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Entry version 204 (25 May 2022)
Sequence version 2 (27 Sep 2005)
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Protein

Protein son of sevenless

Gene

Sos

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Guanine-nucleotide releasing factor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-112412, SOS-mediated signalling
R-DME-1250347, SHC1 events in ERBB4 signaling
R-DME-167044, Signalling to RAS
R-DME-179812, GRB2 events in EGFR signaling
R-DME-180336, SHC1 events in EGFR signaling
R-DME-186763, Downstream signal transduction
R-DME-193648, NRAGE signals death through JNK
R-DME-1963640, GRB2 events in ERBB2 signaling
R-DME-210993, Tie2 Signaling
R-DME-2179392, EGFR Transactivation by Gastrin
R-DME-2424491, DAP12 signaling
R-DME-2428933, SHC-related events triggered by IGF1R
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-2871796, FCERI mediated MAPK activation
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-375165, NCAM signaling for neurite out-growth
R-DME-416482, G alpha (12/13) signalling events
R-DME-5654688, SHC-mediated cascade:FGFR1
R-DME-5654693, FRS-mediated FGFR1 signaling
R-DME-5654699, SHC-mediated cascade:FGFR2
R-DME-5654700, FRS-mediated FGFR2 signaling
R-DME-5654704, SHC-mediated cascade:FGFR3
R-DME-5654706, FRS-mediated FGFR3 signaling
R-DME-5654712, FRS-mediated FGFR4 signaling
R-DME-5654719, SHC-mediated cascade:FGFR4
R-DME-5673001, RAF/MAP kinase cascade
R-DME-74749, Signal attenuation
R-DME-74751, Insulin receptor signalling cascade
R-DME-9013149, RAC1 GTPase cycle
R-DME-9607240, FLT3 Signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P26675

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein son of sevenless
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sos
ORF Names:CG7793
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0001965, Sos

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0001965

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688981 – 1596Protein son of sevenlessAdd BLAST1596

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1550Phosphoserine1 Publication1
Modified residuei1551Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26675

PRoteomics IDEntifications database

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PRIDEi
P26675

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26675

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0001965, Expressed in embryo and 33 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P26675, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P26675, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form a complex with sevenless and DRK.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
60823, 41 interactors

Database of interacting proteins

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DIPi
DIP-22308N

Protein interaction database and analysis system

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IntActi
P26675, 12 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0080118

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P26675

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26675

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26675

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini248 – 434DHPROSITE-ProRule annotationAdd BLAST187
Domaini480 – 588PHPROSITE-ProRule annotationAdd BLAST109
Domaini637 – 792N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST156
Domaini829 – 1066Ras-GEFPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1073 – 1105DisorderedSequence analysisAdd BLAST33
Regioni1175 – 1212DisorderedSequence analysisAdd BLAST38
Regioni1235 – 1291DisorderedSequence analysisAdd BLAST57
Regioni1340 – 1392DisorderedSequence analysisAdd BLAST53
Regioni1465 – 1596DisorderedSequence analysisAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1089 – 1105Polar residuesSequence analysisAdd BLAST17
Compositional biasi1175 – 1196Polar residuesSequence analysisAdd BLAST22
Compositional biasi1275 – 1291Polar residuesSequence analysisAdd BLAST17
Compositional biasi1345 – 1359Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1374 – 1388Pro residuesSequence analysisAdd BLAST15
Compositional biasi1469 – 1485Polar residuesSequence analysisAdd BLAST17
Compositional biasi1492 – 1525Polar residuesSequence analysisAdd BLAST34
Compositional biasi1529 – 1543Basic residuesSequence analysisAdd BLAST15
Compositional biasi1574 – 1596Polar residuesSequence analysisAdd BLAST23

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3417, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002744_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26675

Identification of Orthologs from Complete Genome Data

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OMAi
PPPFEWH

Database of Orthologous Groups

More...
OrthoDBi
576110at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P26675

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.20.10, 1 hit
1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50185

