UniProtKB - P26618 (PGFRA_MOUSE)
Platelet-derived growth factor receptor alpha
Pdgfra
Functioni
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 627 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 818 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 599 – 607 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- growth factor binding Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: MGI
- platelet-derived growth factor alpha-receptor activity Source: UniProtKB
- platelet-derived growth factor binding Source: UniProtKB
- platelet-derived growth factor receptor binding Source: MGI
- protein-containing complex binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- protein kinase activity Source: MGI
- transmembrane receptor protein tyrosine kinase activity Source: MGI
- vascular endothelial growth factor-activated receptor activity Source: UniProtKB
- vascular endothelial growth factor binding Source: MGI
GO - Biological processi
- adrenal gland development Source: MGI
- anatomical structure morphogenesis Source: MGI
- animal organ morphogenesis Source: MGI
- cardiac myofibril assembly Source: UniProtKB
- cell chemotaxis Source: UniProtKB
- cell migration Source: UniProtKB
- cellular response to amino acid stimulus Source: MGI
- cellular response to reactive oxygen species Source: MGI
- embryonic cranial skeleton morphogenesis Source: UniProtKB
- embryonic digestive tract morphogenesis Source: UniProtKB
- estrogen metabolic process Source: MGI
- extracellular matrix organization Source: MGI
- face morphogenesis Source: MGI
- female gonad development Source: MGI
- hematopoietic progenitor cell differentiation Source: MGI
- in utero embryonic development Source: MGI
- Leydig cell differentiation Source: MGI
- lung development Source: MGI
- lung growth Source: MGI
- luteinization Source: MGI
- male genitalia development Source: MGI
- metanephric glomerular capillary formation Source: UniProtKB
- multicellular organism development Source: GO_Central
- negative regulation of platelet activation Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: MGI
- peptidyl-tyrosine phosphorylation Source: UniProtKB
- phosphatidylinositol-mediated signaling Source: UniProtKB
- platelet aggregation Source: UniProtKB
- platelet-derived growth factor receptor-alpha signaling pathway Source: UniProtKB
- platelet-derived growth factor receptor signaling pathway Source: MGI
- positive regulation of branching involved in lung morphogenesis Source: MGI
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: BHF-UCL
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- positive regulation of kinase activity Source: GO_Central
- positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of phospholipase C activity Source: MGI
- protein autophosphorylation Source: UniProtKB
- regulation of chemotaxis Source: MGI
- regulation of mesenchymal stem cell differentiation Source: UniProtKB
- retina vasculature development in camera-type eye Source: UniProtKB
- roof of mouth development Source: MGI
- signal transduction involved in regulation of gene expression Source: MGI
- skeletal system morphogenesis Source: MGI
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
- white fat cell differentiation Source: MGI
- wound healing Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Biological process | Chemotaxis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-1257604, PIP3 activates AKT signaling R-MMU-186763, Downstream signal transduction R-MMU-186797, Signaling by PDGF R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Platelet-derived growth factor receptor alpha (EC:2.7.10.1)Short name: PDGF-R-alpha Short name: PDGFR-alpha Alternative name(s): Alpha platelet-derived growth factor receptor Alpha-type platelet-derived growth factor receptor CD140 antigen-like family member A Platelet-derived growth factor alpha receptor CD_antigen: CD140a |
Gene namesi | Name:Pdgfra |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97530, Pdgfra |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity
Golgi apparatus
- Golgi apparatus 1 Publication
Other locations
- cilium 1 Publication
Golgi apparatus
- Golgi apparatus Source: UniProtKB
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- intrinsic component of plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- axon Source: MGI
- cell junction Source: MGI
- cell surface Source: BHF-UCL
- cilium Source: UniProtKB
- cytoplasm Source: MGI
- microvillus Source: MGI
- protein-containing complex Source: MGI
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 528 | ExtracellularSequence analysisAdd BLAST | 504 | |
Transmembranei | 529 – 549 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 550 – 1089 | CytoplasmicSequence analysisAdd BLAST | 540 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Golgi apparatus, MembranePathology & Biotechi
Disruption phenotypei
Keywords - Diseasei
Proto-oncogeneChemistry databases
ChEMBLi | CHEMBL2096980 |
GuidetoPHARMACOLOGYi | 1803 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000016761 | 25 – 1089 | Platelet-derived growth factor receptor alphaAdd BLAST | 1065 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 42 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 49 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 76 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 150 ↔ 189 | PROSITE-ProRule annotation | ||
Glycosylationi | 179 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 235 ↔ 290 | PROSITE-ProRule annotation | ||
Glycosylationi | 353 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 359 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 435 ↔ 501 | PROSITE-ProRule annotation | ||
Glycosylationi | 458 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 468 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 506 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 572 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 574 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 720 | Phosphotyrosine; by autocatalysisBy similarityCurated | 1 | |
Modified residuei | 731 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 742 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 754 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 762 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 768 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 849 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 988 | Phosphotyrosine; by autocatalysisBy similarity | 1 | |
Modified residuei | 1018 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P26618 |
MaxQBi | P26618 |
PaxDbi | P26618 |
PeptideAtlasi | P26618 |
PRIDEi | P26618 |
PTM databases
GlyGeni | P26618, 10 sites |
iPTMneti | P26618 |
PhosphoSitePlusi | P26618 |
SwissPalmi | P26618 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000029231, Expressed in epididymis and 397 other tissues |
Genevisiblei | P26618, MM |
Interactioni
Subunit structurei
Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand. Interaction with dimeric PDGFA, PDGFB and/or PDGFC leads to receptor dimerization, where both PDGFRA homodimers and heterodimers with PDGFRB are observed.
