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Protein

Peptidyl-prolyl cis-trans isomerase FKBP2

Gene

FKBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Activity regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

  • FK506 binding Source: ProtInc
  • peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP2 (EC:5.2.1.8)
Short name:
PPIase FKBP2
Alternative name(s):
13 kDa FK506-binding protein
Short name:
13 kDa FKBP
Short name:
FKBP-13
FK506-binding protein 2
Short name:
FKBP-2
Immunophilin FKBP13
Rotamase
Gene namesi
Name:FKBP2
Synonyms:FKBP13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173486.12
HGNCiHGNC:3718 FKBP2
MIMi186946 gene
neXtProtiNX_P26885

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2286
OpenTargetsiENSG00000173486
PharmGKBiPA28159

Polymorphism and mutation databases

BioMutaiFKBP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002550622 – 142Peptidyl-prolyl cis-trans isomerase FKBP2Add BLAST121

Proteomic databases

EPDiP26885
PaxDbiP26885
PeptideAtlasiP26885
PRIDEiP26885
ProteomicsDBi54367
TopDownProteomicsiP26885

2D gel databases

OGPiP26885

PTM databases

iPTMnetiP26885
PhosphoSitePlusiP26885

Expressioni

Tissue specificityi

T-cells and thymus.

Gene expression databases

BgeeiENSG00000173486 Expressed in 230 organ(s), highest expression level in pituitary gland
CleanExiHS_FKBP2
ExpressionAtlasiP26885 baseline and differential
GenevisibleiP26885 HS

Organism-specific databases

HPAiCAB025561
HPA049405

Interactioni

Subunit structurei

Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi108576, 47 interactors
IntActiP26885, 9 interactors
STRINGi9606.ENSP00000310935

Structurei

Secondary structure

1142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP26885
SMRiP26885
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26885

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 137PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi139 – 142Prevents secretion from ERSequence analysis4

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiP26885
KOiK09569
OMAiGILGMCE
OrthoDBiEOG091G02W1
PhylomeDBiP26885
TreeFamiTF105292

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P26885-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSWFRVLT VLSICLSAVA TATGAEGKRK LQIGVKKRVD HCPIKSRKGD
60 70 80 90 100
VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE
110 120 130 140
KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL
Length:142
Mass (Da):15,649
Last modified:September 19, 2002 - v2
Checksum:i01024F869BA7B5DA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H0N4F5H0N4_HUMAN
Peptidylprolyl isomerase
FKBP2
102Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0506237R → Q1 PublicationCorresponds to variant dbSNP:rs4672Ensembl.1
Natural variantiVAR_00641021 – 22TA → S. 2
Natural variantiVAR_00641125A → T. 1
Natural variantiVAR_00641297C → Y. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65128 mRNA Translation: AAA58473.1
M75099 mRNA Translation: AAA36563.1
BC003384 mRNA Translation: AAH03384.1
BC091475 mRNA Translation: AAH91475.1
CCDSiCCDS8063.1
PIRiJC1365
RefSeqiNP_001128680.1, NM_001135208.1
NP_004461.2, NM_004470.3
NP_476433.1, NM_057092.2
XP_005273905.1, XM_005273848.3
UniGeneiHs.227729

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486
ENST00000394540; ENSP00000378046; ENSG00000173486
ENST00000449942; ENSP00000398147; ENSG00000173486
GeneIDi2286
KEGGihsa:2286

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65128 mRNA Translation: AAA58473.1
M75099 mRNA Translation: AAA36563.1
BC003384 mRNA Translation: AAH03384.1
BC091475 mRNA Translation: AAH91475.1
CCDSiCCDS8063.1
PIRiJC1365
RefSeqiNP_001128680.1, NM_001135208.1
NP_004461.2, NM_004470.3
NP_476433.1, NM_057092.2
XP_005273905.1, XM_005273848.3
UniGeneiHs.227729

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PBCX-ray1.80A/B/C/D43-142[»]
4NNRX-ray1.98A/B1-142[»]
ProteinModelPortaliP26885
SMRiP26885
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108576, 47 interactors
IntActiP26885, 9 interactors
STRINGi9606.ENSP00000310935

PTM databases

iPTMnetiP26885
PhosphoSitePlusiP26885

Polymorphism and mutation databases

BioMutaiFKBP2

2D gel databases

OGPiP26885

Proteomic databases

EPDiP26885
PaxDbiP26885
PeptideAtlasiP26885
PRIDEiP26885
ProteomicsDBi54367
TopDownProteomicsiP26885

Protocols and materials databases

DNASUi2286
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309366; ENSP00000310935; ENSG00000173486
ENST00000394540; ENSP00000378046; ENSG00000173486
ENST00000449942; ENSP00000398147; ENSG00000173486
GeneIDi2286
KEGGihsa:2286

Organism-specific databases

CTDi2286
DisGeNETi2286
EuPathDBiHostDB:ENSG00000173486.12
GeneCardsiFKBP2
HGNCiHGNC:3718 FKBP2
HPAiCAB025561
HPA049405
MIMi186946 gene
neXtProtiNX_P26885
OpenTargetsiENSG00000173486
PharmGKBiPA28159
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0549 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiP26885
KOiK09569
OMAiGILGMCE
OrthoDBiEOG091G02W1
PhylomeDBiP26885
TreeFamiTF105292

Miscellaneous databases

ChiTaRSiFKBP2 human
EvolutionaryTraceiP26885
GeneWikiiFKBP2
GenomeRNAii2286
PROiPR:P26885
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173486 Expressed in 230 organ(s), highest expression level in pituitary gland
CleanExiHS_FKBP2
ExpressionAtlasiP26885 baseline and differential
GenevisibleiP26885 HS

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP2_HUMAN
AccessioniPrimary (citable) accession number: P26885
Secondary accession number(s): Q5BJH9, Q9BTS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2002
Last modified: November 7, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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