HSD3B2

Functionⁱ

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta₅-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Catalytic activityⁱ

A 3-beta-hydroxy-Delta₅-steroid + NAD⁺ = a 3-oxo-Delta₅-steroid + NADH.

A 3-oxo-Delta₅-steroid = a 3-oxo-Delta₄-steroid.

Pathwayⁱ: steroid biosynthesis

This protein is involved in the pathway steroid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway steroid biosynthesis and in Lipid metabolism.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	154	Proton acceptorBy similarity		1
Binding siteⁱ	158	NADBy similarity		1

GO - Molecular functionⁱ

3-beta-hydroxy-delta5-steroid dehydrogenase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1944309
cholesterol dehydrogenase activity Source: UniProtKB-EC
steroid delta-isomerase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1944309

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

androgen biosynthetic process Source: Reactome
glucocorticoid biosynthetic process Source: Reactome
mineralocorticoid biosynthetic process Source: Reactome
steroid biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 1944309

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Isomerase, Multifunctional enzyme, Oxidoreductase
Biological process	Steroidogenesis
Ligand	NAD

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS10943-MONOMER
BRENDAⁱ	1.1.1.145 2681 5.3.3.1 2681
Reactomeⁱ	R-HSA-193048 Androgen biosynthesis R-HSA-193993 Mineralocorticoid biosynthesis R-HSA-194002 Glucocorticoid biosynthesis
SIGNORⁱ	P26439
UniPathwayⁱ	UPA00062

Chemistry databases

SwissLipidsⁱ	SLP:000001296

SwissLipidsⁱ

SLP:000001296

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 Alternative name(s): 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II Short name: 3-beta-HSD II 3-beta-HSD adrenal and gonadal type Including the following 2 domains: 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145) Alternative name(s): 3-beta-hydroxy-5-ene steroid dehydrogenase Progesterone reductase Steroid Delta-isomerase (EC:5.3.3.1) Alternative name(s): Delta-5-3-ketosteroid isomerase
Gene namesⁱ	Name:HSD3B2 Synonyms:HSDB3B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000203859.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5218 HSD3B2
MIMⁱ	613890 gene
neXtProtⁱ	NX_P26439

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	287 – 307	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Mitochondrion

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Adrenal hyperplasia 2 (AH2)17 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: 'salt wasting' (SW, the most severe type), 'simple virilizing' (SV, less severely affected patients), with normal aldosterone biosynthesis, 'non-classic form' or late-onset (NC or LOAH) and 'cryptic' (asymptomatic). In AH2, virilization is much less marked or does not occur. AH2 is frequently lethal in early life.

Keywords - Diseaseⁱ

Congenital adrenal hyperplasia, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3284
MalaCards human disease database More...MalaCardsⁱ	HSD3B2
MIMⁱ	201810 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000203859
Orphanetⁱ	90791 Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency 3185 Polycystic ovary syndrome
PharmGKBⁱ	PA29487

Chemistry databases

ChEMBLⁱ	CHEMBL3670
Drug and drug target database More...DrugBankⁱ	DB01285 Corticotropin DB00603 Medroxyprogesterone acetate DB00157 NADH DB01108 Trilostane

Polymorphism and mutation databases

BioMutaⁱ	HSD3B2
DMDMⁱ	112770

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000087775	1 – 372	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2Add BLAST		372

Proteomic databases

EPDⁱ	P26439
PaxDbⁱ	P26439
PeptideAtlas More...PeptideAtlasⁱ	P26439
PRIDEⁱ	P26439
ProteomicsDBⁱ	54346 54347 [P26439-2]

PTM databases

iPTMnetⁱ	P26439
PhosphoSitePlusⁱ	P26439

Expressionⁱ

Tissue specificityⁱ

Expressed in adrenal gland, testis and ovary.

Gene expression databases

Bgeeⁱ	ENSG00000203859 Expressed in 93 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_HSD3B2
ExpressionAtlasⁱ	P26439 baseline and differential
Genevisibleⁱ	P26439 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA043261 HPA043264 HPA044028

HPAⁱ

HPA043261
HPA043264
HPA044028

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109517, 22 interactors
CORUMⁱ	P26439
STRINGⁱ	9606.ENSP00000358424

Chemistry databases

BindingDBⁱ

P26439

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P26439
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 3-beta-HSD family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1430 Eukaryota COG0451 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074557
HOVERGENⁱ	HBG000014
KEGG Orthology (KO) More...KOⁱ	K00070
OMAⁱ	YSYQPPF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09QZ
PhylomeDBⁱ	P26439
TreeFamⁱ	TF343138