Interacts (tyrosine phosphorylated) with SHB (via SH2 domain).
Interacts (tyrosine phosphorylated) with SHF (via SH2 domain).
Interacts (tyrosine phosphorylated) with SRC (via SH2 domain).
Interacts (tyrosine phosphorylated) with PIK3R1.
Interacts (tyrosine phosphorylated) with PLCG1 (via SH2 domain).
Interacts (tyrosine phosphorylated) with CRK, GRB2 and GRB7 (By similarity).
By similarityGO - Molecular functioni
- growth factor binding Source: GO_Central
- phosphatidylinositol 3-kinase binding Source: MGI
- platelet-derived growth factor binding Source: UniProtKB
- platelet-derived growth factor receptor binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- vascular endothelial growth factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202088, 4 interactors |
ComplexPortali | CPX-2899, PDGF receptor alpha - PDGF-AA complex CPX-2901, PDGF receptor alpha - PDGF-AB complex CPX-2903, PDGF receptor alpha-beta - PDGF-AB complex CPX-2906, PDGF receptor alpha - PDGF-BB complex CPX-2907, PDGF receptor alpha-beta - PDGF-BB complex CPX-2912, PDGF receptor alpha - PDGF-CC complex CPX-2913, PDGF receptor alpha-beta - PDGF-CC complex CPX-2916, PDGF receptor alpha-beta - PDGF-DD complex |
IntActi | P26618, 3 interactors |
MINTi | P26618 |
STRINGi | 10090.ENSMUSP00000127173 |
Chemistry databases
BindingDBi | P26618 |
Miscellaneous databases
RNActi | P26618, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 113 | Ig-like C2-type 1Add BLAST | 89 | |
Domaini | 117 – 201 | Ig-like C2-type 2Add BLAST | 85 | |
Domaini | 202 – 306 | Ig-like C2-type 3Add BLAST | 105 | |
Domaini | 319 – 410 | Ig-like C2-type 4Add BLAST | 92 | |
Domaini | 414 – 517 | Ig-like C2-type 5Add BLAST | 104 | |
Domaini | 593 – 954 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 362 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000156021 |
HOGENOMi | CLU_000288_49_0_1 |
InParanoidi | P26618 |
OMAi | ERSAYWA |
OrthoDBi | 236292at2759 |
PhylomeDBi | P26618 |
TreeFami | TF325768 |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR027290, PDGFRA IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF500950, Alpha-PDGF_receptor, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGTSHQVFLV LSCLLTGPGL ISCQLLLPSI LPNENEKIVQ LNSSFSLRCV
60 70 80 90 100
GESEVSWQHP MSEEDDPNVE IRSEENNSGL FVTVLEVVNA SAAHTGWYTC
110 120 130 140 150
YYNHTQTDES EIEGRHIYIY VPDPDMAFVP LGMTDSLVIV EEDDSAIIPC
160 170 180 190 200
RTTDPETQVT LHNNGRLVPA SYDSRQGFNG TFSVGPYICE ATVKGRTFKT
210 220 230 240 250
SEFNVYALKA TSELNLEMDA RQTVYKAGET IVVTCAVFNN EVVDLQWTYP
260 270 280 290 300
GEVRNKGITM LEEIKLPSIK LVYTLTVPKA TVKDSGEYEC AARQATKEVK
310 320 330 340 350
EMKRVTISVH EKGFVEIEPT FGQLEAVNLH EVREFVVEVQ AYPTPRISWL
360 370 380 390 400
KDNLTLIENL TEITTDVQKS QETRYQSKLK LIRAKEEDSG HYTIIVQNED
410 420 430 440 450
DVKSYTFELS TLVPASILDL VDDHHGSGGG QTVRCTAEGT PLPEIDWMIC
460 470 480 490 500
KHIKKCNNDT SWTVLASNVS NIITELPRRG RSTVEGRVSF AKVEETIAVR
510 520 530 540 550
CLAKNNLSVV ARELKLVAPT LRSELTVAAA VLVLLVIVIV SLIVLVVIWK
560 570 580 590 600
QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG
610 620 630 640 650
SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH
660 670 680 690 700
LGPHLNIVNL LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFMSQHPEK
710 720 730 740 750
PKKDLDIFGL NPADESTRSY VILSFENNGD YMDMKQADTT QYVPMLERKE
760 770 780 790 800
VSKYSDIQRS LYDRPASYKK KSMLDSEVKN LLSDDDSEGL TLLDLLSFTY
810 820 830 840 850
QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA RDIMHDSNYV
860 870 880 890 900
SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM
910 920 930 940 950
VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV QCWNSEPEKR PSFYHLSEIV
