UniProtKB - P26651 (TTP_HUMAN)
mRNA decay activator protein ZFP36
ZFP36
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 103 – 131 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 141 – 169 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 29 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- C-C chemokine binding Source: UniProtKB
- DNA binding Source: UniProtKB-KW
- enzyme binding Source: BHF-UCL
- heat shock protein binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- mRNA 3'-UTR AU-rich region binding Source: UniProtKB
- mRNA binding Source: UniProtKB
- protein-containing complex binding Source: GO_Central
- protein kinase binding Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA polymerase binding Source: UniProtKB
GO - Biological processi
- 3'-UTR-mediated mRNA destabilization Source: UniProtKB
- 3'-UTR-mediated mRNA stabilization Source: UniProtKB
- cellular response to epidermal growth factor stimulus Source: UniProtKB
- cellular response to fibroblast growth factor stimulus Source: UniProtKB
- cellular response to glucocorticoid stimulus Source: UniProtKB
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: UniProtKB
- cellular response to lipopolysaccharide Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- MAPK cascade Source: UniProtKB
- miRNA mediated inhibition of translation Source: UniProtKB
- mRNA catabolic process Source: UniProtKB
- mRNA transport Source: UniProtKB
- negative regulation of erythrocyte differentiation Source: UniProtKB
- negative regulation of interleukin-2 production Source: UniProtKB
- negative regulation of polynucleotide adenylyltransferase activity Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- negative regulation of viral transcription Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
- nuclear-transcribed mRNA catabolic process, deadenylation-independent decay Source: UniProtKB
- nuclear-transcribed mRNA poly(A) tail shortening Source: BHF-UCL
- p38MAPK cascade Source: UniProtKB
- positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of gene silencing by miRNA Source: UniProtKB
- positive regulation of intracellular mRNA localization Source: UniProtKB
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
- regulation of keratinocyte apoptotic process Source: UniProtKB
- regulation of keratinocyte differentiation Source: UniProtKB
- regulation of keratinocyte proliferation Source: UniProtKB
- regulation of mRNA stability Source: UniProtKB
- regulation of tumor necrosis factor production Source: UniProtKB
- response to starvation Source: UniProtKB
- response to wounding Source: UniProtKB
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Ribonucleoprotein, RNA-binding |
Biological process | Host-virus interaction, mRNA transport, RNA-mediated gene silencing, Transport |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P26651 |
Reactomei | R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
SignaLinki | P26651 |
SIGNORi | P26651 |
Names & Taxonomyi
Protein namesi | Recommended name: mRNA decay activator protein ZFP36CuratedAlternative name(s): G0/G1 switch regulatory protein 24 Growth factor-inducible nuclear protein NUP475Curated Tristetraprolin1 Publication Zinc finger protein 36Imported Short name: Zfp-36By similarity |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12862, ZFP36 |
MIMi | 190700, gene |
neXtProti | NX_P26651 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoplasm and Cytosol
- Cytoplasm 5 Publications
Other locations
- Cytoplasmic granule 1 Publication
- P-body 1 Publication
Note: Shuttles between nucleus and cytoplasm in a CRM1-dependent manner (By similarity). Localized predominantly in the cytoplasm in a p38 MAPK- and YWHAB-dependent manner (By similarity). Colocalizes with SH3KBP1 and MAP3K4 in the cytoplasm (PubMed:20221403). Component of cytoplasmic stress granules (SGs) (By similarity). Localizes to cytoplasmic stress granules upon energy starvation (PubMed:15014438). Localizes in processing bodies (PBs) (PubMed:17369404). Excluded from stress granules in a phosphorylation MAPKAPK2-dependent manner (By similarity). Shuttles in and out of both cytoplasmic P-body and SGs (By similarity).By similarity3 Publications