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR23113, PTHR23113, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00125, Histone, 1 hit
PF00169, PH, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SM00325, RhoGEF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47113, SSF47113, 1 hit
SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P26675-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA
60 70 80 90 100
GLQDCDGYDF TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK
110 120 130 140 150
LCLRLLAMLC AKPLPHSVQD VEEKVNKSFP APIDQWALNE AKEVINSKKR
160 170 180 190 200
KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL VAVLEYISAD ILKMAGDYVI
210 220 230 240 250
KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL PAQRASATYE
260 270 280 290 300
ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE
310 320 330 340 350
VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ
360 370 380 390 400
ASRDALNNLL SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY
410 420 430 440 450
IKHLKDLSSS QDDIESFEQV QGLLHPLHCD LEKVMASLSK ERQVPVSGRV
460 470 480 490 500
RRQLAIERTR ELQMKVEHWE DKDVGQNCNE FIREDSLSKL GSGKRIWSER
510 520 530 540 550
KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR VDINDRPDSD
560 570 580 590 600
DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL
610 620 630 640 650
QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI
660 670 680 690 700
ERLTYHIYAD PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT
710 720 730 740 750
GTAGAGGMGG VGGDKEHKNS HREDWKRYRK EYVQPVQFRV LNVLRHWVDH
760 770 780 790 800
HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW VDSVLKIVQR KNEQEKSNKK
810 820 830 840 850
IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL EFEMYKNVKP
860 870 880 890 900
SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI
910 920 930 940 950
MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL
960 970 980 990 1000
EECRELSDDH LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT
1010 1020 1030 1040 1050
ELINFSKRRK VAEIIGEIQQ YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK
1060 1070 1080 1090 1100
QMSDYLYNES LRIEPRGCKT VPKFPRKWPH IPLKSPGIKP RRQNQTNSSS
1110 1120 1130 1140 1150
KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT AAAANAGSGT
1160 1170 1180 1190 1200
LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA
1210 1220 1230 1240 1250
PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS
1260 1270 1280 1290 1300
DTEAPPSPLP KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS
1310 1320 1330 1340 1350
GGEEFCAGGF YFNSAHQGQP GAVPISPHVN VPMATNMEYR AVPPPLPPRR
1360 1370 1380 1390 1400
KERTESCADM AQKRQAPDAP TLPPRDGELS PPPIPPRLNH STGISYLRQS
1410 1420 1430 1440 1450
HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN QAAAGPISTT
1460 1470 1480 1490 1500
LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST
1510 1520 1530 1540 1550
SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS
1560 1570 1580 1590
SPKEFFPIAT SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE
Length:1,596
Mass (Da):177,934
Last modified:September 27, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i08DB85B59213B964
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13978 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15G → W in AAT94523 (Ref. 6) Curated1
Sequence conflicti232 – 244HILPS…LPAQR → TSCPVPCHFPRS (PubMed:1736363).CuratedAdd BLAST13
Sequence conflicti523A → T in AAT94523 (Ref. 6) Curated1
Sequence conflicti1463P → V in AAB04680 (PubMed:1736363).Curated1
Sequence conflicti1468I → V in AAT94523 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti1256P → L in strain: St_L028 and St_L033. 1
Natural varianti1322A → S in strain: In_L019. 1
Natural varianti1503S → N in strain: In_L019. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M83931 mRNA Translation: AAB04680.1
M77501 Genomic DNA Translation: AAA28904.1
AE014134 Genomic DNA Translation: AAF53336.2
BT015294 mRNA Translation: AAT94523.1
AY058749 mRNA Translation: AAL13978.1 Different initiation.
AF459566 Genomic DNA Translation: AAN61382.1
AF459567 Genomic DNA Translation: AAN61383.1
AF459568 Genomic DNA Translation: AAN61384.1
AF459569 Genomic DNA Translation: AAN61385.1
AF459570 Genomic DNA Translation: AAN61386.1
AF459571 Genomic DNA Translation: AAN61387.1
AF459572 Genomic DNA Translation: AAN61388.1
AF459573 Genomic DNA Translation: AAN61389.1
AF459574 Genomic DNA Translation: AAN61390.1
AF459575 Genomic DNA Translation: AAN61391.1
AF459576 Genomic DNA Translation: AAN61392.1
AF459577 Genomic DNA Translation: AAN61393.1
AF459578 Genomic DNA Translation: AAN61394.1
AF459579 Genomic DNA Translation: AAN61395.1
AF459580 Genomic DNA Translation: AAN61396.1
AF459581 Genomic DNA Translation: AAN61397.1
AF459582 Genomic DNA Translation: AAN61398.1
AF459583 Genomic DNA Translation: AAN61399.1
AF459584 Genomic DNA Translation: AAN61400.1
AF459585 Genomic DNA Translation: AAN61401.1

Protein sequence database of the Protein Information Resource

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PIRi
A41216

NCBI Reference Sequences

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RefSeqi
NP_476597.2, NM_057249.6

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0080541; FBpp0080118; FBgn0001965

