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Entry version 171 (13 Feb 2019)
Sequence version 2 (02 Nov 2010)
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Protein

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Gene

MGAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 PublicationNote: The cofactor is mostly bound to the substrate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei115SubstrateBy similarity1
Binding sitei142SubstrateBy similarity1
Binding sitei188SubstrateBy similarity1
Binding sitei210SubstrateBy similarity1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi211ManganeseBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei289Proton acceptorSequence analysis1
Binding sitei320SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • acetylglucosaminyltransferase activity Source: GO_Central
  • alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity Source: UniProtKB
  • manganese ion binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS05528-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-964739 N-glycan trimming and elongation in the cis-Golgi

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT13 Glycosyltransferase Family 13

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (EC:2.4.1.1011 Publication)
Alternative name(s):
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I1 Publication
Short name:
GNT-I
Short name:
GlcNAc-T I1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MGAT1
Synonyms:GGNT1, GLCT1, GLYT1, MGAT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131446.16

Human Gene Nomenclature Database

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HGNCi
HGNC:7044 MGAT1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
160995 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P26572

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 6CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei7 – 29Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini30 – 445LumenalSequence analysisAdd BLAST416

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
4245

Open Targets

More...
OpenTargetsi
ENSG00000131446

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30779

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2375207

Drug and drug target database

More...
DrugBanki
DB03397 Uridine-Diphosphate-N-Acetylglucosamine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MGAT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033399

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001913841 – 445Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi113 ↔ 143By similarity
Disulfide bondi237 ↔ 303By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P26572

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P26572

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P26572

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P26572

PeptideAtlas

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PeptideAtlasi
P26572

PRoteomics IDEntifications database

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PRIDEi
P26572

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54352

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26572

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P26572

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131446 Expressed in 233 organ(s), highest expression level in omental fat pad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P26572 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26572 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA017432

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MGAT4D.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110401, 16 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P26572

Protein interaction database and analysis system

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IntActi
P26572, 6 interactors

Molecular INTeraction database

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MINTi
P26572

STRING: functional protein association networks

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STRINGi
9606.ENSP00000311888

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P26572

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P26572

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P26572

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyltransferase 13 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1413 Eukaryota
ENOG410XQD8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063632

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG052466

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26572

KEGG Orthology (KO)

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KOi
K00726

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDPSLWC

Database of Orthologous Groups

More...
OrthoDBi
1324622at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26572

TreeFam database of animal gene trees

More...
TreeFami
TF320555

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.550.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004139 Glyco_trans_13
IPR029044 Nucleotide-diphossugar_trans

The PANTHER Classification System

More...
PANTHERi
PTHR10468 PTHR10468, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03071 GNT-I, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53448 SSF53448, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P26572-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLKKQSAGLV LWGAILFVAW NALLLLFFWT RPAPGRPPSV SALDGDPASL
60 70 80 90 100
TREVIRLAQD AEVELERQRG LLQQIGDALS SQRGRVPTAA PPAQPRVPVT
110 120 130 140 150
PAPAVIPILV IACDRSTVRR CLDKLLHYRP SAELFPIIVS QDCGHEETAQ
160 170 180 190 200
AIASYGSAVT HIRQPDLSSI AVPPDHRKFQ GYYKIARHYR WALGQVFRQF
210 220 230 240 250
RFPAAVVVED DLEVAPDFFE YFRATYPLLK ADPSLWCVSA WNDNGKEQMV
260 270 280 290 300
DASRPELLYR TDFFPGLGWL LLAELWAELE PKWPKAFWDD WMRRPEQRQG
310 320 330 340 350
RACIRPEISR TMTFGRKGVS HGQFFDQHLK FIKLNQQFVH FTQLDLSYLQ
360 370 380 390 400
REAYDRDFLA RVYGAPQLQV EKVRTNDRKE LGEVRVQYTG RDSFKAFAKA
410 420 430 440
LGVMDDLKSG VPRAGYRGIV TFQFRGRRVH LAPPLTWEGY DPSWN
Length:445
Mass (Da):50,878
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13402302ED69C302
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF69D6RF69_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHZ8D6RHZ8_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
153Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB69D6RB69_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RD15D6RD15_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9U2D6R9U2_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RA48D6RA48_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RAK2D6RAK2_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBS3D6RBS3_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIS2D6RIS2_HUMAN
Alpha-1,3-mannosyl-glycoprotein 2-b...
MGAT1
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti291W → R in BAG52510 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028272223R → Q. Corresponds to variant dbSNP:rs7726005Ensembl.1
Natural variantiVAR_028273435L → P4 PublicationsCorresponds to variant dbSNP:rs634501Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M55621 mRNA Translation: AAA52563.1
M61829 Genomic DNA Translation: AAA75523.1
AK092256 mRNA Translation: BAG52510.1
AK094130 mRNA Translation: BAG52821.1
AK290769 mRNA Translation: BAF83458.1
CR456861 mRNA Translation: CAG33142.1
AC022413 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53739.1
CH471165 Genomic DNA Translation: EAW53740.1
CH471165 Genomic DNA Translation: EAW53741.1
CH471165 Genomic DNA Translation: EAW53742.1
CH471165 Genomic DNA Translation: EAW53743.1
CH471165 Genomic DNA Translation: EAW53744.1
BC003575 mRNA Translation: AAH03575.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4458.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JH0397 XUHUMB