Cytosol
- cytosol Source: MGI
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: UniProtKB
- P-body Source: UniProtKB
- ribonucleoprotein complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Exosome, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 60 | S → A: Inhibits PKM-induced ZFP36 degradation through a p38 MAPK signaling pathway. 1 Publication | 1 | |
Mutagenesisi | 124 | C → R: Inhibits binding to ARE-containing transcripts. Inhibits binding to and deadenylation activities of ARE-containing mRNAs. Inhibits localization of ARE-containing mRNAs to processing bodies (PBs). 5 Publications | 1 | |
Mutagenesisi | 126 | F → N: Inhibits ARE-containing RNA-binding, deadenylation and RNA decapping activities. 3 Publications | 1 | |
Mutagenesisi | 147 | C → R: Inhibits both ARE-binding and mRNA deadenylation activities. 1 Publication | 1 | |
Mutagenesisi | 309 | P → V: Inhibits interaction with SH3KBP1. 1 Publication | 1 | |
Mutagenesisi | 315 | R → A: Abolishes interaction with CNOT1. 1 Publication | 1 | |
Mutagenesisi | 319 | F → A: Abolishes interaction with CNOT1 and impairs TNF mRNA deadenylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 7538 |
OpenTargetsi | ENSG00000128016 |
PharmGKBi | PA37451 |
Miscellaneous databases
Pharosi | P26651, Tbio |
Genetic variation databases
BioMutai | ZFP36 |
DMDMi | 136471 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089163 | 1 – 326 | mRNA decay activator protein ZFP36Add BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 60 | Phosphoserine; by MAPKAPK2By similarity | 1 | |
Modified residuei | 66 | Phosphoserine2 Publications | 1 | |
Modified residuei | 88 | Phosphoserine1 Publication | 1 | |
Modified residuei | 90 | PhosphoserineBy similarity | 1 | |
Modified residuei | 92 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 93 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 169 | Phosphoserine1 Publication | 1 | |
Modified residuei | 186 | Phosphoserine; by MAPKAPK2Combined sources1 Publication | 1 | |
Modified residuei | 197 | Phosphoserine1 Publication | 1 | |
Modified residuei | 218 | Phosphoserine1 Publication | 1 | |
Modified residuei | 228 | Phosphoserine; by MAPK1; in vitro1 Publication | 1 | |
Modified residuei | 276 | Phosphoserine1 Publication | 1 | |
Modified residuei | 296 | Phosphoserine1 Publication | 1 | |
Modified residuei | 323 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P26651 |
jPOSTi | P26651 |
MassIVEi | P26651 |
PaxDbi | P26651 |
PeptideAtlasi | P26651 |
PRIDEi | P26651 |
ProteomicsDBi | 54360 |
PTM databases
iPTMneti | P26651 |
PhosphoSitePlusi | P26651 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
ExpressionAtlasi | P26651, baseline and differential |
Interactioni
Subunit structurei
Associates with cytoplasmic CCR4-NOT and PAN2-PAN3 deadenylase complexes to trigger ARE-containing mRNA deadenylation and decay processes (By similarity).
Part of a mRNA decay activation complex at least composed of poly(A)-specific exoribonucleases CNOT6, EXOSC2 and XRN1 and mRNA-decapping enzymes DCP1A and DCP2 (PubMed:15687258). Associates with the RNA exosome complex (PubMed:11719186).
Interacts (via phosphorylated form) with 14-3-3 proteins; these interactions promote exclusion of ZFP36 from cytoplasmic stress granules in response to arsenite treatment in a MAPKAPK2-dependent manner and does not prevent CCR4-NOT deadenylase complex recruitment or ZFP36-induced ARE-containing mRNA deadenylation and decay processes (By similarity).
Interacts with 14-3-3 proteins; these interactions occur in response to rapamycin in an Akt-dependent manner (PubMed:16702957).
Interacts with AGO2 and AGO4 (PubMed:15766526).
Interacts (via C-terminus) with CNOT1; this interaction occurs in a RNA-independent manner and induces mRNA deadenylation (PubMed:23644599).
Interacts (via N-terminus) with CNOT6 (PubMed:15687258).
Interacts with CNOT6L (By similarity).
