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Entry version 187 (07 Apr 2021)
Sequence version 2 (11 Jan 2011)
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Protein

NKG2-A/NKG2-B type II integral membrane protein

Gene

KLRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Immune inhibitory receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules. Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self (PubMed:9486650, PubMed:18083576, PubMed:9430220). Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules (PubMed:9485206, PubMed:12165520). Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions (PubMed:9486650, PubMed:9430220, PubMed:9485206, PubMed:30860984). Dominantly counteracts T cell receptor signaling on a subset of memory/effector CD8-positive T cells as part of an antigen-driven response to avoid autoimmunity (PubMed:12387742). On intraepithelial CD8-positive gamma-delta regulatory T cells triggers TGFB1 secretion, which in turn limits the cytotoxic programming of intraepithelial CD8-positive alpha-beta T cells, distinguishing harmless from pathogenic antigens (PubMed:18064301). In HLA-E-rich tumor microenvironment, acts as an immune inhibitory checkpoint and may contribute to progressive loss of effector functions of NK cells and tumor-specific T cells, a state known as cell exhaustion (PubMed:30503213, PubMed:30860984).9 Publications
(Microbial infection) Viruses like human cytomegalovirus have evolved an escape mechanism whereby virus-induced down-regulation of host MHC class I molecules is coupled to the binding of viral peptides to HLA-E, restoring HLA-E expression and inducing HLA-E-dependent NK cell immune tolerance to infected cells. Recognizes HLA-E in complex with human cytomegalovirus UL40-derived peptide (VMAPRTLIL) and inhibits NK cell cytotoxicity.2 Publications
(Microbial infection) May recognize HLA-E in complex with HIV-1 gag/Capsid protein p24-derived peptide (AISPRTLNA) on infected cells and may inhibit NK cell cytotoxicity, a mechanism that allows HIV-1 to escape immune recognition.1 Publication
(Microbial infection) Upon SARS-CoV-2 infection, may contribute to functional exhaustion of cytotoxic NK cells and CD8-positive T cells (PubMed:32203188, PubMed:32859121). On NK cells, may recognize HLA-E in complex with SARS-CoV-2 S/Spike protein S1-derived peptide (LQPRTFLL) expressed on the surface of lung epithelial cells, inducing NK cell exhaustion and dampening antiviral immune surveillance (PubMed:32859121).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity, Innate immunity
LigandLectin

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P26715

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SIGNOR Signaling Network Open Resource

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SIGNORi
P26715

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NKG2-A/NKG2-B type II integral membrane protein
Alternative name(s):
CD159 antigen-like family member A
NK cell receptor A
NKG2-A/B-activating NK receptor
CD_antigen: CD159a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLRC1
Synonyms:NKG2A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6374, KLRC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
161555, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P26715

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000134545.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 70CytoplasmicSequence analysisAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 93Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini94 – 233ExtracellularSequence analysisAdd BLAST140

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi6V → A: Decreases interaction with INPP5D/SHIP-1; when associated A-38. 1 Publication1
Mutagenesisi8Y → F: Impairs phosphorylation, interaction with INPP5D/SHIP-1 and NK cell functional inhibition; when associated F-40. 1 Publication1
Mutagenesisi38I → A: Decreases interaction with INPP5D/SHIP-1; when associated A-6. 1 Publication1
Mutagenesisi40Y → F: Impairs phosphorylation, interaction with INPP5D/SHIP-1 and NK cell functional inhibition; when associated F-8. 1 Publication1
Mutagenesisi137R → A: Reduces binding to HLA-E. 1 Publication1
Mutagenesisi163M → I: Has no impact on the affinity for HLA-E. 1 Publication1
Mutagenesisi167 – 170SIIS → ASIL: Impairs binding to HLA-E. 1 Publication4
Mutagenesisi172S → A: Has no impact on the affinity for HLA-E. 1 Publication1
Mutagenesisi200D → A: Has no impact on the affinity for HLA-E. 1 Publication1
Mutagenesisi202D → A: Has no impact on the affinity for HLA-E. 1 Publication1
Mutagenesisi212Q → A: Reduces binding to HLA-E. 1 Publication1
Mutagenesisi213V → A: Has no impact on the affinity for HLA-E. 1 Publication1
Mutagenesisi215R → A: Reduces binding to HLA-E. 1 Publication1
Mutagenesisi217K → A: Reduces binding to HLA-E. 1 Publication1
Mutagenesisi220Q → A: Has little impact on affinity for HLA-E. 1 Publication1
Mutagenesisi223S → A: Has no impact on affinity for HLA-E. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
3821

