 635	Combined sources	7
Turnⁱ	636 – 638	Combined sources	3
Beta strandⁱ	644 – 647	Combined sources	4
Beta strandⁱ	651 – 653	Combined sources	3
Beta strandⁱ	664 – 669	Combined sources	6
Beta strandⁱ	672 – 679	Combined sources	8
Beta strandⁱ	683 – 686	Combined sources	4
Beta strandⁱ	692 – 696	Combined sources	5
Helixⁱ	697 – 699	Combined sources	3
Helixⁱ	701 – 707	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P26927
SMRⁱ	P26927
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P26927

EvolutionaryTraceⁱ

P26927

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	21 – 105	PANPROSITE-ProRule annotationAdd BLAST	85
Domainⁱ	110 – 186	Kringle 1PROSITE-ProRule annotationAdd BLAST	77
Domainⁱ	191 – 268	Kringle 2PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	283 – 361	Kringle 3PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	370 – 448	Kringle 4PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	484 – 709	Peptidase S1PROSITE-ProRule annotationAdd BLAST	226

Sequence similaritiesⁱ

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Kringle, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IDXR Eukaryota COG5640 LUCA
HOGENOMⁱ	HOG000112892
HOVERGENⁱ	HBG004381
InParanoidⁱ	P26927
PhylomeDBⁱ	P26927

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00108 KR, 4 hits cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR024174 HGF-like IPR000001 Kringle IPR013806 Kringle-like IPR018056 Kringle_CS IPR038178 Kringle_sf IPR003609 Pan_app IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00051 Kringle, 4 hits PF00024 PAN_1, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001152 HGF_MST1, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130 KR, 4 hits SM00473 PAN_AP, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57440 SSF57440, 4 hits
PROSITEⁱ	View protein in PROSITE PS00021 KRINGLE_1, 4 hits PS50070 KRINGLE_2, 4 hits PS50948 PAN, 1 hit PS50240 TRYPSIN_DOM, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P26927-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MGWLPLLLLL TQCLGVPGQR SPLNDFQVLR GTELQHLLHA VVPGPWQEDV 
        60         70         80         90        100
ADAEECAGRC GPLMDCRAFH YNVSSHGCQL LPWTQHSPHT RLRRSGRCDL 
       110        120        130        140        150
FQKKDYVRTC IMNNGVGYRG TMATTVGGLP CQAWSHKFPN DHKYTPTLRN 
       160        170        180        190        200
GLEENFCRNP DGDPGGPWCY TTDPAVRFQS CGIKSCREAA CVWCNGEEYR 
       210        220        230        240        250
GAVDRTESGR ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC RNPDGSERPW 
       260        270        280        290        300
CYTTDPQIER EFCDLPRCGS EAQPRQEATT VSCFRGKGEG YRGTANTTTA 
       310        320        330        340        350
GVPCQRWDAQ IPHQHRFTPE KYACKDLREN FCRNPDGSEA PWCFTLRPGM 
       360        370        380        390        400
RAAFCYQIRR CTDDVRPQDC YHGAGEQYRG TVSKTRKGVQ CQRWSAETPH 
       410        420        430        440        450
KPQFTFTSEP HAQLEENFCR NPDGDSHGPW CYTMDPRTPF DYCALRRCAD 
       460        470        480        490        500
DQPPSILDPP DQVQFEKCGK RVDRLDQRRS KLRVVGGHPG NSPWTVSLRN 
       510        520        530        540        550
RQGQHFCGGS LVKEQWILTA RQCFSSCHMP LTGYEVWLGT LFQNPQHGEP 
       560        570        580        590        600
SLQRVPVAKM VCGPSGSQLV LLKLERSVTL NQRVALICLP PEWYVVPPGT 
       610        620        630        640        650
KCEIAGWGET KGTGNDTVLN VALLNVISNQ ECNIKHRGRV RESEMCTEGL 
       660        670        680        690        700
LAPVGACEGD YGGPLACFTH NCWVLEGIII PNRVCARSRW PAVFTRVSVF 
       710 
VDWIHKVMRL G

