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UniProtKB - P26684 (EDNRA_RAT)
Protein
Endothelin-1 receptor
Gene
Ednra
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
GO - Molecular functioni
- endothelin receptor activity Source: RGD
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGD
- aging Source: RGD
- angiogenesis Source: RGD
- aorta development Source: RGD
- artery smooth muscle contraction Source: RGD
- atrial cardiac muscle tissue development Source: RGD
- axon extension Source: RGD
- axon guidance Source: RGD
- axonogenesis involved in innervation Source: RGD
- blood vessel remodeling Source: RGD
- branching involved in blood vessel morphogenesis Source: RGD
- calcium ion transmembrane transport Source: RGD
- canonical Wnt signaling pathway Source: RGD
- cardiac chamber formation Source: RGD
- cardiac neural crest cell migration involved in outflow tract morphogenesis Source: RGD
- cellular calcium ion homeostasis Source: RGD
- cellular response to follicle-stimulating hormone stimulus Source: RGD
- cellular response to human chorionic gonadotropin stimulus Source: RGD
- cellular response to luteinizing hormone stimulus Source: RGD
- cellular response to mechanical stimulus Source: RGD
- cellular response to organic substance Source: RGD
- cellular response to oxidative stress Source: RGD
- cranial skeletal system development Source: RGD
- embryonic heart tube development Source: RGD
- embryonic skeletal system development Source: RGD
- endothelin receptor signaling pathway Source: RGD
- endothelin receptor signaling pathway involved in heart process Source: RGD
- enteric nervous system development Source: InterPro
- establishment of endothelial barrier Source: RGD
- face development Source: RGD
- fibroblast proliferation Source: RGD
- gene expression Source: RGD
- glomerular endothelium development Source: RGD
- glomerular filtration Source: RGD
- glomerular visceral epithelial cell apoptotic process Source: RGD
- glomerular visceral epithelial cell differentiation Source: RGD
- glomerulus development Source: RGD
- head development Source: RGD
- heart development Source: RGD
- heparin metabolic process Source: RGD
- histamine secretion Source: RGD
- I-kappaB kinase/NF-kappaB signaling Source: RGD
- in utero embryonic development Source: RGD
- left ventricular cardiac muscle tissue morphogenesis Source: RGD
- maternal process involved in parturition Source: RGD
- meiotic cell cycle process involved in oocyte maturation Source: RGD
- mesenchymal cell apoptotic process Source: RGD
- middle ear morphogenesis Source: RGD
- mitochondrion organization Source: RGD
- mitotic cell cycle Source: RGD
- multicellular organism aging Source: RGD
- negative regulation of apoptotic process Source: RGD
- neural crest cell development Source: RGD
- neural crest cell differentiation Source: RGD
- neural crest cell fate commitment Source: RGD
- neuromuscular process Source: RGD
- neuron projection development Source: RGD
- neuron remodeling Source: RGD
- noradrenergic neuron differentiation Source: RGD
- norepinephrine metabolic process Source: RGD
- penile erection Source: RGD
- pharyngeal arch artery morphogenesis Source: RGD
- positive regulation of calcium ion transport Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: RGD
- positive regulation of inflammatory response Source: RGD
- positive regulation of kidney development Source: RGD
- positive regulation of neutrophil chemotaxis Source: RGD
- positive regulation of odontogenesis Source: RGD
- positive regulation of protein phosphorylation Source: RGD
- positive regulation of release of sequestered calcium ion into cytosol Source: RGD
- protein kinase C-activating G protein-coupled receptor signaling pathway Source: RGD
- protein phosphorylation Source: RGD
- protein transmembrane transport Source: RGD
- regulation of blood pressure Source: RGD
- regulation of epithelial cell proliferation Source: RGD
- regulation of glucose transmembrane transport Source: RGD
- regulation of heart rate Source: RGD
- regulation of protein localization to cell leading edge Source: RGD
- renal albumin absorption Source: RGD
- renal sodium ion absorption Source: RGD
- respiratory gaseous exchange by respiratory system Source: RGD
- response to acetylcholine Source: RGD
- response to amphetamine Source: RGD
- response to hypoxia Source: RGD
- response to lipopolysaccharide Source: RGD
- response to morphine Source: RGD
- response to organic cyclic compound Source: RGD
- response to organic substance Source: RGD
- response to wounding Source: RGD
- Rho protein signal transduction Source: RGD
- semaphorin-plexin signaling pathway involved in axon guidance Source: RGD
- sensory perception of pain Source: RGD
- smooth muscle cell proliferation Source: RGD
- sodium ion homeostasis Source: RGD
- specification of segmental identity, mandibular segment Source: RGD
- specification of segmental identity, maxillary segment Source: RGD
- sympathetic nervous system development Source: RGD
- sympathetic neuron axon guidance Source: RGD
- thyroid gland development Source: RGD
- vascular associated smooth muscle cell development Source: RGD