960 970 980 990 1000
ENLLPGQYKK SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL
1010 1020 1030 1040 1050
KDWEGGLDEQ RLSADSGYII PLPDIDPVPE EEDLGKRNRH SSQTSEESAI
1060 1070 1080
ETGSSSSTFI KREDETIEDI DMMDDIGIDS SDLVEDSFL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YUD9 | A0A0J9YUD9_MOUSE | Platelet-derived growth factor rece... | Pdgfra | 139 | Annotation score: | ||
A0A0J9YV87 | A0A0J9YV87_MOUSE | Platelet-derived growth factor rece... | Pdgfra | 481 | Annotation score: | ||
A0A0J9YVF3 | A0A0J9YVF3_MOUSE | Platelet-derived growth factor rece... | Pdgfra | 243 | Annotation score: | ||
A0A0J9YV49 | A0A0J9YV49_MOUSE | Platelet-derived growth factor rece... | Pdgfra | 88 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 65 | D → E in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 65 | D → E in AAA39904 (PubMed:1321404).Curated | 1 | |
Sequence conflicti | 192 | T → A in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 202 | E → A in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 252 | E → G in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 271 | L → V in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 322 | G → S in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 326 | A → P in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 439 – 440 | GT → EG in AAA39733 (PubMed:2174116).Curated | 2 | |
Sequence conflicti | 472 | I → V in BAE37548 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 529 | A → E in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 737 | A → D in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 849 | Y → D in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 936 | E → D in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 950 | V → L in AAA39733 (PubMed:2174116).Curated | 1 | |
Sequence conflicti | 1005 | G → S in AAA39904 (PubMed:1321404).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031877 | 775 – 790 | DSEVK…DSEGL → GKSAHAHSGKYDLSVV in isoform 2. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_031878 | 791 – 1089 | Missing in isoform 2. 1 PublicationAdd BLAST | 299 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57683 mRNA Translation: AAA39733.1 M84607 mRNA Translation: AAA39904.1 AK081664 mRNA Translation: BAC38283.1 AK136490 mRNA Translation: BAE23004.1 AK147267 mRNA Translation: BAE27808.1 AK163952 mRNA Translation: BAE37548.1 BC053036 mRNA Translation: AAH53036.1 |
CCDSi | CCDS19351.1 [P26618-1] CCDS89929.1 [P26618-2] |
PIRi | I57511, S33727 |
RefSeqi | NP_001076785.1, NM_001083316.2 [P26618-1] NP_001334647.1, NM_001347718.1 [P26618-2] NP_001334648.1, NM_001347719.1 [P26618-2] NP_035188.2, NM_011058.3 [P26618-1] XP_006504324.1, XM_006504261.3 [P26618-1] XP_006504325.1, XM_006504262.3 [P26618-1] XP_006504326.1, XM_006504263.3 [P26618-1] |
Genome annotation databases
Ensembli | ENSMUST00000000476; ENSMUSP00000000476; ENSMUSG00000029231 [P26618-1] ENSMUST00000168162; ENSMUSP00000127173; ENSMUSG00000029231 [P26618-1] ENSMUST00000201711; ENSMUSP00000143891; ENSMUSG00000029231 [P26618-2] ENSMUST00000202681; ENSMUSP00000143906; ENSMUSG00000029231 [P26618-2] |
GeneIDi | 18595 |
KEGGi | mmu:18595 |
UCSCi | uc008xub.1, mouse [P26618-2] uc008xuc.1, mouse [P26618-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M57683 mRNA Translation: AAA39733.1 M84607 mRNA Translation: AAA39904.1 AK081664 mRNA Translation: BAC38283.1 AK136490 mRNA Translation: BAE23004.1 AK147267 mRNA Translation: BAE27808.1 AK163952 mRNA Translation: BAE37548.1 BC053036 mRNA Translation: AAH53036.1 |
CCDSi | CCDS19351.1 [P26618-1] CCDS89929.1 [P26618-2] |
