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UniProtKB - P26927 (HGFL_HUMAN)

Entry version 203 (25 May 2022)
Sequence version 2 (15 May 2007)
Previous versions | rss
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Protein

Hepatocyte growth factor-like protein

Gene

MST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although related to peptidase S1 family, the active site residues characteristic of serine proteases appear to be absent from this protein, which may therefore lack protease activity.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionSerine protease homolog

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P26927

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8852405, Signaling by MST1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P26927

SIGNOR Signaling Network Open Resource

More...SIGNORi		P26927

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.975

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatocyte growth factor-like protein
Alternative name(s):
Macrophage stimulatory protein
Macrophage-stimulating protein
Short name:
MSP
Cleaved into the following 2 chains:
Hepatocyte growth factor-like protein alpha chain
Hepatocyte growth factor-like protein beta chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MST1
Synonyms:D3F15S2, DNF15S2, HGFL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7380, MST1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142408, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P26927

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

MST1 variant Cys-689 may be associated with inflammatory bowel disease (IBD), a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is unsure whether Cys-689 itself or a variation in linkage disequilibrium with Cys-689 is responsible for the association with IBD.2 Publications

Organism-specific databases

DisGeNET

More...DisGeNETi		4485

MalaCards human disease database

More...MalaCardsi		MST1

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171, Primary sclerosing cholangitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA31185

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P26927, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6042

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MST1

Domain mapping of disease mutations (DMDM)

More...DMDMi		147744563

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002808519 – 711Hepatocyte growth factor-like proteinAdd BLAST693
ChainiPRO_000002808619 – 483Hepatocyte growth factor-like protein alpha chainCuratedAdd BLAST465
ChainiPRO_0000028087484 – 711Hepatocyte growth factor-like protein beta chainCuratedAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi56 ↔ 78By similarity
Disulfide bondi60 ↔ 66By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 186By similarity
Disulfide bondi131 ↔ 169By similarity
Disulfide bondi157 ↔ 181By similarity
Disulfide bondi191 ↔ 268By similarity
Disulfide bondi194 ↔ 324By similarity
Disulfide bondi212 ↔ 251By similarity
Disulfide bondi240 ↔ 263By similarity
Disulfide bondi283 ↔ 361By similarity
Glycosylationi296N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi304 ↔ 343By similarity
Disulfide bondi332 ↔ 355By similarity
Disulfide bondi370 ↔ 448By similarity
Disulfide bondi391 ↔ 431By similarity
Disulfide bondi419 ↔ 443By similarity
Disulfide bondi468 ↔ 588Interchain (between alpha and beta chains)
Disulfide bondi507 ↔ 523By similarity
Disulfide bondi602 ↔ 667By similarity
Glycosylationi615N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi632 ↔ 646By similarity
Disulfide bondi657 ↔ 685By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved after Arg-483, probably by HPN/Hepsin, to yield the active form consisting of two disulfide-linked chains.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-2672

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P26927

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P26927

MaxQB - The MaxQuant DataBase

More...MaxQBi		P26927

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P26927

PeptideAtlas

More...PeptideAtlasi		P26927

PRoteomics IDEntifications database

More...PRIDEi		P26927

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54368

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1310, 5 N-Linked glycans (5 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P26927, 6 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P26927

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P26927

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimer of an alpha chain and a beta chain linked by a disulfide bond.

Interacts (via beta chain) with MST1R (via SEMA domain).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110591, 15 interactors

Database of interacting proteins

More...DIPi		DIP-6028N

Protein interaction database and analysis system

More...IntActi		P26927, 9 interactors

Molecular INTeraction database

More...MINTi		P26927

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000414287

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P26927

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P26927, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1711
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P26927

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P26927

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P26927

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 105PANPROSITE-ProRule annotationAdd BLAST85
Domaini110 – 186Kringle 1PROSITE-ProRule annotationAdd BLAST77
Domaini191 – 268Kringle 2PROSITE-ProRule annotationAdd BLAST78
Domaini283 – 361Kringle 3PROSITE-ProRule annotationAdd BLAST79
Domaini370 – 448Kringle 4PROSITE-ProRule annotationAdd BLAST79
Domaini484 – 709Peptidase S1PROSITE-ProRule annotationAdd BLAST226

