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Protein

Anaerobic sulfite reductase subunit B

Gene

asrB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This enzyme catalyzes the hydrogen sulfide production from sulfite. It is strictly anaerobic. It is regulated by electron acceptors rather than by cysteine.

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterBy similarityNote: Binds 1 [2Fe-2S] cluster per subunit.By similarity
  • FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Pathwayi: sulfite reduction

This protein is involved in the pathway sulfite reduction, which is part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfite reduction and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166NADBy similarity1
Metal bindingi240Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi245Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi248Iron-sulfur (2Fe-2S)Sequence analysis1
Metal bindingi256Iron-sulfur (2Fe-2S)Sequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi113 – 129FADBy similarityAdd BLAST17
Nucleotide bindingi168 – 213NADBy similarityAdd BLAST46

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12545
SENT99287:G1FZD-2571-MONOMER
UniPathwayiUPA00370

Names & Taxonomyi

Protein namesi
Recommended name:
Anaerobic sulfite reductase subunit B
Gene namesi
Name:asrB
Ordered Locus Names:STM2549
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483851 – 272Anaerobic sulfite reductase subunit BAdd BLAST272

Proteomic databases

PaxDbiP26475
PRIDEiP26475

Expressioni

Inductioni

By sulfite. Repressed by oxygen.

Interactioni

Subunit structurei

The anaerobic sulfite reductase seems to consist of three subunits.

Protein-protein interaction databases

STRINGi99287.STM2549

Structurei

3D structure databases

ProteinModelPortaliP26475
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 105FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST92

Sequence similaritiesi

Belongs to the PyrK family.Curated

Phylogenomic databases

eggNOGiENOG4107SHJ Bacteria
COG0543 LUCA
HOGENOMiHOG000225119
KOiK16951
OMAiNTARYGK
PhylomeDBiP26475

Family and domain databases

InterProiView protein in InterPro
IPR012165 Cyt_c3_hydrogenase_gsu
IPR019480 Dihydroorotate_DH_Fe-S-bd
IPR017927 Fd_Rdtase_FAD-bd
IPR001433 OxRdtase_FAD/NAD-bd
IPR017938 Riboflavin_synthase-like_b-brl
IPR014260 Sulphite_reductase_B
PfamiView protein in Pfam
PF10418 DHODB_Fe-S_bind, 1 hit
PF00175 NAD_binding_1, 1 hit
PIRSFiPIRSF006816 Cyc3_hyd_g, 1 hit
SUPFAMiSSF63380 SSF63380, 1 hit
TIGRFAMsiTIGR02911 sulfite_red_B, 1 hit
PROSITEiView protein in PROSITE
PS51384 FAD_FR, 1 hit

Sequencei

Sequence statusi: Complete.

P26475-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHCSCHDKP QHSLLPAAYR ILSITRHTPL EWNFRVAVDF PAHWGQFVEV
60 70 80 90 100
SLPRVGEAPI SVSDYGDGWI DLLIRNVGKV TSALFTLKEG DNVWLRGCYG
110 120 130 140 150
NGYPVDTLRH KPLLVVAGGT GVAPVKGLMR YFVENPQEIG QLDMILGYKN
160 170 180 190 200
RDCVLYKEEM ATWRGKHNLV LTLDEGEADD RYQIGRVTDR LADMTLSDID
210 220 230 240 250
TMQAIVVGPP IMITFTVKML LQKGLKPEQI WVDYERRMAC SVGKCGHCRM
260 270
GEVYVCTDGP IFNYAVAQRF AD
Length:272
Mass (Da):30,609
Last modified:January 23, 2002 - v2
Checksum:i5C73ACCC200AE302
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16P → A in AAA99276 (PubMed:1704886).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57706 Genomic DNA Translation: AAA99276.1
AE006468 Genomic DNA Translation: AAL21443.1
PIRiB38453
RefSeqiNP_461484.1, NC_003197.2
WP_000017587.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL21443; AAL21443; STM2549
GeneIDi1254071
KEGGistm:STM2549
PATRICifig|99287.12.peg.2689

Similar proteinsi

Entry informationi

Entry nameiASRB_SALTY
AccessioniPrimary (citable) accession number: P26475
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2002
Last modified: May 23, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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