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Protein

40S ribosomal protein S7-A

Gene

RPS7A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (PubMed:22096102). eS7 is involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (PubMed:15590835).1 Publication1 Publication

Miscellaneous

Present with 41000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS7 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal small subunit biogenesis Source: GO_Central
  • ribosome biogenesis Source: SGD
  • rRNA methylation Source: Reactome
  • rRNA processing Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-33629-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SCE-72702 Ribosomal scanning and start codon recognition
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S7-A1 Publication
Alternative name(s):
RP30
RP40
Gene namesi
Name:RPS7A1 Publication
Synonyms:RPS30
Ordered Locus Names:YOR096W
ORF Names:YOR3177W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

SGDiS000005622 RPS7A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001742122 – 19040S ribosomal protein S7-AAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine2 Publications1
Cross-linki124Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP26786
PaxDbiP26786
PRIDEiP26786
TopDownProteomicsiP26786

PTM databases

iPTMnetiP26786

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102). Interacts with snoRNA U3. uS11 interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3 (PubMed:15590835).1 Publication2 Publications

Protein-protein interaction databases

BioGridi34494, 134 interactors
DIPiDIP-2592N
IntActiP26786, 61 interactors
MINTiP26786
STRINGi4932.YOR096W

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP26786
SMRiP26786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014122
HOGENOMiHOG000197237
InParanoidiP26786
KOiK02993
OMAiMFIGERK
OrthoDBiEOG092C4XAM

Family and domain databases

InterProiView protein in InterPro
IPR000554 Ribosomal_S7e
PANTHERiPTHR11278 PTHR11278, 1 hit
PfamiView protein in Pfam
PF01251 Ribosomal_S7e, 1 hit
PROSITEiView protein in PROSITE
PS00948 RIBOSOMAL_S7E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26786-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAPQAKILS QAPTELELQV AQAFVELENS SPELKAELRP LQFKSIREID
60 70 80 90 100
VAGGKKALAI FVPVPSLAGF HKVQTKLTRE LEKKFQDRHV IFLAERRILP
110 120 130 140 150
KPSRTSRQVQ KRPRSRTLTA VHDKILEDLV FPTEIVGKRV RYLVGGNKIQ
160 170 180 190
KVLLDSKDVQ QIDYKLESFQ AVYNKLTGKQ IVFEIPSETH
Length:190
Mass (Da):21,622
Last modified:January 23, 2007 - v4
Checksum:i0096C3D7B6A196A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24F → E AA sequence (PubMed:1544921).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64018.1 Sequence problems.
Z75004 Genomic DNA Translation: CAA99293.1
BK006948 Genomic DNA Translation: DAA10873.1
PIRiS66981
RefSeqiNP_014739.1, NM_001183515.1

