Endothelin-1 receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• endothelin receptor activity Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.2

    "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor."
    Lin H.Y., Kaji E.H., Winkel G.K., Ives H.E., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:3185-3189(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

GO - Biological processⁱ

• adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: RGD
• aging Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Age-related changes in endothelin-1 receptor subtypes in rat heart."
    Del Ry S., Maltinti M., Giannessi D., Cavallini G., Bergamini E.
    Exp Aging Res 34:251-266(2008) [PubMed] [Europe PMC] [Abstract]
• artery smooth muscle contraction Source: RGD
• branching involved in blood vessel morphogenesis Source: RGD
• cellular response to mechanical stimulus Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes."
    Naka T., Sakoda T., Doi T., Akagami T., Tsujino T., Masuyama T., Ohyanagi M.
    Prep Biochem Biotechnol 38:201-212(2008) [PubMed] [Europe PMC] [Abstract]
• enteric nervous system development Source: InterPro
• fibroblast proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Thrombin-stimulated proliferation is mediated by endothelin-1 in cultured rat gingival fibroblasts."
    Ohuchi N., Hayashi K., Iwamoto K., Koike K., Kizawa Y., Nukaga M., Kakegawa T., Murakami H.
    Fundam Clin Pharmacol 24:501-508(2010) [PubMed] [Europe PMC] [Abstract]
• glomerular filtration Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat."
    Saleh M.A., Boesen E.I., Pollock J.S., Savin V.J., Pollock D.M.
    Hypertension 56:942-949(2010) [PubMed] [Europe PMC] [Abstract]
• head development Source: RGD
• heart development Source: RGD
• histamine secretion Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 induces organ-specific histamine liberation and neutrophil granulocyte accumulation in the rat."
    Kaszaki J., Czobel M., Szalay L., Nagy S., Boros M.
    Inflamm Res 57:396-402(2008) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGD
• maternal process involved in parturition Source: RGDInferred from expression patternⁱ
  • "Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor."
    Comellas A.P., Briva A., Dada L.A., Butti M.L., Trejo H.E., Yshii C., Azzam Z.S., Litvan J., Chen J., Lecuona E., Pesce L.M., Yanagisawa M., Sznajder J.I.
    Am J Respir Crit Care Med 179:113-122(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney."
    Yoo K.H., Yim H.E., Jang G.Y., Bae I.S., Choi B.M., Hong Y.S., Lee J.W.
    J Korean Med Sci 24:138-145(2009) [PubMed] [Europe PMC] [Abstract]
• neural crest cell development Source: RGD
• penile erection Source: RGDInferred from mutant phenotypeⁱ
  • "Murine and rat cavernosal responses to endothelin-1 and urotensin-II Vasoactive Peptide Symposium."
    Carneiro F.S., Carneiro Z.N., Giachini F.R., Lima V.V., Nogueira E., Rainey W.E., Tostes R.C., Webb R.C.
    J Am Soc Hypertens 2:439-447(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of calcium ion transport Source: RGDInferred from mutant phenotypeⁱ
  • "ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells."
    Ceccarelli F., Scavuzzo M.C., Giusti L., Bigini G., Costa B., Carnicelli V., Zucchi R., Lucacchini A., Mazzoni M.R.
    Biochem Pharmacol 65:783-793(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney."
    Yoo K.H., Yim H.E., Jang G.Y., Bae I.S., Choi B.M., Hong Y.S., Lee J.W.
    J Korean Med Sci 24:138-145(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cytosolic calcium ion concentration Source: RGDInferred from direct assayⁱ
  • Ref.2