Open Targets

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OpenTargetsi
ENSG00000134545

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30163

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P26715, Tbio

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2849

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
KLRC1

Domain mapping of disease mutations (DMDM)

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DMDMi
317373399

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000466591 – 233NKG2-A/NKG2-B type II integral membrane proteinAdd BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8Phosphotyrosine1 Publication1
Modified residuei40Phosphotyrosine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi116Interchain (with C-59 in KLRD1)1 Publication
Disulfide bondi119 ↔ 1301 Publication
Disulfide bondi147 ↔ 2291 Publication
Glycosylationi151N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi208 ↔ 2211 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P26715

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P26715

MaxQB - The MaxQuant DataBase

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MaxQBi
P26715

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P26715

PeptideAtlas

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PeptideAtlasi
P26715

PRoteomics IDEntifications database

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PRIDEi
P26715

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
54362 [P26715-1]
54363 [P26715-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P26715, 4 sites

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P26715

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P26715

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in NK cells (at protein level) (PubMed:9430220, PubMed:9485206, PubMed:20952657). Expressed in intraepithelial CD8-positive T cell subsets with higher frequency in gamma-delta T cells than alpha-beta T cells (at protein level) (PubMed:18064301). Expressed in memory gamma-delta T cells (at protein level) (PubMed:20952657). Restricted to a subset of memory/effector CD8-positive alpha-beta T cells (at protein level) (PubMed:12387742). Expressed in intratumoral NK and CD8-positive T cells (PubMed:30503213). Expressed in melanoma-specific cytotoxic T cell clones (at protein level) (PubMed:9485206). KLRD1-KLRC1 and KLRD1-KLRC2 are differentially expressed in NK and T cell populations, with only minor subsets expressing both receptor complexes (at protein level) (PubMed:20952657).6 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in memory CD8-positive alpha-beta T cell clones upon antigen-specific stimulation.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134545, Expressed in granulocyte and 107 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P26715, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P26715, HS

Organism-specific databases

Human Protein Atlas

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HPAi
ENSG00000134545, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with KLRD1; disulfide-linked (PubMed:18083576, PubMed:18332182, PubMed:18448674). KLRD1-KLRC1 heterodimer interacts with peptide-bound HLA-E-B2M heterotrimeric complex (PubMed:18083576). Competes with KLRC2 for its interaction with HLA-E (PubMed:18083576).

Interacts (via ITIM) with INPP5D/SHIP-1 and INPPL1/SHIP-2 (via SH2 domain).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
P26715
With#Exp.IntAct
ATP6V0B [Q99437]3EBI-9018187,EBI-3904417
ATP6V0C [P27449]3EBI-9018187,EBI-721179
BMP10 [O95393]3EBI-9018187,EBI-3922513
BRICD5 - isoform 2 [Q6PL45-2]3EBI-9018187,EBI-12244618
CALR [P27797]3EBI-9018187,EBI-1049597
CD151 [P48509]3EBI-9018187,EBI-10210332
CD82 [P27701]3EBI-9018187,EBI-682379
CDK5R1 [Q15078]3EBI-9018187,EBI-746189
CGRRF1 [Q99675]3EBI-9018187,EBI-2130213
CLDN11 [O75508]3EBI-9018187,EBI-12820543
CLEC2D - isoform 2 [Q9UHP7-3]4EBI-9018187,EBI-11749983
CLEC7A - isoform 6 [Q9BXN2-6]3EBI-9018187,EBI-11989440
CLRN2 [A0PK11]3EBI-9018187,EBI-12813623
CTXN3 [Q4LDR2]3EBI-9018187,EBI-12019274
CYB561A3 [Q8NBI2]3EBI-9018187,EBI-10269179
DLST [P36957]3EBI-9018187,EBI-351007
EMP1 [P54849]3EBI-9018187,EBI-4319440
EMP3 [P54852]4EBI-9018187,EBI-3907816
ERMP1 [Q7Z2K6]3EBI-9018187,EBI-10976398
GJB2 [P29033]3EBI-9018187,EBI-3905204
GJB4 [Q9NTQ9]3EBI-9018187,EBI-12831526
GJB6 [O95452]3EBI-9018187,EBI-13345609
GPR61 [Q9BZJ8]3EBI-9018187,EBI-12808020
ITM2B [Q9Y287]3EBI-9018187,EBI-2866431
KLRD1 [Q13241]5EBI-9018187,EBI-9018174
KLRG1 [Q96E93]3EBI-9018187,EBI-750770
LSMEM2 [Q8N112]3EBI-9018187,EBI-10264855
MAL [P21145]6EBI-9018187,EBI-3932027
MALL [Q13021]3EBI-9018187,EBI-750078
MS4A13 [Q5J8X5]3EBI-9018187,EBI-12070086
NEK7 [Q8TDX7]3EBI-9018187,EBI-1055945
NKG7 [Q16617]3EBI-9018187,EBI-3919611
PLP1 - isoform DM-20 [P60201-2]3EBI-9018187,EBI-12188331
PMP22 [Q01453]6EBI-9018187,EBI-2845982
SFTPC [P11686]3EBI-9018187,EBI-10197617
TMEM182 [Q6ZP80]3EBI-9018187,EBI-10255122
TMEM262 [E9PQX1]3EBI-9018187,EBI-17180389
TMEM54 [Q969K7]3EBI-9018187,EBI-3922833
TMPPE [Q6ZT21]3EBI-9018187,EBI-11724433
TSPO2 [Q5TGU0]3EBI-9018187,EBI-12195249
TTMP [Q5BVD1]3EBI-9018187,EBI-10243654
UNC93B1 [Q9H1C4]3EBI-9018187,EBI-4401271
UPK1B [O75841]3EBI-9018187,EBI-12237619
VAMP5 [O95183]3EBI-9018187,EBI-10191195
VTI1B [Q9UEU0]3EBI-9018187,EBI-723716
ZFPL1 [O95159]3EBI-9018187,EBI-718439

