HMGB2

Functionⁱ

Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).By similarity1 Publication7 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	9 – 79	HMG box 1PROSITE-ProRule annotationAdd BLAST		71
DNA bindingⁱ	95 – 163	HMG box 2PROSITE-ProRule annotationAdd BLAST		69

GO - Molecular functionⁱ

chemoattractant activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19811285
damaged DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 8226934
DNA binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11909973
DNA binding, bending
Source: UniProtKB
Inferred from direct assayⁱ
- 11909973
- 8339930
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19223331
double-stranded DNA binding Source: UniProtKB
drug binding Source: AgBase
enhancer sequence-specific DNA binding Source: AgBase
four-way junction DNA binding Source: AgBase
non-sequence-specific DNA binding, bending Source: AgBase
protein domain specific binding Source: Ensembl
RAGE receptor binding
Source: UniProtKB
Inferred from genetic interactionⁱ
- 19811285
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889
single-stranded DNA binding Source: UniProtKB
supercoiled DNA binding Source: AgBase
transcription factor binding Source: AgBase
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19965638

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic DNA fragmentation Source: Reactome
cell chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 19811285
cellular response to lipopolysaccharide
Source: UniProtKB
Inferred from expression patternⁱ
- 19811285
chromatin organization
Source: UniProtKB
Non-traceable author statementⁱ
- 11909973
defense response to Gram-negative bacterium
Source: AgBase
Inferred from direct assayⁱ
- 23877675
defense response to Gram-positive bacterium
Source: AgBase
Inferred from direct assayⁱ
- 23877675
DNA geometric change Source: AgBase
DNA ligation involved in DNA repair Source: UniProtKB
DNA topological change Source: UniProtKB
inflammatory response to antigenic stimulus Source: AgBase
innate immune response Source: UniProtKB-KW
male gonad development Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
negative regulation of transcription, DNA-templated
Source: BHF-UCL
Inferred from direct assayⁱ
- 9636147
nucleosome assembly
Source: UniProtKB
Non-traceable author statementⁱ
- 11909973
positive regulation of DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19965638
positive regulation of endothelial cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 19811285
positive regulation of erythrocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19965638
positive regulation of innate immune response Source: Ensembl
positive regulation of interferon-beta production Source: Ensembl
positive regulation of megakaryocyte differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19965638
positive regulation of nuclease activity
Source: UniProtKB
Inferred from direct assayⁱ
- 978439
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 19965638
positive regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 19223331
- 19965638
regulation of neurogenesis Source: AgBase
regulation of stem cell proliferation Source: AgBase
regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 7797075
response to drug Source: AgBase
response to lipopolysaccharide Source: AgBase
response to steroid hormone Source: Ensembl
spermatid nucleus differentiation Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW
V(D)J recombination Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Chemotaxis, DNA recombination, Immunity, Inflammatory response, Innate immunity, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211227 Activation of DNA fragmentation factor
SIGNORⁱ	P26583

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: High mobility group protein B2 Alternative name(s): High mobility group protein 2 Short name: HMG-2
Gene namesⁱ	Name:HMGB2 Synonyms:HMG2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164104.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5000 HMGB2
MIMⁱ	163906 gene
neXtProtⁱ	NX_P26583

Keywords - Cellular componentⁱ

Chromosome, Cytoplasm, Nucleus, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3148
Open Targets More...OpenTargetsⁱ	ENSG00000164104
PharmGKBⁱ	PA35091

Polymorphism and mutation databases

BioMutaⁱ	HMGB2
DMDMⁱ	123374

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048534	1 – 209	High mobility group protein B2Add BLAST		209

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	3	N6-acetyllysineBy similarity	1
Disulfide bondⁱ	23 ↔ 45	In disulfide HMGB2; alternateBy similarity
Modified residueⁱ	23	Cysteine sulfonic acid (-SO3H); alternateBy similarity	1
Modified residueⁱ	30	N6-acetyllysineCombined sources	1
Modified residueⁱ	35	PhosphoserineCombined sources	1
Modified residueⁱ	43	N6-acetyllysineBy similarity	1
Modified residueⁱ	45	Cysteine sulfonic acid (-SO3H); alternateBy similarity	1
Modified residueⁱ	90	N6-acetyllysineBy similarity	1
Modified residueⁱ	100	PhosphoserineBy similarity	1
Modified residueⁱ	106	Cysteine sulfonic acid (-SO3H)By similarity	1
Modified residueⁱ	114	N6-acetyllysineBy similarity	1
Modified residueⁱ	141	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so).By similarity1 Publication

Acetylation enhances nucleosome binding and chromation remodeling activity.1 Publication

Keywords - PTMⁱ

Acetylation, Disulfide bond, Oxidation, Phosphoprotein

Proteomic databases

EPDⁱ	P26583
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P26583
PaxDbⁱ	P26583
PeptideAtlas More...PeptideAtlasⁱ	P26583
PRIDEⁱ	P26583
ProteomicsDBⁱ	54353
TopDownProteomicsⁱ	P26583