Family and domain databases

InterProⁱ	View protein in InterPro IPR002225 3Beta_OHSteriod_DH/Estase IPR036291 NAD(P)-bd_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01073 3Beta_HSD, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P26439-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWSCLVTGA GGLLGQRIVR LLVEEKELKE IRALDKAFRP ELREEFSKLQ 
        60         70         80         90        100
NRTKLTVLEG DILDEPFLKR ACQDVSVVIH TACIIDVFGV THRESIMNVN 
       110        120        130        140        150
VKGTQLLLEA CVQASVPVFI YTSSIEVAGP NSYKEIIQNG HEEEPLENTW 
       160        170        180        190        200
PTPYPYSKKL AEKAVLAANG WNLKNGDTLY TCALRPTYIY GEGGPFLSAS 
       210        220        230        240        250
INEALNNNGI LSSVGKFSTV NPVYVGNVAW AHILALRALR DPKKAPSVRG 
       260        270        280        290        300
QFYYISDDTP HQSYDNLNYI LSKEFGLRLD SRWSLPLTLM YWIGFLLEVV 
       310        320        330        340        350
SFLLSPIYSY QPPFNRHTVT LSNSVFTFSY KKAQRDLAYK PLYSWEEAKQ 
       360        370 
KTVEWVGSLV DRHKETLKSK TQ

Length:372

Mass (Da):42,052

Last modified:January 23, 2007 - v2

Checksum:ⁱ8E0D933488988451

GO

Isoform 2 (identifier: P26439-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
103-222: GTQLLLEACV...SVGKFSTVNP → ELQNKIKLTV...FIDEKTRTEQ
223-372: Missing.

« Hide

        10         20         30         40         50
MGWSCLVTGA GGLLGQRIVR LLVEEKELKE IRALDKAFRP ELREEFSKLQ 
        60         70         80         90        100
NRTKLTVLEG DILDEPFLKR ACQDVSVVIH TACIIDVFGV THRESIMNVN 
       110        120        130        140        150
VKELQNKIKL TVLEGDILDE PFLKRACQDV SVVIHTACII DVFGVTHRQS 
       160        170        180        190        200
IMNVNVKGRV AWGGDKARWG NEDQKEGQEG KRSLSIEHLL CSGPSDFADH 
       210        220 
YQLGELKAAI FSFIDEKTRT EQ

Show »

Length:222

Mass (Da):24,987

Checksum:ⁱ48A60A9900F0C500

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q5QP01	Q5QP01_HUMAN		3 beta-hydroxysteroid dehydrogenase... 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2	HSD3B2	195	Annotation score:

