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Protein

Paired box protein Pax-6

Gene

pax6a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor expressed in spatially restricted regions of the neural tube during embryonic development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi229 – 288HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-6
Alternative name(s):
Pax[Zf-a]
Gene namesi
Name:pax6a
Synonyms:pax[zf-a], paxzf-a
ORF Names:si:dkeyp-46c10.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 25

Organism-specific databases

ZFINiZDB-GENE-990415-200 pax6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501911 – 437Paired box protein Pax-6Add BLAST437

Proteomic databases

PaxDbiP26630

PTM databases

iPTMnetiP26630

Expressioni

Tissue specificityi

Spatially restricted regions of the neural tube.

Gene expression databases

BgeeiENSDARG00000103379 Expressed in 72 organ(s), highest expression level in retina
ExpressionAtlasiP26630 baseline and differential

Interactioni

Protein-protein interaction databases

ELMiP26630
STRINGi7955.ENSDARP00000115545

Structurei

3D structure databases

ProteinModelPortaliP26630
SMRiP26630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 149PairedPROSITE-ProRule annotationAdd BLAST127

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi298 – 437Pro/Ser/Thr-richAdd BLAST140

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Paired box

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230939
HOVERGENiHBG009115
InParanoidiP26630
KOiK08031
OrthoDBiEOG091G0S4E

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform Short (identifier: P26630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPQKEYYNRA TWESGVASMM QNSHSGVNQL GGVFVNGRPL PDSTRQKIVE
60 70 80 90 100
LAHSGARPCD ISRILQVSNG CVSKILGRYY ETGSIRPRAI GGSKPRVATP
110 120 130 140 150
EVVGKIAQYK RECPSIFAWE IRDRLLSEGV CTNDNIPSVS SINRVLRNLA
160 170 180 190 200
SEKQQMGADG MYEKLRMLNG QTGTWGTRPG WYPGTSVPGQ PNQDGCQQSD
210 220 230 240 250
GGGENTNSIS SNGEDSDETQ MRLQLKRKLQ RNRTSFTQEQ IEALEKEFER
260 270 280 290 300
THYPDVFARE RLAAKIDLPE ARIQVWFSNR RAKWRREEKL RNQRRQASNS
310 320 330 340 350
SSHIPISSSF STSVYQPIPQ PTTPVSFTSG SMLGRSDTAL TNTYSALPPM
360 370 380 390 400
PSFTMANNLP MQPSQTSSYS CMLPTSPSVN GRSYDTYTPP HMQAHMNSQS
410 420 430
MAASGTTSTG LISPGVSVPV QVPGSEPDMS QYWPRLQ
Length:437
Mass (Da):48,425
Last modified:August 1, 1992 - v1
Checksum:i01D0999EFCA22837
GO
Isoform Long (identifier: P26630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     66-66: Q → QTHADAKVQVLDNEN

Show »
Length:451
Mass (Da):49,961
Checksum:i04DFCD94BCCF2433
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IXU2A0A0R4IXU2_DANRE
Paired box protein Pax-6
pax6a
441Annotation score:
A0A0R4I9X4A0A0R4I9X4_DANRE
Paired box protein Pax-6
pax6a
96Annotation score:
A0A0R4IPK2A0A0R4IPK2_DANRE
Paired box protein Pax-6
pax6a
138Annotation score:
A0A0R4IQ98A0A0R4IQ98_DANRE
Paired box protein Pax-6
pax6a
114Annotation score:
A0A0R4IBK7A0A0R4IBK7_DANRE
Paired box protein Pax-6
pax6a
113Annotation score:
A0A0R4IDV2A0A0R4IDV2_DANRE
Paired box protein Pax-6
pax6a
74Annotation score:
A0A0R4IJK8A0A0R4IJK8_DANRE
Paired box protein Pax-6
pax6a
17Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00236766Q → QTHADAKVQVLDNEN in isoform Long. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61389 mRNA Translation: CAA43661.1
X63183 mRNA Translation: CAA44867.1
AL929172 Genomic DNA Translation: CAM16649.1
BC066722 mRNA Translation: AAH66722.1
PIRiI50108
RefSeqiNP_571379.1, NM_131304.1 [P26630-2]
XP_009296158.1, XM_009297883.2 [P26630-1]
XP_017209537.1, XM_017354048.1 [P26630-2]
UniGeneiDr.24244

Genome annotation databases

EnsembliENSDART00000162485; ENSDARP00000139430; ENSDARG00000103379 [P26630-1]
ENSDART00000164384; ENSDARP00000135767; ENSDARG00000103379 [P26630-2]
GeneIDi30567
KEGGidre:30567

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61389 mRNA Translation: CAA43661.1
X63183 mRNA Translation: CAA44867.1
AL929172 Genomic DNA Translation: CAM16649.1
BC066722 mRNA Translation: AAH66722.1
PIRiI50108
RefSeqiNP_571379.1, NM_131304.1 [P26630-2]
XP_009296158.1, XM_009297883.2 [P26630-1]
XP_017209537.1, XM_017354048.1 [P26630-2]
UniGeneiDr.24244

3D structure databases

ProteinModelPortaliP26630
SMRiP26630
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiP26630
STRINGi7955.ENSDARP00000115545

PTM databases

iPTMnetiP26630

Proteomic databases

PaxDbiP26630

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000162485; ENSDARP00000139430; ENSDARG00000103379 [P26630-1]
ENSDART00000164384; ENSDARP00000135767; ENSDARG00000103379 [P26630-2]
GeneIDi30567
KEGGidre:30567

Organism-specific databases

CTDi30567
ZFINiZDB-GENE-990415-200 pax6a

Phylogenomic databases

eggNOGiKOG0849 Eukaryota
ENOG410XS01 LUCA
GeneTreeiENSGT00680000099553
HOGENOMiHOG000230939
HOVERGENiHBG009115
InParanoidiP26630
KOiK08031
OrthoDBiEOG091G0S4E

Miscellaneous databases

PROiPR:P26630

Gene expression databases

BgeeiENSDARG00000103379 Expressed in 72 organ(s), highest expression level in retina
ExpressionAtlasiP26630 baseline and differential

Family and domain databases

CDDicd00086 homeodomain, 1 hit
cd00131 PAX, 1 hit
Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR001523 Paired_dom
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF00292 PAX, 1 hit
PRINTSiPR00027 PAIREDBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00351 PAX, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS00034 PAIRED_1, 1 hit
PS51057 PAIRED_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPAX6_DANRE
AccessioniPrimary (citable) accession number: P26630
Secondary accession number(s): A2AUN5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 10, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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