PTM databases

iPTMnetⁱ	P26583
PhosphoSitePlusⁱ	P26583
SwissPalmⁱ	P26583

Miscellaneous databases

PMAP-CutDBⁱ	P26583

PMAP-CutDBⁱ

P26583

Expressionⁱ

Tissue specificityⁱ

Expressed in gastric and intestinal tissues (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000164104 Expressed in 233 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_HMGB2
ExpressionAtlasⁱ	P26583 baseline and differential
Genevisibleⁱ	P26583 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037206 HPA003506 HPA053314

HPAⁱ

CAB037206
HPA003506
HPA053314

Interactionⁱ

Subunit structureⁱ

Interacts with POU2F2, POU2F1 and POU3F1 (By similarity). Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2 (By similarity). Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET (PubMed:11909973). Interacts with LEF1 (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PKNOX1	Q96I87	3	EBI-1057009,EBI-10173774

With

Entry

#Exp.

IntAct

Notes

PKNOX1

Q96I87

3

EBI-1057009,EBI-10173774

GO - Molecular functionⁱ

chemoattractant activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19811285
protein domain specific binding Source: Ensembl
RAGE receptor binding
Source: UniProtKB
Inferred from genetic interactionⁱ
- 19811285
transcription factor binding Source: AgBase

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109391, 51 interactors
CORUMⁱ	P26583
IntActⁱ	P26583, 25 interactors
Molecular INTeraction database More...MINTⁱ	P26583
STRINGⁱ	9606.ENSP00000296503

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P26583
SMRⁱ	P26583
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	165 – 180	Required for chemotactic activity1 PublicationAdd BLAST		16

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	186 – 209	Asp/Glu-rich (acidic)Add BLAST		24

Domainⁱ

Both, HMG box 1 and HMG box 2, show antimicrobial activity.1 Publication

Sequence similaritiesⁱ

Belongs to the HMGB family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0381 Eukaryota COG5648 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119164
HOGENOMⁱ	HOG000197861
HOVERGENⁱ	HBG009000
InParanoidⁱ	P26583
KEGG Orthology (KO) More...KOⁱ	K11295
OMAⁱ	ADDTWRA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P81
PhylomeDBⁱ	P26583
TreeFamⁱ	TF105371

Family and domain databases

Gene3Dⁱ	1.10.30.10, 2 hits
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR017967 HMG_boxA_CS IPR031075 HMGB2
PANTHERⁱ	PTHR13711:SF181 PTHR13711:SF181, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF09011 HMG_box_2, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 2 hits
SUPFAMⁱ	SSF47095 SSF47095, 2 hits
PROSITEⁱ	View protein in PROSITE PS00353 HMG_BOX_1, 1 hit PS50118 HMG_BOX_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P26583-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKGDPNKPR GKMSSYAFFV QTCREEHKKK HPDSSVNFAE FSKKCSERWK 
        60         70         80         90        100
TMSAKEKSKF EDMAKSDKAR YDREMKNYVP PKGDKKGKKK DPNAPKRPPS 
       110        120        130        140        150
AFFLFCSEHR PKIKSEHPGL SIGDTAKKLG EMWSEQSAKD KQPYEQKAAK 
       160        170        180        190        200
LKEKYEKDIA AYRAKGKSEA GKKGPGRPTG SKKKNEPEDE EEEEEEEDED 

EEEEDEDEE

Length:209

Mass (Da):24,034

Last modified:January 23, 2007 - v2

Checksum:ⁱ5E65292BC4AD8373

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6R9A6	D6R9A6_HUMAN		High mobility group protein B2 High mobility group protein B2	HMGB2	134	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	163	R → G in CAA78938 (PubMed:1475204).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83665 Genomic DNA Translation: AAA58659.1 X62534 mRNA Translation: CAA44395.1 BT019782 mRNA Translation: AAV38585.1 AK311864 mRNA Translation: BAG34805.1 CH471056 Genomic DNA Translation: EAX04758.1 CH471056 Genomic DNA Translation: EAX04759.1 BC001063 mRNA Translation: AAH01063.1 BC100019 mRNA Translation: AAI00020.1 Z17240 mRNA Translation: CAA78938.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3816.1
PIRⁱ	A42425 NSHUH2 S30221
NCBI Reference Sequences More...RefSeqⁱ	NP_001124160.1, NM_001130688.1 NP_001124161.1, NM_001130689.1 NP_002120.1, NM_002129.3
UniGeneⁱ	Hs.434953

Genome annotation databases

Ensemblⁱ	ENST00000296503; ENSP00000296503; ENSG00000164104 ENST00000438704; ENSP00000404912; ENSG00000164104 ENST00000446922; ENSP00000393448; ENSG00000164104
GeneIDⁱ	3148
KEGGⁱ	hsa:3148
UCSC genome browser More...UCSCⁱ	uc003ita.4 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P26583	High mobility group protein B2		BOVIN		209	UniRef100_P26583
HMGB2 isoform 1		PANTR		209
High mobility group protein B2		MACMU		209
high mobility group protein B2		TURTR		209
Uncharacterized protein		COLAP		209
+5

