CD27

Functionⁱ

Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

GO - Molecular functionⁱ

cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12324477
transmembrane signaling receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 14556986
tumor necrosis factor-activated receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell surface receptor signaling pathway
Source: UniProtKB
Non-traceable author statementⁱ
- 14556986
extrinsic apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 9177220
immune response Source: GO_Central
immunoglobulin mediated immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 14556986
inflammatory response Source: GO_Central
multicellular organism development Source: GO_Central
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 12324477
negative regulation of T cell apoptotic process Source: Ensembl
positive regulation of B cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 10809378
positive regulation of JNK cascade Source: UniProtKB
positive regulation of NIK/NF-kappaB signaling
Source: UniProtKB
Non-traceable author statementⁱ
- 12324477
positive regulation of T cell differentiation Source: InterPro
regulation of cell proliferation Source: GO_Central
response to ethanol Source: Ensembl
response to lipopolysaccharide Source: GO_Central
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SIGNORⁱ	P26842

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD27 antigen Alternative name(s): CD27L receptor T-cell activation antigen CD27 T14 Tumor necrosis factor receptor superfamily member 7 CD_antigen: CD27
Gene namesⁱ	Name:CD27 Synonyms:TNFRSF7
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139193.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11922 CD27
MIMⁱ	186711 gene
neXtProtⁱ	NX_P26842

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 191	ExtracellularSequence analysisAdd BLAST	172
Transmembraneⁱ	192 – 212	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	213 – 260	CytoplasmicSequence analysisAdd BLAST	48

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Lymphoproliferative syndrome 2 (LPFS2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	939
MalaCards human disease database More...MalaCardsⁱ	CD27
MIMⁱ	615122 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000139193
Orphanetⁱ	238505 Autosomal recessive lymphoproliferative disease
PharmGKBⁱ	PA162382107

Chemistry databases

ChEMBLⁱ	CHEMBL3713333

ChEMBLⁱ

CHEMBL3713333

Polymorphism and mutation databases

BioMutaⁱ	CD27
DMDMⁱ	269849546

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	1 PublicationAdd BLAST		19
ChainⁱPRO_0000034571	20 – 260	CD27 antigenAdd BLAST		241

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	27 ↔ 39	PROSITE-ProRule annotation
Disulfide bondⁱ	40 ↔ 53	PROSITE-ProRule annotation
Disulfide bondⁱ	43 ↔ 62	PROSITE-ProRule annotation
Disulfide bondⁱ	65 ↔ 81	PROSITE-ProRule annotation
Disulfide bondⁱ	84 ↔ 96	PROSITE-ProRule annotation
Disulfide bondⁱ	87 ↔ 104	PROSITE-ProRule annotation
Glycosylationⁱ	95	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	106 ↔ 117	PROSITE-ProRule annotation
Disulfide bondⁱ	112 ↔ 120	PROSITE-ProRule annotation
Glycosylationⁱ	127	O-linked (GalNAc...) serine1 Publication	1
Modified residueⁱ	219	PhosphoserineSequence analysis	1

Post-translational modificationⁱ

Phosphorylated.

O-glycosylated with core 1 or possibly core 8 glycans.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P26842
PaxDbⁱ	P26842
PeptideAtlas More...PeptideAtlasⁱ	P26842
PRIDEⁱ	P26842
ProteomicsDBⁱ	54366

PTM databases

GlyConnectⁱ	800
iPTMnetⁱ	P26842
PhosphoSitePlusⁱ	P26842
SwissPalmⁱ	P26842
UniCarbKBⁱ	P26842

Miscellaneous databases

PMAP-CutDBⁱ	P26842

PMAP-CutDBⁱ

P26842

Expressionⁱ

Tissue specificityⁱ

Found in most T-lymphocytes.

