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Protein

Virulence sensor protein BvgS

Gene

bvgS

Organism
Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals (By similarity).By similarity

Catalytic activityi

ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processTwo-component regulatory system, Virulence
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBBRO257310:G1GSX-3041-MONOMER
BRENDAi2.7.13.3 227

Names & Taxonomyi

Protein namesi
Recommended name:
Virulence sensor protein BvgS (EC:2.7.13.3)
Gene namesi
Name:bvgS
Ordered Locus Names:BB2995
OrganismiBordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) (Alcaligenes bronchisepticus)
Taxonomic identifieri257310 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001027 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini33 – 307CytoplasmicSequence analysisAdd BLAST275
Transmembranei308 – 331HelicalSequence analysisAdd BLAST24
Topological domaini332 – 541PeriplasmicSequence analysisAdd BLAST210
Transmembranei542 – 563HelicalSequence analysisAdd BLAST22
Topological domaini564 – 1238CytoplasmicSequence analysisAdd BLAST675

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000003236831 – 1238Virulence sensor protein BvgSAdd BLAST1208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei729Phosphohistidine; by autocatalysisPROSITE-ProRule annotation1
Modified residuei10234-aspartylphosphatePROSITE-ProRule annotation1
Modified residuei1172PhosphohistidinePROSITE-ProRule annotation1

Post-translational modificationi

Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP26762

Interactioni

Protein-protein interaction databases

STRINGi257310.BB2995

Structurei

3D structure databases

ProteinModelPortaliP26762
SMRiP26762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini580 – 651PASPROSITE-ProRule annotationAdd BLAST72
Domaini652 – 708PACPROSITE-ProRule annotationAdd BLAST57
Domaini726 – 948Histidine kinasePROSITE-ProRule annotationAdd BLAST223
Domaini974 – 1095Response regulatoryPROSITE-ProRule annotationAdd BLAST122
Domaini1133 – 1228HPtPROSITE-ProRule annotationAdd BLAST96

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZU Bacteria
ENOG410XNMH LUCA
HOGENOMiHOG000269369
KOiK07679
OMAiHWILPYR
OrthoDBiPOG091H03T5

