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Protein

Peptidyl-prolyl cis-trans isomerase FKBP1A

Gene

Fkbp1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).By similarity

Activity regulationi

Inhibited by both FK506 and rapamycin.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

ReactomeiR-MMU-2173789 TGF-beta receptor signaling activates SMADs

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP1A (EC:5.2.1.8By similarity)
Short name:
PPIase FKBP1A
Alternative name(s):
12 kDa FK506-binding protein
Short name:
12 kDa FKBP
Short name:
FKBP-12
Calstabin-1
FK506-binding protein 1A
Short name:
FKBP-1A
Immunophilin FKBP12
Rotamase
Gene namesi
Name:Fkbp1a
Synonyms:Fkbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95541 Fkbp1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Sarcoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000752901 – 108Peptidyl-prolyl cis-trans isomerase FKBP1AAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysine; alternateCombined sources1
Modified residuei53N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP26883
MaxQBiP26883
PaxDbiP26883
PeptideAtlasiP26883
PRIDEiP26883

PTM databases

iPTMnetiP26883
PhosphoSitePlusiP26883

Expressioni

Gene expression databases

BgeeiENSMUSG00000032966 Expressed in 313 organ(s), highest expression level in nucleus accumbens
CleanExiMM_FKBP1A
ExpressionAtlasiP26883 baseline and differential
GenevisibleiP26883 MM

Interactioni

Subunit structurei

Interacts with TGFBR1; prevents TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive conformation (By similarity). Interacts with ACVR1B and SMAD7 (By similarity). Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1) (PubMed:18268335). Interacts directly with RYR2 and RYR3 (By similarity). Interacts directly with RYR1 (By similarity). Interacts with GLMN; rapamycin and FK506 abolish the interaction with GLMN in a dose dependent manner (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Ryr1E9PZQ02EBI-6379901,EBI-642079

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199682, 3 interactors
DIPiDIP-29707N
IntActiP26883, 4 interactors
MINTiP26883
STRINGi10090.ENSMUSP00000037206

Structurei

3D structure databases

ProteinModelPortaliP26883
SMRiP26883
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 108PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST89

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiP26883
KOiK09568
OMAiRVIAGWD
TreeFamiTF105291

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P26883-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVQVETISP GDGRTFPKRG QTCVVHYTGM LEDGKKFDSS RDRNKPFKFT
60 70 80 90 100
LGKQEVIRGW EEGVAQMSVG QRAKLIISSD YAYGATGHPG IIPPHATLVF

DVELLKLE
Length:108
Mass (Da):11,923
Last modified:January 23, 2007 - v2
Checksum:i8C265ED5803F6987
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6X9I3F6X9I3_MOUSE
Peptidylprolyl isomerase
Fkbp1a
161Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60203 mRNA Translation: CAA42762.1
U65100, U65098, U65099 Genomic DNA Translation: AAB17554.1
AF483488 mRNA Translation: AAL90762.1
AF483489 mRNA Translation: AAL90763.1
AK002777 mRNA Translation: BAB22351.1
AK010693 mRNA Translation: BAB27125.1
AK019362 mRNA Translation: BAB31680.1
AK154751 mRNA Translation: BAE32804.1
AK168333 mRNA Translation: BAE40271.1
AK169186 mRNA Translation: BAE40963.1
AK169242 mRNA Translation: BAE41008.1
BC004671 mRNA Translation: AAH04671.1
CCDSiCCDS16869.1
PIRiJH0528
RefSeqiNP_001289006.1, NM_001302077.1
NP_001289007.1, NM_001302078.1
NP_001289008.1, NM_001302079.1
NP_001289009.1, NM_001302080.1
NP_032045.1, NM_008019.3
UniGeneiMm.278458

Genome annotation databases

EnsembliENSMUST00000044011; ENSMUSP00000037206; ENSMUSG00000032966
GeneIDi14225
KEGGimmu:14225
UCSCiuc008ndy.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60203 mRNA Translation: CAA42762.1
U65100, U65098, U65099 Genomic DNA Translation: AAB17554.1
AF483488 mRNA Translation: AAL90762.1
AF483489 mRNA Translation: AAL90763.1
AK002777 mRNA Translation: BAB22351.1
AK010693 mRNA Translation: BAB27125.1
AK019362 mRNA Translation: BAB31680.1
AK154751 mRNA Translation: BAE32804.1
AK168333 mRNA Translation: BAE40271.1
AK169186 mRNA Translation: BAE40963.1
AK169242 mRNA Translation: BAE41008.1
BC004671 mRNA Translation: AAH04671.1
CCDSiCCDS16869.1
PIRiJH0528
RefSeqiNP_001289006.1, NM_001302077.1
NP_001289007.1, NM_001302078.1
NP_001289008.1, NM_001302079.1
NP_001289009.1, NM_001302080.1
NP_032045.1, NM_008019.3
UniGeneiMm.278458

3D structure databases

ProteinModelPortaliP26883
SMRiP26883
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199682, 3 interactors
DIPiDIP-29707N
IntActiP26883, 4 interactors
MINTiP26883
STRINGi10090.ENSMUSP00000037206

PTM databases

iPTMnetiP26883
PhosphoSitePlusiP26883

Proteomic databases

EPDiP26883
MaxQBiP26883
PaxDbiP26883
PeptideAtlasiP26883
PRIDEiP26883

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044011; ENSMUSP00000037206; ENSMUSG00000032966
GeneIDi14225
KEGGimmu:14225
UCSCiuc008ndy.2 mouse

Organism-specific databases

CTDi2280
MGIiMGI:95541 Fkbp1a

Phylogenomic databases

eggNOGiKOG0544 Eukaryota
COG0545 LUCA
GeneTreeiENSGT00760000119159
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiP26883
KOiK09568
OMAiRVIAGWD
TreeFamiTF105291

Enzyme and pathway databases

ReactomeiR-MMU-2173789 TGF-beta receptor signaling activates SMADs

Miscellaneous databases

PROiPR:P26883
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032966 Expressed in 313 organ(s), highest expression level in nucleus accumbens
CleanExiMM_FKBP1A
ExpressionAtlasiP26883 baseline and differential
GenevisibleiP26883 MM

Family and domain databases

InterProiView protein in InterPro
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFKB1A_MOUSE
AccessioniPrimary (citable) accession number: P26883
Secondary accession number(s): Q545E9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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