Sequence cautionⁱ

The sequence AAC60600 differs from that shown. Reason: Frameshift at position 186. The frameshift is caused by a single nucleotide insertion which is found in AH2.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	52 – 53	RT → KI in AAD14329 (PubMed:7588414).Curated	2
Sequence conflictⁱ	92 – 94	HRE → RRQ in AAD14329 (PubMed:7588414).Curated	3
Sequence conflictⁱ	232	H → L in BAD96717 (Ref. 4) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_010517	10	A → E in AH2; activity abolished. 2 PublicationsCorresponds to variant dbSNP:rs28934880EnsemblClinVar.	1
Natural variantⁱVAR_010518	10	A → V in AH2; nonsalt-wasting form. 1 Publication	1
Natural variantⁱVAR_010519	15	G → D in AH2; activity abolished. 2 Publications	1
Natural variantⁱVAR_048099	74	D → N. Corresponds to variant dbSNP:rs4986954Ensembl.	1
Natural variantⁱVAR_070028	82	A → P in AH2. 1 Publication	1
Natural variantⁱVAR_010520	82	A → T in AH2. 2 PublicationsCorresponds to variant dbSNP:rs757033996Ensembl.	1
Natural variantⁱVAR_014818	94	E → Q1 PublicationCorresponds to variant dbSNP:rs6211Ensembl.	1
Natural variantⁱVAR_010521	100	N → S in AH2; nonsalt-wasting form. 2 PublicationsCorresponds to variant dbSNP:rs1388517943Ensembl.	1
Natural variantⁱVAR_010522	108	L → W in AH2; activity abolished. 2 Publications	1
Natural variantⁱVAR_010523	129	G → R in AH2; nonsalt-wasting form. 3 PublicationsCorresponds to variant dbSNP:rs587628683Ensembl.	1
Natural variantⁱVAR_000006	142	E → K in AH2; activity abolished. 3 PublicationsCorresponds to variant dbSNP:rs80358219EnsemblClinVar.	1
Natural variantⁱVAR_010524	155	P → L in AH2; nonsalt-wasting form. 1 PublicationCorresponds to variant dbSNP:rs779418168Ensembl.	1
Natural variantⁱVAR_010525	167	A → V in AH2; late onset; almost normal activity. 1 PublicationCorresponds to variant dbSNP:rs35486059Ensembl.	1
Natural variantⁱVAR_010526	173	L → R in AH2; nonsalt-wasting form. 2 PublicationsCorresponds to variant dbSNP:rs762479018Ensembl.	1
Natural variantⁱVAR_010527	186	P → L in AH2; activity abolished. 2 Publications	1
Natural variantⁱVAR_000007	205	L → P in AH2. 2 Publications	1
Natural variantⁱVAR_010528	213	S → G in AH2; late onset; partial loss of activity. 1 PublicationCorresponds to variant dbSNP:rs759422374Ensembl.	1
Natural variantⁱVAR_010529	216	K → E in AH2; late onset; partial loss of activity. 1 Publication	1
Natural variantⁱVAR_010530	222	P → H in AH2; nonsalt-wasting form; activity abolished. 1 Publication	1
Natural variantⁱVAR_010531	222	P → Q in AH2; activity abolished. 2 PublicationsCorresponds to variant dbSNP:rs765547422Ensembl.	1
Natural variantⁱVAR_015411	222	P → T in AH2. 1 PublicationCorresponds to variant dbSNP:rs80358220EnsemblClinVar.	1
Natural variantⁱVAR_010532	231 – 238	Missing in AH2; activity abolished.	8
Natural variantⁱVAR_010533	236	L → S in AH2; mild; 100% of activity. 2 PublicationsCorresponds to variant dbSNP:rs35887327EnsemblClinVar.	1
Natural variantⁱVAR_000008	245	A → P in AH2; loss of 88% of activity. 2 Publications	1
Natural variantⁱVAR_000009	253	Y → N in AH2; activity abolished. 2 PublicationsCorresponds to variant dbSNP:rs1399005702Ensembl.	1
Natural variantⁱVAR_000010	254	Y → D in AH2; activity abolished. 2 PublicationsCorresponds to variant dbSNP:rs1411029929Ensembl.	1
Natural variantⁱVAR_010534	259	T → M in AH2; activity abolished. 2 PublicationsCorresponds to variant dbSNP:rs80358221EnsemblClinVar.	1
Natural variantⁱVAR_000011	259	T → R in AH2; activity abolished. 2 Publications	1
Natural variantⁱVAR_010535	294	G → V in AH2; nonsalt-wasting form; activity abolished. 1 Publication	1
Natural variantⁱVAR_065665	341	P → L in AH2; strongly reduced activity. 1 PublicationCorresponds to variant dbSNP:rs121964897EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_037399	103 – 222	GTQLL…STVNP → ELQNKIKLTVLEGDILDEPF LKRACQDVSVVIHTACIIDV FGVTHRQSIMNVNVKGRVAW GGDKARWGNEDQKEGQEGKR SLSIEHLLCSGPSDFADHYQ LGELKAAIFSFIDEKTRTEQ in isoform 2. 1 PublicationAdd BLAST		120
Alternative sequenceⁱVSP_037400	223 – 372	Missing in isoform 2. 1 PublicationAdd BLAST		150

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M77144 Genomic DNA Translation: AAA36014.1 M67466 mRNA Translation: AAA36016.1 CR627415 mRNA Translation: CAH10504.1 AK222997 mRNA Translation: BAD96717.1 AL359553 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56700.1 BC038419 mRNA Translation: AAH38419.1 BC131488 mRNA Translation: AAI31489.1 S80140 Genomic DNA Translation: AAD14329.1 S60309 Genomic DNA Translation: AAC60599.1 S60310 Genomic DNA Translation: AAC60600.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS902.1 [P26439-1]
PIRⁱ	A39488 DEHUH2
NCBI Reference Sequences More...RefSeqⁱ	NP_000189.1, NM_000198.3 [P26439-1] NP_001159592.1, NM_001166120.1 [P26439-1]
UniGeneⁱ	Hs.654399

Genome annotation databases

Ensemblⁱ	ENST00000369416; ENSP00000358424; ENSG00000203859 [P26439-1] ENST00000543831; ENSP00000445122; ENSG00000203859 [P26439-1]
GeneIDⁱ	3284
KEGGⁱ	hsa:3284
UCSC genome browser More...UCSCⁱ	uc001eht.4 human [P26439-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P26439	Hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 2, isoform CRA_a		HUMAN		372	UniRef100_P26439
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (Fragment)		HUMAN		195
Truncated HSD3B2		HUMAN		229

Protein	Similar proteins		Species	Score	Length	Source
P26439	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1		HUMAN		373	UniRef90_P26439
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1		MACMU		373
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1		CHLSB		375
Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1		PONAB		375
Uncharacterized protein		MACNE		373
+40

Protein	Similar proteins		Species	Score	Length	Source
P26439	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1		RAT		373	UniRef50_P22071
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2		MESAU		373
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase		PIG		373
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 3		MOUSE		373
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase		HORSE		373
+286
P26439-2	Uncharacterized protein (Fragment)		MACMU		223	UniRef50_P26439-2
Uncharacterized protein (Fragment)		MACFA		223