Gene expression databases

Bgeeⁱ	ENSG00000139193
CleanExⁱ	HS_CD27
Genevisibleⁱ	P26842 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002420 HPA038936

HPAⁱ

CAB002420
HPA038936

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with SIVA1 and TRAF2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ACTN2	P35609	3	EBI-520729,EBI-77797
SIVA1	O15304	3	EBI-520729,EBI-520756

Show more details

Protein-protein interaction databases

BioGridⁱ	107377, 32 interactors
ELMⁱ	P26842
IntActⁱ	P26842, 5 interactors
STRINGⁱ	9606.ENSP00000266557

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	31 – 34	Combined sources	4
Turnⁱ	35 – 37	Combined sources	3
Beta strandⁱ	38 – 41	Combined sources	4
Beta strandⁱ	47 – 51	Combined sources	5
Beta strandⁱ	61 – 64	Combined sources	4
Turnⁱ	67 – 69	Combined sources	3
Beta strandⁱ	74 – 76	Combined sources	3
Beta strandⁱ	88 – 94	Combined sources	7
Beta strandⁱ	98 – 100	Combined sources	3
Beta strandⁱ	103 – 105	Combined sources	3
Beta strandⁱ	112 – 114	Combined sources	3
Beta strandⁱ	117 – 120	Combined sources	4

3D structure databases

ProteinModelPortalⁱ	P26842
SMRⁱ	P26842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	26 – 63	TNFR-Cys 1Add BLAST	38
Repeatⁱ	64 – 104	TNFR-Cys 2Add BLAST	41
Repeatⁱ	105 – 141	TNFR-Cys 3Add BLAST	37

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IZUP Eukaryota ENOG410ZDEA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049297
HOGENOMⁱ	HOG000082545
HOVERGENⁱ	HBG018200
InParanoidⁱ	P26842
KEGG Orthology (KO) More...KOⁱ	K05144
OMAⁱ	YSCPREE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KN1
PhylomeDBⁱ	P26842
TreeFamⁱ	TF336960

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13408 TNFRSF7, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR022328 TNFR_7 IPR034000 TNFRSF7_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01960 TNFACTORR7
SMARTⁱ	View protein in SMART SM00208 TNFR, 2 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P26842-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV 
        60         70         80         90        100
KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA 
       110        120        130        140        150
NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE 
       160        170        180        190        200
MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF 
       210        220        230        240        250
LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE EGSTIPIQED 
       260
YRKPEPACSP

Length:260

Mass (Da):29,137

Last modified:November 24, 2009 - v2

Checksum:ⁱ43C38B895B2AD4E2

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069793	53	C → Y in LPFS2. 1 PublicationCorresponds to variant dbSNP:rs397514667EnsemblClinVar.	1
Natural variantⁱVAR_016148	59	A → T3 PublicationsCorresponds to variant dbSNP:rs25680Ensembl.	1
Natural variantⁱVAR_052348	233	H → R5 PublicationsCorresponds to variant dbSNP:rs2532502Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63928 mRNA Translation: AAA58411.1 AK315732 mRNA Translation: BAG38087.1 AY504961 Genomic DNA Translation: AAR84239.1 AC005840 Genomic DNA No translation available. BC012160 mRNA Translation: AAH12160.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8545.1
PIRⁱ	A46517
NCBI Reference Sequences More...RefSeqⁱ	NP_001233.1, NM_001242.4
UniGeneⁱ	Hs.355307

Genome annotation databases

Ensemblⁱ	ENST00000266557; ENSP00000266557; ENSG00000139193
GeneIDⁱ	939
KEGGⁱ	hsa:939
UCSC genome browser More...UCSCⁱ	uc001qod.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P26842	UPI0004F21DB7		PAPAN		265
CD27 isoform 1		PANTR		260
CD27 molecule		PANPA		260
CD27 molecule		MACMU		260
CD27 molecule		MACFA		260
+11

Protein	Similar proteins		Species	Score	Length
P26842	UPI0004F21DB7		PAPAN		265
CD27 isoform 1		PANTR		260
CD27 molecule		PANPA		260
CD27 isoform 1		PONAB		260
UPI00020ADD55		NOMLE		260
+36