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
110020, 42 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-2502, CD94-NKG2A natural killer receptor complex

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P26715

Protein interaction database and analysis system

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IntActi
P26715, 49 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000438038

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
P26715, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1233
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P26715

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26715

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 231C-type lectinPROSITE-ProRule annotationAdd BLAST114

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi6 – 11Immunoreceptor tyrosine-based inhibition motif (ITIM)1 Publication6
Motifi38 – 43Immunoreceptor tyrosine-based inhibition motif (ITIM)1 Publication6

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cytosolic N-terminus contains two immunoreceptor tyrosine-based inhibitory motifs (ITIMs), which are essential for the association with INPP5D/SHIP-1 and INPPL1/SHIP-2 phosphatases and functional inhibition.1 Publication

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S6IE, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000164619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_049894_9_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P26715

Identification of Orthologs from Complete Genome Data

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OMAi
TMIVITP

Database of Orthologous Groups

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OrthoDBi
1161111at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P26715

TreeFam database of animal gene trees

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TreeFami
TF336674

Family and domain databases

Conserved Domains Database

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CDDi
cd03593, CLECT_NK_receptors_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR033992, NKR-like_CTLD

Pfam protein domain database

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Pfami
View protein in Pfam
PF00059, Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00034, CLECT, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform NKG2-A (identifier: P26715-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNQGVIYSD LNLPPNPKRQ QRKPKGNKNS ILATEQEITY AELNLQKASQ
60 70 80 90 100
DFQGNDKTYH CKDLPSAPEK LIVGILGIIC LILMASVVTI VVIPSTLIQR
110 120 130 140 150
HNNSSLNTRT QKARHCGHCP EEWITYSNSC YYIGKERRTW EESLLACTSK
160 170 180 190 200
NSSLLSIDNE EEMKFLSIIS PSSWIGVFRN SSHHPWVTMN GLAFKHEIKD
210 220 230
SDNAELNCAV LQVNRLKSAQ CGSSIIYHCK HKL
Length:233
Mass (Da):26,314
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93879A5C8D110C62
GO
Isoform NKG2-B (identifier: P26715-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     96-113: Missing.

Show »
Length:215
Mass (Da):24,250
Checksum:iFEEE7322C85B2EAE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5GYZ0F5GYZ0_HUMAN
NKG2-A/NKG2-B type II integral memb...
KLRC1
228Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGB7H0YGB7_HUMAN
NKG2-A/NKG2-B type II integral memb...
KLRC1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05012029N → S5 PublicationsCorresponds to variant dbSNP:rs2253849Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00306296 – 113Missing in isoform NKG2-B. 2 PublicationsAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
X54867 mRNA Translation: CAA38649.1
X54868 mRNA Translation: CAA38650.1
U54786 U54785 Genomic DNA Translation: AAB17133.1
AF023840 Genomic DNA Translation: AAC17488.1
AF461812 mRNA Translation: AAL65234.1
AC068775 Genomic DNA No translation available.
BC012550 mRNA Translation: AAH12550.1
BC053840 mRNA Translation: AAH53840.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8625.1 [P26715-1]
CCDS8626.1 [P26715-2]

