RPL16B

Functionⁱ

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

There are 2 genes for uL13 in yeast.Curated

GO - Molecular functionⁱ

mRNA binding Source: GO_Central
RNA binding
Source: SGD
Inferred from direct assayⁱ
- 6337137
structural constituent of ribosome Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cytoplasmic translation
Source: SGD
Inferred by curatorⁱ
- 11983894
translation Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33099-MONOMER
Reactomeⁱ	R-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane R-SCE-72689 Formation of a pool of free 40S subunits R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

BioCycⁱ

YEAST:G3O-33099-MONOMER

Reactomeⁱ

R-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 60S ribosomal protein L16-B1 Publication Alternative name(s): L21 Large ribosomal subunit protein uL13-B1 Publication RP23 YL15
Gene namesⁱ	Name:RPL16B1 Publication Synonyms:RP23, RPL21B Ordered Locus Names:YNL069C ORF Names:N2377
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XIV

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL069C
Saccharomyces Genome Database More...SGDⁱ	S000005013 RPL16B

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed2 Publications
ChainⁱPRO_0000133792	2 – 198	60S ribosomal protein L16-BAdd BLAST		197

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserine; partial2 Publications	1
Modified residueⁱ	43	PhosphoserineCombined sources	1
Cross-linkⁱ	176	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residueⁱ	181	PhosphoserineCombined sources	1
Modified residueⁱ	185	PhosphoserineCombined sources	1
Modified residueⁱ	187	PhosphoserineCombined sources	1

Post-translational modificationⁱ

N-terminally acetylated by acetyltransferase NatA.2 Publications

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P26785
PaxDbⁱ	P26785
PRIDEⁱ	P26785

PTM databases

iPTMnetⁱ	P26785

iPTMnetⁱ

P26785

Interactionⁱ

Subunit structureⁱ

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridⁱ	35754, 121 interactors
IntActⁱ	P26785, 26 interactors
Molecular INTeraction database More...MINTⁱ	P26785
STRINGⁱ	4932.YNL069C

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4V88	X-ray	3.00	BO/DO	4-162	[»]
				BO/DO	144-182	[»]
ProteinModelPortalⁱ	P26785
SMRⁱ	P26785
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the universal ribosomal protein uL13 family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010799
HOGENOMⁱ	HOG000225289
InParanoidⁱ	P26785
KEGG Orthology (KO) More...KOⁱ	K02872
OMAⁱ	KHNREMK
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5KDG

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00392 Ribosomal_L13, 1 hit
Gene3Dⁱ	3.90.1180.10, 1 hit
HAMAPⁱ	MF_01366 Ribosomal_L13, 1 hit
InterProⁱ	View protein in InterPro IPR005822 Ribosomal_L13 IPR023563 Ribosomal_L13_CS IPR005755 Ribosomal_L13_euk/arc IPR036899 Ribosomal_L13_sf
PANTHERⁱ	PTHR11545 PTHR11545, 1 hit PTHR11545:SF3 PTHR11545:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00572 Ribosomal_L13, 1 hit
PIRSFⁱ	PIRSF002181 Ribosomal_L13, 1 hit
SUPFAMⁱ	SSF52161 SSF52161, 1 hit
TIGRFAMsⁱ	TIGR01077 L13_A_E, 1 hit
PROSITEⁱ	View protein in PROSITE PS00783 RIBOSOMAL_L13, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P26785-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSQPVVVIDA KDHLLGRLAS TIAKQVLNGQ KIVVVRAEAL NISGEFFRNK 
        60         70         80         90        100
LKYHDFLRKA TAFNKTRGPF HFRAPSRILY KAIRGMVSHK TARGKAALER 
       110        120        130        140        150
LKIFEGIPPP YDKKKRVVVP QALRVLRLKP GRKYTTLGKL STSVGWKYED 
       160        170        180        190 
VVAKLEDKRK VRSAEYYAKK RAFTKKVSSA SAAASESDVA KQLASFGY

