PTBP1

Functionⁱ

Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806).6 Publications

GO - Molecular functionⁱ

poly-pyrimidine tract binding
Source: ProtInc
Traceable author statementⁱ
- 1906036
pre-mRNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16260624
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

fibroblast growth factor receptor signaling pathway Source: Reactome
IRES-dependent viral translational initiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21518806
mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 1906036
mRNA splicing, via spliceosome Source: Reactome
negative regulation of mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 15009664
negative regulation of muscle cell differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 21518792
negative regulation of RNA splicing
Source: UniProtKB
Inferred from direct assayⁱ
- 18335065
positive regulation of calcineurin-NFAT signaling cascade
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23853098
positive regulation of protein dephosphorylation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23853098
regulation of alternative mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 16260624
- 21518792
RNA metabolic process Source: Reactome
RNA splicing
Source: ProtInc
Traceable author statementⁱ
- 1906036

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Repressor, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803529 FGFR2 alternative splicing R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Reactomeⁱ

R-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Polypyrimidine tract-binding protein 1 Short name: PTB Alternative name(s): 57 kDa RNA-binding protein PPTB-1 Heterogeneous nuclear ribonucleoprotein I Short name: hnRNP I
Gene namesⁱ	Name:PTBP1 Synonyms:PTB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000011304.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9583 PTBP1
MIMⁱ	600693 gene
neXtProtⁱ	NX_P26599

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5725
Open Targets More...OpenTargetsⁱ	ENSG00000011304
PharmGKBⁱ	PA33934

Chemistry databases

ChEMBLⁱ	CHEMBL1293230

ChEMBLⁱ

CHEMBL1293230

Polymorphism and mutation databases

BioMutaⁱ	PTBP1
DMDMⁱ	131528

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081737	1 – 531	Polypyrimidine tract-binding protein 1Add BLAST		531

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources1 Publication	1
Modified residueⁱ	16	PhosphoserineCombined sources	1
Cross-linkⁱ	65	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	127	PhosphotyrosineCombined sources	1
Modified residueⁱ	138	PhosphothreonineCombined sources	1
Modified residueⁱ	141	PhosphoserineCombined sources	1
Cross-linkⁱ	218	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	433	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P26599
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P26599
PaxDbⁱ	P26599
PeptideAtlas More...PeptideAtlasⁱ	P26599
PRIDEⁱ	P26599
ProteomicsDBⁱ	54354 54355 [P26599-2] 54356 [P26599-3]
TopDownProteomicsⁱ	P26599-1 [P26599-1] P26599-2 [P26599-2]

2D gel databases

SWISS-2DPAGEⁱ	P26599

SWISS-2DPAGEⁱ

P26599

PTM databases

iPTMnetⁱ	P26599
PhosphoSitePlusⁱ	P26599
SwissPalmⁱ	P26599

Miscellaneous databases

PMAP-CutDBⁱ	P26599

PMAP-CutDBⁱ

P26599

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000011304 Expressed in 241 organ(s), highest expression level in embryo
CleanExⁱ	HS_PTBP1
ExpressionAtlasⁱ	P26599 baseline and differential
Genevisibleⁱ	P26599 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013507

HPAⁱ

CAB013507

Interactionⁱ

Subunit structureⁱ

Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P29991	5	EBI-350540,EBI-8826689	From Dengue virus type 2 (strain 16681-PDK53).
hnrnpab	Q7ZYE9	4	EBI-350540,EBI-1086317	From Xenopus laevis.
PCBP1	Q15365	2	EBI-350540,EBI-946095
QKI	Q96PU8	3	EBI-350540,EBI-945792
RBM10	P98175	4	EBI-350540,EBI-721525
SFPQ	P23246	2	EBI-350540,EBI-355453
SNRPA	P09012	5	EBI-350540,EBI-607085

Protein-protein interaction databases

BioGridⁱ	111697, 208 interactors
CORUMⁱ	P26599
ELMⁱ	P26599
IntActⁱ	P26599, 57 interactors
Molecular INTeraction database More...MINTⁱ	P26599
STRINGⁱ	9606.ENSP00000349428