Interacts (via C-terminus) with CNOT7; this interaction occurs in a RNA-independent manner, induces mRNA deadenylation and is inhibited in a phosphorylation MAPKAPK2-dependent manner (PubMed:25106868).
Interacts (via unphosphorylated form) with CNOT8; this interaction occurs in a RNA-independent manner and is inhibited in a phosphorylation MAPKAPK2-dependent manner (By similarity).
Interacts with DCP1A (PubMed:15687258).
Interacts (via N-terminus) with DCP2 (PubMed:15687258, PubMed:16364915).
Interacts with EDC3 (PubMed:16364915).
Interacts (via N-terminus) with EXOSC2 (PubMed:15687258).
Interacts with heat shock 70 kDa proteins (PubMed:20221403).
Interacts with KHSRP; this interaction increases upon cytokine-induced treatment (PubMed:16126846).
Interacts with MAP3K4; this interaction enhances the association with SH3KBP1/CIN85 (PubMed:20221403).
Interacts with MAPKAPK2; this interaction occurs upon skeletal muscle satellite cell activation (By similarity).
Interacts with NCL (PubMed:20221403).
Interacts with NUP214; this interaction increases upon lipopolysaccharide (LPS) stimulation (PubMed:14766228).
Interacts with PABPC1; this interaction occurs in a RNA-dependent manner (PubMed:20221403).
Interacts (via hypophosphorylated form) with PABPN1 (via RRM domain and C-terminal arginine-rich region); this interaction occurs in the nucleus in a RNA-independent manner, decreases in presence of single-stranded poly(A) RNA-oligomer and in a p38 MAPK-dependent-manner and inhibits nuclear poly(A) tail synthesis (By similarity).
Interacts with PAN2 (By similarity).
Interacts (via C3H1-type zinc finger domains) with PKM (PubMed:26926077).
Interacts (via C3H1-type zinc finger domains) with nuclear RNA poly(A) polymerase (By similarity).
Interacts with PPP2CA; this interaction occurs in LPS-stimulated cells and induces ZFP36 dephosphorylation, and hence may promote ARE-containing mRNAs decay (By similarity).
Interacts (via C-terminus) with PRR5L (via C-terminus); this interaction may accelerate ZFP36-mediated mRNA decay during stress (PubMed:21964062).
Interacts (via C-terminus) with SFN; this interaction occurs in a phosphorylation-dependent manner (By similarity).
Interacts (via extreme C-terminal region) with SH3KBP1/CIN85 (via SH3 domains); this interaction enhances MAP3K4-induced phosphorylation of ZFP36 at Ser-66 and Ser-93 and does not alter neither ZFP36 binding to ARE-containing transcripts nor TNF-alpha mRNA decay (PubMed:20221403).
Interacts with XRN1 (PubMed:15687258).
Interacts (via C-terminus and Ser-186 phosphorylated form) with YWHAB; this interaction occurs in a p38/MAPKAPK2-dependent manner, increases cytoplasmic localization of ZFP36 and protects ZFP36 from Ser-186 dephosphorylation by serine/threonine phosphatase 2A, and hence may be crucial for stabilizing ARE-containing mRNAs (By similarity).
Interacts (via phosphorylated form) with YWHAE (By similarity).
Interacts (via C-terminus) with YWHAG; this interaction occurs in a phosphorylation-dependent manner (By similarity).
Interacts with YWHAH; this interaction occurs in a phosphorylation-dependent manner (By similarity).
Interacts with YWHAQ; this interaction occurs in a phosphorylation-dependent manner (By similarity).
Interacts with (via C-terminus) YWHAZ; this interaction occurs in a phosphorylation-dependent manner (By similarity).
Interacts (via P-P-P-P-G repeats) with GIGYF2; the interaction is direct (By similarity).
By similarity12 Publications(Microbial infection) Interacts (via C-terminus) with HTLV-1 TAX (via C-terminus); this interaction inhibits HTLV-1 TAX to transactivate viral long terminal repeat (LTR) promoter (PubMed:14679154).