Length:711

Mass (Da):80,320

Last modified:May 15, 2007 - v2

Checksum:ⁱ2E4B3C7D4AA9B566

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

G3XAK1	G3XAK1_HUMAN	Hepatocyte growth factor-like prote... Hepatocyte growth factor-like protein (Macrophage stimulating 1 (Hepatocyte growth factor-like), isoform CRA_b)	MST1 hCG_2001992	725	Annotation score:
H7C0F8	H7C0F8_HUMAN	Hepatocyte growth factor-like prote... Hepatocyte growth factor-like protein	MST1	195	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	292	R → G AA sequence (PubMed:1827141).Curated	1
Sequence conflictⁱ	304	C → E AA sequence (PubMed:1827141).Curated	1
Sequence conflictⁱ	306	R → E AA sequence (PubMed:1827141).Curated	1
Sequence conflictⁱ	550	Missing AA sequence (PubMed:1827141).Curated	1
Sequence conflictⁱ	593	W → E AA sequence (PubMed:1827141).Curated	1
Sequence conflictⁱ	623	L → F in AAA59872 (PubMed:8393443).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_006631	13	C → Y1 Publication	1
Natural variantⁱVAR_006632	212	C → F.	1
Natural variantⁱVAR_059787	551	S → G. Corresponds to variant dbSNP:rs6791037Ensembl.	1
Natural variantⁱVAR_070224	689	R → C Common polymorphism; may be associated with inflammatory bowel disease; results in reduced binding affinity to MST1R. 3 PublicationsCorresponds to variant dbSNP:rs3197999Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74178 mRNA Translation: AAA50165.1 U37055 Genomic DNA Translation: AAC50471.1 L11924 mRNA Translation: AAA59872.1 AC099668 Genomic DNA No translation available. BC048330 mRNA Translation: AAH48330.1
PIRⁱ	A40331 A47136
NCBI Reference Sequences More...RefSeqⁱ	NP_066278.3, NM_020998.3
UniGeneⁱ	Hs.349110 Hs.512587

Genome annotation databases

Ensemblⁱ	ENST00000383728; ENSP00000373234; ENSG00000173531
GeneIDⁱ	4485
KEGGⁱ	hsa:4485

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P26927	Hepatocyte growth factor-like protein		HUMAN		725	UniRef100_P26927
UPI0005D0163A		HUMAN		515

Protein	Similar proteins		Species	Score	Length	Source
P26927	Hepatocyte growth factor-like protein		HUMAN		725	UniRef90_P26927
MST1 isoform 3		PANTR		725
Macrophage stimulating 1		SAIBB		725
Uncharacterized protein		PROCO		725
Uncharacterized protein		CALJA		725
+42

Protein	Similar proteins		Species	Score	Length	Source
P26927	Hepatocyte growth factor-like protein		BOVIN		712	UniRef50_P26927
Putative macrophage stimulating 1-like protein		HUMAN		715
Hepatocyte growth factor-like protein		MOUSE		716
Uncharacterized protein		CHLSB		725
MST1 isoform 3		PANTR		725
+399

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M74178 mRNA Translation: AAA50165.1 U37055 Genomic DNA Translation: AAC50471.1 L11924 mRNA Translation: AAA59872.1 AC099668 Genomic DNA No translation available. BC048330 mRNA Translation: AAH48330.1
PIRⁱ	A40331 A47136
RefSeqⁱ	NP_066278.3, NM_020998.3
UniGeneⁱ	Hs.349110 Hs.512587

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2ASU	X-ray	1.85	A	465-483	[»]
				B	484-711	[»]
	4QT8	X-ray	3.00	C/D	465-711	[»]
ProteinModelPortalⁱ	P26927
SMRⁱ	P26927
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110591, 6 interactors
DIPⁱ	DIP-6028N
IntActⁱ	P26927, 8 interactors
MINTⁱ	P26927
STRINGⁱ	9606.ENSP00000414287