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	53 – 55	Combined sources	3
Beta strandⁱ	60 – 63	Combined sources	4
Helixⁱ	72 – 82	Combined sources	11
Beta strandⁱ	85 – 91	Combined sources	7
Turnⁱ	92 – 95	Combined sources	4
Beta strandⁱ	96 – 103	Combined sources	8
Helixⁱ	104 – 114	Combined sources	11
Beta strandⁱ	127 – 130	Combined sources	4
Beta strandⁱ	132 – 135	Combined sources	4
Turnⁱ	142 – 145	Combined sources	4
Beta strandⁱ	182 – 190	Combined sources	9
Helixⁱ	197 – 204	Combined sources	8
Helixⁱ	205 – 207	Combined sources	3
Beta strandⁱ	210 – 218	Combined sources	9
Beta strandⁱ	221 – 229	Combined sources	9
Helixⁱ	231 – 241	Combined sources	11
Beta strandⁱ	245 – 247	Combined sources	3
Beta strandⁱ	250 – 257	Combined sources	8
Beta strandⁱ	259 – 262	Combined sources	4
Beta strandⁱ	269 – 274	Combined sources	6
Turnⁱ	289 – 291	Combined sources	3
Turnⁱ	294 – 296	Combined sources	3
Helixⁱ	329 – 332	Combined sources	4
Beta strandⁱ	339 – 342	Combined sources	4
Beta strandⁱ	346 – 348	Combined sources	3
Helixⁱ	351 – 359	Combined sources	9
Beta strandⁱ	365 – 368	Combined sources	4
Turnⁱ	371 – 373	Combined sources	3
Beta strandⁱ	378 – 380	Combined sources	3
Turnⁱ	382 – 384	Combined sources	3
Helixⁱ	385 – 394	Combined sources	10
Beta strandⁱ	400 – 403	Combined sources	4
Beta strandⁱ	405 – 408	Combined sources	4
Beta strandⁱ	417 – 425	Combined sources	9
Beta strandⁱ	427 – 431	Combined sources	5
Beta strandⁱ	437 – 440	Combined sources	4
Helixⁱ	444 – 446	Combined sources	3
Beta strandⁱ	455 – 458	Combined sources	4
Helixⁱ	467 – 476	Combined sources	10
Beta strandⁱ	483 – 488	Combined sources	6
Beta strandⁱ	494 – 497	Combined sources	4
Helixⁱ	501 – 511	Combined sources	11
Beta strandⁱ	515 – 519	Combined sources	5
Beta strandⁱ	524 – 527	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P26599
SMRⁱ	P26599
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P26599

EvolutionaryTraceⁱ

P26599

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	59 – 143	RRM 1PROSITE-ProRule annotationAdd BLAST	85
Domainⁱ	184 – 260	RRM 2PROSITE-ProRule annotationAdd BLAST	77
Domainⁱ	337 – 411	RRM 3PROSITE-ProRule annotationAdd BLAST	75
Domainⁱ	454 – 529	RRM 4PROSITE-ProRule annotationAdd BLAST	76

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	316 – 323	Poly-Ala		8

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG1190 Eukaryota ENOG410XPMZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074508
HOGENOMⁱ	HOG000231699
HOVERGENⁱ	HBG069548
InParanoidⁱ	P26599
KEGG Orthology (KO) More...KOⁱ	K13218
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Z5R
PhylomeDBⁱ	P26599
TreeFamⁱ	TF319824

