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UniProtKB - P26637 (SYLC_YEAST)
Protein
Leucine--tRNA ligase, cytoplasmic
Gene
CDC60
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 158000 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
- EC:6.1.1.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 732 | ATPBy similarity | 1 |
GO - Molecular functioni
- aminoacyl-tRNA editing activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- leucine-tRNA ligase activity Source: SGD
GO - Biological processi
- leucyl-tRNA aminoacylation Source: SGD
- regulation of TORC1 signaling Source: SGD
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 6.1.1.4, 984 |
Names & Taxonomyi
Protein namesi | Recommended name: Leucine--tRNA ligase, cytoplasmic (EC:6.1.1.4)Alternative name(s): Leucyl-tRNA synthetase Short name: LeuRS |
Gene namesi | Name:CDC60 Ordered Locus Names:YPL160W ORF Names:P2564 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006081, CDC60 |
VEuPathDBi | FungiDB:YPL160W |
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: SGD
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000152155 | 2 – 1090 | Leucine--tRNA ligase, cytoplasmicAdd BLAST | 1089 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 142 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
MaxQBi | P26637 |
PaxDbi | P26637 |
PRIDEi | P26637 |
PTM databases
iPTMneti | P26637 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36023, 359 interactors |
DIPi | DIP-6365N |
IntActi | P26637, 19 interactors |
MINTi | P26637 |
STRINGi | 4932.YPL160W |
Chemistry databases
BindingDBi | P26637 |
Miscellaneous databases
RNActi | P26637, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 66 – 76 | 'HIGH' regionAdd BLAST | 11 | |
Motifi | 729 – 733 | 'KMSKS' region | 5 |
Sequence similaritiesi
Belongs to the class-I aminoacyl-tRNA synthetase family.Curated
Phylogenomic databases
eggNOGi | KOG0437, Eukaryota |
GeneTreei | ENSGT00390000012163 |
HOGENOMi | CLU_004174_1_1_1 |
InParanoidi | P26637 |
OMAi | RWQFNHL |
Family and domain databases
Gene3Di | 3.40.50.620, 1 hit 3.90.740.10, 1 hit |
InterProi | View protein in InterPro IPR002300, aa-tRNA-synth_Ia IPR004493, Leu-tRNA-synth_Ia_arc/euk IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR45794, PTHR45794, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 2 hits |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00395, leuS_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26637-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSGLVLENT ARRDALIAIE KKYQKIWAEE HQFEIDAPSI EDEPITMDSE
60 70 80 90 100
ELHRTYPKFM SSMAYPYMNG VMHAGHCFTL SKVEFSIGFE RMNGKRALFP
110 120 130 140 150
LGFHCTGMPI LACADKLKRE AELFGKNFDN VPAEEEEIKE ETPAEKDHED
160 170 180 190 200
VTKFKAKKSK AAAKKGRGKY QFEIMLQLGI PREEIIKFAD AKYWLTYFPP
210 220 230 240 250
LCESDCTSLG ARIDWRRSFV TTDANPYYDA FIRWQMNKLK AAGKIKFGER
260 270 280 290 300
YTIYSEKDGQ ACMDHDRQSG EGVTPQEYIG VKIEALEFAD DAAKIIDSSS
310 320 330 340 350
DLDKSKKFYF VAATLRPETM YGQTCCFVSP TIEYGIFDAG DSYFITTERA
360 370 380 390 400
FKNMSYQKLT PKRGFYKPIV TVPGKAFIGT KIHAPQSVYP ELRILPMETV
410 420 430 440 450
IATKGTGVVT CVPSNSPDDY ITTKDLLHKP EYYGIKPEWI DHEIVPIMHT
460 470 480 490 500
EKYGDLTAKA IVEEKKIQSP KDKNLLAEAK KIAYKEDYYT GTMIYGPYKG
510 520 530 540 550
EKVEQAKNKV KADMIAAGEA FVYNEPESQV MSRSGDDCIV SLEDQWYVDY
