We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P26647 (PLSC_ECOLI)
Protein
1-acyl-sn-glycerol-3-phosphate acyltransferase
Gene
plsC
Organism
Escherichia coli (strain K12)
Status
Functioni
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor.
1 PublicationCatalytic activityi
- EC:2.3.1.51
- a 1-acyl-sn-glycero-3-phosphate + a fatty acyl-[ACP] = a 1,2-diacyl-sn-glycero-3-phosphate + holo-[ACP]EC:2.3.1.n4
: CDP-diacylglycerol biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate. This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- 1-acylglycerol-3-phosphate O-acyltransferase activity Source: EcoCyc
GO - Biological processi
- CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
- phosphatidic acid biosynthetic process Source: EcoCyc
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Enzyme and pathway databases
BioCyci | EcoCyc:1-ACYLGLYCEROL-3-P-ACYLTRANSFER-MONOMER |
UniPathwayi | UPA00557;UER00613 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:plsC Synonyms:parF Ordered Locus Names:b3018, JW2986 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane 1 Publication; Peripheral membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000208168 | 1 – 245 | 1-acyl-sn-glycerol-3-phosphate acyltransferaseAdd BLAST | 245 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-formylmethionine1 Publication | 1 |
Keywords - PTMi
FormylationProteomic databases
jPOSTi | P26647 |
PaxDbi | P26647 |
PRIDEi | P26647 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261779, 258 interactors |
DIPi | DIP-10516N |
IntActi | P26647, 2 interactors |
STRINGi | 511145.b3018 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 73 – 78 | HXXXXD motif | 6 |
Domaini
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity
Sequence similaritiesi
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated
Phylogenomic databases
eggNOGi | COG0204, Bacteria |
HOGENOMi | CLU_027938_10_3_6 |
InParanoidi | P26647 |
PhylomeDBi | P26647 |
Family and domain databases
InterProi | View protein in InterPro IPR004552, AGP_acyltrans IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
TIGRFAMsi | TIGR00530, AGP_acyltrn, 1 hit |
i Sequence
Sequence statusi: Complete.
P26647-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLYIFRLIIT VIYSILVCVF GSIYCLFSPR NPKHVATFGH MFGRLAPLFG
60 70 80 90 100
LKVECRKPTD AESYGNAIYI ANHQNNYDMV TASNIVQPPT VTVGKKSLLW
110 120 130 140 150
IPFFGQLYWL TGNLLIDRNN RTKAHGTIAE VVNHFKKRRI SIWMFPEGTR
160 170 180 190 200
SRGRGLLPFK TGAFHAAIAA GVPIIPVCVS TTSNKINLNR LHNGLVIVEM
210 220 230 240
LPPIDVSQYG KDQVRELAAH CRSIMEQKIA ELDKEVAERE AAGKV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63491 Genomic DNA Translation: AAA24397.1 U28377 Genomic DNA Translation: AAA69186.1 U00096 Genomic DNA Translation: AAC76054.1 AP009048 Genomic DNA Translation: BAE77074.1 |
PIRi | S20460 |
RefSeqi | NP_417490.1, NC_000913.3 WP_000965722.1, NZ_SSZK01000023.1 |
Genome annotation databases
EnsemblBacteriai | AAC76054; AAC76054; b3018 BAE77074; BAE77074; BAE77074 |
GeneIDi | 947496 |
KEGGi | ecj:JW2986 eco:b3018 |
PATRICi | fig|1411691.4.peg.3712 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M63491 Genomic DNA Translation: AAA24397.1 U28377 Genomic DNA Translation: AAA69186.1 U00096 Genomic DNA Translation: AAC76054.1 AP009048 Genomic DNA Translation: BAE77074.1 |
PIRi | S20460 |
RefSeqi | NP_417490.1, NC_000913.3 WP_000965722.1, NZ_SSZK01000023.1 |
3D structure databases
SMRi | P26647 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261779, 258 interactors |
DIPi | DIP-10516N |
IntActi | P26647, 2 interactors |
STRINGi | 511145.b3018 |
Chemistry databases
ChEMBLi | CHEMBL3309004 |
Proteomic databases
jPOSTi | P26647 |
PaxDbi | P26647 |
PRIDEi | P26647 |
Genome annotation databases
EnsemblBacteriai | AAC76054; AAC76054; b3018 BAE77074; BAE77074; BAE77074 |
GeneIDi | 947496 |
KEGGi | ecj:JW2986 eco:b3018 |
PATRICi | fig|1411691.4.peg.3712 |
Organism-specific databases
EchoBASEi | EB1351 |
Phylogenomic databases
eggNOGi | COG0204, Bacteria |
HOGENOMi | CLU_027938_10_3_6 |
InParanoidi | P26647 |
PhylomeDBi | P26647 |
Enzyme and pathway databases
UniPathwayi | UPA00557;UER00613 |
BioCyci | EcoCyc:1-ACYLGLYCEROL-3-P-ACYLTRANSFER-MONOMER |
Miscellaneous databases
PROi | PR:P26647 |
Family and domain databases
InterProi | View protein in InterPro IPR004552, AGP_acyltrans IPR002123, Plipid/glycerol_acylTrfase |
Pfami | View protein in Pfam PF01553, Acyltransferase, 1 hit |
SMARTi | View protein in SMART SM00563, PlsC, 1 hit |
TIGRFAMsi | TIGR00530, AGP_acyltrn, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLSC_ECOLI | |
Accessioni | P26647Primary (citable) accession number: P26647 Secondary accession number(s): Q2M9I2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families