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12777 RRM1_PTBP1, 1 hit cd12693 RRM2_PTBP1_like, 1 hit cd12695 RRM3_PTBP1, 1 hit
Gene3Dⁱ	3.30.70.330, 4 hits
InterProⁱ	View protein in InterPro IPR006536 HnRNP-L/PTB IPR012677 Nucleotide-bd_a/b_plait_sf IPR034798 PTBP1/2/3_RRM2 IPR035000 PTBP1_RRM1 IPR035001 PTBP1_RRM3 IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 4 hits
SUPFAMⁱ	SSF54928 SSF54928, 4 hits
TIGRFAMsⁱ	TIGR01649 hnRNP-L_PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 4 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P26599-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD 
        60         70         80         90        100
SRSAGVPSRV IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE 
       110        120        130        140        150
MNTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA 
       160        170        180        190        200
LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL 
       210        220        230        240        250
HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC 
       260        270        280        290        300
CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGLS 
       310        320        330        340        350
VPNVHGALAP LAIPSAAAAA AAAGRIAIPG LAGAGNSVLL VSNLNPERVT 
       360        370        380        390        400
PQSLFILFGV YGDVQRVKIL FNKKENALVQ MADGNQAQLA MSHLNGHKLH 
       410        420        430        440        450
GKPIRITLSK HQNVQLPREG QEDQGLTKDY GNSPLHRFKK PGSKNFQNIF 
       460        470        480        490        500
PPSATLHLSN IPPSVSEEDL KVLFSSNGGV VKGFKFFQKD RKMALIQMGS 
       510        520        530 
VEEAVQALID LHNHDLGENH HLRVSFSKST I

Length:531

Mass (Da):57,221

Last modified:August 1, 1992 - v1

Checksum:ⁱBE12D5EA21537BED

GO

Isoform 2 (identifier: P26599-2) [UniParc]FASTA Add to basket

Also known as: PTB2

The sequence of this isoform differs from the canonical sequence as follows:
297-297: F → FASPYAGAGFPPTFAIPQAA

« Hide

        10         20         30         40         50
MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD 
        60         70         80         90        100
SRSAGVPSRV IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE 
       110        120        130        140        150
MNTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA 
       160        170        180        190        200
LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL 
       210        220        230        240        250
HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC 
       260        270        280        290        300
CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFASP 
       310        320        330        340        350
YAGAGFPPTF AIPQAAGLSV PNVHGALAPL AIPSAAAAAA AAGRIAIPGL 
       360        370        380        390        400
AGAGNSVLLV SNLNPERVTP QSLFILFGVY GDVQRVKILF NKKENALVQM 
       410        420        430        440        450
ADGNQAQLAM SHLNGHKLHG KPIRITLSKH QNVQLPREGQ EDQGLTKDYG 
       460        470        480        490        500
NSPLHRFKKP GSKNFQNIFP PSATLHLSNI PPSVSEEDLK VLFSSNGGVV 
       510        520        530        540        550
KGFKFFQKDR KMALIQMGSV EEAVQALIDL HNHDLGENHH LRVSFSKSTI

Show »

Length:550

Mass (Da):59,037

Checksum:ⁱ70CB96D0530CA091

GO

Isoform 3 (identifier: P26599-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
297-297: F → FGAPGIISASPYAGAGFPPTFAIPQAA

« Hide

        10         20         30         40         50
MDGIVPDIAV GTKRGSDELF STCVTNGPFI MSSNSASAAN GNDSKKFKGD 
        60         70         80         90        100
SRSAGVPSRV IHIRKLPIDV TEGEVISLGL PFGKVTNLLM LKGKNQAFIE 
       110        120        130        140        150
MNTEEAANTM VNYYTSVTPV LRGQPIYIQF SNHKELKTDS SPNQARAQAA 
       160        170        180        190        200
LQAVNSVQSG NLALAASAAA VDAGMAMAGQ SPVLRIIVEN LFYPVTLDVL 
       210        220        230        240        250
HQIFSKFGTV LKIITFTKNN QFQALLQYAD PVSAQHAKLS LDGQNIYNAC 
       260        270        280        290        300
CTLRIDFSKL TSLNVKYNND KSRDYTRPDL PSGDSQPSLD QTMAAAFGAP 
       310        320        330        340        350
GIISASPYAG AGFPPTFAIP QAAGLSVPNV HGALAPLAIP SAAAAAAAAG 
       360        370        380        390        400
RIAIPGLAGA GNSVLLVSNL NPERVTPQSL FILFGVYGDV QRVKILFNKK 
       410        420        430        440        450
ENALVQMADG NQAQLAMSHL NGHKLHGKPI RITLSKHQNV QLPREGQEDQ 
       460        470        480        490        500
GLTKDYGNSP LHRFKKPGSK NFQNIFPPSA TLHLSNIPPS VSEEDLKVLF 
       510        520        530        540        550
SSNGGVVKGF KFFQKDRKMA LIQMGSVEEA VQALIDLHNH DLGENHHLRV 