NCBI Reference Sequences

More...
RefSeqi
NP_001108089.1, NM_001114617.1
NP_001108090.1, NM_001114618.1
NP_001108091.1, NM_001114619.1
NP_001108092.1, NM_001114620.1
NP_002397.2, NM_002406.3
XP_005265972.1, XM_005265915.1
XP_005265973.1, XM_005265916.1
XP_006714929.1, XM_006714866.1
XP_011532861.1, XM_011534559.1
XP_011532862.1, XM_011534560.1
XP_011532863.1, XM_011534561.1
XP_011532864.1, XM_011534562.1
XP_011532865.1, XM_011534563.2
XP_016864975.1, XM_017009486.1
XP_016864976.1, XM_017009487.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.519818
Hs.736216

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000307826; ENSP00000311888; ENSG00000131446
ENST00000333055; ENSP00000332073; ENSG00000131446
ENST00000393340; ENSP00000377010; ENSG00000131446
ENST00000427865; ENSP00000402838; ENSG00000131446
ENST00000446023; ENSP00000404718; ENSG00000131446

Database of genes from NCBI RefSeq genomes

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GeneIDi
4245

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4245

UCSC genome browser

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UCSCi
uc003mmg.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - GTase

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M55621 mRNA Translation: AAA52563.1
M61829 Genomic DNA Translation: AAA75523.1
AK092256 mRNA Translation: BAG52510.1
AK094130 mRNA Translation: BAG52821.1
AK290769 mRNA Translation: BAF83458.1
CR456861 mRNA Translation: CAG33142.1
AC022413 Genomic DNA No translation available.
CH471165 Genomic DNA Translation: EAW53739.1
CH471165 Genomic DNA Translation: EAW53740.1
CH471165 Genomic DNA Translation: EAW53741.1
CH471165 Genomic DNA Translation: EAW53742.1
CH471165 Genomic DNA Translation: EAW53743.1
CH471165 Genomic DNA Translation: EAW53744.1
BC003575 mRNA Translation: AAH03575.1
CCDSiCCDS4458.1
PIRiJH0397 XUHUMB
RefSeqiNP_001108089.1, NM_001114617.1
NP_001108090.1, NM_001114618.1
NP_001108091.1, NM_001114619.1
NP_001108092.1, NM_001114620.1
NP_002397.2, NM_002406.3
XP_005265972.1, XM_005265915.1
XP_005265973.1, XM_005265916.1
XP_006714929.1, XM_006714866.1
XP_011532861.1, XM_011534559.1
XP_011532862.1, XM_011534560.1
XP_011532863.1, XM_011534561.1
XP_011532864.1, XM_011534562.1
XP_011532865.1, XM_011534563.2
XP_016864975.1, XM_017009486.1
XP_016864976.1, XM_017009487.1
UniGeneiHs.519818
Hs.736216

3D structure databases

ProteinModelPortaliP26572
SMRiP26572
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110401, 16 interactors
CORUMiP26572
IntActiP26572, 6 interactors
MINTiP26572
STRINGi9606.ENSP00000311888

Chemistry databases

BindingDBiP26572
ChEMBLiCHEMBL2375207
DrugBankiDB03397 Uridine-Diphosphate-N-Acetylglucosamine

Protein family/group databases

CAZyiGT13 Glycosyltransferase Family 13

PTM databases

iPTMnetiP26572
PhosphoSitePlusiP26572

Polymorphism and mutation databases

BioMutaiMGAT1
DMDMi311033399

Proteomic databases

EPDiP26572
jPOSTiP26572
MaxQBiP26572
PaxDbiP26572
PeptideAtlasiP26572
PRIDEiP26572
ProteomicsDBi54352

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4245
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307826; ENSP00000311888; ENSG00000131446
ENST00000333055; ENSP00000332073; ENSG00000131446
ENST00000393340; ENSP00000377010; ENSG00000131446
ENST00000427865; ENSP00000402838; ENSG00000131446
ENST00000446023; ENSP00000404718; ENSG00000131446
GeneIDi4245
KEGGihsa:4245
UCSCiuc003mmg.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4245
DisGeNETi4245
EuPathDBiHostDB:ENSG00000131446.16

GeneCards: human genes, protein and diseases

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GeneCardsi
MGAT1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0005500
HIX0164288
HGNCiHGNC:7044 MGAT1
HPAiHPA017432
MIMi160995 gene
neXtProtiNX_P26572
OpenTargetsiENSG00000131446
PharmGKBiPA30779

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1413 Eukaryota
ENOG410XQD8 LUCA
GeneTreeiENSGT00530000063632
HOVERGENiHBG052466
InParanoidiP26572
KOiK00726
OMAiQDPSLWC
OrthoDBi1324622at2759
PhylomeDBiP26572
TreeFamiTF320555

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:HS05528-MONOMER
ReactomeiR-HSA-964739 N-glycan trimming and elongation in the cis-Golgi

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MGAT1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MGAT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4245

Protein Ontology

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PROi
PR:P26572

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000131446 Expressed in 233 organ(s), highest expression level in omental fat pad
ExpressionAtlasiP26572 baseline and differential
GenevisibleiP26572 HS

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR004139 Glyco_trans_13
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR10468 PTHR10468, 1 hit
PfamiView protein in Pfam
PF03071 GNT-I, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMGAT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26572
Secondary accession number(s): A8K404
, B3KRU8, D3DWR1, Q6IBE3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 2, 2010
Last modified: February 13, 2019
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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