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Protein

Mitotic check point protein BUB2

Gene

BUB2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis. This cell-cycle arrest depends upon inhibition of the GTP-binding protein TEM1 by the BFA1/BUB2 complex.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-32760-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mitotic check point protein BUB2
Alternative name(s):
Cell cycle arrest protein BUB2
Gene namesi
Name:BUB2
Ordered Locus Names:YMR055C
ORF Names:YM9796.08C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR055C
SGDiS000004659 BUB2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002080081 – 306Mitotic check point protein BUB2Add BLAST306

Proteomic databases

MaxQBiP26448
PaxDbiP26448
PRIDEiP26448
TopDownProteomicsiP26448

Interactioni

Subunit structurei

Interacts with BFA1.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi35231, 219 interactors
ComplexPortaliCPX-964 Bfa1-Bub2 complex
DIPiDIP-1215N
IntActiP26448, 44 interactors
MINTiP26448
STRINGi4932.YMR055C

Structurei

3D structure databases

ProteinModelPortaliP26448
SMRiP26448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 235Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Belongs to the BUB2 family.Curated

Phylogenomic databases

HOGENOMiHOG000212290
InParanoidiP26448
KOiK02179
OMAiCEVREKI
OrthoDBiEOG092C3NH7

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

Sequencei

Sequence statusi: Complete.

P26448-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIEDLISN PPLLLHSSLS QLRYLILSEG LPISEDKQQQ RTRCYVWTVL
60 70 80 90 100
SQTSMEASTQ RYLALLKLGP PSTTIYQKIK NDTSRTFQTD PNFRNRVSED
110 120 130 140 150
ALIRCLSCFA WQTQQRRQKT RFGRIPVSTY VQGMNVLLAP LLYSCPSEPM
160 170 180 190 200
AYQLFTKLCY EMIPTYLTKN LNGAQNGAKL LDISLRIIDP KLSKFLSDNL
210 220 230 240 250
LTAEIYGMPS ILTLSSCNKP LDQVIKLWDF MFAYGFHMNI LFVVAFLVKM
260 270 280 290 300
RSKVFKSDSP VNLLRQFPDF DADEIIRLGV GFIAKIPAQI YDLLVDHLTD

PDIYIP
Length:306
Mass (Da):35,028
Last modified:August 1, 1992 - v1
Checksum:iA1DDBFB548E81EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64706 Genomic DNA Translation: AAA16885.1
Z49703 Genomic DNA Translation: CAA89765.1
BK006946 Genomic DNA Translation: DAA09954.1
PIRiA39654
RefSeqiNP_013771.1, NM_001182553.1

Genome annotation databases

EnsemblFungiiYMR055C; YMR055C; YMR055C
GeneIDi855077
KEGGisce:YMR055C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M64706 Genomic DNA Translation: AAA16885.1
Z49703 Genomic DNA Translation: CAA89765.1
BK006946 Genomic DNA Translation: DAA09954.1
PIRiA39654
RefSeqiNP_013771.1, NM_001182553.1

3D structure databases

ProteinModelPortaliP26448
SMRiP26448
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35231, 219 interactors
ComplexPortaliCPX-964 Bfa1-Bub2 complex
DIPiDIP-1215N
IntActiP26448, 44 interactors
MINTiP26448
STRINGi4932.YMR055C

Proteomic databases

MaxQBiP26448
PaxDbiP26448
PRIDEiP26448
TopDownProteomicsiP26448

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR055C; YMR055C; YMR055C
GeneIDi855077
KEGGisce:YMR055C

Organism-specific databases

EuPathDBiFungiDB:YMR055C
SGDiS000004659 BUB2

Phylogenomic databases

HOGENOMiHOG000212290
InParanoidiP26448
KOiK02179
OMAiCEVREKI
OrthoDBiEOG092C3NH7

Enzyme and pathway databases

BioCyciYEAST:G3O-32760-MONOMER

Miscellaneous databases

PROiPR:P26448

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBUB2_YEAST
AccessioniPrimary (citable) accession number: P26448
Secondary accession number(s): D6VZN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: October 10, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
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Main funding by: National Institutes of Health

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