SFSKSTI

Show »

Length:557

Mass (Da):59,633

Checksum:ⁱDAFE52BAC0E4BE5C

GO

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A6NLN1	A6NLN1_HUMAN	Polypyrimidine tract binding protei... Polypyrimidine tract binding protein 1, isoform CRA_b (Polypyrimidine tract-binding protein 1)	PTBP1 hCG_20560	527	Annotation score:
	A0A0D9SF20	A0A0D9SF20_HUMAN	Polypyrimidine tract binding protei... Polypyrimidine tract binding protein 1, isoform CRA_e (Polypyrimidine tract-binding protein 1)	PTBP1 hCG_20560	197	Annotation score:
	A0A0U1RRM4	A0A0U1RRM4_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	588	Annotation score:
	K7EKJ7	K7EKJ7_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	237	Annotation score:
	K7EK45	K7EK45_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	256	Annotation score:
	A0A087WU68	A0A087WU68_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	227	Annotation score:
	K7ES59	K7ES59_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	149	Annotation score:
	A0A087WUW5	A0A087WUW5_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	81	Annotation score:
	K7ELW5	K7ELW5_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	105	Annotation score:
	K7EKX4	K7EKX4_HUMAN	Polypyrimidine tract-binding protei... Polypyrimidine tract-binding protein 1	PTBP1	56	Annotation score:
There is more potential isoformShow all

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_005802	297	F → FASPYAGAGFPPTFAIPQAA in isoform 2. Curated		1
Alternative sequenceⁱVSP_043649	297	F → FGAPGIISASPYAGAGFPPT FAIPQAA in isoform 3. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62006 mRNA Translation: CAA43973.1 X65371 mRNA Translation: CAA46443.1 X65372 mRNA Translation: CAA46444.1 X60648 mRNA Translation: CAA43056.1 X66975 mRNA Translation: CAA47386.1 BT006819 mRNA Translation: AAP35465.1 AC006273 Genomic DNA Translation: AAC99798.1 CH471242 Genomic DNA Translation: EAW61154.1 BC002397 mRNA Translation: AAH02397.1 BC004383 mRNA Translation: AAH04383.1 BC013694 mRNA Translation: AAH13694.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32859.1 [P26599-1] CCDS42456.1 [P26599-3] CCDS45892.1 [P26599-2]
PIRⁱ	S23016
NCBI Reference Sequences More...RefSeqⁱ	NP_002810.1, NM_002819.4 [P26599-3] NP_114367.1, NM_031990.3 [P26599-2] NP_114368.1, NM_031991.3 [P26599-1]
UniGeneⁱ	Hs.172550

Genome annotation databases

Ensemblⁱ	ENST00000349038; ENSP00000014112; ENSG00000011304 [P26599-1] ENST00000356948; ENSP00000349428; ENSG00000011304 [P26599-3] ENST00000394601; ENSP00000408096; ENSG00000011304 [P26599-2]
GeneIDⁱ	5725
KEGGⁱ	hsa:5725
UCSC genome browser More...UCSCⁱ	uc002lpp.3 human [P26599-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P26599	PTBP1 isoform 5		PANTR		531	UniRef100_P26599
PTBP1 isoform 5		PONAB		531
P26599-2	PTBP1 isoform 4		PANTR		550	UniRef100_K7B371
PTBP1 isoform 4		PONAB		550
UPI0000EE82C6		NOMLE		520
P26599-3	PTBP1 isoform 1		PANTR		557	UniRef100_H2R1D9
PTBP1 isoform 1		PONAB		557