Genome annotation databases

EnsemblFungiiYOR096W; YOR096W; YOR096W
GeneIDi854263
KEGGisce:YOR096W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X94335 Genomic DNA Translation: CAA64018.1 Sequence problems.
Z75004 Genomic DNA Translation: CAA99293.1
BK006948 Genomic DNA Translation: DAA10873.1
PIRiS66981
RefSeqiNP_014739.1, NM_001183515.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10S71-190[»]
3J6Yelectron microscopy6.10S71-190[»]
3J77electron microscopy6.20S71-190[»]
3J78electron microscopy6.30S71-190[»]
4U3MX-ray3.00S7/s72-190[»]
4U3NX-ray3.20S7/s72-190[»]
4U3UX-ray2.90S7/s72-190[»]
4U4NX-ray3.10S7/s72-190[»]
4U4OX-ray3.60S7/s72-190[»]
4U4QX-ray3.00S7/s72-190[»]
4U4RX-ray2.80S7/s72-190[»]
4U4UX-ray3.00S7/s72-190[»]
4U4YX-ray3.20S7/s72-190[»]
4U4ZX-ray3.10S7/s72-190[»]
4U50X-ray3.20S7/s72-190[»]
4U51X-ray3.20S7/s72-190[»]
4U52X-ray3.00S7/s72-190[»]
4U53X-ray3.30S7/s72-190[»]
4U55X-ray3.20S7/s72-190[»]
4U56X-ray3.45S7/s72-190[»]
4U6FX-ray3.10S7/s72-190[»]
4V88X-ray3.00AH/CH1-190[»]
4V8Yelectron microscopy4.30AH1-190[»]
4V8Zelectron microscopy6.60AH1-190[»]
4V92electron microscopy3.70H4-187[»]
5DATX-ray3.15S7/s72-190[»]
5DC3X-ray3.25S7/s72-190[»]
5DGEX-ray3.45S7/s72-190[»]
5DGFX-ray3.30S7/s72-190[»]
5DGVX-ray3.10S7/s72-190[»]
5FCIX-ray3.40S7/s72-190[»]
5FCJX-ray3.10S7/s72-190[»]
5I4LX-ray3.10S7/s72-187[»]
5JUOelectron microscopy4.00EB1-190[»]
5JUPelectron microscopy3.50EB1-190[»]
5JUSelectron microscopy4.20EB1-190[»]
5JUTelectron microscopy4.00EB1-190[»]
5JUUelectron microscopy4.00EB1-190[»]
5LL6electron microscopy3.90U1-190[»]
5LYBX-ray3.25S7/s72-187[»]
5M1Jelectron microscopy3.30H24-187[»]
5MC6electron microscopy3.80U1-190[»]
5MEIX-ray3.50I/s72-187[»]
5NDGX-ray3.70S7/s73-187[»]
5NDVX-ray3.30S7/s72-187[»]
5NDWX-ray3.70S7/s74-187[»]
5OBMX-ray3.40S7/s72-187[»]
5ON6X-ray3.10I/s72-187[»]
5TBWX-ray3.00I/s72-187[»]
5TGAX-ray3.30S7/s72-187[»]
5TGMX-ray3.50S7/s72-187[»]
5TZSelectron microscopy5.1071-190[»]
5WLCelectron microscopy3.80L71-190[»]
5WYJelectron microscopy8.70SI1-190[»]
5WYKelectron microscopy4.50SI1-190[»]
6EMLelectron microscopy3.60U1-190[»]
6FAIelectron microscopy3.40H1-190[»]
6GQ1electron microscopy4.40x4-187[»]
6GQBelectron microscopy3.90x4-187[»]
6GQVelectron microscopy4.00x4-187[»]
ProteinModelPortaliP26786
SMRiP26786
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34494, 134 interactors
DIPiDIP-2592N
IntActiP26786, 61 interactors
MINTiP26786
STRINGi4932.YOR096W

PTM databases

iPTMnetiP26786

Proteomic databases

MaxQBiP26786
PaxDbiP26786
PRIDEiP26786
TopDownProteomicsiP26786

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR096W; YOR096W; YOR096W
GeneIDi854263
KEGGisce:YOR096W

Organism-specific databases

SGDiS000005622 RPS7A

Phylogenomic databases

GeneTreeiENSGT00390000014122
HOGENOMiHOG000197237
InParanoidiP26786
KOiK02993
OMAiMFIGERK
OrthoDBiEOG092C4XAM

Enzyme and pathway databases

BioCyciYEAST:G3O-33629-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-SCE-72702 Ribosomal scanning and start codon recognition
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

PROiPR:P26786

Family and domain databases

InterProiView protein in InterPro
IPR000554 Ribosomal_S7e
PANTHERiPTHR11278 PTHR11278, 1 hit
PfamiView protein in Pfam
PF01251 Ribosomal_S7e, 1 hit
PROSITEiView protein in PROSITE
PS00948 RIBOSOMAL_S7E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRS7A_YEAST
AccessioniPrimary (citable) accession number: P26786
Secondary accession number(s): D6W2F7, Q08502
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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