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Protein

Protein A46

Gene

VACWR172

Organism
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Acts close to the plasma membrane and targets several host TIR-domain containing adaptor proteins including MYD88, TIRAP, TRIF and TICAM2. In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation.2 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host NF-kappa-B by virus, Inhibition of host RLR pathway by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein A46
Gene namesi
Ordered Locus Names:VACWR172
ORF Names:A46R
OrganismiVaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR))
Taxonomic identifieri10254 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeOrthopoxvirusVaccinia virus
Virus hostiBos taurus (Bovine) [TaxID: 9913]
Proteomesi
  • UP000000344 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000993351 – 240Protein A46Add BLAST240

Interactioni

Subunit structurei

Tetramer (PubMed:27973613). Interacts with host MYD88, TRF4, TICAM2 and MAL (PubMed:20802145).2 Publications

Protein-protein interaction databases

ELMiP26672

Structurei

Secondary structure

1240
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP26672
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the poxviridae A46R protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000Q4

Family and domain databases

InterProiView protein in InterPro
IPR022819 Poxvirus
PfamiView protein in Pfam
PF06227 Poxvirus, 1 hit

Sequencei

Sequence statusi: Complete.

P26672-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFDISVNAS KTINALVYFS TQQNKLVIRN EVNDTHYTVE FDRDKVVDTF
60 70 80 90 100
ISYNRHNDTI EIRGVLPEET NIGCAVNTPV SMTYLYNKYS FKLILAEYIR
110 120 130 140 150
HRNTISGNIY SALMTLDDLA IKQYGDIDLL FNEKLKVDSD SGLFDFVNFV
160 170 180 190 200
KDMICCDSRI VVALSSLVSK HWELTNKKYR CMALAEHISD SIPISELSRL
210 220 230 240
RYNLCKYLRG HTESIEDKFD YFEDDDSSTC SAVTDRETDV
Length:240
Mass (Da):27,635
Last modified:August 1, 1992 - v1
Checksum:i0D5F3324E187A665
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72474 Genomic DNA Translation: AAA48313.1
D11079 Genomic DNA Translation: BAA01820.1
AY243312 Genomic DNA Translation: AAO89451.1
PIRiJQ1784
RefSeqiYP_233054.1, NC_006998.1

Genome annotation databases

GeneIDi3707702
KEGGivg:3707702

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M72474 Genomic DNA Translation: AAA48313.1
D11079 Genomic DNA Translation: BAA01820.1
AY243312 Genomic DNA Translation: AAO89451.1
PIRiJQ1784
RefSeqiYP_233054.1, NC_006998.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LQKX-ray1.99A/B/C/D87-229[»]
5EZUX-ray1.55A/B1-83[»]
SMRiP26672
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP26672

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3707702
KEGGivg:3707702

Phylogenomic databases

OrthoDBiVOG090000Q4

Family and domain databases

InterProiView protein in InterPro
IPR022819 Poxvirus
PfamiView protein in Pfam
PF06227 Poxvirus, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA46_VACCW
AccessioniPrimary (citable) accession number: P26672
Secondary accession number(s): Q76ZN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: August 30, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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