560 570 580 590 600
GEESWKKQAI ECLEGMQLFA PEVKNAFEGV LDWLKNWAVC RTYGLGTRLP
610 620 630 640 650
WDEKYLVESL SDSTIYQSFY TIAHLLFKDY YGNEIGPLGI SADQMTDEVF
660 670 680 690 700
DYIFQHQDDV KNTNIPLPAL QKLRREFEYF YPLDVSISGK DLIPNHLTFF
710 720 730 740 750
IYTHVALFPK KFWPKGIRAN GHLMLNNSKM SKSTGNFMTL EQTVEKFGAD
760 770 780 790 800
AARIAFADAG DTVEDANFDE SNANAAILRL FNLKEWAEEI TKESNLRTGE
810 820 830 840 850
ITDFFDIAFE HEMNALIEKT YEQYALTNYK NALKYGLFDF QAARDYYREA
860 870 880 890 900
SGVMHKDLIA RYIETQALLL APIAPHFAEY IYREVLGNQT SVQNAKFPRA
910 920 930 940 950
SKPVDKGVLA ALDYLRNLQR SIREGEGQAL KKKKGKSAEI DASKPVKLTL
960 970 980 990 1000
LISESFPEWQ SQCVEIVRKL FSEQTLDDNK KVREHIEPKE MKRAMPFISL
1010 1020 1030 1040 1050
LKQRLANEKP EDVFERELQF SEIDTVKAAA RNVKKAAQAL KIAEFSAISF
1060 1070 1080 1090
PYGAKTGKDI FTGEEVEIPP VTKIVENAVP GNPGVVFQNI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62878 Genomic DNA Translation: CAA44671.1 X96770 Genomic DNA Translation: CAA65561.1 Z73516 Genomic DNA Translation: CAA97865.1 BK006949 Genomic DNA Translation: DAA11274.1 |
PIRi | JC1421 |
RefSeqi | NP_015165.1, NM_001183974.1 |
Genome annotation databases
EnsemblFungii | YPL160W_mRNA; YPL160W; YPL160W |
GeneIDi | 855943 |
KEGGi | sce:YPL160W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62878 Genomic DNA Translation: CAA44671.1 X96770 Genomic DNA Translation: CAA65561.1 Z73516 Genomic DNA Translation: CAA97865.1 BK006949 Genomic DNA Translation: DAA11274.1 |
PIRi | JC1421 |
RefSeqi | NP_015165.1, NM_001183974.1 |
3D structure databases
SMRi | P26637 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36023, 359 interactors |
DIPi | DIP-6365N |
IntActi | P26637, 19 interactors |
MINTi | P26637 |
STRINGi | 4932.YPL160W |
Chemistry databases
BindingDBi | P26637 |
ChEMBLi | CHEMBL1075253 |
DrugCentrali | P26637 |
PTM databases
iPTMneti | P26637 |
Proteomic databases
MaxQBi | P26637 |
PaxDbi | P26637 |
PRIDEi | P26637 |
Genome annotation databases
EnsemblFungii | YPL160W_mRNA; YPL160W; YPL160W |
GeneIDi | 855943 |
KEGGi | sce:YPL160W |
Organism-specific databases
SGDi | S000006081, CDC60 |
VEuPathDBi | FungiDB:YPL160W |
Phylogenomic databases
eggNOGi | KOG0437, Eukaryota |
GeneTreei | ENSGT00390000012163 |
HOGENOMi | CLU_004174_1_1_1 |
InParanoidi | P26637 |
OMAi | RWQFNHL |
Enzyme and pathway databases
BRENDAi | 6.1.1.4, 984 |
Miscellaneous databases
PROi | PR:P26637 |
RNActi | P26637, protein |
Family and domain databases
Gene3Di | 3.40.50.620, 1 hit 3.90.740.10, 1 hit |
InterProi | View protein in InterPro IPR002300, aa-tRNA-synth_Ia IPR004493, Leu-tRNA-synth_Ia_arc/euk IPR013155, M/V/L/I-tRNA-synth_anticd-bd IPR014729, Rossmann-like_a/b/a_fold IPR009080, tRNAsynth_Ia_anticodon-bd IPR009008, Val/Leu/Ile-tRNA-synth_edit |
PANTHERi | PTHR45794, PTHR45794, 1 hit |
Pfami | View protein in Pfam PF08264, Anticodon_1, 1 hit PF00133, tRNA-synt_1, 2 hits |
SUPFAMi | SSF47323, SSF47323, 1 hit SSF50677, SSF50677, 1 hit |
TIGRFAMsi | TIGR00395, leuS_arch, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SYLC_YEAST | |
Accessioni | P26637Primary (citable) accession number: P26637 Secondary accession number(s): D6W3K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 187 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries - SIMILARITY comments
Index of protein domains and families