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Plasminogen subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QRJ0, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P26927

Database of Orthologous Groups

More...OrthoDBi		164039at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P26927

Family and domain databases

Conserved Domains Database

More...CDDi		cd00108, KR, 4 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
2.40.20.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024174, HGF/MST1
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR043575, MSP_HGFL
IPR003609, Pan_app
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00051, Kringle, 4 hits
PF00024, PAN_1, 1 hit
PF00089, Trypsin, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001152, HGF_MST1, 1 hit
PIRSF500185, MSP_HGFL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00130, KR, 4 hits
SM00473, PAN_AP, 1 hit
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF57440, SSF57440, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00021, KRINGLE_1, 4 hits
PS50070, KRINGLE_2, 4 hits
PS50948, PAN, 1 hit
PS50240, TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P26927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWLPLLLLL TQCLGVPGQR SPLNDFQVLR GTELQHLLHA VVPGPWQEDV 
        60         70         80         90        100
ADAEECAGRC GPLMDCRAFH YNVSSHGCQL LPWTQHSPHT RLRRSGRCDL 
       110        120        130        140        150
FQKKDYVRTC IMNNGVGYRG TMATTVGGLP CQAWSHKFPN DHKYTPTLRN 
       160        170        180        190        200
GLEENFCRNP DGDPGGPWCY TTDPAVRFQS CGIKSCREAA CVWCNGEEYR 
       210        220        230        240        250
GAVDRTESGR ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC RNPDGSERPW 
       260        270        280        290        300
CYTTDPQIER EFCDLPRCGS EAQPRQEATT VSCFRGKGEG YRGTANTTTA 
       310        320        330        340        350
GVPCQRWDAQ IPHQHRFTPE KYACKDLREN FCRNPDGSEA PWCFTLRPGM 
       360        370        380        390        400
RAAFCYQIRR CTDDVRPQDC YHGAGEQYRG TVSKTRKGVQ CQRWSAETPH 
       410        420        430        440        450
KPQFTFTSEP HAQLEENFCR NPDGDSHGPW CYTMDPRTPF DYCALRRCAD 
       460        470        480        490        500
DQPPSILDPP DQVQFEKCGK RVDRLDQRRS KLRVVGGHPG NSPWTVSLRN 
       510        520        530        540        550
RQGQHFCGGS LVKEQWILTA RQCFSSCHMP LTGYEVWLGT LFQNPQHGEP 
       560        570        580        590        600
SLQRVPVAKM VCGPSGSQLV LLKLERSVTL NQRVALICLP PEWYVVPPGT 
       610        620        630        640        650
KCEIAGWGET KGTGNDTVLN VALLNVISNQ ECNIKHRGRV RESEMCTEGL 
       660        670        680        690        700
LAPVGACEGD YGGPLACFTH NCWVLEGIII PNRVCARSRW PAVFTRVSVF 
       710 
VDWIHKVMRL G
Length:711
Mass (Da):80,320
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E4B3C7D4AA9B566
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAK1G3XAK1_HUMAN
Hepatocyte growth factor-like prote...
MST1 hCG_2001992
725Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0F8H7C0F8_HUMAN
Hepatocyte growth factor-like prote...
MST1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292R → G AA sequence (PubMed:1827141).Curated1
Sequence conflicti304C → E AA sequence (PubMed:1827141).Curated1
Sequence conflicti306R → E AA sequence (PubMed:1827141).Curated1
Sequence conflicti550Missing AA sequence (PubMed:1827141).Curated1
Sequence conflicti593W → E AA sequence (PubMed:1827141).Curated1
Sequence conflicti623L → F in AAA59872 (PubMed:8393443).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00663113C → Y1 Publication1
Natural variantiVAR_006632212C → F. 1
Natural variantiVAR_059787551S → G. Corresponds to variant dbSNP:rs6791037Ensembl.1
Natural variantiVAR_070224689R → C May be associated with inflammatory bowel disease; results in reduced binding affinity to MST1R. 3 PublicationsCorresponds to variant dbSNP:rs3197999Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M74178 mRNA Translation: AAA50165.1
U37055 Genomic DNA Translation: AAC50471.1
L11924 mRNA Translation: AAA59872.1
AC099668 Genomic DNA No translation available.
BC048330 mRNA Translation: AAH48330.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40331, A47136