PIRi | I57511, S33727 |
RefSeqi | NP_001076785.1, NM_001083316.2 [P26618-1] NP_001334647.1, NM_001347718.1 [P26618-2] NP_001334648.1, NM_001347719.1 [P26618-2] NP_035188.2, NM_011058.3 [P26618-1] XP_006504324.1, XM_006504261.3 [P26618-1] XP_006504325.1, XM_006504262.3 [P26618-1] XP_006504326.1, XM_006504263.3 [P26618-1] |
3D structure databases
SMRi | P26618 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 202088, 4 interactors |
ComplexPortali | CPX-2899, PDGF receptor alpha - PDGF-AA complex CPX-2901, PDGF receptor alpha - PDGF-AB complex CPX-2903, PDGF receptor alpha-beta - PDGF-AB complex CPX-2906, PDGF receptor alpha - PDGF-BB complex CPX-2907, PDGF receptor alpha-beta - PDGF-BB complex CPX-2912, PDGF receptor alpha - PDGF-CC complex CPX-2913, PDGF receptor alpha-beta - PDGF-CC complex CPX-2916, PDGF receptor alpha-beta - PDGF-DD complex |
IntActi | P26618, 3 interactors |
MINTi | P26618 |
STRINGi | 10090.ENSMUSP00000127173 |
Chemistry databases
BindingDBi | P26618 |
ChEMBLi | CHEMBL2096980 |
GuidetoPHARMACOLOGYi | 1803 |
PTM databases
GlyGeni | P26618, 10 sites |
iPTMneti | P26618 |
PhosphoSitePlusi | P26618 |
SwissPalmi | P26618 |
Proteomic databases
jPOSTi | P26618 |
MaxQBi | P26618 |
PaxDbi | P26618 |
PeptideAtlasi | P26618 |
PRIDEi | P26618 |
Protocols and materials databases
ABCDi | P26618, 4 sequenced antibodies |
Antibodypediai | 1381, 2076 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000000476; ENSMUSP00000000476; ENSMUSG00000029231 [P26618-1] ENSMUST00000168162; ENSMUSP00000127173; ENSMUSG00000029231 [P26618-1] ENSMUST00000201711; ENSMUSP00000143891; ENSMUSG00000029231 [P26618-2] ENSMUST00000202681; ENSMUSP00000143906; ENSMUSG00000029231 [P26618-2] |
GeneIDi | 18595 |
KEGGi | mmu:18595 |
UCSCi | uc008xub.1, mouse [P26618-2] uc008xuc.1, mouse [P26618-1] |
Organism-specific databases
CTDi | 5156 |
MGIi | MGI:97530, Pdgfra |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000156021 |
HOGENOMi | CLU_000288_49_0_1 |
InParanoidi | P26618 |
OMAi | ERSAYWA |
OrthoDBi | 236292at2759 |
PhylomeDBi | P26618 |
TreeFami | TF325768 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 3474 |
Reactomei | R-MMU-1257604, PIP3 activates AKT signaling R-MMU-186763, Downstream signal transduction R-MMU-186797, Signaling by PDGF R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Miscellaneous databases
BioGRID-ORCSi | 18595, 1 hit in 17 CRISPR screens |
ChiTaRSi | Pdgfra, mouse |
PROi | PR:P26618 |
RNActi | P26618, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029231, Expressed in epididymis and 397 other tissues |
Genevisiblei | P26618, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 5 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR027290, PDGFRA IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom IPR001824, Tyr_kinase_rcpt_3_CS |
Pfami | View protein in Pfam PF07679, I-set, 2 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF500950, Alpha-PDGF_receptor, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 4 hits SM00408, IGc2, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 4 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit PS00240, RECEPTOR_TYR_KIN_III, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PGFRA_MOUSE | |
Accessioni | P26618Primary (citable) accession number: P26618 Secondary accession number(s): Q3TQ37 Q8C4N3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | February 26, 2008 | |
Last modified: | December 2, 2020 | |
This is version 203 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human and mouse protein kinases
Human and mouse protein kinases: classification and index