Protein sequence database of the Protein Information Resource

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PIRi
PT0372

NCBI Reference Sequences

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RefSeqi
NP_002250.1, NM_002259.4 [P26715-1]
NP_015567.1, NM_007328.3 [P26715-2]
NP_998822.1, NM_213657.2
NP_998823.1, NM_213658.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000347831; ENSP00000256965; ENSG00000134545 [P26715-2]
ENST00000359151; ENSP00000352064; ENSG00000134545 [P26715-1]
ENST00000408006; ENSP00000385304; ENSG00000134545 [P26715-2]
ENST00000544822; ENSP00000438038; ENSG00000134545 [P26715-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3821

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3821

UCSC genome browser

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UCSCi
uc001qyl.5, human [P26715-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

NKG-2A

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54867 mRNA Translation: CAA38649.1
X54868 mRNA Translation: CAA38650.1
U54786 U54785 Genomic DNA Translation: AAB17133.1
AF023840 Genomic DNA Translation: AAC17488.1
AF461812 mRNA Translation: AAL65234.1
AC068775 Genomic DNA No translation available.
BC012550 mRNA Translation: AAH12550.1
BC053840 mRNA Translation: AAH53840.1
CCDSiCCDS8625.1 [P26715-1]
CCDS8626.1 [P26715-2]
PIRiPT0372
RefSeqiNP_002250.1, NM_002259.4 [P26715-1]
NP_015567.1, NM_007328.3 [P26715-2]
NP_998822.1, NM_213657.2
NP_998823.1, NM_213658.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RMXNMR-B1-15[»]
2YU7NMR-B33-47[»]
3BDWX-ray2.50B/D113-232[»]
3CDGX-ray3.40F/K113-232[»]
3CIIX-ray4.41H/J113-232[»]
SMRiP26715
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110020, 42 interactors
ComplexPortaliCPX-2502, CD94-NKG2A natural killer receptor complex
ELMiP26715
IntActiP26715, 49 interactors
STRINGi9606.ENSP00000438038

Chemistry databases

GuidetoPHARMACOLOGYi2849

PTM databases

GlyGeniP26715, 4 sites
iPTMnetiP26715
PhosphoSitePlusiP26715

Genetic variation databases

BioMutaiKLRC1
DMDMi317373399

Proteomic databases

jPOSTiP26715
MassIVEiP26715
MaxQBiP26715
PaxDbiP26715
PeptideAtlasiP26715
PRIDEiP26715
ProteomicsDBi54362 [P26715-1]
54363 [P26715-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P26715, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
23336, 611 antibodies

The DNASU plasmid repository

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DNASUi
3821

Genome annotation databases

EnsembliENST00000347831; ENSP00000256965; ENSG00000134545 [P26715-2]
ENST00000359151; ENSP00000352064; ENSG00000134545 [P26715-1]
ENST00000408006; ENSP00000385304; ENSG00000134545 [P26715-2]
ENST00000544822; ENSP00000438038; ENSG00000134545 [P26715-1]
GeneIDi3821
KEGGihsa:3821
UCSCiuc001qyl.5, human [P26715-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3821
DisGeNETi3821

GeneCards: human genes, protein and diseases

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GeneCardsi
KLRC1
HGNCiHGNC:6374, KLRC1
HPAiENSG00000134545, Group enriched (blood, lymphoid tissue)
MIMi161555, gene
neXtProtiNX_P26715
OpenTargetsiENSG00000134545
PharmGKBiPA30163
VEuPathDBiHostDB:ENSG00000134545.13

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S6IE, Eukaryota
GeneTreeiENSGT00940000164619
HOGENOMiCLU_049894_9_2_1
InParanoidiP26715
OMAiTMIVITP
OrthoDBi1161111at2759
PhylomeDBiP26715
TreeFamiTF336674

Enzyme and pathway databases

PathwayCommonsiP26715
ReactomeiR-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
SIGNORiP26715

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3821, 2 hits in 957 CRISPR screens
EvolutionaryTraceiP26715

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3821
PharosiP26715, Tbio

Protein Ontology

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PROi
PR:P26715
RNActiP26715, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134545, Expressed in granulocyte and 107 other tissues
ExpressionAtlasiP26715, baseline and differential
GenevisibleiP26715, HS

Family and domain databases

CDDicd03593, CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR033992, NKR-like_CTLD
PfamiView protein in Pfam
PF00059, Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 1 hit
SUPFAMiSSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041, C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNKG2A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26715
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 11, 2011
Last modified: April 7, 2021
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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