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Protein

Surface composition regulator

Gene

glgS

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major determinant of cell surface composition. Negatively regulates motility, adhesion and synthesis of biofilm exopolysaccharides.UniRule annotation1 Publication

Caution

Was originally thought to be involved in glycogen synthesis, but it was shown later that its effect on glycogen metabolism is probably indirect.2 Publications

GO - Biological processi

  • negative regulation of bacterial-type flagellum-dependent cell motility Source: EcoCyc
  • negative regulation of single-species biofilm formation on inanimate substrate Source: EcoCyc
  • positive regulation of cellular carbohydrate metabolic process Source: EcoCyc

Enzyme and pathway databases

BioCyciEcoCyc:EG11381-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Surface composition regulator1 PublicationUniRule annotation
Gene namesi
Name:glgS1 Publication
Synonyms:scoR1 Publication
Ordered Locus Names:b3049, JW3021
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11381 glgS

Pathology & Biotechi

Disruption phenotypei

Deletion mutants show increased flagella and fimbriae production, are hypermotile, and exhibit increased biofilm formation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000715991 – 66Surface composition regulatorAdd BLAST66

Proteomic databases

PaxDbiP26649
PRIDEiP26649

Expressioni

Inductioni

Expression is dependent on RpoS.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262385, 14 interactors
IntActiP26649, 2 interactors
STRINGi316385.ECDH10B_3223

Structurei

Secondary structure

166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni3 – 6Combined sources4
Helixi7 – 24Combined sources18
Helixi30 – 36Combined sources7
Helixi41 – 59Combined sources19

3D structure databases

ProteinModelPortaliP26649
SMRiP26649
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26649

Family & Domainsi

Sequence similaritiesi

Belongs to the GlgS family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105WWV Bacteria
ENOG411240A LUCA
HOGENOMiHOG000004893
OMAiHRSWFCK

Family and domain databases

Gene3Di1.20.970.20, 1 hit
HAMAPiMF_00525 GlgS, 1 hit
InterProiView protein in InterPro
IPR015065 GlgS
IPR036295 GlgS_sf
PfamiView protein in Pfam
PF08971 GlgS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD054490 GlgS, 1 hit
SUPFAMiSSF109747 SSF109747, 1 hit

Sequencei

Sequence statusi: Complete.

P26649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHSLNSLNN FDFLARSFAR MHAEGRPVDI LAVTGNMDEE HRTWFCARYA
60
WYCQQMMQAR ELELEH
Length:66
Mass (Da):7,892
Last modified:August 1, 1992 - v1
Checksum:iD047AB6E7AD67523
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11885 Genomic DNA Translation: CAA77940.1
U00096 Genomic DNA Translation: AAC76085.1
AP009048 Genomic DNA Translation: BAA16577.1
PIRiS25201
RefSeqiNP_417521.1, NC_000913.3
WP_000350095.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76085; AAC76085; b3049
BAA16577; BAA16577; BAA16577
GeneIDi947533
KEGGiecj:JW3021
eco:b3049
PATRICifig|1411691.4.peg.3682

Similar proteinsi

Entry informationi

Entry nameiGLGS_ECOLI
AccessioniPrimary (citable) accession number: P26649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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