NCBI Reference Sequences

More...RefSeqi		NP_066278.3, NM_020998.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4485

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4485

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74178 mRNA Translation: AAA50165.1
U37055 Genomic DNA Translation: AAC50471.1
L11924 mRNA Translation: AAA59872.1
AC099668 Genomic DNA No translation available.
BC048330 mRNA Translation: AAH48330.1
PIRiA40331, A47136
RefSeqiNP_066278.3, NM_020998.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ASUX-ray1.85A465-483[»]
B484-711[»]
4QT8X-ray3.00C/D465-711[»]
AlphaFoldDBiP26927
SMRiP26927
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110591, 15 interactors
DIPiDIP-6028N
IntActiP26927, 9 interactors
MINTiP26927
STRINGi9606.ENSP00000414287

Chemistry databases

BindingDBiP26927
ChEMBLiCHEMBL6042

Protein family/group databases

MEROPSiS01.975

PTM databases

GlyConnecti1310, 5 N-Linked glycans (5 sites)
GlyGeniP26927, 6 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
iPTMnetiP26927
PhosphoSitePlusiP26927

Genetic variation databases

BioMutaiMST1
DMDMi147744563

Proteomic databases

CPTACinon-CPTAC-2672
jPOSTiP26927
MassIVEiP26927
MaxQBiP26927
PaxDbiP26927
PeptideAtlasiP26927
PRIDEiP26927
ProteomicsDBi54368

Protocols and materials databases

The CPTC Antibody Portal

More...CPTCi		P26927, 1 antibody

The DNASU plasmid repository

More...DNASUi		4485

Genome annotation databases

GeneIDi4485
KEGGihsa:4485

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4485
DisGeNETi4485

GeneCards: human genes, protein and diseases

More...GeneCardsi		MST1
HGNCiHGNC:7380, MST1
MalaCardsiMST1
MIMi142408, gene
neXtProtiNX_P26927
Orphaneti171, Primary sclerosing cholangitis
PharmGKBiPA31185

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QRJ0, Eukaryota
InParanoidiP26927
OrthoDBi164039at2759
PhylomeDBiP26927

Enzyme and pathway databases

PathwayCommonsiP26927
ReactomeiR-HSA-8852405, Signaling by MST1
SignaLinkiP26927
SIGNORiP26927

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4485, 301 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MST1, human
EvolutionaryTraceiP26927

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MST1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4485
PharosiP26927, Tchem

Protein Ontology

More...PROi		PR:P26927
RNActiP26927, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Family and domain databases

CDDicd00108, KR, 4 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
2.40.20.10, 4 hits
InterProiView protein in InterPro
IPR024174, HGF/MST1
IPR000001, Kringle
IPR013806, Kringle-like
IPR018056, Kringle_CS
IPR038178, Kringle_sf
IPR043575, MSP_HGFL
IPR003609, Pan_app
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR001254, Trypsin_dom
PfamiView protein in Pfam
PF00051, Kringle, 4 hits
PF00024, PAN_1, 1 hit
PF00089, Trypsin, 1 hit
PIRSFiPIRSF001152, HGF_MST1, 1 hit
PIRSF500185, MSP_HGFL, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00130, KR, 4 hits
SM00473, PAN_AP, 1 hit
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF57440, SSF57440, 4 hits
PROSITEiView protein in PROSITE
PS00021, KRINGLE_1, 4 hits
PS50070, KRINGLE_2, 4 hits
PS50948, PAN, 1 hit
PS50240, TRYPSIN_DOM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHGFL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26927
Secondary accession number(s): A6NLA3
, A8MSX3, Q13350, Q14870, Q6GTN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: May 15, 2007
Last modified: May 25, 2022
This is version 203 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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