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Protein

Protein S100-A4

Gene

S100A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • actin binding Source: Ensembl
  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: ProtInc
  • identical protein binding Source: IntAct
  • RAGE receptor binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transition metal ion binding Source: InterPro

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

SIGNORiP26447

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A4
Alternative name(s):
Calvasculin
Metastasin
Placental calcium-binding protein
Protein Mts1
S100 calcium-binding protein A4
Gene namesi
Name:S100A4
Synonyms:CAPL, MTS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196154.11
HGNCiHGNC:10494 S100A4
MIMi114210 gene
neXtProtiNX_P26447

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6275
OpenTargetsiENSG00000196154
PharmGKBiPA34906

Chemistry databases

ChEMBLiCHEMBL2362976
DrugBankiDB00831 Trifluoperazine

Polymorphism and mutation databases

BioMutaiS100A4
DMDMi115601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439772 – 101Protein S100-A4Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei7N6-acetyllysineCombined sources1
Modified residuei35N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP26447
MaxQBiP26447
PaxDbiP26447
PeptideAtlasiP26447
PRIDEiP26447
ProteomicsDBi54351
TopDownProteomicsiP26447

2D gel databases

DOSAC-COBS-2DPAGEiP26447
SWISS-2DPAGEiP26447

PTM databases

iPTMnetiP26447
PhosphoSitePlusiP26447

Expressioni

Tissue specificityi

Ubiquitously expressed.

Gene expression databases

BgeeiENSG00000196154 Expressed in 222 organ(s), highest expression level in synovial joint
CleanExiHS_S100A4
GenevisibleiP26447 HS

Organism-specific databases

HPAiCAB002618
CAB027387
CAB058698
CAB068227
CAB068228
HPA007973

Interactioni

Subunit structurei

Homodimer. Interacts with PPFIBP1 in a calcium-dependent mode.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112183, 111 interactors
DIPiDIP-44938N
IntActiP26447, 42 interactors
MINTiP26447
STRINGi9606.ENSP00000346294

Structurei

Secondary structure

1101
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP26447
SMRiP26447
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26447

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYVZ Eukaryota
ENOG4111DV3 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP26447
OMAiCVAMMCN
OrthoDBiEOG091G10JX
PhylomeDBiP26447
TreeFamiTF332727

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P26447-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACPLEKALD VMVSTFHKYS GKEGDKFKLN KSELKELLTR ELPSFLGKRT
60 70 80 90 100
DEAAFQKLMS NLDSNRDNEV DFQEYCVFLS CIAMMCNEFF EGFPDKQPRK

K
Length:101
Mass (Da):11,729
Last modified:August 1, 1992 - v1
Checksum:i286D2B7B07EDB562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80563 mRNA Translation: AAA51920.1
Z18950 Genomic DNA Translation: CAA79474.1
Z33457 Genomic DNA Translation: CAA83880.1
CR450345 mRNA Translation: CAG29341.1
AK292083 mRNA Translation: BAF84772.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53310.1
CH471121 Genomic DNA Translation: EAW53311.1
CH471121 Genomic DNA Translation: EAW53312.1
CH471121 Genomic DNA Translation: EAW53313.1
CH471121 Genomic DNA Translation: EAW53314.1
CH471121 Genomic DNA Translation: EAW53315.1
BC000838 mRNA Translation: AAH00838.1
BC016300 mRNA Translation: AAH16300.1
CCDSiCCDS1042.1
PIRiA48219
RefSeqiNP_002952.1, NM_002961.2
NP_062427.1, NM_019554.2
UniGeneiHs.654444