- vasoconstriction Source: RGD
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin-1 receptorCuratedAlternative name(s): Endothelin receptor type AImported Short name: ET-A Short name: ET-AR |
Gene namesi | Name:EdnraImported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2535, Ednra |
Subcellular locationi
Plasma membrane
Nucleus
- nuclear membrane Source: RGD
Plasma Membrane
- T-tubule Source: RGD
Other locations
- cell periphery Source: RGD
- integral component of membrane Source: UniProtKB-KW
- membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 80 | ExtracellularSequence analysisAdd BLAST | 60 | |
Transmembranei | 81 – 102 | Helical; Name=1Sequence analysisAdd BLAST | 22 | |
Topological domaini | 103 – 112 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 113 – 132 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Topological domaini | 133 – 159 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 160 – 181 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 182 – 205 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 206 – 229 | Helical; Name=4Sequence analysisAdd BLAST | 24 | |
Topological domaini | 230 – 256 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 257 – 278 | Helical; Name=5Sequence analysisAdd BLAST | 22 | |
Topological domaini | 279 – 306 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 307 – 328 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 329 – 347 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 348 – 372 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 373 – 426 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL4566 |
DrugCentrali | P26684 |
GuidetoPHARMACOLOGYi | 219 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000012724 | 21 – 426 | Endothelin-1 receptorAdd BLAST | 406 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 158 ↔ 239 | PROSITE-ProRule annotation | ||
Modified residuei | 424 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P26684 |
PTM databases
GlyGeni | P26684, 2 sites |
PhosphoSitePlusi | P26684 |
Expressioni
Tissue specificityi
Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.
Interactioni
Subunit structurei
Interacts with HDAC7 and KAT5.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000054967 |
Chemistry databases
BindingDBi | P26684 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P26684 |
OrthoDBi | 876925at2759 |
PhylomeDBi | P26684 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR002175, ETA_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00570, ENDOTHELINAR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P26684-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVLCFLASF WLALVGGAIA DNAERYSANL SSHVEDFTPF PGTEFNFLGT
60 70 80 90 100
TLQPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEQHRTCM LNATTKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM
410 420
NGTSIQWKNQ EQNHNTERSS HKDSMN
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA1Y2B8 | A1Y2B8_RAT | Endothelin receptor type A | Ednra | 399 | Annotation score: | ||
A0A0G2JSX5 | A0A0G2JSX5_RAT | Endothelin receptor type A | Ednra | 426 | Annotation score: | ||
A1Y2R8 | A1Y2R8_RAT | Endothelin receptor type A | Ednra | 259 | Annotation score: | ||
A1Y2R7 | A1Y2R7_RAT | Endothelin receptor type A | Ednra | 161 | Annotation score: | ||
A1Y2R9 | A1Y2R9_RAT | Endothelin receptor type A | Ednra | 144 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | N → D in AAA41114 (PubMed:1849646).Curated | 1 | |
Sequence conflicti | 53 | Q → R in AAA41114 (PubMed:1849646).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60786 mRNA Translation: AAA41114.1 |
PIRi | A40440 |
RefSeqi | NP_036682.1, NM_012550.2 XP_008770693.1, XM_008772471.1 |
Genome annotation databases
GeneIDi | 24326 |
KEGGi | rno:24326 |
UCSCi | RGD:2535, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M60786 mRNA Translation: AAA41114.1 |
PIRi | A40440 |
RefSeqi | NP_036682.1, NM_012550.2 XP_008770693.1, XM_008772471.1 |
3D structure databases
SMRi | P26684 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000054967 |
Chemistry databases
BindingDBi | P26684 |
ChEMBLi | CHEMBL4566 |
DrugCentrali | P26684 |
GuidetoPHARMACOLOGYi | 219 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P26684, 2 sites |
PhosphoSitePlusi | P26684 |
Proteomic databases
PaxDbi | P26684 |
Genome annotation databases
GeneIDi | 24326 |
KEGGi | rno:24326 |
UCSCi | RGD:2535, rat |
Organism-specific databases
CTDi | 1909 |
RGDi | 2535, Ednra |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
InParanoidi | P26684 |
OrthoDBi | 876925at2759 |
PhylomeDBi | P26684 |
TreeFami | TF331292 |
Enzyme and pathway databases
Reactomei | R-RNO-375276, Peptide ligand-binding receptors R-RNO-416476, G alpha (q) signalling events |
Miscellaneous databases
PROi | PR:P26684 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR002175, ETA_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00570, ENDOTHELINAR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EDNRA_RAT | |
Accessioni | P26684Primary (citable) accession number: P26684 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | July 1, 1993 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families