Chemistry databases

ChEMBLⁱ	CHEMBL6042

ChEMBLⁱ

CHEMBL6042

Protein family/group databases

MEROPSⁱ	S01.975

MEROPSⁱ

S01.975

PTM databases

GlyConnectⁱ	1310
iPTMnetⁱ	P26927
PhosphoSitePlusⁱ	P26927

Polymorphism and mutation databases

BioMutaⁱ	MST1
DMDMⁱ	147744563

Proteomic databases

MaxQBⁱ	P26927
PaxDbⁱ	P26927
PeptideAtlasⁱ	P26927
PRIDEⁱ	P26927
ProteomicsDBⁱ	54368

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000383728; ENSP00000373234; ENSG00000173531
GeneIDⁱ	4485
KEGGⁱ	hsa:4485

Organism-specific databases

CTDⁱ	4485
DisGeNETⁱ	4485
GeneCardsⁱ	MST1
H-InvDBⁱ	HIX0024339
HGNCⁱ	HGNC:7380 MST1
HPAⁱ	HPA024036
MalaCardsⁱ	MST1
MIMⁱ	142408 gene
neXtProtⁱ	NX_P26927
Orphanetⁱ	171 Primary sclerosing cholangitis
PharmGKBⁱ	PA31185
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IDXR Eukaryota COG5640 LUCA
HOGENOMⁱ	HOG000112892
HOVERGENⁱ	HBG004381
InParanoidⁱ	P26927
PhylomeDBⁱ	P26927

Enzyme and pathway databases

Reactomeⁱ	R-HSA-8852405 Signaling by MST1
SignaLinkⁱ	P26927
SIGNORⁱ	P26927

Miscellaneous databases

ChiTaRSⁱ	MST1 human
EvolutionaryTraceⁱ	P26927
GeneWikiⁱ	MST1
GenomeRNAiⁱ	4485
PMAP-CutDBⁱ	P26927
Protein Ontology More...PROⁱ	PR:P26927
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	HS_MST1

CleanExⁱ

HS_MST1

Family and domain databases

CDDⁱ	cd00108 KR, 4 hits cd00190 Tryp_SPc, 1 hit
Gene3Dⁱ	2.40.20.10, 4 hits
InterProⁱ	View protein in InterPro IPR024174 HGF-like IPR000001 Kringle IPR013806 Kringle-like IPR018056 Kringle_CS IPR038178 Kringle_sf IPR003609 Pan_app IPR009003 Peptidase_S1_PA IPR001314 Peptidase_S1A IPR001254 Trypsin_dom
Pfamⁱ	View protein in Pfam PF00051 Kringle, 4 hits PF00024 PAN_1, 1 hit PF00089 Trypsin, 1 hit
PIRSFⁱ	PIRSF001152 HGF_MST1, 1 hit
PRINTSⁱ	PR00722 CHYMOTRYPSIN
SMARTⁱ	View protein in SMART SM00130 KR, 4 hits SM00473 PAN_AP, 1 hit SM00020 Tryp_SPc, 1 hit
SUPFAMⁱ	SSF50494 SSF50494, 1 hit SSF57440 SSF57440, 4 hits
PROSITEⁱ	View protein in PROSITE PS00021 KRINGLE_1, 4 hits PS50070 KRINGLE_2, 4 hits PS50948 PAN, 1 hit PS50240 TRYPSIN_DOM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HGFL_HUMAN
Accessionⁱ	P26927Primary (citable) accession number: P26927 Secondary accession number(s): A6NLA3 , A8MSX3, Q13350, Q14870, Q6GTN4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	May 15, 2007
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Peptidase families
Classification of peptidase families and list of entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P26927 (HGFL_HUMAN)

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Hepatocyte growth factor-like protein

MST1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