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Entry version 112 (02 Dec 2020)
Sequence version 2 (28 Feb 2003)
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Protein

Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE

Gene

nifE

Organism
Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Fe-Mo cofactor biosynthesis

This protein is involved in the pathway Fe-Mo cofactor biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway Fe-Mo cofactor biosynthesis and in Cofactor biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNitrogen fixation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BDIA224911:G1G3J-1765-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00782

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nifE
Ordered Locus Names:blr1745
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224911 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBradyrhizobiaceaeBradyrhizobium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002526 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001531131 – 547Nitrogenase iron-molybdenum cofactor biosynthesis protein NifEAdd BLAST547

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
224911.27349998

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P26506

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NifD/NifK/NifE/NifN family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2710, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_025876_1_1_5

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26506

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTWDIRG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26506

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1100, 1 hit
3.40.50.12380, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007419, BFD-like_2Fe2S-bd_dom
IPR041854, BFD-like_2Fe2S-bd_dom_sf
IPR000510, Nase/OxRdtase_comp1
IPR000318, Nase_comp1_CS
IPR005973, NifE
IPR042459, NifE_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04324, Fer2_BFD, 1 hit
PF00148, Oxidored_nitro, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01283, nifE, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00699, NITROGENASE_1_1, 1 hit
PS00090, NITROGENASE_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P26506-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLAATVQD IFDEPGCAKN GSKSEAERRN GCTRQLQPGS AAGGCAFDGA
60 70 80 90 100
KVALQPFTDV AHLVHGPIAC EGNSWDNRGA ASSGSDLWRT AFTTDLSETD
110 120 130 140 150
IVFGGEKRLC KAIKEIIDKC DPPAIFVYQT CIPAMIGDDI NAVCKAASRR
160 170 180 190 200
FSKPVIPINS PGFAGSKNLG NKLAGEALLD YVIGTREPDY TTPYDINLIG
210 220 230 240 250
EYNLSGELWQ VKPVLDELGV RILCCISGDG KYREVASSHR ARAAMLVCSK
260 270 280 290 300
SMINVARKME QRYGIPFFEG SFYGIQDSSE SLRQIARLLV ERGAPADLLG
310 320 330 340 350
RTEAVIAREE ARAWAAIQPY KPRLEGKRAL LMTGGVKSWS VVSALQEAGL
360 370 380 390 400
ELVGTSVKKS TMEDKERIKE LMGQDAHMID DMTAREMYKM LKDAEADIML
410 420 430 440 450
SGGKSQFVAL KAAVPWVDIN QERCHAYMGY AGIVKLVEEI DNSLSSPMWE
460 470 480 490 500
QLRRPAPWEA LAKAREQMQS MAAIAGDPVL AETARRARNI CVCNRVDLGT
510 520 530 540
IEDAISVHGL RSVAAVREHT NAAGGCCQGR IEDMLMSEPS DMRQAAE
Length:547
Mass (Da):59,509
Last modified:February 28, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF91DDCCF3984308B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58T → N in CAA40213 (PubMed:2266945).Curated1
Sequence conflicti79G → A in CAA40213 (PubMed:2266945).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X56894 Genomic DNA Translation: CAA40213.1
AF322012 Genomic DNA Translation: AAG60731.1
BA000040 Genomic DNA Translation: BAC47010.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S12263, NIZJME

NCBI Reference Sequences

More...
RefSeqi
NP_768385.1, NC_004463.1
WP_011084554.1, NZ_CP011360.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAC47010; BAC47010; BAC47010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
46488959

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bja:blr1745

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224911.44.peg.1210

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56894 Genomic DNA Translation: CAA40213.1
AF322012 Genomic DNA Translation: AAG60731.1
BA000040 Genomic DNA Translation: BAC47010.1
PIRiS12263, NIZJME
RefSeqiNP_768385.1, NC_004463.1
WP_011084554.1, NZ_CP011360.1

3D structure databases

SMRiP26506
ModBaseiSearch...

Protein-protein interaction databases

STRINGi224911.27349998

Genome annotation databases

EnsemblBacteriaiBAC47010; BAC47010; BAC47010
GeneIDi46488959
KEGGibja:blr1745
PATRICifig|224911.44.peg.1210

Phylogenomic databases

eggNOGiCOG2710, Bacteria
HOGENOMiCLU_025876_1_1_5
InParanoidiP26506
OMAiYTWDIRG
PhylomeDBiP26506

Enzyme and pathway databases

UniPathwayiUPA00782
BioCyciBDIA224911:G1G3J-1765-MONOMER

Family and domain databases

Gene3Di1.10.10.1100, 1 hit
3.40.50.12380, 1 hit
InterProiView protein in InterPro
IPR007419, BFD-like_2Fe2S-bd_dom
IPR041854, BFD-like_2Fe2S-bd_dom_sf
IPR000510, Nase/OxRdtase_comp1
IPR000318, Nase_comp1_CS
IPR005973, NifE
IPR042459, NifE_C
PfamiView protein in Pfam
PF04324, Fer2_BFD, 1 hit
PF00148, Oxidored_nitro, 1 hit
TIGRFAMsiTIGR01283, nifE, 1 hit
PROSITEiView protein in PROSITE
PS00699, NITROGENASE_1_1, 1 hit
PS00090, NITROGENASE_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNIFE_BRADU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26506
Secondary accession number(s): Q9ANN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: February 28, 2003
Last modified: December 2, 2020
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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