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Protein

Ciliary neurotrophic factor

Gene

CNTF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: ProtInc
  • cytokine activity Source: GO_Central
  • growth factor activity Source: BHF-UCL
  • interleukin-6 receptor binding Source: BHF-UCL
  • protein-containing complex binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6788467 IL-6-type cytokine receptor ligand interactions
SignaLinkiP26441
SIGNORiP26441

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:CNTF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000242689.2
HGNCiHGNC:2169 CNTF
MIMi118945 gene
neXtProtiNX_P26441

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1270
OpenTargetsiENSG00000242689
PharmGKBiPA26683

Polymorphism and mutation databases

BioMutaiCNTF

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495191 – 200Ciliary neurotrophic factorAdd BLAST200

Proteomic databases

PaxDbiP26441
PeptideAtlasiP26441
PRIDEiP26441
ProteomicsDBi54349

PTM databases

PhosphoSitePlusiP26441

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiENSG00000242689
CleanExiHS_CNTF
GenevisibleiP26441 HS

Organism-specific databases

HPAiHPA019654

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • ciliary neurotrophic factor receptor binding Source: ProtInc
  • cytokine activity Source: GO_Central
  • growth factor activity Source: BHF-UCL
  • interleukin-6 receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107670, 16 interactors
CORUMiP26441
DIPiDIP-5776N
IntActiP26441, 17 interactors
MINTiP26441
STRINGi9606.ENSP00000355370

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 41Combined sources29
Helixi69 – 95Combined sources27
Turni96 – 98Combined sources3
Beta strandi99 – 101Combined sources3
Helixi104 – 129Combined sources26
Beta strandi138 – 140Combined sources3
Helixi152 – 180Combined sources29

3D structure databases

ProteinModelPortaliP26441
SMRiP26441
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26441

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiENOG410IGEN Eukaryota
ENOG410YYIH LUCA
GeneTreeiENSGT00420000029890
HOGENOMiHOG000059605
HOVERGENiHBG005362
InParanoidiP26441
KOiK05420
OMAiKLWGLKV
OrthoDBiEOG091G0R1O
PhylomeDBiP26441
TreeFamiTF336237

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000151 Ciliary_neurotrophic_fac_CNTF
PANTHERiPTHR15196 PTHR15196, 1 hit
PfamiView protein in Pfam
PF01110 CNTF, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

P26441-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL
60 70 80 90 100
DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP
110 120 130 140 150
TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG
160 170 180 190 200
LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM
Length:200
Mass (Da):22,931
Last modified:August 1, 1992 - v1
Checksum:iEDD9D895BDA6F35A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03377749N → S. Corresponds to variant dbSNP:rs17152779Ensembl.1
Natural variantiVAR_013924182H → R1 PublicationCorresponds to variant dbSNP:rs6266Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60542 Genomic DNA Translation: CAA43032.1
X60477, X60478 Genomic DNA Translation: CAA43009.1
X55889, X55890 Genomic DNA Translation: CAA39374.1
AK314118 mRNA Translation: BAG36809.1
CH471076 Genomic DNA Translation: EAW73819.1
BC068030 mRNA Translation: AAH68030.1
BC074963 mRNA Translation: AAH74963.1
BC074964 mRNA Translation: AAH74964.1
CCDSiCCDS31554.1
PIRiJH0455 UNHUCF
RefSeqiNP_000605.1, NM_000614.3
UniGeneiHs.524920

Genome annotation databases

EnsembliENST00000361987; ENSP00000355370; ENSG00000242689
GeneIDi1270
KEGGihsa:1270
UCSCiuc001nna.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNTF_HUMAN
AccessioniPrimary (citable) accession number: P26441
Secondary accession number(s): B2RAB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: July 18, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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