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M77144 Genomic DNA Translation: AAA36014.1 M67466 mRNA Translation: AAA36016.1 CR627415 mRNA Translation: CAH10504.1 AK222997 mRNA Translation: BAD96717.1 AL359553 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56700.1 BC038419 mRNA Translation: AAH38419.1 BC131488 mRNA Translation: AAI31489.1 S80140 Genomic DNA Translation: AAD14329.1 S60309 Genomic DNA Translation: AAC60599.1 S60310 Genomic DNA Translation: AAC60600.1 Frameshift.
CCDSⁱ	CCDS902.1 [P26439-1]
PIRⁱ	A39488 DEHUH2
RefSeqⁱ	NP_000189.1, NM_000198.3 [P26439-1] NP_001159592.1, NM_001166120.1 [P26439-1]
UniGeneⁱ	Hs.654399

3D structure databases

ProteinModelPortalⁱ	P26439
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109517, 22 interactors
CORUMⁱ	P26439
STRINGⁱ	9606.ENSP00000358424

Chemistry databases

BindingDBⁱ	P26439
ChEMBLⁱ	CHEMBL3670
DrugBankⁱ	DB01285 Corticotropin DB00603 Medroxyprogesterone acetate DB00157 NADH DB01108 Trilostane
SwissLipidsⁱ	SLP:000001296

PTM databases

iPTMnetⁱ	P26439
PhosphoSitePlusⁱ	P26439

Polymorphism and mutation databases

BioMutaⁱ	HSD3B2
DMDMⁱ	112770

Proteomic databases

EPDⁱ	P26439
PaxDbⁱ	P26439
PeptideAtlasⁱ	P26439
PRIDEⁱ	P26439
ProteomicsDBⁱ	54346 54347 [P26439-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3284
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369416; ENSP00000358424; ENSG00000203859 [P26439-1] ENST00000543831; ENSP00000445122; ENSG00000203859 [P26439-1]
GeneIDⁱ	3284
KEGGⁱ	hsa:3284
UCSCⁱ	uc001eht.4 human [P26439-1]

Organism-specific databases

CTDⁱ	3284
DisGeNETⁱ	3284
EuPathDBⁱ	HostDB:ENSG00000203859.9
GeneCardsⁱ	HSD3B2
HGNCⁱ	HGNC:5218 HSD3B2
HPAⁱ	HPA043261 HPA043264 HPA044028
MalaCardsⁱ	HSD3B2
MIMⁱ	201810 phenotype 613890 gene
neXtProtⁱ	NX_P26439
OpenTargetsⁱ	ENSG00000203859
Orphanetⁱ	90791 Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency 3185 Polycystic ovary syndrome
PharmGKBⁱ	PA29487
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1430 Eukaryota COG0451 LUCA
GeneTreeⁱ	ENSGT00550000074557
HOVERGENⁱ	HBG000014
KOⁱ	K00070
OMAⁱ	YSYQPPF
OrthoDBⁱ	EOG091G09QZ
PhylomeDBⁱ	P26439
TreeFamⁱ	TF343138

Enzyme and pathway databases

UniPathwayⁱ	UPA00062
BioCycⁱ	MetaCyc:HS10943-MONOMER
BRENDAⁱ	1.1.1.145 2681 5.3.3.1 2681
Reactomeⁱ	R-HSA-193048 Androgen biosynthesis R-HSA-193993 Mineralocorticoid biosynthesis R-HSA-194002 Glucocorticoid biosynthesis
SIGNORⁱ	P26439

Miscellaneous databases

ChiTaRSⁱ	HSD3B2 human
GeneWikiⁱ	HSD3B2
GenomeRNAiⁱ	3284
Protein Ontology More...PROⁱ	PR:P26439
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000203859 Expressed in 93 organ(s), highest expression level in adrenal gland
CleanExⁱ	HS_HSD3B2
ExpressionAtlasⁱ	P26439 baseline and differential
Genevisibleⁱ	P26439 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002225 3Beta_OHSteriod_DH/Estase IPR036291 NAD(P)-bd_dom_sf
Pfamⁱ	View protein in Pfam PF01073 3Beta_HSD, 1 hit
SUPFAMⁱ	SSF51735 SSF51735, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	3BHS2_HUMAN
Accessionⁱ	P26439Primary (citable) accession number: P26439 Secondary accession number(s): A2RRA5 Q9UD08
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	October 10, 2018
	This is version 193 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PATHWAY comments
Index of metabolic and biosynthesis pathways
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P26439 (3BHS2_HUMAN)

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3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: steroid biosynthesis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Endoplasmic reticulum

Endoplasmic reticulum

Mitochondrion

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Pathwayⁱ: steroid biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