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Protein

Maltoporin

Gene

lamB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the transport of maltose and maltodextrins. Does not act as a receptor for phages.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei31Greasy slide, important in sugar transport1 Publication1
Sitei66Greasy slide, important in sugar transport1 Publication1
Sitei99Greasy slide, important in sugar transport1 Publication1
Sitei143Important in sugar transport1 Publication1
Sitei252Greasy slide, important in sugar transport1 Publication1
Sitei393Greasy slide, important in sugar transport1 Publication1
Sitei451Greasy slide, important in sugar transport1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionPorin
Biological processIon transport, Sugar transport, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SENT99287:STM4231-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Maltoporin
Alternative name(s):
Maltose-inducible porin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lamB
Synonyms:malL1 Publication
Ordered Locus Names:STM4231
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26Periplasmic1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 35Beta stranded1 Publication9
Topological domaini36 – 64Extracellular1 PublicationAdd BLAST29
Transmembranei65 – 78Beta stranded1 PublicationAdd BLAST14
Topological domaini79 – 80Periplasmic1 Publication2
Transmembranei81 – 93Beta stranded1 PublicationAdd BLAST13
Topological domaini94 – 104Extracellular1 PublicationAdd BLAST11
Transmembranei105 – 115Beta stranded1 PublicationAdd BLAST11
Topological domaini116 – 122Periplasmic1 Publication7
Transmembranei123 – 130Beta stranded1 Publication8
Topological domaini131 – 148Extracellular1 PublicationAdd BLAST18
Transmembranei149 – 159Beta stranded1 PublicationAdd BLAST11
Topological domaini160 – 161Periplasmic1 Publication2
Transmembranei162 – 173Beta stranded1 PublicationAdd BLAST12
Topological domaini174 – 191Extracellular1 PublicationAdd BLAST18
Transmembranei192 – 205Beta stranded1 PublicationAdd BLAST14
Topological domaini206 – 209Periplasmic1 Publication4
Transmembranei210 – 222Beta stranded1 PublicationAdd BLAST13
Topological domaini223 – 234Extracellular1 PublicationAdd BLAST12
Transmembranei235 – 248Beta stranded1 PublicationAdd BLAST14
Topological domaini249 – 250Periplasmic1 Publication2
Transmembranei251 – 263Beta stranded1 PublicationAdd BLAST13
Topological domaini264 – 300Extracellular1 PublicationAdd BLAST37
Transmembranei301 – 315Beta stranded1 PublicationAdd BLAST15
Topological domaini316 – 317Periplasmic1 Publication2
Transmembranei318 – 333Beta stranded1 PublicationAdd BLAST16
Topological domaini334 – 336Extracellular1 Publication3
Transmembranei337 – 351Beta stranded1 PublicationAdd BLAST15
Topological domaini352 – 353Periplasmic1 Publication2
Transmembranei354 – 369Beta stranded1 PublicationAdd BLAST16
Topological domaini370 – 372Extracellular1 Publication3
Transmembranei373 – 388Beta stranded1 PublicationAdd BLAST16
Topological domaini389 – 395Periplasmic1 Publication7
Transmembranei396 – 410Beta stranded1 PublicationAdd BLAST15
Topological domaini411 – 436Extracellular1 PublicationAdd BLAST26
Transmembranei437 – 451Beta stranded1 PublicationAdd BLAST15
Topological domaini452Periplasmic1 Publication1

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02379 Beta-D-Glucose

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Add BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002518026 – 452MaltoporinAdd BLAST427

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi47 ↔ 631 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26466

PRoteomics IDEntifications database

More...
PRIDEi
P26466

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By maltose.Curated

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer formed of three 18-stranded antiparallel beta-barrels, containing three independent channels.1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
99287.STM4231

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P26466

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26466

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P26466

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni134 – 143Substrate1 Publication10

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108KDD Bacteria
COG4580 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000218083

KEGG Orthology (KO)

More...
KOi
K02024

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYGRANA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26466

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01346 Maltoporin-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.170.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01301 LamB, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023738 Maltoporin
IPR003192 Porin_LamB
IPR036998 Porin_LamB_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02264 LamB, 1 hit

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD008788 Porin_LamB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P26466-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMITLRKLPL AVAVAAGVMS AQAMAVDFHG YARSGIGWTG SGGEQQCFQA
60 70 80 90 100
TGAQSKYRLG NECETYAELK LGQEVWKEGD KSFYFDTNVA YSVNQQNDWE
110 120 130 140 150
STDPAFREAN VQGKNLIEWL PGSTIWAGKR FYQRHDVHMI DFYYWDISGP
160 170 180 190 200
GAGIENIDLG FGKLSLAATR STEAGGSYTF SSQNIYDEVK DTANDVFDVR
210 220 230 240 250
LAGLQTNPDG VLELGVDYGR ANTTDGYKLA DGASKDGWMF TAEHTQSMLK
260 270 280 290 300
GYNKFVVQYA TDAMTTQGKG QARGSDGSSS FTEELSDGTK INYANKVINN
310 320 330 340 350
NGNMWRILDH GAISLGDKWD LMYVGMYQNI DWDNNLGTEW WTVGVRPMYK
360 370 380 390 400
WTPIMSTLLE VGYDNVKSQQ TGDRNNQYKI TLAQQWQAGD SIWSRPAIRI
410 420 430 440 450
FATYAKWDEK WGYIKDGDNI SRYAAATNSG ISTNSRGDSD EWTFGAQMEI

WW
Length:452
Mass (Da):50,549
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE5148050ECABF063
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X54292 Genomic DNA Translation: CAA38187.1
AE006468 Genomic DNA Translation: AAL23055.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A60177

NCBI Reference Sequences

More...
RefSeqi
NP_463096.1, NC_003197.2
WP_000973645.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL23055; AAL23055; STM4231

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1255757

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stm:STM4231

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|99287.12.peg.4451

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54292 Genomic DNA Translation: CAA38187.1
AE006468 Genomic DNA Translation: AAL23055.1
PIRiA60177
RefSeqiNP_463096.1, NC_003197.2
WP_000973645.1, NC_003197.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MPRX-ray2.80A/B/C26-452[»]
2MPRX-ray2.40A/B/C26-452[»]
ProteinModelPortaliP26466
SMRiP26466
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi99287.STM4231

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose

Proteomic databases

PaxDbiP26466
PRIDEiP26466

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL23055; AAL23055; STM4231
GeneIDi1255757
KEGGistm:STM4231
PATRICifig|99287.12.peg.4451

Phylogenomic databases

eggNOGiENOG4108KDD Bacteria
COG4580 LUCA
HOGENOMiHOG000218083
KOiK02024
OMAiDYGRANA
PhylomeDBiP26466

Enzyme and pathway databases

BioCyciSENT99287:STM4231-MONOMER

Miscellaneous databases

EvolutionaryTraceiP26466

Family and domain databases

CDDicd01346 Maltoporin-like, 1 hit
Gene3Di2.40.170.10, 1 hit
HAMAPiMF_01301 LamB, 1 hit
InterProiView protein in InterPro
IPR023738 Maltoporin
IPR003192 Porin_LamB
IPR036998 Porin_LamB_sf
PfamiView protein in Pfam
PF02264 LamB, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD008788 Porin_LamB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMB_SALTY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26466
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: November 1, 1997
Last modified: December 5, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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