    "Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor."
    Lin H.Y., Kaji E.H., Winkel G.K., Ives H.E., Lodish H.F.
    Proc. Natl. Acad. Sci. U.S.A. 88:3185-3189(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells."
    Ceccarelli F., Scavuzzo M.C., Giusti L., Bigini G., Costa B., Carnicelli V., Zucchi R., Lucacchini A., Mazzoni M.R.
    Biochem Pharmacol 65:783-793(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells."
    Yahiaoui L., Villeneuve A., Valderrama-Carvajal H., Burke F., Fixman E.D.
    Cell Physiol Biochem 17:37-46(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of inflammatory response Source: RGDInferred from mutant phenotypeⁱ
  • "ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury."
    Plusczyk T., Witzel B., Menger M.D., Schilling M.
    Am J Physiol Gastrointest Liver Physiol 285:G145-53(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of kidney development Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin A receptor blockade influences apoptosis and cellular proliferation in the developing rat kidney."
    Yoo K.H., Yim H.E., Jang G.Y., Bae I.S., Choi B.M., Hong Y.S., Lee J.W.
    J Korean Med Sci 24:138-145(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 induces organ-specific histamine liberation and neutrophil granulocyte accumulation in the rat."
    Kaszaki J., Czobel M., Szalay L., Nagy S., Boros M.
    Inflamm Res 57:396-402(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of odontogenesis Source: RGDInferred from mutant phenotypeⁱ
  • "Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation."
    Someya A., Yuyama H., Fujimori A., Ukai M., Fukushima S., Sasamata M.
    Eur J Pharmacol 543:14-20(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein phosphorylation Source: RGDInferred from mutant phenotypeⁱ
  • "Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1."
    Zeidan A., Broman J., Hellstrand P., Sward K.
    Arterioscler Thromb Vasc Biol 23:1528-1534(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of release of sequestered calcium ion into cytosol Source: RGDInferred from mutant phenotypeⁱ
  • "ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells."
    Ceccarelli F., Scavuzzo M.C., Giusti L., Bigini G., Costa B., Carnicelli V., Zucchi R., Lucacchini A., Mazzoni M.R.
    Biochem Pharmacol 65:783-793(2003) [PubMed] [Europe PMC] [Abstract]
• protein kinase C-activating G protein-coupled receptor signaling pathway Source: RGDInferred from mutant phenotypeⁱ
  • "ETA receptor-mediated Ca2+ mobilisation in H9c2 cardiac cells."
    Ceccarelli F., Scavuzzo M.C., Giusti L., Bigini G., Costa B., Carnicelli V., Zucchi R., Lucacchini A., Mazzoni M.R.
    Biochem Pharmacol 65:783-793(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "ETA receptor blockade induces tubular cell proliferation and cyst growth in rats with polycystic kidney disease."
    Hocher B., Kalk P., Slowinski T., Godes M., Mach A., Herzfeld S., Wiesner D., Arck P.C., Neumayer H.H., Nafz B.
    J Am Soc Nephrol 14:367-376(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of glucose transmembrane transport Source: RGD
• respiratory gaseous exchange by respiratory system Source: RGD
• response to hypoxia Source: RGD
• response to lipopolysaccharide Source: RGDInferred from mutant phenotypeⁱ
  • "Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1."
    Mansart A., Ruff L.J., Ariaans M.P., Ross J.J., Reilly C.S., Brown N.J., Kaufman S., Brookes Z.L.
    Naunyn Schmiedebergs Arch Pharmacol 381:555-562(2010) [PubMed] [Europe PMC] [Abstract]
• response to morphine Source: RGDInferred from mutant phenotypeⁱ
  • "Role of endothelin (ETA) receptors in neonatal morphine withdrawal."
    Puppala B.L., Bhalla S., Matwyshyn G., Gulati A.
    Peptides 27:1514-1519(2006) [PubMed] [Europe PMC] [Abstract]
  • "Involvement of central endothelin receptors in neonatal morphine withdrawal."
    Puppala B.L., Bhalla S., Matwyshyn G., Gulati A.
    Exp Biol Med (Maywood) 231:1157-1160(2006) [PubMed] [Europe PMC] [Abstract]
• response to organic cyclic compound Source: RGDInferred from expression patternⁱ
  • "Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation."
    Dingemann J., Doi T., Ruttenstock E., Puri P.
    Pediatr Surg Int 26:65-69(2010) [PubMed] [Europe PMC] [Abstract]
• Rho protein signal transduction Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells."
    Yahiaoui L., Villeneuve A., Valderrama-Carvajal H., Burke F., Fixman E.D.
    Cell Physiol Biochem 17:37-46(2006) [PubMed] [Europe PMC] [Abstract]
• sensory perception of pain Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors."
    Chichorro J.G., Fiuza C.R., Bressan E., Claudino R.F., Leite D.F., Rae G.A.
    Brain Res 1345:73-83(2010) [PubMed] [Europe PMC] [Abstract]
• smooth muscle cell proliferation Source: RGDInferred from mutant phenotypeⁱ
  • "Endothelin-1 regulates proliferative responses, both alone and synergistically with PDGF, in rat tracheal smooth muscle cells."
    Yahiaoui L., Villeneuve A., Valderrama-Carvajal H., Burke F., Fixman E.D.
    Cell Physiol Biochem 17:37-46(2006) [PubMed] [Europe PMC] [Abstract]
• vasoconstriction Source: RGDInferred from mutant phenotypeⁱ
  • "Dual constrictor and dilator actions of ET(B) receptors in the rat renal microcirculation: interactions with ET(A) receptors."
    Just A., Olson A.J., Arendshorst W.J.
    Am J Physiol Renal Physiol 286:F660-8(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MGVLCFLASF WLALVGGAIA DNAERYSANL SSHVEDFTPF PGTEFNFLGT 
        60         70         80         90        100
TLQPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT 
       110        120        130        140        150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH 
       160        170        180        190        200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL 
       210        220        230        240        250
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEQHRTCM LNATTKFMEF 
       260        270        280        290        300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ 
       310        320        330        340        350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM 
       360        370        380        390        400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM 
       410        420 
NGTSIQWKNQ EQNHNTERSS HKDSMN                           

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. SIMILARITY comments
   Index of protein domains and families