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Protein

Cardiac phospholamban

Gene

PLN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca2+. Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation.2 Publications

Miscellaneous

For practical reasons, PLN activity is most often studied with ATP2A1 instead of ATP2A2.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase binding Source: BHF-UCL
  • ATPase inhibitor activity Source: BHF-UCL
  • calcium channel regulator activity Source: InterPro
  • enzyme inhibitor activity Source: BHF-UCL
  • identical protein binding Source: BHF-UCL

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases

SIGNOR Signaling Network Open Resource

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SIGNORi
P26678

Protein family/group databases

Transport Classification Database

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TCDBi
1.A.50.1.1 the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cardiac phospholamban
Short name:
PLB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLN
Synonyms:PLB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000198523.5

Human Gene Nomenclature Database

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HGNCi
HGNC:9080 PLN

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
172405 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P26678

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 31CytoplasmicCuratedAdd BLAST31
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalCuratedAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Mitochondrion, Sarcoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, dilated 1P (CMD1P)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
See also OMIM:609909
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0259899R → C in CMD1P; impairs phosphorylation by PKA and inhibition of ATP2A1-mediated calcium uptake. 3 PublicationsCorresponds to variant dbSNP:rs111033559EnsemblClinVar.1
Natural variantiVAR_0729259R → H in CMD1P; impairs phosphorylation by PKA and inhibition of ATP2A1-mediated calcium uptake. 2 PublicationsCorresponds to variant dbSNP:rs754782171EnsemblClinVar.1
Natural variantiVAR_0729269R → L in CMD1P; impairs phosphorylation by PKA and inhibition of ATP2A1-mediated calcium uptake. 2 Publications1
Natural variantiVAR_02599014Missing in CMD1P; impairs phosphorylation by PKA, destabilizes the homopentamer and mildly reduces inhibition of ATP2A1-mediated calcium uptake. 3 Publications1
Cardiomyopathy, familial hypertrophic 18 (CMH18)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
See also OMIM:613874

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi13R → A: Abolishes phosphorylation by PKA. 1 Publication1
Mutagenesisi14R → A: Abolishes phosphorylation by PKA. 1 Publication1
Mutagenesisi16S → A: Abolishes phosphorylation by PKA. 1 Publication1
Mutagenesisi17T → A: No effect on phosphorylation by PKA. 1 Publication1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
5350

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
PLN

MalaCards human disease database

More...
MalaCardsi
PLN
MIMi609909 phenotype
613874 phenotype

Open Targets

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OpenTargetsi
ENSG00000198523

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
154 Familial isolated dilated cardiomyopathy
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA272

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PLN

Domain mapping of disease mutations (DMDM)

More...
DMDMi
130774

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001912441 – 52Cardiac phospholambanAdd BLAST52

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineBy similarity1
Modified residuei16Phosphoserine; by PKA and DMPK2 Publications1
Modified residuei17Phosphothreonine; by CaMK21 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi36S-palmitoyl cysteineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes.3 Publications
Palmitoylated by ZDHHC16, promoting formation of the homopentamer.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26678

PeptideAtlas

More...
PeptideAtlasi
P26678

PRoteomics IDEntifications database

More...
PRIDEi
P26678

ProteomicsDB human proteome resource

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ProteomicsDBi
54361

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P26678

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26678

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P26678

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Heart muscle (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198523 Expressed in 192 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_PLN

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P26678 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P26678 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB005597
HPA026900

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homopentamer (PubMed:16043693, PubMed:16897780). Interacts with HAX1 and ATP2A2 (PubMed:17241641).3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111365, 9 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-51 Cardiac phospholamban complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P26678

Database of interacting proteins

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DIPi
DIP-33582N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P26678

Protein interaction database and analysis system

More...
IntActi
P26678, 50 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350132

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P26678

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P26678

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26678

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 22Involved in HAX1 binding7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the phospholamban family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J7H0 Eukaryota
ENOG4111BFT LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002403

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000115660

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108280

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P26678

KEGG Orthology (KO)

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KOi
K05852

Identification of Orthologs from Complete Genome Data

More...
OMAi
MERVQHM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26678

TreeFam database of animal gene trees

More...
TreeFami
TF330750

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR005984 PLB

The PANTHER Classification System

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PANTHERi
PTHR21194 PTHR21194, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04272 Phospholamban, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF001665 PLB, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD014689 P_lamban, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01294 P_lamban, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P26678-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKVQYLTRS AIRRASTIEM PQQARQKLQN LFINFCLILI CLLLICIIVM

