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Protein

CCAAT/enhancer-binding protein gamma

Gene

Cebpg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the promoter and the enhancer of the alpha-1-fetoprotein gene (PubMed:1377818). Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (By similarity). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
CCAAT/enhancer-binding protein gamma
Short name:
C/EBP gamma
Gene namesi
Name:Cebpg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2330 Cebpg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000766301 – 150CCAAT/enhancer-binding protein gammaAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP26801
PRIDEiP26801

PTM databases

iPTMnetiP26801
PhosphoSitePlusiP26801

Expressioni

Gene expression databases

BgeeiENSRNOG00000021144 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiP26801 baseline and differential
GenevisibleiP26801 RN

Interactioni

Subunit structurei

Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB (PubMed:1377818). Interacts with ZNF638; this interaction increases transcriptional activation (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247340, 3 interactors
STRINGi10116.ENSRNOP00000028703

Structurei

3D structure databases

ProteinModelPortaliP26801
SMRiP26801
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 125bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni66 – 93Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni97 – 118Leucine-zipperPROSITE-ProRule annotationAdd BLAST22

Sequence similaritiesi

Belongs to the bZIP family. C/EBP subfamily.Curated

Phylogenomic databases

eggNOGiENOG410ISXZ Eukaryota
ENOG41128ZN LUCA
GeneTreeiENSGT00530000063192
HOGENOMiHOG000057291
HOVERGENiHBG050880
InParanoidiP26801
KOiK10049
OMAiRSKQKAM
OrthoDBiEOG091G11FC
PhylomeDBiP26801
TreeFamiTF105009

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequencei

Sequence statusi: Complete.

P26801-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKLSQPAST AGVNGISVIH TQAHASGLQQ VPQLVPAGPG GGGKAVPPSK
60 70 80 90 100
QSKKSSPMDR NSDEYRQRRE RNNMAVKKSR LKSKQKAQDT LQRVNQLKEE
110 120 130 140 150
NERLEAKIKL LTKELSVLKD LFLEHAHNLA DNVQPISTET TVANSDNTGQ
Length:150
Mass (Da):16,388
Last modified:October 1, 1996 - v2
Checksum:iB7B1686652E52326
GO

Sequence cautioni

The sequence CAA45745 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64403 mRNA Translation: CAA45745.1 Different initiation.
PIRiS26300
RefSeqiNP_036963.1, NM_012831.1
UniGeneiRn.10332

Genome annotation databases

EnsembliENSRNOT00000028703; ENSRNOP00000028703; ENSRNOG00000021144
GeneIDi25301
KEGGirno:25301
UCSCiRGD:2330 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64403 mRNA Translation: CAA45745.1 Different initiation.
PIRiS26300
RefSeqiNP_036963.1, NM_012831.1
UniGeneiRn.10332

3D structure databases

ProteinModelPortaliP26801
SMRiP26801
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247340, 3 interactors
STRINGi10116.ENSRNOP00000028703

PTM databases

iPTMnetiP26801
PhosphoSitePlusiP26801

Proteomic databases

PaxDbiP26801
PRIDEiP26801

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028703; ENSRNOP00000028703; ENSRNOG00000021144
GeneIDi25301
KEGGirno:25301
UCSCiRGD:2330 rat

Organism-specific databases

CTDi1054
RGDi2330 Cebpg

Phylogenomic databases

eggNOGiENOG410ISXZ Eukaryota
ENOG41128ZN LUCA
GeneTreeiENSGT00530000063192
HOGENOMiHOG000057291
HOVERGENiHBG050880
InParanoidiP26801
KOiK10049
OMAiRSKQKAM
OrthoDBiEOG091G11FC
PhylomeDBiP26801
TreeFamiTF105009

Miscellaneous databases

PROiPR:P26801

Gene expression databases

BgeeiENSRNOG00000021144 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiP26801 baseline and differential
GenevisibleiP26801 RN

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEBPG_RAT
AccessioniPrimary (citable) accession number: P26801
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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