Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endothelin-1 receptor

Gene

Ednra

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

GO - Molecular functioni

  • endothelin receptor activity Source: RGD

GO - Biological processi

  • aging Source: RGD
  • cellular response to mechanical stimulus Source: RGD
  • enteric nervous system development Source: InterPro
  • fibroblast proliferation Source: RGD
  • glomerular filtration Source: RGD
  • histamine secretion Source: RGD
  • maternal process involved in parturition Source: RGD
  • negative regulation of apoptotic process Source: RGD
  • penile erection Source: RGD
  • positive regulation of calcium ion transport Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: RGD
  • positive regulation of inflammatory response Source: RGD
  • positive regulation of kidney development Source: RGD
  • positive regulation of neutrophil chemotaxis Source: RGD
  • positive regulation of odontogenesis Source: RGD
  • positive regulation of protein phosphorylation Source: RGD
  • positive regulation of release of sequestered calcium ion into cytosol Source: RGD
  • protein kinase C-activating G-protein coupled receptor signaling pathway Source: RGD
  • regulation of blood pressure Source: InterPro
  • regulation of epithelial cell proliferation Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to morphine Source: RGD
  • response to organic cyclic compound Source: RGD
  • Rho protein signal transduction Source: RGD
  • sensory perception of pain Source: RGD
  • smooth muscle cell proliferation Source: RGD
  • vasoconstriction Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-1 receptorCurated
Alternative name(s):
Endothelin receptor type AImported
Short name:
ET-A
Short name:
ET-AR
Gene namesi
Name:EdnraImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2535 Ednra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 80ExtracellularSequence analysisAdd BLAST60
Transmembranei81 – 102Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini103 – 112CytoplasmicSequence analysis10
Transmembranei113 – 132Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini133 – 159ExtracellularSequence analysisAdd BLAST27
Transmembranei160 – 181Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini182 – 205CytoplasmicSequence analysisAdd BLAST24
Transmembranei206 – 229Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini230 – 256ExtracellularSequence analysisAdd BLAST27
Transmembranei257 – 278Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini279 – 306CytoplasmicSequence analysisAdd BLAST28
Transmembranei307 – 328Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini329 – 347ExtracellularSequence analysisAdd BLAST19
Transmembranei348 – 372Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini373 – 426CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4566
GuidetoPHARMACOLOGYi219

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001272421 – 426Endothelin-1 receptorAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 239PROSITE-ProRule annotation
Modified residuei424PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP26684

PTM databases

PhosphoSitePlusiP26684

Expressioni

Tissue specificityi

Predominantly expressed in vascular smooth muscle cells of a variety of issues, bronchial smooth muscle cells, myocardium, and the pituitary gland.

Interactioni

Subunit structurei

Interacts with HDAC7 and KAT5.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000054967

Chemistry databases

BindingDBiP26684

Structurei

3D structure databases

ProteinModelPortaliP26684
SMRiP26684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000272623
HOVERGENiHBG051443
InParanoidiP26684
KOiK04197
PhylomeDBiP26684
TreeFamiTF331292

Family and domain databases

InterProiView protein in InterPro
IPR000499 Endthln_rcpt
IPR002175 ETA_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00570 ENDOTHELINAR
PR00366 ENDOTHELINR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26684-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVLCFLASF WLALVGGAIA DNAERYSANL SSHVEDFTPF PGTEFNFLGT
60 70 80 90 100
TLQPPNLALP SNGSMHGYCP QQTKITTAFK YINTVISCTI FIVGMVGNAT
110 120 130 140 150
LLRIIYQNKC MRNGPNALIA SLALGDLIYV VIDLPINVFK LLAGRWPFDH
160 170 180 190 200
NDFGVFLCKL FPFLQKSSVG ITVLNLCALS VDRYRAVASW SRVQGIGIPL
210 220 230 240 250
ITAIEIVSIW ILSFILAIPE AIGFVMVPFE YKGEQHRTCM LNATTKFMEF
260 270 280 290 300
YQDVKDWWLF GFYFCMPLVC TAIFYTLMTC EMLNRRNGSL RIALSEHLKQ
310 320 330 340 350
RREVAKTVFC LVVIFALCWF PLHLSRILKK TVYDEMDKNR CELLSFLLLM
360 370 380 390 400
DYIGINLATM NSCINPIALY FVSKKFKNCF QSCLCCCCHQ SKSLMTSVPM
410 420
NGTSIQWKNQ EQNHNTERSS HKDSMN
Length:426
Mass (Da):48,245
Last modified:July 1, 1993 - v2
Checksum:iE8A24683DBB78BB8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46N → D in AAA41114 (PubMed:1849646).Curated1
Sequence conflicti53Q → R in AAA41114 (PubMed:1849646).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60786 mRNA Translation: AAA41114.1
PIRiA40440
RefSeqiNP_036682.1, NM_012550.2
XP_008770693.1, XM_008772471.1
UniGeneiRn.10915

Genome annotation databases

GeneIDi24326
KEGGirno:24326
UCSCiRGD:2535 rat

Similar proteinsi

Entry informationi

Entry nameiEDNRA_RAT
AccessioniPrimary (citable) accession number: P26684
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: July 1, 1993
Last modified: May 23, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health