Protein	Similar proteins		Species	Score	Length	Source
P26583	High mobility group protein B2		BOVIN		209	UniRef90_P26583
HMGB2 isoform 1		PANTR		209
High mobility group protein B2		MACMU		209
high mobility group protein B2		TURTR		209
Uncharacterized protein		COLAP		209
+71

Protein	Similar proteins		Species	Score	Length	Source
P26583	High mobility group protein B2		BOVIN		209	UniRef50_P26583
HMGB2 isoform 1		PANTR		209
High mobility group protein B2		MACMU		209
high mobility group protein B2		TURTR		209
Uncharacterized protein		COLAP		209
+331

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M83665 Genomic DNA Translation: AAA58659.1 X62534 mRNA Translation: CAA44395.1 BT019782 mRNA Translation: AAV38585.1 AK311864 mRNA Translation: BAG34805.1 CH471056 Genomic DNA Translation: EAX04758.1 CH471056 Genomic DNA Translation: EAX04759.1 BC001063 mRNA Translation: AAH01063.1 BC100019 mRNA Translation: AAI00020.1 Z17240 mRNA Translation: CAA78938.1
CCDSⁱ	CCDS3816.1
PIRⁱ	A42425 NSHUH2 S30221
RefSeqⁱ	NP_001124160.1, NM_001130688.1 NP_001124161.1, NM_001130689.1 NP_002120.1, NM_002129.3
UniGeneⁱ	Hs.434953

3D structure databases

ProteinModelPortalⁱ	P26583
SMRⁱ	P26583
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109391, 51 interactors
CORUMⁱ	P26583
IntActⁱ	P26583, 25 interactors
MINTⁱ	P26583
STRINGⁱ	9606.ENSP00000296503

PTM databases

iPTMnetⁱ	P26583
PhosphoSitePlusⁱ	P26583
SwissPalmⁱ	P26583

Polymorphism and mutation databases

BioMutaⁱ	HMGB2
DMDMⁱ	123374

Proteomic databases

EPDⁱ	P26583
MaxQBⁱ	P26583
PaxDbⁱ	P26583
PeptideAtlasⁱ	P26583
PRIDEⁱ	P26583
ProteomicsDBⁱ	54353
TopDownProteomicsⁱ	P26583

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3148
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296503; ENSP00000296503; ENSG00000164104 ENST00000438704; ENSP00000404912; ENSG00000164104 ENST00000446922; ENSP00000393448; ENSG00000164104
GeneIDⁱ	3148
KEGGⁱ	hsa:3148
UCSCⁱ	uc003ita.4 human

Organism-specific databases

CTDⁱ	3148
DisGeNETⁱ	3148
EuPathDBⁱ	HostDB:ENSG00000164104.11
GeneCardsⁱ	HMGB2
HGNCⁱ	HGNC:5000 HMGB2
HPAⁱ	CAB037206 HPA003506 HPA053314
MIMⁱ	163906 gene
neXtProtⁱ	NX_P26583
OpenTargetsⁱ	ENSG00000164104
PharmGKBⁱ	PA35091
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0381 Eukaryota COG5648 LUCA
GeneTreeⁱ	ENSGT00760000119164
HOGENOMⁱ	HOG000197861
HOVERGENⁱ	HBG009000
InParanoidⁱ	P26583
KOⁱ	K11295
OMAⁱ	ADDTWRA
OrthoDBⁱ	EOG091G0P81
PhylomeDBⁱ	P26583
TreeFamⁱ	TF105371

Enzyme and pathway databases

Reactomeⁱ	R-HSA-211227 Activation of DNA fragmentation factor
SIGNORⁱ	P26583

Miscellaneous databases

ChiTaRSⁱ	HMGB2 human
GeneWikiⁱ	HMGB2
GenomeRNAiⁱ	3148
PMAP-CutDBⁱ	P26583
Protein Ontology More...PROⁱ	PR:P26583
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164104 Expressed in 233 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_HMGB2
ExpressionAtlasⁱ	P26583 baseline and differential
Genevisibleⁱ	P26583 HS

Family and domain databases

Gene3Dⁱ	1.10.30.10, 2 hits
InterProⁱ	View protein in InterPro IPR009071 HMG_box_dom IPR036910 HMG_box_dom_sf IPR017967 HMG_boxA_CS IPR031075 HMGB2
PANTHERⁱ	PTHR13711:SF181 PTHR13711:SF181, 1 hit
Pfamⁱ	View protein in Pfam PF00505 HMG_box, 1 hit PF09011 HMG_box_2, 1 hit
SMARTⁱ	View protein in SMART SM00398 HMG, 2 hits
SUPFAMⁱ	SSF47095 SSF47095, 2 hits
PROSITEⁱ	View protein in PROSITE PS00353 HMG_BOX_1, 1 hit PS50118 HMG_BOX_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMGB2_HUMAN
Accessionⁱ	P26583Primary (citable) accession number: P26583 Secondary accession number(s): B2R4K8, D3DP37, Q5U072
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P26583 (HMGB2_HUMAN)

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High mobility group protein B2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Other locations

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