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UniProtKB - P26842 (CD27_HUMAN)
Protein
CD27 antigen
Gene
CD27
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.
GO - Molecular functioni
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- transmembrane signaling receptor activity Source: UniProtKB
GO - Biological processi
- cell surface receptor signaling pathway Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- immunoglobulin mediated immune response Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of T cell apoptotic process Source: Ensembl
- positive regulation of B cell differentiation Source: UniProtKB
- positive regulation of JNK cascade Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: UniProtKB
- positive regulation of T cell differentiation Source: InterPro
- response to ethanol Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | P26842 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | P26842 |
SIGNORi | P26842 |
Names & Taxonomyi
Protein namesi | Recommended name: CD27 antigenAlternative name(s): CD27L receptor T-cell activation antigen CD27 T14 Tumor necrosis factor receptor superfamily member 7 CD_antigen: CD27 |
Gene namesi | Name:CD27 Synonyms:TNFRSF7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11922, CD27 |
MIMi | 186711, gene |
neXtProti | NX_P26842 |
VEuPathDBi | HostDB:ENSG00000139193 |
Subcellular locationi
Other locations
Extracellular region or secreted
- extracellular region Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 191 | ExtracellularSequence analysisAdd BLAST | 172 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 260 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Lymphoproliferative syndrome 2 (LPFS2)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069793 | 53 | C → Y in LPFS2. 1 PublicationCorresponds to variant dbSNP:rs397514667EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 939 |
MalaCardsi | CD27 |
MIMi | 615122, phenotype |
OpenTargetsi | ENSG00000139193 |
Orphaneti | 238505, Combined immunodeficiency due to CD27 deficiency |
PharmGKBi | PA162382107 |
Miscellaneous databases
Pharosi | P26842, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3713333 |
Genetic variation databases
BioMutai | CD27 |
DMDMi | 269849546 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000034571 | 20 – 260 | CD27 antigenAdd BLAST | 241 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 39 | PROSITE-ProRule annotation | ||
Disulfide bondi | 40 ↔ 53 | PROSITE-ProRule annotation | ||
Disulfide bondi | 43 ↔ 62 | PROSITE-ProRule annotation | ||
Disulfide bondi | 65 ↔ 81 | PROSITE-ProRule annotation | ||
Disulfide bondi | 84 ↔ 96 | PROSITE-ProRule annotation | ||
Disulfide bondi | 87 ↔ 104 | PROSITE-ProRule annotation | ||
Glycosylationi | 95 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 112 ↔ 120 | PROSITE-ProRule annotation | ||
Glycosylationi | 127 | O-linked (GalNAc...) serine1 Publication | 1 | |
Modified residuei | 219 | PhosphoserineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated.
O-glycosylated with core 1 or possibly core 8 glycans.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P26842 |
jPOSTi | P26842 |
MassIVEi | P26842 |
PaxDbi | P26842 |
PeptideAtlasi | P26842 |
PRIDEi | P26842 |
ProteomicsDBi | 54366 |
PTM databases
GlyConnecti | 800, 3 N-Linked glycans (1 site), 1 O-Linked glycan (1 site) |
GlyGeni | P26842, 4 sites, 3 N-linked glycans (1 site), 2 O-linked glycans (3 sites) |
iPTMneti | P26842 |
PhosphoSitePlusi | P26842 |
SwissPalmi | P26842 |
Expressioni
Tissue specificityi
Found in most T-lymphocytes.
Gene expression databases
Bgeei | ENSG00000139193, Expressed in lymph node and 157 other tissues |
Genevisiblei | P26842, HS |
Organism-specific databases
HPAi | ENSG00000139193, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Homodimer.
Interacts with SIVA1 and TRAF2.
2 PublicationsBinary interactionsi
P26842
Protein-protein interaction databases
BioGRIDi | 107377, 76 interactors |
ELMi | P26842 |
IntActi | P26842, 28 interactors |
STRINGi | 9606.ENSP00000266557 |
Miscellaneous databases
RNActi | P26842, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P26842 |
SMRi | P26842 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 63 | TNFR-Cys 1Add BLAST | 38 | |
Repeati | 64 – 104 | TNFR-Cys 2Add BLAST | 41 | |
Repeati | 105 – 141 | TNFR-Cys 3Add BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 219 – 260 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 233 – 248 | Basic and acidic residuesSequence analysisAdd BLAST | 16 |
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SBE3, Eukaryota |
GeneTreei | ENSGT00510000049297 |
HOGENOMi | CLU_067121_0_0_1 |
InParanoidi | P26842 |
OMAi | HGEAAQC |
OrthoDBi | 577429at2759 |
PhylomeDBi | P26842 |
TreeFami | TF336960 |
Family and domain databases
CDDi | cd13408, TNFRSF7, 1 hit |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR022328, TNFR_7 IPR034000, TNFRSF7_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 1 hit |
PRINTSi | PR01960, TNFACTORR7 |