Protein	Similar proteins		Species	Score	Length	Source
P26599	PTBP1 isoform 5		PANTR		531	UniRef90_P26599
PTBP1 isoform 5		PONAB		531
Polypyrimidine tract-binding protein 1 (Fragment)		HUMAN		149
Uncharacterized protein		AOTNA		531
Polypyrimidine tract binding protein 1		CALJA		531
+15
P26599-2	Uncharacterized protein		MACMU		549	UniRef90_F7GF13
polypyrimidine tract-binding protein 1 isoform X2		DIPOR		575
polypyrimidine tract-binding protein 1 isoform X7		Enhydra lutris kenyoni		550
polypyrimidine tract-binding protein 1 isoform X2		ODORO		550
PTBP1 isoform 4		PANTR		550
+18
P26599-3	Polypyrimidine tract-binding protein 1		RAT		555	UniRef90_Q00438
Polypyrimidine tract-binding protein 1		PIG		557
polypyrimidine tract-binding protein 1 isoform X2		LIPVE		560
Uncharacterized protein		MACMU		558
Uncharacterized protein		CERAT		526
+217

Protein	Similar proteins		Species	Score	Length	Source
P26599	Polypyrimidine tract-binding protein 1		PIG		557	UniRef50_P26599
Polypyrimidine tract-binding protein 1		RAT		555
Polypyrimidine tract-binding protein 1		BOVIN		531
PTBP1 isoform 5		PANTR		531
PTBP1 isoform 5		PONAB		531
+758
P26599-2	Uncharacterized protein		CHICK		600	UniRef50_F1NRD6
Polypyrimidine tract-binding protein 2 isoform x4		Limosa lapponica baueri		600
Polypyrimidine tract-binding protein 2 isoform B		Patagioenas fasciata monilis		589
Uncharacterized protein		PELSI		588
Uncharacterized protein (Fragment)		Micrurus lemniscatus carvalhoi		127
+134

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X62006 mRNA Translation: CAA43973.1 X65371 mRNA Translation: CAA46443.1 X65372 mRNA Translation: CAA46444.1 X60648 mRNA Translation: CAA43056.1 X66975 mRNA Translation: CAA47386.1 BT006819 mRNA Translation: AAP35465.1 AC006273 Genomic DNA Translation: AAC99798.1 CH471242 Genomic DNA Translation: EAW61154.1 BC002397 mRNA Translation: AAH02397.1 BC004383 mRNA Translation: AAH04383.1 BC013694 mRNA Translation: AAH13694.1
CCDSⁱ	CCDS32859.1 [P26599-1] CCDS42456.1 [P26599-3] CCDS45892.1 [P26599-2]
PIRⁱ	S23016
RefSeqⁱ	NP_002810.1, NM_002819.4 [P26599-3] NP_114367.1, NM_031990.3 [P26599-2] NP_114368.1, NM_031991.3 [P26599-1]
UniGeneⁱ	Hs.172550

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1QM9	NMR	-	A	335-531	[»]
	1SJQ	NMR	-	A	55-147	[»]
	1SJR	NMR	-	A	147-301	[»]
	2AD9	NMR	-	A	49-146	[»]
	2ADB	NMR	-	A	172-298	[»]
	2ADC	NMR	-	A	324-531	[»]
	2EVZ	NMR	-	A	324-531	[»]
	2N3O	NMR	-	A	41-163	[»]
	3ZZY	X-ray	1.40	A/B	156-285	[»]
	3ZZZ	X-ray	1.55	A/B	156-285	[»]
ProteinModelPortalⁱ	P26599
SMRⁱ	P26599
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111697, 208 interactors
CORUMⁱ	P26599
ELMⁱ	P26599
IntActⁱ	P26599, 57 interactors
MINTⁱ	P26599
STRINGⁱ	9606.ENSP00000349428

