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Entry version 194 (22 Apr 2020)
Sequence version 2 (15 May 2007)
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Protein

Hepatocyte growth factor-like protein

Gene

MST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although related to peptidase S1 family, the active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack protease activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSerine protease homolog

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8852405 Signaling by MST1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P26927

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P26927

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.975

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatocyte growth factor-like protein
Alternative name(s):
Macrophage stimulatory protein
Macrophage-stimulating protein
Short name:
MSP
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MST1
Synonyms:D3F15S2, DNF15S2, HGFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7380 MST1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
142408 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P26927

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD.2 Publications

Organism-specific databases

DisGeNET

More...
DisGeNETi
4485

MalaCards human disease database

More...
MalaCardsi
MST1

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
171 Primary sclerosing cholangitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31185

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P26927 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6042

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MST1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147744563

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002808519 – 711Hepatocyte growth factor-like proteinAdd BLAST693
ChainiPRO_000002808619 – 483Hepatocyte growth factor-like protein alpha chainCuratedAdd BLAST465
ChainiPRO_0000028087484 – 711Hepatocyte growth factor-like protein beta chainCuratedAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 78By similarity
Disulfide bondi60 ↔ 66By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 186By similarity
Disulfide bondi131 ↔ 169By similarity
Disulfide bondi157 ↔ 181By similarity
Disulfide bondi191 ↔ 268By similarity
Disulfide bondi194 ↔ 324By similarity
Disulfide bondi212 ↔ 251By similarity
Disulfide bondi240 ↔ 263By similarity
Disulfide bondi283 ↔ 361By similarity
Glycosylationi296N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi304 ↔ 343By similarity
Disulfide bondi332 ↔ 355By similarity
Disulfide bondi370 ↔ 448By similarity
Disulfide bondi391 ↔ 431By similarity
Disulfide bondi419 ↔ 443By similarity
Disulfide bondi468 ↔ 588Interchain (between alpha and beta chains)
Disulfide bondi507 ↔ 523By similarity
Disulfide bondi602 ↔ 667By similarity
Glycosylationi615N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi632 ↔ 646By similarity
Disulfide bondi657 ↔ 685By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-2672

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P26927

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P26927

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P26927

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26927

PeptideAtlas

More...
PeptideAtlasi
P26927

PRoteomics IDEntifications database

More...
PRIDEi
P26927

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
54368

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1310

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26927

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26927

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond.

Interacts (via beta chain) with MST1R (via SEMA domain).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110591, 8 interactors

Database of interacting proteins

More...
DIPi
DIP-6028N

Protein interaction database and analysis system

More...
IntActi
P26927, 9 interactors

Molecular INTeraction database

More...
MINTi
P26927

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000414287

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P26927

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P26927 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26927

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26927

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 105PANPROSITE-ProRule annotationAdd BLAST85
Domaini110 – 186Kringle 1PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini283 – 361Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini370 – 448Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini484 – 709Peptidase S1PROSITE-ProRule annotationAdd BLAST226

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IDXR Eukaryota
COG5640 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26927

KEGG Orthology (KO)

More...
KOi
K23441

Database of Orthologous Groups

More...
OrthoDBi
164039at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26927

