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Protein

Interleukin-6

Gene

IL6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor
Biological processAcute phase

Enzyme and pathway databases

ReactomeiR-BTA-1059683 Interleukin-6 signaling
R-BTA-110056 MAPK3 (ERK1) activation
R-BTA-112411 MAPK1 (ERK2) activation
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-6
Short name:
IL-6
Gene namesi
Name:IL6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 4

Organism-specific databases

VGNCiVGNC:30166 IL6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29By similarityAdd BLAST29
ChainiPRO_000001557330 – 208Interleukin-6Add BLAST179

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi72 ↔ 78By similarity
Modified residuei81PhosphoserineBy similarity1
Disulfide bondi101 ↔ 111By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26892
PRIDEiP26892

Expressioni

Gene expression databases

BgeeiENSBTAG00000014921 Expressed in 6 organ(s), highest expression level in lung

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019865

Structurei

3D structure databases

ProteinModelPortaliP26892
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330
HOVERGENiHBG000471
InParanoidiP26892
KOiK05405
OMAiGFNKETC
OrthoDBiEOG091G0NW5
TreeFamiTF335984

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26892-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSRFTSAFT PFAVSLGLLL VMTSAFPTPG PLGEDFKNDT TPGRLLLTTP
60 70 80 90 100
EKTEALIKRM VDKISAMRKE ICEKNDECES SKETLAENKL NLPKMEEKDG
110 120 130 140 150
CFQSGFNQAI CLIRTTAGLL EYQIYLDYLQ NEYEGNQENV RDLRKNIRTL
160 170 180 190 200
IQILKQKIAD LITTPATNTD LLEKMQSSNE WVKNAKIILI LRNLENFLQF

SLRAIRMK
Length:208
Mass (Da):23,759
Last modified:August 1, 1992 - v1
Checksum:iA0F000B9BA2EC341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57317 mRNA Translation: CAA40572.1
EU276071 mRNA Translation: ABX72069.1
BC123577 mRNA Translation: AAI23578.1
PIRiA56610
RefSeqiNP_776348.1, NM_173923.2
UniGeneiBt.3686

Genome annotation databases

EnsembliENSBTAT00000019865; ENSBTAP00000019865; ENSBTAG00000014921
GeneIDi280826
KEGGibta:280826

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57317 mRNA Translation: CAA40572.1
EU276071 mRNA Translation: ABX72069.1
BC123577 mRNA Translation: AAI23578.1
PIRiA56610
RefSeqiNP_776348.1, NM_173923.2
UniGeneiBt.3686

3D structure databases

ProteinModelPortaliP26892
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019865

Proteomic databases

PaxDbiP26892
PRIDEiP26892

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000019865; ENSBTAP00000019865; ENSBTAG00000014921
GeneIDi280826
KEGGibta:280826

Organism-specific databases

CTDi3569
VGNCiVGNC:30166 IL6

Phylogenomic databases

eggNOGiENOG410IW11 Eukaryota
ENOG4112BXV LUCA
GeneTreeiENSGT00390000000878
HOGENOMiHOG000236330
HOVERGENiHBG000471
InParanoidiP26892
KOiK05405
OMAiGFNKETC
OrthoDBiEOG091G0NW5
TreeFamiTF335984

Enzyme and pathway databases

ReactomeiR-BTA-1059683 Interleukin-6 signaling
R-BTA-110056 MAPK3 (ERK1) activation
R-BTA-112411 MAPK1 (ERK2) activation
R-BTA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-BTA-8957275 Post-translational protein phosphorylation

Gene expression databases

BgeeiENSBTAG00000014921 Expressed in 6 organ(s), highest expression level in lung

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR003574 IL-6
IPR030474 IL-6/GCSF/MGF
IPR030473 IL6/GCSF/MGF_CS
PANTHERiPTHR45110 PTHR45110, 1 hit
PfamiView protein in Pfam
PF00489 IL6, 1 hit
PIRSFiPIRSF001935 IL6_MGF_GCSF, 1 hit
PRINTSiPR00433 IL6GCSFMGF
SMARTiView protein in SMART
SM00126 IL6, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00254 INTERLEUKIN_6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL6_BOVIN
AccessioniPrimary (citable) accession number: P26892
Secondary accession number(s): A9QWQ9, Q08DT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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