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M63928 mRNA Translation: AAA58411.1 AK315732 mRNA Translation: BAG38087.1 AY504961 Genomic DNA Translation: AAR84239.1 AC005840 Genomic DNA No translation available. BC012160 mRNA Translation: AAH12160.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8545.1
PIRⁱ	A46517
NCBI Reference Sequences More...RefSeqⁱ	NP_001233.1, NM_001242.4
UniGeneⁱ	Hs.355307

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5TL5	X-ray	1.80	A	21-121	[»]
	5TLJ	X-ray	3.50	X	21-121	[»]
	5TLK	X-ray	2.70	X/Y	21-121	[»]
ProteinModelPortalⁱ	P26842
SMRⁱ	P26842
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107377, 32 interactors
ELMⁱ	P26842
IntActⁱ	P26842, 5 interactors
STRINGⁱ	9606.ENSP00000266557

Chemistry databases

ChEMBLⁱ	CHEMBL3713333

ChEMBLⁱ

CHEMBL3713333

PTM databases

GlyConnectⁱ	800
iPTMnetⁱ	P26842
PhosphoSitePlusⁱ	P26842
SwissPalmⁱ	P26842
UniCarbKBⁱ	P26842

Polymorphism and mutation databases

BioMutaⁱ	CD27
DMDMⁱ	269849546

Proteomic databases

EPDⁱ	P26842
PaxDbⁱ	P26842
PeptideAtlas More...PeptideAtlasⁱ	P26842
PRIDEⁱ	P26842
ProteomicsDBⁱ	54366

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	939
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000266557; ENSP00000266557; ENSG00000139193
GeneIDⁱ	939
KEGGⁱ	hsa:939
UCSC genome browser More...UCSCⁱ	uc001qod.4 human

Organism-specific databases

CTDⁱ	939
DisGeNET More...DisGeNETⁱ	939
EuPathDBⁱ	HostDB:ENSG00000139193.3
GeneCardsⁱ	CD27
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11922 CD27
Human Protein Atlas More...HPAⁱ	CAB002420 HPA038936
MalaCards human disease database More...MalaCardsⁱ	CD27
MIMⁱ	186711 gene 615122 phenotype
neXtProtⁱ	NX_P26842
Open Targets More...OpenTargetsⁱ	ENSG00000139193
Orphanetⁱ	238505 Autosomal recessive lymphoproliferative disease
PharmGKBⁱ	PA162382107
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IZUP Eukaryota ENOG410ZDEA LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000049297
HOGENOMⁱ	HOG000082545
HOVERGENⁱ	HBG018200
InParanoidⁱ	P26842
KEGG Orthology (KO) More...KOⁱ	K05144
OMAⁱ	YSCPREE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KN1
PhylomeDBⁱ	P26842
TreeFamⁱ	TF336960

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SIGNORⁱ	P26842

Miscellaneous databases

ChiTaRSⁱ	CD27 human
GeneWikiⁱ	CD27
GenomeRNAiⁱ	939
PMAP-CutDBⁱ	P26842
Protein Ontology More...PROⁱ	PR:P26842
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139193
CleanExⁱ	HS_CD27
Genevisibleⁱ	P26842 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd13408 TNFRSF7, 1 hit
InterProⁱ	View protein in InterPro IPR001368 TNFR/NGFR_Cys_rich_reg IPR022328 TNFR_7 IPR034000 TNFRSF7_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00020 TNFR_c6, 1 hit
PRINTSⁱ	PR01960 TNFACTORR7
SMARTⁱ	View protein in SMART SM00208 TNFR, 2 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD27_HUMAN
Accessionⁱ	P26842Primary (citable) accession number: P26842 Secondary accession number(s): B2RDZ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	November 24, 2009
	Last modified:	July 18, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P26842 (CD27_HUMAN)

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CD27 antigen

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