UniProtKB - P26801 (CEBPG_RAT)
CCAAT/enhancer-binding protein gamma
Cebpg
Functioni
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (PubMed:1377818).
Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity).
Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter (By similarity).
By similarity1 PublicationGO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor binding Source: UniProtKB
- double-stranded DNA binding Source: RGD
- protein-containing complex binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: RGD
- RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending Source: RGD
- sequence-specific DNA binding Source: UniProtKB
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- B cell differentiation Source: UniProtKB
- enucleate erythrocyte differentiation Source: UniProtKB
- immune response Source: UniProtKB
- liver development Source: UniProtKB
- mRNA metabolic process Source: RGD
- natural killer cell mediated cytotoxicity Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of DNA repair Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: RGD
- regulation of transcription by RNA polymerase II Source: RGD
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: CCAAT/enhancer-binding protein gammaShort name: C/EBP gamma |
Gene namesi | Name:Cebpg |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2330, Cebpg |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
- RNA polymerase II transcription regulator complex Source: RGD
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076630 | 1 – 150 | CCAAT/enhancer-binding protein gammaAdd BLAST | 150 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 3 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | P26801 |
PTM databases
iPTMneti | P26801 |
PhosphoSitePlusi | P26801 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000021144, Expressed in testis and 21 other tissues |
ExpressionAtlasi | P26801, baseline and differential |
Genevisiblei | P26801, RN |
Interactioni
Subunit structurei
Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB (PubMed:1377818).
Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).
By similarity1 PublicationGO - Molecular functioni
- DNA-binding transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 247340, 3 interactors |
STRINGi | 10116.ENSRNOP00000028703 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 125 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 27 – 94 | DisorderedSequence analysisAdd BLAST | 68 | |
Regioni | 66 – 93 | Basic motifPROSITE-ProRule annotationAdd BLAST | 28 | |
Regioni | 97 – 118 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 94 | Basic and acidic residuesSequence analysisAdd BLAST | 39 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000160676 |
HOGENOMi | CLU_146813_0_0_1 |
InParanoidi | P26801 |
OMAi | HAHNFAD |
OrthoDBi | 1532157at2759 |
PhylomeDBi | P26801 |
TreeFami | TF105009 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSKLSQPAST AGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQPISTET TVANSDNTGQ
Sequence cautioni
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64403 mRNA Translation: CAA45745.1 Different initiation. |
PIRi | S26300 |
RefSeqi | NP_036963.1, NM_012831.1 |
Genome annotation databases
GeneIDi | 25301 |
KEGGi | rno:25301 |
UCSCi | RGD:2330, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X64403 mRNA Translation: CAA45745.1 Different initiation. |
PIRi | S26300 |
RefSeqi | NP_036963.1, NM_012831.1 |
3D structure databases
AlphaFoldDBi | P26801 |
SMRi | P26801 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 247340, 3 interactors |
STRINGi | 10116.ENSRNOP00000028703 |
PTM databases
iPTMneti | P26801 |
PhosphoSitePlusi | P26801 |
Proteomic databases
PaxDbi | P26801 |
Genome annotation databases
GeneIDi | 25301 |
KEGGi | rno:25301 |
UCSCi | RGD:2330, rat |
Organism-specific databases
CTDi | 1054 |
RGDi | 2330, Cebpg |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000160676 |
HOGENOMi | CLU_146813_0_0_1 |
InParanoidi | P26801 |
OMAi | HAHNFAD |
OrthoDBi | 1532157at2759 |
PhylomeDBi | P26801 |
TreeFami | TF105009 |
Miscellaneous databases
PROi | PR:P26801 |
Gene expression databases
Bgeei | ENSRNOG00000021144, Expressed in testis and 21 other tissues |
ExpressionAtlasi | P26801, baseline and differential |
Genevisiblei | P26801, RN |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CEBPG_RAT | |
Accessioni | P26801Primary (citable) accession number: P26801 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families