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Protein

NKG2-C type II integral membrane protein

Gene

KLRC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • MHC class I protein complex binding Source: UniProtKB
  • protein antigen binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLectin

Enzyme and pathway databases

ReactomeiR-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
NKG2-C type II integral membrane protein
Alternative name(s):
CD159 antigen-like family member C
NK cell receptor C
NKG2-C-activating NK receptor
CD_antigen: CD159c
Gene namesi
Name:KLRC2
Synonyms:NKG2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000205809.9
HGNCiHGNC:6375 KLRC2
MIMi602891 gene
neXtProtiNX_P26717

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicSequence analysisAdd BLAST70
Transmembranei71 – 93Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini94 – 231ExtracellularSequence analysisAdd BLAST138

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3822
PharmGKBiPA30164

Polymorphism and mutation databases

BioMutaiKLRC2
DMDMi20141529

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466621 – 231NKG2-C type II integral membrane proteinAdd BLAST231

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi100N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 128PROSITE-ProRule annotation
Disulfide bondi145 ↔ 227PROSITE-ProRule annotation
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi206 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP26717
PaxDbiP26717
PeptideAtlasiP26717
PRIDEiP26717
ProteomicsDBi54364

Expressioni

Tissue specificityi

Natural killer cells.

Gene expression databases

BgeeiENSG00000205809 Expressed in 85 organ(s), highest expression level in substantia nigra
CleanExiHS_KLRC2
ExpressionAtlasiP26717 baseline and differential
GenevisibleiP26717 HS

Organism-specific databases

HPAiHPA058052

Interactioni

Subunit structurei

Can form disulfide-bonded heterodimer with CD94. Interacts with TYROBP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110021, 2 interactors
IntActiP26717, 6 interactors
STRINGi9606.ENSP00000371327

Structurei

Secondary structure

1231
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP26717
SMRiP26717
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26717

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 229C-type lectinPROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW4 Eukaryota
ENOG410ZFTY LUCA
HOGENOMiHOG000220925
HOVERGENiHBG077044
InParanoidiP26717
KOiK06541
PhylomeDBiP26717
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P26717-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKQRGTFSE VSLAQDPKRQ QRKPKGNKSS ISGTEQEIFQ VELNLQNPSL
60 70 80 90 100
NHQGIDKIYD CQGLLPPPEK LTAEVLGIIC IVLMATVLKT IVLIPFLEQN
110 120 130 140 150
NSSPNTRTQK ARHCGHCPEE WITYSNSCYY IGKERRTWEE SLLACTSKNS
160 170 180 190 200
SLLSIDNEEE MKFLASILPS SWIGVFRNSS HHPWVTINGL AFKHKIKDSD
210 220 230
NAELNCAVLQ VNRLKSAQCG SSMIYHCKHK L
Length:231
Mass (Da):26,072
Last modified:January 23, 2002 - v2
Checksum:i6B971EECD7542930
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPJ4J3KPJ4_HUMAN
NKG2-C type II integral membrane pr...
KLRC2
231Annotation score:
F5H518F5H518_HUMAN
NKG2-C type II integral membrane pr...
KLRC2
172Annotation score:
H0YFK4H0YFK4_HUMAN
NKG2-C type II integral membrane pr...
KLRC2
103Annotation score:
A0A087WV37A0A087WV37_HUMAN
NKG2-C type II integral membrane pr...
KLRC2
124Annotation score:
H0YGY2H0YGY2_HUMAN
NKG2-C type II integral membrane pr...
KLRC2
85Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti161M → I in CAA38651 (PubMed:2007850).Curated1

Polymorphismi

Two alleles are known. The sequence shown is that of allele NKG2-C*01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0134042S → N in allele NKG2-C*02. 1 PublicationCorresponds to variant dbSNP:rs28403159Ensembl.1
Natural variantiVAR_013405102S → F in allele NKG2-C*02. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54869 mRNA Translation: CAA38651.1
AJ001684 Genomic DNA Translation: CAA04922.1
AF260134 mRNA Translation: AAF86972.1
Y13055 mRNA Translation: CAA73498.1
AC068775 Genomic DNA No translation available.
BC093644 mRNA Translation: AAH93644.1
BC112039 mRNA Translation: AAI12040.1
CCDSiCCDS31745.1
PIRiPT0374
RefSeqiNP_002251.2, NM_002260.3
UniGeneiHs.591157

Genome annotation databases

EnsembliENST00000381902; ENSP00000371327; ENSG00000205809
GeneIDi3822
KEGGihsa:3822
UCSCiuc001qyk.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54869 mRNA Translation: CAA38651.1
AJ001684 Genomic DNA Translation: CAA04922.1
AF260134 mRNA Translation: AAF86972.1
Y13055 mRNA Translation: CAA73498.1
AC068775 Genomic DNA No translation available.
BC093644 mRNA Translation: AAH93644.1
BC112039 mRNA Translation: AAI12040.1
CCDSiCCDS31745.1
PIRiPT0374
RefSeqiNP_002251.2, NM_002260.3
UniGeneiHs.591157

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L35NMR-A72-100[»]
ProteinModelPortaliP26717
SMRiP26717
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110021, 2 interactors
IntActiP26717, 6 interactors
STRINGi9606.ENSP00000371327

Polymorphism and mutation databases

BioMutaiKLRC2
DMDMi20141529

Proteomic databases

MaxQBiP26717
PaxDbiP26717
PeptideAtlasiP26717
PRIDEiP26717
ProteomicsDBi54364

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381902; ENSP00000371327; ENSG00000205809
GeneIDi3822
KEGGihsa:3822
UCSCiuc001qyk.4 human

Organism-specific databases

CTDi3822
DisGeNETi3822
EuPathDBiHostDB:ENSG00000205809.9
GeneCardsiKLRC2
HGNCiHGNC:6375 KLRC2
HPAiHPA058052
MIMi602891 gene
neXtProtiNX_P26717
PharmGKBiPA30164
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWW4 Eukaryota
ENOG410ZFTY LUCA
HOGENOMiHOG000220925
HOVERGENiHBG077044
InParanoidiP26717
KOiK06541
PhylomeDBiP26717
TreeFamiTF336674

Enzyme and pathway databases

ReactomeiR-HSA-2172127 DAP12 interactions
R-HSA-2424491 DAP12 signaling

Miscellaneous databases

EvolutionaryTraceiP26717
GeneWikiiKLRC2
GenomeRNAii3822
PROiPR:P26717
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000205809 Expressed in 85 organ(s), highest expression level in substantia nigra
CleanExiHS_KLRC2
ExpressionAtlasiP26717 baseline and differential
GenevisibleiP26717 HS

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNKG2C_HUMAN
AccessioniPrimary (citable) accession number: P26717
Secondary accession number(s): O43802, Q52M74, Q9NR42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2002
Last modified: September 12, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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