1 PublicationBinary interactionsi
Hide detailsP26651
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- C-C chemokine binding Source: UniProtKB
- enzyme binding Source: BHF-UCL
- heat shock protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- RNA polymerase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113370, 172 interactors |
CORUMi | P26651 |
DIPi | DIP-29845N |
IntActi | P26651, 29 interactors |
STRINGi | 9606.ENSP00000469647 |
Miscellaneous databases
RNActi | P26651, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P26651 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 71 – 75 | P-P-P-P-G | 5 | |
Repeati | 198 – 202 | P-P-P-P-G | 5 | |
Repeati | 219 – 223 | P-P-P-P-G | 5 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 174 | Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)1 PublicationAdd BLAST | 174 | |
Regioni | 1 – 100 | Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation1 PublicationAdd BLAST | 100 | |
Regioni | 1 – 15 | Necessary for nuclear exportBy similarityAdd BLAST | 15 | |
Regioni | 95 – 168 | Necessary for nuclear localizationBy similarityAdd BLAST | 74 | |
Regioni | 97 – 173 | Necessary for RNA-binding2 PublicationsAdd BLAST | 77 | |
Regioni | 100 – 326 | Necessary for localization of ARE-containing mRNAs to processing bodies (PBs)1 PublicationAdd BLAST | 227 | |
Regioni | 103 – 194 | Necessary for interaction with PABPN1By similarityAdd BLAST | 92 | |
Regioni | 174 – 326 | Necessary for mRNA decay activation1 PublicationAdd BLAST | 153 | |
Regioni | 312 – 326 | Interaction with CNOT11 PublicationAdd BLAST | 15 |
Domaini
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 103 – 131 | C3H1-type 1PROSITE-ProRule annotationAdd BLAST | 29 | |
Zinc fingeri | 141 – 169 | C3H1-type 2PROSITE-ProRule annotationAdd BLAST | 29 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1677, Eukaryota |
GeneTreei | ENSGT00940000162360 |
InParanoidi | P26651 |
OrthoDBi | 1541140at2759 |
PhylomeDBi | P26651 |
TreeFami | TF315463 |
Family and domain databases
IDEALi | IID00655 |
InterProi | View protein in InterPro IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
Pfami | View protein in Pfam PF00642, zf-CCCH, 2 hits |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 2 hits |
SUPFAMi | SSF90229, SSF90229, 2 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDLTAIYESL LSLSPDVPVP SDHGGTESSP GWGSSGPWSL SPSDSSPSGV
60 70 80 90 100
TSRLPGRSTS LVEGRSCGWV PPPPGFAPLA PRLGPELSPS PTSPTATSTT
110 120 130 140 150
PSRYKTELCR TFSESGRCRY GAKCQFAHGL GELRQANRHP KYKTELCHKF
160 170 180 190 200
YLQGRCPYGS RCHFIHNPSE DLAAPGHPPV LRQSISFSGL PSGRRTSPPP
210 220 230 240 250
PGLAGPSLSS SSFSPSSSPP PPGDLPLSPS AFSAAPGTPL ARRDPTPVCC
260 270 280 290 300
PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE
310 320
AGVFAPPQPV AAPRRLPIFN RISVSE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QY76 | M0QY76_HUMAN | Zinc finger protein 36, C3H type, h... | ZFP36 hCG_43352 | 332 | Annotation score: | ||
M0R252 | M0R252_HUMAN | mRNA decay activator protein ZFP36 | ZFP36 | 65 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021064 | 37 | P → S1 PublicationCorresponds to variant dbSNP:rs17878633EnsemblClinVar. | 1 | |
Natural variantiVAR_052324 | 55 | P → S. Corresponds to variant dbSNP:rs2229272Ensembl. | 1 | |
