UniProtKB - P26794 (PIM1_RAT)
Serine/threonine-protein kinase pim-1
Pim1
Functioni
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 67 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 121 | ATP; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Binding sitei | 128 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 167 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 44 – 52 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- manganese ion binding Source: UniProtKB
- protein serine/threonine kinase activator activity Source: RGD
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- ribosomal small subunit binding Source: RGD
- transcription factor binding Source: RGD
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cell cycle Source: UniProtKB-KW
- cellular detoxification Source: UniProtKB
- hyaluronan metabolic process Source: RGD
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of DNA-binding transcription factor activity Source: RGD
- positive regulation of brown fat cell differentiation Source: UniProtKB
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of cardioblast proliferation Source: RGD
- positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: RGD
- positive regulation of protein serine/threonine kinase activity Source: RGD
- positive regulation of transcription, DNA-templated Source: RGD
- protein autophosphorylation Source: RGD
- protein phosphorylation Source: UniProtKB
- protein stabilization Source: RGD
- regulation of hematopoietic stem cell proliferation Source: RGD
- regulation of transmembrane transporter activity Source: UniProtKB
- vitamin D receptor signaling pathway Source: RGD
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Cell cycle |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Pim1 Synonyms:Pim-1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3330, Pim1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: Ensembl
Nucleus
Plasma Membrane
- plasma membrane Source: RGD
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086530 | 1 – 313 | Serine/threonine-protein kinase pim-1Add BLAST | 313 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 8 | PhosphoserineBy similarity | 1 | |
Modified residuei | 98 | PhosphoserineBy similarity | 1 | |
Modified residuei | 261 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | P26794 |
PRIDEi | P26794 |
PTM databases
PhosphoSitePlusi | P26794 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000000529, Expressed in testis and 20 other tissues |
Genevisiblei | P26794, RN |
Interactioni
Subunit structurei
Binds to RP9 (By similarity).
Interacts with CDKN1B and FOXO3 (By similarity).
Interacts (via N-terminal 96 residues) with CDC25A.
Interacts with BAD (By similarity).
Interacts with PPP2CA; this interaction promotes dephosphorylation of PIM1, ubiquitination and proteasomal degradation (By similarity).
Interacts with HSP90, this interaction stabilizes PIM1 protein levels.
Interacts (ubiquitinated form) with HSP70 and promotes its proteosomal degradation (By similarity).
Interacts with CDKN1A (By similarity).
Interacts with CDC25C (By similarity).
Interacts (via N-terminal 96 residues) with CDC25A.
Interacts with MAP3K5 (By similarity).
Interacts with MYC (By similarity).
By similarityGO - Molecular functioni
- transcription factor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000637 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 38 – 290 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 253 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000153394 |
HOGENOMi | CLU_000288_63_0_1 |
InParanoidi | P26794 |
OMAi | CHDCGVL |
OrthoDBi | 930292at2759 |
PhylomeDBi | P26794 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017348, PIM1/2/3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037993, STPK_Pim-1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MLLSKINSLA HLRAAPCNDL HANKLAPGKE KEPLESQYQV GPLLGSGGFG
60 70 80 90 100
SVYSGIRVAD NLPVAIKHVE KDRISDWGEL PNGTRVPMEV VLLKKVSSGF
110 120 130 140 150
SGVIRLLDWF ERPDSFVLIL ERPEPVQDLF DFITERGALQ EELARSFFWQ
160 170 180 190 200
VLEAVRHCHN CGVLHRDIKD ENILIDLNRG ELKLIDFGSG ALLKDTVYTD
210 220 230 240 250
FDGTRVYSPP EWIRYHRYHG RSAAVWSLGI LLYDMVCGDI PFEHDEEIVK
260 270 280 290 300
GQVYFRQRVS SECQHLIRWC LSLRPSDRPS FEEIQNHPWM QDVLLPQATA
310
EIHLHSLSPS PSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63675 mRNA Translation: CAA45214.1 |
PIRi | S26298 |
RefSeqi | NP_058730.1, NM_017034.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000637; ENSRNOP00000000637; ENSRNOG00000000529 |
GeneIDi | 24649 |
KEGGi | rno:24649 |
UCSCi | RGD:3330, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63675 mRNA Translation: CAA45214.1 |
PIRi | S26298 |
RefSeqi | NP_058730.1, NM_017034.1 |
3D structure databases
SMRi | P26794 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000000637 |
PTM databases
PhosphoSitePlusi | P26794 |
Proteomic databases
PaxDbi | P26794 |
PRIDEi | P26794 |
Genome annotation databases
Ensembli | ENSRNOT00000000637; ENSRNOP00000000637; ENSRNOG00000000529 |
GeneIDi | 24649 |
KEGGi | rno:24649 |
UCSCi | RGD:3330, rat |
Organism-specific databases
CTDi | 5292 |
RGDi | 3330, Pim1 |
Phylogenomic databases
eggNOGi | KOG0583, Eukaryota |
GeneTreei | ENSGT00940000153394 |
HOGENOMi | CLU_000288_63_0_1 |
InParanoidi | P26794 |
OMAi | CHDCGVL |
OrthoDBi | 930292at2759 |
PhylomeDBi | P26794 |
Miscellaneous databases
PROi | PR:P26794 |
Gene expression databases
Bgeei | ENSRNOG00000000529, Expressed in testis and 20 other tissues |
Genevisiblei | P26794, RN |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR017348, PIM1/2/3 IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037993, STPK_Pim-1, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PIM1_RAT | |
Accessioni | P26794Primary (citable) accession number: P26794 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families