Length:198

Mass (Da):22,249

Last modified:January 23, 2007 - v3

Checksum:ⁱ959CFEC64DAF2F83

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	14	L → H AA sequence (PubMed:1544921).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X86470 Genomic DNA Translation: CAA60191.1 X86470 Genomic DNA Translation: CAA60192.1 Z71345 Genomic DNA Translation: CAA95943.1 BK006947 Genomic DNA Translation: DAA10476.1
PIRⁱ	S53911
NCBI Reference Sequences More...RefSeqⁱ	NP_014330.1, NM_001182907.1

Genome annotation databases

EnsemblFungiⁱ	YNL069C; YNL069C; YNL069C
GeneIDⁱ	855655
KEGGⁱ	sce:YNL069C

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P26785	Ribosomal protein L16B		YEAS1		198
Rpl16bp		YEAS8		198
RPL16Bp Ribosomal 60S subunit protein L16B		Saccharomyces sp. 'boulardii'		198
Rpl16bp		YEASA		113
Rpl16bp		SACCK		113
+9

Protein	Similar proteins		Species	Score	Length
P26785	Ribosomal protein L16B		YEAS1		198
Rpl16bp		YEAS8		198
RPL16Bp Ribosomal 60S subunit protein L16B		Saccharomyces sp. 'boulardii'		198
Rpl16bp		YEASA		113
Rpl16bp		SACCK		113
+335

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X86470 Genomic DNA Translation: CAA60191.1 X86470 Genomic DNA Translation: CAA60192.1 Z71345 Genomic DNA Translation: CAA95943.1 BK006947 Genomic DNA Translation: DAA10476.1
PIRⁱ	S53911
NCBI Reference Sequences More...RefSeqⁱ	NP_014330.1, NM_001182907.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4V88	X-ray	3.00	BO/DO	4-162	[»]
				BO/DO	144-182	[»]
ProteinModelPortalⁱ	P26785
SMRⁱ	P26785
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	35754, 121 interactors
IntActⁱ	P26785, 26 interactors
Molecular INTeraction database More...MINTⁱ	P26785
STRINGⁱ	4932.YNL069C

PTM databases

iPTMnetⁱ	P26785

iPTMnetⁱ

P26785

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P26785
PaxDbⁱ	P26785
PRIDEⁱ	P26785

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YNL069C; YNL069C; YNL069C
GeneIDⁱ	855655
KEGGⁱ	sce:YNL069C

Organism-specific databases

EuPathDBⁱ	FungiDB:YNL069C
Saccharomyces Genome Database More...SGDⁱ	S000005013 RPL16B

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010799
HOGENOMⁱ	HOG000225289
InParanoidⁱ	P26785
KEGG Orthology (KO) More...KOⁱ	K02872
OMAⁱ	KHNREMK
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C5KDG

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-33099-MONOMER
Reactomeⁱ	R-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane R-SCE-72689 Formation of a pool of free 40S subunits R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

BioCycⁱ

YEAST:G3O-33099-MONOMER

Reactomeⁱ

R-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P26785

PROⁱ

PR:P26785

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00392 Ribosomal_L13, 1 hit
Gene3Dⁱ	3.90.1180.10, 1 hit
HAMAPⁱ	MF_01366 Ribosomal_L13, 1 hit
InterProⁱ	View protein in InterPro IPR005822 Ribosomal_L13 IPR023563 Ribosomal_L13_CS IPR005755 Ribosomal_L13_euk/arc IPR036899 Ribosomal_L13_sf
PANTHERⁱ	PTHR11545 PTHR11545, 1 hit PTHR11545:SF3 PTHR11545:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00572 Ribosomal_L13, 1 hit
PIRSFⁱ	PIRSF002181 Ribosomal_L13, 1 hit
SUPFAMⁱ	SSF52161 SSF52161, 1 hit
TIGRFAMsⁱ	TIGR01077 L13_A_E, 1 hit
PROSITEⁱ	View protein in PROSITE PS00783 RIBOSOMAL_L13, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RL16B_YEAST
Accessionⁱ	P26785Primary (citable) accession number: P26785 Secondary accession number(s): D6W1B0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	May 23, 2018
	This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Ribosomal proteins
Ribosomal proteins families and list of entries
SIMILARITY comments
Index of protein domains and families
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names

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UniProtKB - P26785 (RL16B_YEAST)

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60S ribosomal protein L16-B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Cytosol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