Natural variantiVAR_021065 | 259 | I → F1 PublicationCorresponds to variant dbSNP:rs17886974Ensembl. | 1 | |
Natural variantiVAR_021066 | 324 | V → F1 PublicationCorresponds to variant dbSNP:rs17884899Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92843 mRNA Translation: AAA58489.1 M92844 Genomic DNA Translation: AAC37600.1 M63625 mRNA Translation: AAA61240.1 AK314042 mRNA Translation: BAG36751.1 AY771351 Genomic DNA Translation: AAV28731.1 BC009693 mRNA Translation: AAH09693.1 |
CCDSi | CCDS12534.2 |
PIRi | S34427 |
RefSeqi | NP_003398.2, NM_003407.3 |
Genome annotation databases
Ensembli | ENST00000597629; ENSP00000469647; ENSG00000128016 |
GeneIDi | 7538 |
KEGGi | hsa:7538 |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M92843 mRNA Translation: AAA58489.1 M92844 Genomic DNA Translation: AAC37600.1 M63625 mRNA Translation: AAA61240.1 AK314042 mRNA Translation: BAG36751.1 AY771351 Genomic DNA Translation: AAV28731.1 BC009693 mRNA Translation: AAH09693.1 |
CCDSi | CCDS12534.2 |
PIRi | S34427 |
RefSeqi | NP_003398.2, NM_003407.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4J8S | X-ray | 1.55 | B | 312-326 | [»] | |
SMRi | P26651 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113370, 172 interactors |
CORUMi | P26651 |
DIPi | DIP-29845N |
IntActi | P26651, 29 interactors |
STRINGi | 9606.ENSP00000469647 |
PTM databases
iPTMneti | P26651 |
PhosphoSitePlusi | P26651 |
Genetic variation databases
BioMutai | ZFP36 |
DMDMi | 136471 |
Proteomic databases
EPDi | P26651 |
jPOSTi | P26651 |
MassIVEi | P26651 |
PaxDbi | P26651 |
PeptideAtlasi | P26651 |
PRIDEi | P26651 |
ProteomicsDBi | 54360 |
Protocols and materials databases
Antibodypediai | 1121, 344 antibodies |
DNASUi | 7538 |
Genome annotation databases
Ensembli | ENST00000597629; ENSP00000469647; ENSG00000128016 |
GeneIDi | 7538 |
KEGGi | hsa:7538 |
Organism-specific databases
CTDi | 7538 |
DisGeNETi | 7538 |
GeneCardsi | ZFP36 |
HGNCi | HGNC:12862, ZFP36 |
MIMi | 190700, gene |
neXtProti | NX_P26651 |
OpenTargetsi | ENSG00000128016 |
PharmGKBi | PA37451 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1677, Eukaryota |
GeneTreei | ENSGT00940000162360 |
InParanoidi | P26651 |
OrthoDBi | 1541140at2759 |
PhylomeDBi | P26651 |
TreeFami | TF315463 |
Enzyme and pathway databases
PathwayCommonsi | P26651 |
Reactomei | R-HSA-450513, Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
SignaLinki | P26651 |
SIGNORi | P26651 |
Miscellaneous databases
BioGRID-ORCSi | 7538, 24 hits in 1014 CRISPR screens |
ChiTaRSi | ZFP36, human |
GeneWikii | ZFP36 |
GenomeRNAii | 7538 |
Pharosi | P26651, Tbio |
PROi | PR:P26651 |
RNActi | P26651, protein |
SOURCEi | Search... |
Gene expression databases
ExpressionAtlasi | P26651, baseline and differential |
Family and domain databases
IDEALi | IID00655 |
InterProi | View protein in InterPro IPR000571, Znf_CCCH IPR036855, Znf_CCCH_sf |
Pfami | View protein in Pfam PF00642, zf-CCCH, 2 hits |
SMARTi | View protein in SMART SM00356, ZnF_C3H1, 2 hits |
SUPFAMi | SSF90229, SSF90229, 2 hits |
PROSITEi | View protein in PROSITE PS50103, ZF_C3H1, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTP_HUMAN | |
Accessioni | P26651Primary (citable) accession number: P26651 Secondary accession number(s): B2RA54 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 194 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references