Chemistry databases

ChEMBLⁱ	CHEMBL1293230

ChEMBLⁱ

CHEMBL1293230

PTM databases

iPTMnetⁱ	P26599
PhosphoSitePlusⁱ	P26599
SwissPalmⁱ	P26599

Polymorphism and mutation databases

BioMutaⁱ	PTBP1
DMDMⁱ	131528

2D gel databases

SWISS-2DPAGEⁱ	P26599

SWISS-2DPAGEⁱ

P26599

Proteomic databases

EPDⁱ	P26599
MaxQBⁱ	P26599
PaxDbⁱ	P26599
PeptideAtlasⁱ	P26599
PRIDEⁱ	P26599
ProteomicsDBⁱ	54354 54355 [P26599-2] 54356 [P26599-3]
TopDownProteomicsⁱ	P26599-1 [P26599-1] P26599-2 [P26599-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5725
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000349038; ENSP00000014112; ENSG00000011304 [P26599-1] ENST00000356948; ENSP00000349428; ENSG00000011304 [P26599-3] ENST00000394601; ENSP00000408096; ENSG00000011304 [P26599-2]
GeneIDⁱ	5725
KEGGⁱ	hsa:5725
UCSCⁱ	uc002lpp.3 human [P26599-1]

Organism-specific databases

CTDⁱ	5725
DisGeNETⁱ	5725
EuPathDBⁱ	HostDB:ENSG00000011304.17
GeneCardsⁱ	PTBP1
H-InvDBⁱ	HIX0137476
HGNCⁱ	HGNC:9583 PTBP1
HPAⁱ	CAB013507
MIMⁱ	600693 gene
neXtProtⁱ	NX_P26599
OpenTargetsⁱ	ENSG00000011304
PharmGKBⁱ	PA33934
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1190 Eukaryota ENOG410XPMZ LUCA
GeneTreeⁱ	ENSGT00550000074508
HOGENOMⁱ	HOG000231699
HOVERGENⁱ	HBG069548
InParanoidⁱ	P26599
KOⁱ	K13218
OrthoDBⁱ	EOG091G0Z5R
PhylomeDBⁱ	P26599
TreeFamⁱ	TF319824

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6803529 FGFR2 alternative splicing R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Reactomeⁱ

R-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Miscellaneous databases

ChiTaRSⁱ	PTBP1 human
EvolutionaryTraceⁱ	P26599
GeneWikiⁱ	PTBP1
GenomeRNAiⁱ	5725
PMAP-CutDBⁱ	P26599
Protein Ontology More...PROⁱ	PR:P26599
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000011304 Expressed in 241 organ(s), highest expression level in embryo
CleanExⁱ	HS_PTBP1
ExpressionAtlasⁱ	P26599 baseline and differential
Genevisibleⁱ	P26599 HS

Family and domain databases

CDDⁱ	cd12777 RRM1_PTBP1, 1 hit cd12693 RRM2_PTBP1_like, 1 hit cd12695 RRM3_PTBP1, 1 hit
Gene3Dⁱ	3.30.70.330, 4 hits
InterProⁱ	View protein in InterPro IPR006536 HnRNP-L/PTB IPR012677 Nucleotide-bd_a/b_plait_sf IPR034798 PTBP1/2/3_RRM2 IPR035000 PTBP1_RRM1 IPR035001 PTBP1_RRM3 IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 4 hits
SUPFAMⁱ	SSF54928 SSF54928, 4 hits
TIGRFAMsⁱ	TIGR01649 hnRNP-L_PTB, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTBP1_HUMAN
Accessionⁱ	P26599Primary (citable) accession number: P26599 Secondary accession number(s): Q9BUQ0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	August 1, 1992
	Last modified:	November 7, 2018
	This is version 213 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P26599 (PTBP1_HUMAN)

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Polypyrimidine tract-binding protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