Family and domain databases

CDDicd00075 HATPase_c, 1 hit
cd00082 HisKA, 1 hit
cd00088 HPT, 1 hit
cd00130 PAS, 1 hit
cd00156 REC, 1 hit
Gene3Di1.20.120.160, 1 hit
3.30.565.10, 1 hit
InterProiView protein in InterPro
IPR011006 CheY-like_superfamily
IPR003594 HATPase_C
IPR036890 HATPase_C_sf
IPR005467 His_kinase_dom
IPR003661 HisK_dim/P
IPR036097 HisK_dim/P_sf
IPR036641 HPT_dom_sf
IPR000014 PAS
IPR000700 PAS-assoc_C
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR004358 Sig_transdc_His_kin-like_C
IPR008207 Sig_transdc_His_kin_Hpt_dom
IPR001789 Sig_transdc_resp-reg_receiver
IPR001638 Solute-binding_3/MltF_N
PfamiView protein in Pfam
PF02518 HATPase_c, 1 hit
PF00512 HisKA, 1 hit
PF01627 Hpt, 1 hit
PF00989 PAS, 1 hit
PF00072 Response_reg, 1 hit
PF00497 SBP_bac_3, 2 hits
PRINTSiPR00344 BCTRLSENSOR
SMARTiView protein in SMART
SM00387 HATPase_c, 1 hit
SM00388 HisKA, 1 hit
SM00073 HPT, 1 hit
SM00091 PAS, 1 hit
SM00062 PBPb, 2 hits
SM00448 REC, 1 hit
SUPFAMiSSF47226 SSF47226, 2 hits
SSF47384 SSF47384, 1 hit
SSF52172 SSF52172, 1 hit
SSF55785 SSF55785, 1 hit
SSF55874 SSF55874, 1 hit
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50109 HIS_KIN, 1 hit
PS50894 HPT, 1 hit
PS50113 PAC, 1 hit
PS50112 PAS, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26762-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPHRLYPR SLICLAQALL AWALLAWAPA QASQELTLVG KAAVPDVEIA
60 70 80 90 100
LDGDDWRWLA RKRVLTLGVY APDIPPFDVT YDERYEGLTA DYMAIIAHNL
110 120 130 140 150
GVQAKVLRYP TREQAVGALE SGQIDLIGTV NGIEGRLQSL RLSVPYAADH
160 170 180 190 200
PVLVMPIGAR RAPPADLAGQ RLAVDANYLP RETLQQAYPQ ATLHYFPSSE
210 220 230 240 250
QALAAVAYGQ ADVFIGDALT TSHLVSQSYF NDVRVVAPAQ IVTGGESFGV
260 270 280 290 300
RADNTRLLRV VNAVLEAIPA SERRSLIYRW GLGSSISLDF ARPAYSAREQ
310 320 330 340 350
QWMANHPVVK VAVLNLFAPF TLFRTDEQFG GISAAVLQLL QLRTGLDFQI
360 370 380 390 400
IGVDTVEELI AKLRSGEADM AGALFVNAAR ESVLSFSRPY VRNGMVIVTR
410 420 430 440 450
QDPAAPADAD HLDGRTIAMV RNSAAIPLLQ QRYPQAKVVT ADNPTEAMLL
460 470 480 490 500
VADGQADAVV QTQISASYYV NRYFAGKLRI ASALDLPPAE IALATARGQT
510 520 530 540 550
ELISILNKAL YSISNDELAS IVSRWRGSDG DPRTWYAYRN EIYLLIGLGL
560 570 580 590 600
LSALLFLSWI VYLRRQIRQR KRAERALNDQ LEFMRVLIDG TPNPIYVRDK
610 620 630 640 650
EGRMLLCNDA YLDTFGVTAD AVLGKTIPEA NVVGDPALAR EMHEFLLTRM
660 670 680 690 700
SAEREPRFED RDVTLHGRTR HVYQWTVPYG DSLGELKGII GGWIDITERA
710 720 730 740 750
ELLRELHDAK ESADAANRAK TTFLATMSHE IRTPMNAIIG MLELALLRPA
760 770 780 790 800
DQEPDRQSIQ VAYDSARSLL ELIGDILDIA KIEAGKFDLA PVRTALRALP
810 820 830 840 850
EGAIRVFDGL ARQKGIELVL KTDIVGVDDV LIDPLRMKQV LSNLVGNAIK
860 870 880 890 900
FTTEGQVVLT VTARPDGEAA HVQFSVSDTG CGISEADQRQ LFKPFSQVGG
910 920 930 940 950
SAEAGPAPGT GLGLSISRRL VELMGGTLVM RSAPGVGTTV SVDLRLTMVE
960 970 980 990 1000
KSAQATPPAA AAQATPSKPQ VSLRVLVVDD HKPNLMLLRQ QLDYLGQRVV
1010 1020 1030 1040 1050
AADSGEAALA LWHEHAFDVV ITDCNMPGIN GYELARRIRA AEAAPGYGRT
1060 1070 1080 1090 1100
RCILFGFTAS AQMDEAQRCR AAGMDDCLFK PIGVDALRQR LNEAAARAAL
1110 1120 1130 1140 1150
PTPPSPQAAA PATHDATPAA FSAESILALT QNDEALIRQL LEELIRTNRA
1160 1170 1180 1190 1200
DVDQLQKLHQ QADWPKVSDM AHRLAGGARV VDAKAMIDTA LALEKKAQGQ
1210 1220 1230
AGPSPEIDGM VRTLAAQSAA LETQLRAWLE QRPHQGQP
Length:1,238
Mass (Da):134,811
Last modified:September 19, 2003 - v2
Checksum:i74DCB538B77A0F3E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti50A → T in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti395M → L in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti651S → A in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti1008A → S in CAA41252 (PubMed:1791760).Curated1
Sequence conflicti1067 – 1068QR → HA in CAA41252 (PubMed:1791760).Curated2
Sequence conflicti1144L → V in CAA41252 (PubMed:1791760).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58355 Genomic DNA Translation: CAA41252.1
BX640446 Genomic DNA Translation: CAE33487.1
PIRiS17944
RefSeqiWP_010926708.1, NC_002927.3

Genome annotation databases

EnsemblBacteriaiCAE33487; CAE33487; BB2995
KEGGibbr:BB2995

Similar proteinsi

Entry informationi

Entry nameiBVGS_BORBR
AccessioniPrimary (citable) accession number: P26762
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 19, 2003
Last modified: May 23, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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