Database of genes from NCBI RefSeq genomes

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GeneIDi
34790

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7793

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83931 mRNA Translation: AAB04680.1
M77501 Genomic DNA Translation: AAA28904.1
AE014134 Genomic DNA Translation: AAF53336.2
BT015294 mRNA Translation: AAT94523.1
AY058749 mRNA Translation: AAL13978.1 Different initiation.
AF459566 Genomic DNA Translation: AAN61382.1
AF459567 Genomic DNA Translation: AAN61383.1
AF459568 Genomic DNA Translation: AAN61384.1
AF459569 Genomic DNA Translation: AAN61385.1
AF459570 Genomic DNA Translation: AAN61386.1
AF459571 Genomic DNA Translation: AAN61387.1
AF459572 Genomic DNA Translation: AAN61388.1
AF459573 Genomic DNA Translation: AAN61389.1
AF459574 Genomic DNA Translation: AAN61390.1
AF459575 Genomic DNA Translation: AAN61391.1
AF459576 Genomic DNA Translation: AAN61392.1
AF459577 Genomic DNA Translation: AAN61393.1
AF459578 Genomic DNA Translation: AAN61394.1
AF459579 Genomic DNA Translation: AAN61395.1
AF459580 Genomic DNA Translation: AAN61396.1
AF459581 Genomic DNA Translation: AAN61397.1
AF459582 Genomic DNA Translation: AAN61398.1
AF459583 Genomic DNA Translation: AAN61399.1
AF459584 Genomic DNA Translation: AAN61400.1
AF459585 Genomic DNA Translation: AAN61401.1
PIRiA41216
RefSeqiNP_476597.2, NM_057249.6

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AZENMR-B1342-1350[»]
AlphaFoldDBiP26675
SMRiP26675
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi60823, 41 interactors
DIPiDIP-22308N
IntActiP26675, 12 interactors
STRINGi7227.FBpp0080118

PTM databases

iPTMnetiP26675

Proteomic databases

PaxDbiP26675
PRIDEiP26675

Genome annotation databases

EnsemblMetazoaiFBtr0080541; FBpp0080118; FBgn0001965
GeneIDi34790
KEGGidme:Dmel_CG7793

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
34790
FlyBaseiFBgn0001965, Sos
VEuPathDBiVectorBase:FBgn0001965

Phylogenomic databases

eggNOGiKOG3417, Eukaryota
HOGENOMiCLU_002744_2_0_1
InParanoidiP26675
OMAiPPPFEWH
OrthoDBi576110at2759
PhylomeDBiP26675

Enzyme and pathway databases

ReactomeiR-DME-112412, SOS-mediated signalling
R-DME-1250347, SHC1 events in ERBB4 signaling
R-DME-167044, Signalling to RAS
R-DME-179812, GRB2 events in EGFR signaling
R-DME-180336, SHC1 events in EGFR signaling
R-DME-186763, Downstream signal transduction
R-DME-193648, NRAGE signals death through JNK
R-DME-1963640, GRB2 events in ERBB2 signaling
R-DME-210993, Tie2 Signaling
R-DME-2179392, EGFR Transactivation by Gastrin
R-DME-2424491, DAP12 signaling
R-DME-2428933, SHC-related events triggered by IGF1R
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-2871796, FCERI mediated MAPK activation
R-DME-2871809, FCERI mediated Ca+2 mobilization
R-DME-375165, NCAM signaling for neurite out-growth
R-DME-416482, G alpha (12/13) signalling events
R-DME-5654688, SHC-mediated cascade:FGFR1
R-DME-5654693, FRS-mediated FGFR1 signaling
R-DME-5654699, SHC-mediated cascade:FGFR2
R-DME-5654700, FRS-mediated FGFR2 signaling
R-DME-5654704, SHC-mediated cascade:FGFR3
R-DME-5654706, FRS-mediated FGFR3 signaling
R-DME-5654712, FRS-mediated FGFR4 signaling
R-DME-5654719, SHC-mediated cascade:FGFR4
R-DME-5673001, RAF/MAP kinase cascade
R-DME-74749, Signal attenuation
R-DME-74751, Insulin receptor signalling cascade
R-DME-9013149, RAC1 GTPase cycle
R-DME-9607240, FLT3 Signaling
SignaLinkiP26675

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
34790, 0 hits in 3 CRISPR screens
EvolutionaryTraceiP26675

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
34790

Protein Ontology

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PROi
PR:P26675

Gene expression databases

BgeeiFBgn0001965, Expressed in embryo and 33 other tissues
ExpressionAtlasiP26675, baseline and differential
GenevisibleiP26675, DM

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
cd00160, RhoGEF, 1 hit
Gene3Di1.10.20.10, 1 hit
1.10.840.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
IDEALiIID50185
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR009072, Histone-fold
IPR007125, Histone_H2A/H2B/H3
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
PANTHERiPTHR23113, PTHR23113, 1 hit
PfamiView protein in Pfam
PF00125, Histone, 1 hit
PF00169, PH, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SM00325, RhoGEF, 1 hit
SUPFAMiSSF47113, SSF47113, 1 hit
SSF48065, SSF48065, 1 hit
SSF48366, SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSOS_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26675
Secondary accession number(s): Q6AWF4
, Q8I067, Q8I0F7, Q8ITK2, Q95TI8, Q969D6, Q9VJV9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: September 27, 2005
Last modified: May 25, 2022
This is version 204 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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