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.20.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001152 HGF_MST1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P26927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWLPLLLLL TQCLGVPGQR SPLNDFQVLR GTELQHLLHA VVPGPWQEDV
60 70 80 90 100
ADAEECAGRC GPLMDCRAFH YNVSSHGCQL LPWTQHSPHT RLRRSGRCDL
110 120 130 140 150
FQKKDYVRTC IMNNGVGYRG TMATTVGGLP CQAWSHKFPN DHKYTPTLRN
160 170 180 190 200
GLEENFCRNP DGDPGGPWCY TTDPAVRFQS CGIKSCREAA CVWCNGEEYR
210 220 230 240 250
GAVDRTESGR ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC RNPDGSERPW
260 270 280 290 300
CYTTDPQIER EFCDLPRCGS EAQPRQEATT VSCFRGKGEG YRGTANTTTA
310 320 330 340 350
GVPCQRWDAQ IPHQHRFTPE KYACKDLREN FCRNPDGSEA PWCFTLRPGM
360 370 380 390 400
RAAFCYQIRR CTDDVRPQDC YHGAGEQYRG TVSKTRKGVQ CQRWSAETPH
410 420 430 440 450
KPQFTFTSEP HAQLEENFCR NPDGDSHGPW CYTMDPRTPF DYCALRRCAD
460 470 480 490 500
DQPPSILDPP DQVQFEKCGK RVDRLDQRRS KLRVVGGHPG NSPWTVSLRN
510 520 530 540 550
RQGQHFCGGS LVKEQWILTA RQCFSSCHMP LTGYEVWLGT LFQNPQHGEP
560 570 580 590 600
SLQRVPVAKM VCGPSGSQLV LLKLERSVTL NQRVALICLP PEWYVVPPGT
610 620 630 640 650
KCEIAGWGET KGTGNDTVLN VALLNVISNQ ECNIKHRGRV RESEMCTEGL
660 670 680 690 700
LAPVGACEGD YGGPLACFTH NCWVLEGIII PNRVCARSRW PAVFTRVSVF
710
VDWIHKVMRL G
Length:711
Mass (Da):80,320
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E4B3C7D4AA9B566
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAK1G3XAK1_HUMAN
Hepatocyte growth factor-like prote...
MST1 hCG_2001992
725Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0F8H7C0F8_HUMAN
Hepatocyte growth factor-like prote...
MST1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292R → G AA sequence (PubMed:1827141).Curated1
Sequence conflicti304C → E AA sequence (PubMed:1827141).Curated1
Sequence conflicti306R → E AA sequence (PubMed:1827141).Curated1
Sequence conflicti550Missing AA sequence (PubMed:1827141).Curated1
Sequence conflicti593W → E AA sequence (PubMed:1827141).Curated1
Sequence conflicti623L → F in AAA59872 (PubMed:8393443).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00663113C → Y1 Publication1
Natural variantiVAR_006632212C → F. 1
Natural variantiVAR_059787551S → G. Corresponds to variant dbSNP:rs6791037Ensembl.1
Natural variantiVAR_070224689R → C Common polymorphism; may be associated with inflammatory bowel disease; results in reduced binding affinity to MST1R. 3 PublicationsCorresponds to variant dbSNP:rs3197999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M74178 mRNA Translation: AAA50165.1
U37055 Genomic DNA Translation: AAC50471.1
L11924 mRNA Translation: AAA59872.1
AC099668 Genomic DNA No translation available.
BC048330 mRNA Translation: AAH48330.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40331 A47136

NCBI Reference Sequences

More...
RefSeqi
NP_066278.3, NM_020998.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383728; ENSP00000373234; ENSG00000173531

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4485

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74178 mRNA Translation: AAA50165.1
U37055 Genomic DNA Translation: AAC50471.1
L11924 mRNA Translation: AAA59872.1
AC099668 Genomic DNA No translation available.
BC048330 mRNA Translation: AAH48330.1
PIRiA40331 A47136
RefSeqiNP_066278.3, NM_020998.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ASUX-ray1.85A465-483[»]
B484-711[»]
4QT8X-ray3.00C/D465-711[»]
SMRiP26927
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi110591, 8 interactors
DIPiDIP-6028N
IntActiP26927, 9 interactors
MINTiP26927
STRINGi9606.ENSP00000414287

Chemistry databases

BindingDBiP26927
ChEMBLiCHEMBL6042

Protein family/group databases

MEROPSiS01.975

PTM databases

GlyConnecti1310
iPTMnetiP26927
PhosphoSitePlusiP26927

Polymorphism and mutation databases

BioMutaiMST1
DMDMi147744563

Proteomic databases

CPTACinon-CPTAC-2672
jPOSTiP26927
MassIVEiP26927
MaxQBiP26927
PaxDbiP26927
PeptideAtlasiP26927
PRIDEiP26927
ProteomicsDBi54368

Genome annotation databases

EnsembliENST00000383728; ENSP00000373234; ENSG00000173531
GeneIDi4485
KEGGihsa:4485

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4485
DisGeNETi4485

GeneCards: human genes, protein and diseases

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GeneCardsi
MST1
HGNCiHGNC:7380 MST1
MalaCardsiMST1
MIMi142408 gene
neXtProtiNX_P26927
Orphaneti171 Primary sclerosing cholangitis
PharmGKBiPA31185

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IDXR Eukaryota
COG5640 LUCA
InParanoidiP26927
KOiK23441
OrthoDBi164039at2759
PhylomeDBiP26927

Enzyme and pathway databases

ReactomeiR-HSA-8852405 Signaling by MST1
SignaLinkiP26927
SIGNORiP26927

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MST1 human
EvolutionaryTraceiP26927

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MST1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4485
PharosiP26927 Tbio

Protein Ontology

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PROi
PR:P26927
RNActiP26927 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Family and domain databases

CDDicd00108 KR, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR024174 HGF-like
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
IPR003609 Pan_app
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
PfamiView protein in Pfam
PF00051 Kringle, 4 hits
PF00024 PAN_1, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF001152 HGF_MST1, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130 KR, 4 hits
SM00473 PAN_AP, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF57440 SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 4 hits
PS50070 KRINGLE_2, 4 hits
PS50948 PAN, 1 hit
PS50240 TRYPSIN_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHGFL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26927
Secondary accession number(s): A6NLA3
, A8MSX3, Q13350, Q14870, Q6GTN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 15, 2007
Last modified: April 22, 2020
This is version 194 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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