Cebpg

Functionⁱ

Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (PubMed:1377818). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 1377818
DNA-binding transcription factor activity Source: InterPro
double-stranded DNA binding
Source: RGD
Inferred from direct assayⁱ
- 1377818
protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1377818
protein homodimerization activity Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding, bending
Source: RGD
Inferred from direct assayⁱ
- 1377818
sequence-specific DNA binding Source: UniProtKB
transcription factor binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 7665092

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation Source: UniProtKB
enucleate erythrocyte differentiation Source: UniProtKB
immune response Source: UniProtKB
liver development
Source: UniProtKB
Inferred from expression patternⁱ
- 1377818
mRNA metabolic process Source: Ensembl
natural killer cell mediated cytotoxicity Source: UniProtKB
negative regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 7501458
positive regulation of DNA repair
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 16255782
positive regulation of interferon-gamma biosynthetic process Source: UniProtKB
regulation of transcription by RNA polymerase II
Source: RGD
Inferred from expression patternⁱ
- 1377818

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CCAAT/enhancer-binding protein gamma Short name: C/EBP gamma
Gene namesⁱ	Name:Cebpg
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 1

Organism-specific databases

Rat genome database More...RGDⁱ	2330 Cebpg

RGDⁱ

2330 Cebpg

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076630	1 – 150	CCAAT/enhancer-binding protein gammaAdd BLAST		150

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	3	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	P26801
PRIDEⁱ	P26801

PTM databases

iPTMnetⁱ	P26801
PhosphoSitePlusⁱ	P26801

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000021144 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P26801 baseline and differential
Genevisibleⁱ	P26801 RN

Interactionⁱ

Subunit structureⁱ

Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB (PubMed:1377818). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

protein heterodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1377818
protein homodimerization activity Source: Ensembl
transcription factor binding
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 7665092

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247340, 3 interactors
STRINGⁱ	10116.ENSRNOP00000028703

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P26801
SMRⁱ	P26801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	62 – 125	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	66 – 93	Basic motifPROSITE-ProRule annotationAdd BLAST		28
Regionⁱ	97 – 118	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		22

Sequence similaritiesⁱ

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410ISXZ Eukaryota ENOG41128ZN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063192
HOGENOMⁱ	HOG000057291
HOVERGENⁱ	HBG050880
InParanoidⁱ	P26801
KEGG Orthology (KO) More...KOⁱ	K10049
OMAⁱ	RSKQKAM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G11FC
PhylomeDBⁱ	P26801
TreeFamⁱ	TF105009

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P26801-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSKLSQPAST AGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK 
        60         70         80         90        100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE 
       110        120        130        140        150
NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQPISTET TVANSDNTGQ

Length:150

Mass (Da):16,388

Last modified:October 1, 1996 - v2

Checksum:ⁱB7B1686652E52326

GO

Sequence cautionⁱ

The sequence CAA45745 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64403 mRNA Translation: CAA45745.1 Different initiation.
PIRⁱ	S26300
NCBI Reference Sequences More...RefSeqⁱ	NP_036963.1, NM_012831.1
UniGeneⁱ	Rn.10332

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028703; ENSRNOP00000028703; ENSRNOG00000021144
GeneIDⁱ	25301
KEGGⁱ	rno:25301
UCSC genome browser More...UCSCⁱ	RGD:2330 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P26801	CCAAT/enhancer binding protein (C/EBP), gamma		RAT		150	UniRef100_P26801
UPI0004E48AC6		RAT		316

Protein	Similar proteins		Species	Score	Length	Source
P26801	CCAAT/enhancer binding protein (C/EBP), gamma		RAT		150	UniRef90_P26801
UPI0004E48AC6		RAT		316

Protein	Similar proteins		Species	Score	Length	Source
P26801	CCAAT/enhancer-binding protein gamma		MOUSE		150	UniRef50_P53568
Putative CCAAT/enhancer-binding protein gamma		Daphnia magna		93
CCAAT/enhancer-binding protein gamma		CRIGR		93
CCAAT/enhancer binding protein (C/EBP), gamma		PANTR		150
CCAAT/enhancer-binding protein gamma		MACMU		150
+21

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64403 mRNA Translation: CAA45745.1 Different initiation.
PIRⁱ	S26300
RefSeqⁱ	NP_036963.1, NM_012831.1
UniGeneⁱ	Rn.10332

3D structure databases

ProteinModelPortalⁱ	P26801
SMRⁱ	P26801
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247340, 3 interactors
STRINGⁱ	10116.ENSRNOP00000028703

PTM databases

iPTMnetⁱ	P26801
PhosphoSitePlusⁱ	P26801

Proteomic databases

PaxDbⁱ	P26801
PRIDEⁱ	P26801

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000028703; ENSRNOP00000028703; ENSRNOG00000021144
GeneIDⁱ	25301
KEGGⁱ	rno:25301
UCSCⁱ	RGD:2330 rat

Organism-specific databases

CTDⁱ	1054
RGDⁱ	2330 Cebpg

Phylogenomic databases

eggNOGⁱ	ENOG410ISXZ Eukaryota ENOG41128ZN LUCA
GeneTreeⁱ	ENSGT00530000063192
HOGENOMⁱ	HOG000057291
HOVERGENⁱ	HBG050880
InParanoidⁱ	P26801
KOⁱ	K10049
OMAⁱ	RSKQKAM
OrthoDBⁱ	EOG091G11FC
PhylomeDBⁱ	P26801
TreeFamⁱ	TF105009

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P26801

PROⁱ

PR:P26801

Gene expression databases

Bgeeⁱ	ENSRNOG00000021144 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasⁱ	P26801 baseline and differential
Genevisibleⁱ	P26801 RN

Family and domain databases

InterProⁱ	View protein in InterPro IPR004827 bZIP
Pfamⁱ	View protein in Pfam PF07716 bZIP_2, 1 hit
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEBPG_RAT
Accessionⁱ	P26801Primary (citable) accession number: P26801
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P26801 (CEBPG_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

CCAAT/enhancer-binding protein gamma

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