SMARTi | View protein in SMART SM00208, TNFR, 2 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit PS50050, TNFR_NGFR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26842-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV
60 70 80 90 100
KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA
110 120 130 140 150
NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE
160 170 180 190 200
MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF
210 220 230 240 250
LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCHYSCPREE EGSTIPIQED
260
YRKPEPACSP
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069793 | 53 | C → Y in LPFS2. 1 PublicationCorresponds to variant dbSNP:rs397514667EnsemblClinVar. | 1 | |
Natural variantiVAR_016148 | 59 | A → T3 PublicationsCorresponds to variant dbSNP:rs25680Ensembl. | 1 | |
Natural variantiVAR_052348 | 233 | H → R5 PublicationsCorresponds to variant dbSNP:rs2532502EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63928 mRNA Translation: AAA58411.1 AK315732 mRNA Translation: BAG38087.1 AY504961 Genomic DNA Translation: AAR84239.1 AC005840 Genomic DNA No translation available. BC012160 mRNA Translation: AAH12160.1 |
CCDSi | CCDS8545.1 |
PIRi | A46517 |
RefSeqi | NP_001233.1, NM_001242.4 |
Genome annotation databases
Ensembli | ENST00000266557.4; ENSP00000266557.3; ENSG00000139193.4 |
GeneIDi | 939 |
KEGGi | hsa:939 |
MANE-Selecti | ENST00000266557.4; ENSP00000266557.3; NM_001242.5; NP_001233.2 |
UCSCi | uc001qod.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63928 mRNA Translation: AAA58411.1 AK315732 mRNA Translation: BAG38087.1 AY504961 Genomic DNA Translation: AAR84239.1 AC005840 Genomic DNA No translation available. BC012160 mRNA Translation: AAH12160.1 |
CCDSi | CCDS8545.1 |
PIRi | A46517 |
RefSeqi | NP_001233.1, NM_001242.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5TL5 | X-ray | 1.80 | A | 21-121 | [»] | |
5TLJ | X-ray | 3.50 | X | 21-121 | [»] | |
5TLK | X-ray | 2.70 | X/Y | 21-121 | [»] | |
7KX0 | X-ray | 2.69 | D/E/F | 23-127 | [»] | |
AlphaFoldDBi | P26842 | |||||
SMRi | P26842 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107377, 76 interactors |
ELMi | P26842 |
IntActi | P26842, 28 interactors |
STRINGi | 9606.ENSP00000266557 |
Chemistry databases
ChEMBLi | CHEMBL3713333 |
PTM databases
GlyConnecti | 800, 3 N-Linked glycans (1 site), 1 O-Linked glycan (1 site) |
GlyGeni | P26842, 4 sites, 3 N-linked glycans (1 site), 2 O-linked glycans (3 sites) |
iPTMneti | P26842 |
PhosphoSitePlusi | P26842 |
SwissPalmi | P26842 |
Genetic variation databases
BioMutai | CD27 |
DMDMi | 269849546 |
Proteomic databases
EPDi | P26842 |
jPOSTi | P26842 |
MassIVEi | P26842 |
PaxDbi | P26842 |
PeptideAtlasi | P26842 |
PRIDEi | P26842 |
ProteomicsDBi | 54366 |
Protocols and materials databases
ABCDi | P26842, 16 sequenced antibodies |
Antibodypediai | 3716, 2127 antibodies from 50 providers |
CPTCi | P26842, 3 antibodies |
DNASUi | 939 |
Genome annotation databases
Ensembli | ENST00000266557.4; ENSP00000266557.3; ENSG00000139193.4 |
GeneIDi | 939 |
KEGGi | hsa:939 |
MANE-Selecti | ENST00000266557.4; ENSP00000266557.3; NM_001242.5; NP_001233.2 |
UCSCi | uc001qod.4, human |
Organism-specific databases
CTDi | 939 |
DisGeNETi | 939 |
GeneCardsi | CD27 |
HGNCi | HGNC:11922, CD27 |
HPAi | ENSG00000139193, Tissue enriched (lymphoid) |
MalaCardsi | CD27 |
MIMi | 186711, gene 615122, phenotype |
neXtProti | NX_P26842 |
OpenTargetsi | ENSG00000139193 |
Orphaneti | 238505, Combined immunodeficiency due to CD27 deficiency |
PharmGKBi | PA162382107 |
VEuPathDBi | HostDB:ENSG00000139193 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SBE3, Eukaryota |
GeneTreei | ENSGT00510000049297 |
HOGENOMi | CLU_067121_0_0_1 |
InParanoidi | P26842 |
OMAi | HGEAAQC |
OrthoDBi | 577429at2759 |
PhylomeDBi | P26842 |
TreeFami | TF336960 |
Enzyme and pathway databases
PathwayCommonsi | P26842 |
Reactomei | R-HSA-5669034, TNFs bind their physiological receptors |
SignaLinki | P26842 |
SIGNORi | P26842 |
Miscellaneous databases
BioGRID-ORCSi | 939, 15 hits in 1068 CRISPR screens |
GeneWikii | CD27 |
GenomeRNAii | 939 |
Pharosi | P26842, Tbio |
PROi | PR:P26842 |
RNActi | P26842, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000139193, Expressed in lymph node and 157 other tissues |
Genevisiblei | P26842, HS |
Family and domain databases
CDDi | cd13408, TNFRSF7, 1 hit |
InterProi | View protein in InterPro IPR001368, TNFR/NGFR_Cys_rich_reg IPR022328, TNFR_7 IPR034000, TNFRSF7_N |
Pfami | View protein in Pfam PF00020, TNFR_c6, 1 hit |
PRINTSi | PR01960, TNFACTORR7 |
SMARTi | View protein in SMART SM00208, TNFR, 2 hits |
PROSITEi | View protein in PROSITE PS00652, TNFR_NGFR_1, 1 hit PS50050, TNFR_NGFR_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CD27_HUMAN | |
Accessioni | P26842Primary (citable) accession number: P26842 Secondary accession number(s): B2RDZ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | November 24, 2009 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references