UniProtKB - P26648 (FTSP_ECOLI)
Protein
Cell division protein FtsP
Gene
ftsP
Organism
Escherichia coli (strain K12)
Status
Functioni
Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress.UniRule annotation1 Publication
Miscellaneous
Is used as a model substrate in studies of the twin-arginine translocation (Tat) protein transport system.
GO - Molecular functioni
- copper ion binding Source: InterPro
- oxidoreductase activity Source: GO_Central
GO - Biological processi
- cell division Source: CACAO
- FtsZ-dependent cytokinesis Source: UniProtKB-UniRule
- response to ionizing radiation Source: EcoCyc
- response to oxidative stress Source: EcoCyc
Keywordsi
Biological process | Cell cycle, Cell division |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11376-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division protein FtsPUniRule annotation |
Gene namesi | Name:ftsPUniRule annotation Synonyms:sufI Ordered Locus Names:b3017, JW2985 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Other locations
- Periplasm UniRule annotation2 Publications
Note: Localizes to the division septum. Localization requires FtsZ, FtsQ, FtsL and FtsN.
Other locations
- cell division site Source: EcoCyc
- outer membrane-bounded periplasmic space Source: EcoCyc
Keywords - Cellular componenti
PeriplasmPathology & Biotechi
Disruption phenotypei
Cells lacking this gene are sensitive to oxidative stress and DNA damage at high temperature. They also exhibit filamentation.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Tat-type signalUniRule annotation1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000002993 | 28 – 470 | Cell division protein FtsPAdd BLAST | 443 |
Post-translational modificationi
Exported by the Tat system. The position of the signal peptide cleavage has been experimentally proven. Can also be exported by the Sec system.
Proteomic databases
jPOSTi | P26648 |
PaxDbi | P26648 |
PRIDEi | P26648 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4260932, 62 interactors 849379, 3 interactors |
DIPi | DIP-10942N |
IntActi | P26648, 9 interactors |
STRINGi | 511145.b3017 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P26648 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P26648 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 164 | Plastocyanin-likeUniRule annotationAdd BLAST | 97 |
Sequence similaritiesi
Belongs to the FtsP family.UniRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG2132, Bacteria |
HOGENOMi | CLU_009100_2_4_6 |
InParanoidi | P26648 |
PhylomeDBi | P26648 |
Family and domain databases
Gene3Di | 2.60.40.420, 3 hits |
HAMAPi | MF_00915, FtsP, 1 hit |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_2 IPR011707, Cu-oxidase_3 IPR008972, Cupredoxin IPR026589, FtsP IPR006311, TAT_signal IPR019546, TAT_signal_bac_arc |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 1 hit |
SUPFAMi | SSF49503, SSF49503, 3 hits |
TIGRFAMsi | TIGR01409, TAT_signal_seq, 1 hit |
PROSITEi | View protein in PROSITE PS51318, TAT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26648-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLSRRQFIQ ASGIALCAGA VPLKASAAGQ QQPLPVPPLL ESRRGQPLFM
60 70 80 90 100
TVQRAHWSFT PGTRASVWGI NGRYLGPTIR VWKGDDVKLI YSNRLTENVS
110 120 130 140 150
MTVAGLQVPG PLMGGPARMM SPNADWAPVL PIRQNAATLW YHANTPNRTA
160 170 180 190 200
QQVYNGLAGM WLVEDEVSKS LPIPNHYGVD DFPVIIQDKR LDNFGTPEYN
210 220 230 240 250
EPGSGGFVGD TLLVNGVQSP YVEVSRGWVR LRLLNASNSR RYQLQMNDGR
260 270 280 290 300
PLHVISGDQG FLPAPVSVKQ LSLAPGERRE ILVDMSNGDE VSITCGEAAS
310 320 330 340 350
IVDRIRGFFE PSSILVSTLV LTLRPTGLLP LVTDSLPMRL LPTEIMAGSP
360 370 380 390 400
IRSRDISLGD DPGINGQLWD VNRIDVTAQQ GTWERWTVRA DEPQAFHIEG
410 420 430 440 450
VMFQIRNVNG AMPFPEDRGW KDTVWVDGQV ELLVYFGQPS WAHFPFYFNS
460 470
QTLEMADRGS IGQLLVNPVP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69185.1 U00096 Genomic DNA Translation: AAC76053.1 AP009048 Genomic DNA Translation: BAE77073.1 M63491 Genomic DNA Translation: AAA24398.1 |
PIRi | G65088 |
RefSeqi | NP_417489.1, NC_000913.3 WP_000059388.1, NZ_SSZK01000023.1 |
Genome annotation databases
EnsemblBacteriai | AAC76053; AAC76053; b3017 BAE77073; BAE77073; BAE77073 |
GeneIDi | 57729161 944982 |
KEGGi | ecj:JW2985 eco:b3017 |
PATRICi | fig|1411691.4.peg.3713 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28377 Genomic DNA Translation: AAA69185.1 U00096 Genomic DNA Translation: AAC76053.1 AP009048 Genomic DNA Translation: BAE77073.1 M63491 Genomic DNA Translation: AAA24398.1 |
PIRi | G65088 |
RefSeqi | NP_417489.1, NC_000913.3 WP_000059388.1, NZ_SSZK01000023.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2UXT | X-ray | 1.90 | A/B | 28-470 | [»] | |
2UXV | X-ray | 2.61 | A/B | 28-470 | [»] | |
SMRi | P26648 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 4260932, 62 interactors 849379, 3 interactors |
DIPi | DIP-10942N |
IntActi | P26648, 9 interactors |
STRINGi | 511145.b3017 |
Proteomic databases
jPOSTi | P26648 |
PaxDbi | P26648 |
PRIDEi | P26648 |
Genome annotation databases
EnsemblBacteriai | AAC76053; AAC76053; b3017 BAE77073; BAE77073; BAE77073 |
GeneIDi | 57729161 944982 |
KEGGi | ecj:JW2985 eco:b3017 |
PATRICi | fig|1411691.4.peg.3713 |
Organism-specific databases
EchoBASEi | EB1350 |
Phylogenomic databases
eggNOGi | COG2132, Bacteria |
HOGENOMi | CLU_009100_2_4_6 |
InParanoidi | P26648 |
PhylomeDBi | P26648 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11376-MONOMER |
Miscellaneous databases
EvolutionaryTracei | P26648 |
PROi | PR:P26648 |
Family and domain databases
Gene3Di | 2.60.40.420, 3 hits |
HAMAPi | MF_00915, FtsP, 1 hit |
InterProi | View protein in InterPro IPR001117, Cu-oxidase IPR011706, Cu-oxidase_2 IPR011707, Cu-oxidase_3 IPR008972, Cupredoxin IPR026589, FtsP IPR006311, TAT_signal IPR019546, TAT_signal_bac_arc |
Pfami | View protein in Pfam PF00394, Cu-oxidase, 1 hit PF07731, Cu-oxidase_2, 1 hit PF07732, Cu-oxidase_3, 1 hit |
SUPFAMi | SSF49503, SSF49503, 3 hits |
TIGRFAMsi | TIGR01409, TAT_signal_seq, 1 hit |
PROSITEi | View protein in PROSITE PS51318, TAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FTSP_ECOLI | |
Accessioni | P26648Primary (citable) accession number: P26648 Secondary accession number(s): Q2M9I3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | November 1, 1995 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families