Genome annotation databases

EnsembliENST00000354332; ENSP00000346294; ENSG00000196154
ENST00000368714; ENSP00000357703; ENSG00000196154
ENST00000368715; ENSP00000357704; ENSG00000196154
ENST00000368716; ENSP00000357705; ENSG00000196154
GeneIDi6275
KEGGihsa:6275
UCSCiuc001fby.4 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M80563 mRNA Translation: AAA51920.1
Z18950 Genomic DNA Translation: CAA79474.1
Z33457 Genomic DNA Translation: CAA83880.1
CR450345 mRNA Translation: CAG29341.1
AK292083 mRNA Translation: BAF84772.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53310.1
CH471121 Genomic DNA Translation: EAW53311.1
CH471121 Genomic DNA Translation: EAW53312.1
CH471121 Genomic DNA Translation: EAW53313.1
CH471121 Genomic DNA Translation: EAW53314.1
CH471121 Genomic DNA Translation: EAW53315.1
BC000838 mRNA Translation: AAH00838.1
BC016300 mRNA Translation: AAH16300.1
CCDSiCCDS1042.1
PIRiA48219
RefSeqiNP_002952.1, NM_002961.2
NP_062427.1, NM_019554.2
UniGeneiHs.654444

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1M31NMR-A/B1-101[»]
2LNKNMR-A/B1-101[»]
2MRDNMR-A/B1-101[»]
2Q91X-ray1.63A/B1-101[»]
3C1VX-ray1.50A/B/C/D1-101[»]
3CGAX-ray2.03A/B1-101[»]
3KO0X-ray2.30A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T1-101[»]
3M0WX-ray2.80A/B/C/D/E/F/G/H/I/J2-101[»]
3ZWHX-ray1.94A/B1-101[»]
4CFQX-ray1.37A/B/C/D1-88[»]
4CFRX-ray1.40A/B1-101[»]
4ETOX-ray1.54A/B1-93[»]
4HSZX-ray2.25A/B/C/D1-93[»]
5LPUX-ray2.10C/D1-101[»]
ProteinModelPortaliP26447
SMRiP26447
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112183, 111 interactors
DIPiDIP-44938N
IntActiP26447, 42 interactors
MINTiP26447
STRINGi9606.ENSP00000346294

Chemistry databases

ChEMBLiCHEMBL2362976
DrugBankiDB00831 Trifluoperazine

PTM databases

iPTMnetiP26447
PhosphoSitePlusiP26447

Polymorphism and mutation databases

BioMutaiS100A4
DMDMi115601

2D gel databases

DOSAC-COBS-2DPAGEiP26447
SWISS-2DPAGEiP26447

Proteomic databases

EPDiP26447
MaxQBiP26447
PaxDbiP26447
PeptideAtlasiP26447
PRIDEiP26447
ProteomicsDBi54351
TopDownProteomicsiP26447

Protocols and materials databases

DNASUi6275
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354332; ENSP00000346294; ENSG00000196154
ENST00000368714; ENSP00000357703; ENSG00000196154
ENST00000368715; ENSP00000357704; ENSG00000196154
ENST00000368716; ENSP00000357705; ENSG00000196154
GeneIDi6275
KEGGihsa:6275
UCSCiuc001fby.4 human

Organism-specific databases

CTDi6275
DisGeNETi6275
EuPathDBiHostDB:ENSG00000196154.11
GeneCardsiS100A4
HGNCiHGNC:10494 S100A4
HPAiCAB002618
CAB027387
CAB058698
CAB068227
CAB068228
HPA007973
MIMi114210 gene
neXtProtiNX_P26447
OpenTargetsiENSG00000196154
PharmGKBiPA34906
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYVZ Eukaryota
ENOG4111DV3 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP26447
OMAiCVAMMCN
OrthoDBiEOG091G10JX
PhylomeDBiP26447
TreeFamiTF332727

Enzyme and pathway databases

SIGNORiP26447

Miscellaneous databases

ChiTaRSiS100A4 human
EvolutionaryTraceiP26447
GeneWikiiS100A4
GenomeRNAii6275
PROiPR:P26447
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196154 Expressed in 222 organ(s), highest expression level in synovial joint
CleanExiHS_S100A4
GenevisibleiP26447 HS

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS10A4_HUMAN
AccessioniPrimary (citable) accession number: P26447
Secondary accession number(s): A8K7R8, D3DV46, Q6ICP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: November 7, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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