LL
Length:52
Mass (Da):6,109
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0766304A76A854D3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0259899R → C in CMD1P; impairs phosphorylation by PKA and inhibition of ATP2A1-mediated calcium uptake. 3 PublicationsCorresponds to variant dbSNP:rs111033559EnsemblClinVar.1
Natural variantiVAR_0729259R → H in CMD1P; impairs phosphorylation by PKA and inhibition of ATP2A1-mediated calcium uptake. 2 PublicationsCorresponds to variant dbSNP:rs754782171EnsemblClinVar.1
Natural variantiVAR_0729269R → L in CMD1P; impairs phosphorylation by PKA and inhibition of ATP2A1-mediated calcium uptake. 2 Publications1
Natural variantiVAR_02599014Missing in CMD1P; impairs phosphorylation by PKA, destabilizes the homopentamer and mildly reduces inhibition of ATP2A1-mediated calcium uptake. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63603 mRNA Translation: AAA60083.1
M60411 mRNA Translation: AAA60109.1
AF177764 Genomic DNA Translation: AAD55950.1
BC005269 mRNA Translation: AAH05269.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5120.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40424

NCBI Reference Sequences

More...
RefSeqi
NP_002658.1, NM_002667.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.170839
Hs.745010

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000357525; ENSP00000350132; ENSG00000198523

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5350

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5350

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63603 mRNA Translation: AAA60083.1
M60411 mRNA Translation: AAA60109.1
AF177764 Genomic DNA Translation: AAD55950.1
BC005269 mRNA Translation: AAH05269.1
CCDSiCCDS5120.1
PIRiA40424
RefSeqiNP_002658.1, NM_002667.4
UniGeneiHs.170839
Hs.745010

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K9Nmodel-A/B/C/D/E35-52[»]
1KCHmodel-A/B/C/D/E35-52[»]
1PLNmodel-A/B/C/D/E35-52[»]
1PLPNMR-A1-24[»]
1PSLmodel-A/B/C/D/E1-52[»]
1ZLLNMR-A/B/C/D/E1-52[»]
2HYNNMR-A/B/C/D/E1-52[»]
ProteinModelPortaliP26678
SMRiP26678
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111365, 9 interactors
ComplexPortaliCPX-51 Cardiac phospholamban complex
CORUMiP26678
DIPiDIP-33582N
ELMiP26678
IntActiP26678, 50 interactors
STRINGi9606.ENSP00000350132

Protein family/group databases

TCDBi1.A.50.1.1 the phospholamban (ca(2+)-channel and ca(2+)-atpase regulator) (plb) family

PTM databases

iPTMnetiP26678
PhosphoSitePlusiP26678

Polymorphism and mutation databases

BioMutaiPLN
DMDMi130774

Proteomic databases

PaxDbiP26678
PeptideAtlasiP26678
PRIDEiP26678
ProteomicsDBi54361
TopDownProteomicsiP26678

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5350
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357525; ENSP00000350132; ENSG00000198523
GeneIDi5350
KEGGihsa:5350

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5350
DisGeNETi5350
EuPathDBiHostDB:ENSG00000198523.5

GeneCards: human genes, protein and diseases

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GeneCardsi
PLN
GeneReviewsiPLN
HGNCiHGNC:9080 PLN
HPAiCAB005597
HPA026900
MalaCardsiPLN
MIMi172405 gene
609909 phenotype
613874 phenotype
neXtProtiNX_P26678
OpenTargetsiENSG00000198523
Orphaneti154 Familial isolated dilated cardiomyopathy
155 NON RARE IN EUROPE: Familial isolated hypertrophic cardiomyopathy
PharmGKBiPA272

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410J7H0 Eukaryota
ENOG4111BFT LUCA
GeneTreeiENSGT00390000002403
HOGENOMiHOG000115660
HOVERGENiHBG108280
InParanoidiP26678
KOiK05852
OMAiMERVQHM
PhylomeDBiP26678
TreeFamiTF330750

Enzyme and pathway databases

ReactomeiR-HSA-5578775 Ion homeostasis
R-HSA-936837 Ion transport by P-type ATPases
SIGNORiP26678

Miscellaneous databases

EvolutionaryTraceiP26678

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Phospholamban

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5350

Protein Ontology

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PROi
PR:P26678

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000198523 Expressed in 192 organ(s), highest expression level in heart
CleanExiHS_PLN
ExpressionAtlasiP26678 baseline and differential
GenevisibleiP26678 HS

Family and domain databases

InterProiView protein in InterPro
IPR005984 PLB
PANTHERiPTHR21194 PTHR21194, 1 hit
PfamiView protein in Pfam
PF04272 Phospholamban, 1 hit
PIRSFiPIRSF001665 PLB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD014689 P_lamban, 1 hit
TIGRFAMsiTIGR01294 P_lamban, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPLA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26678
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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