UniProtKB - P26435 (NTCP_RAT)
Protein
Sodium/bile acid cotransporter
Gene
Slc10a1
Organism
Rattus norvegicus (Rat)
Status
Functioni
The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.
GO - Molecular functioni
- bile acid:sodium symporter activity Source: RGD
- bile acid transmembrane transporter activity Source: RGD
GO - Biological processi
- bile acid and bile salt transport Source: RGD
- bile acid signaling pathway Source: RGD
- cellular response to drug Source: RGD
- regulation of bile acid secretion Source: RGD
- regulation of gene expression Source: RGD
- response to 17alpha-ethynylestradiol Source: RGD
- response to ethanol Source: RGD
- response to nutrient levels Source: RGD
- response to organic cyclic compound Source: RGD
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
Reactomei | R-RNO-159418, Recycling of bile acids and salts |
Protein family/group databases
TCDBi | 2.A.28.1.1, the bile acid:na(+) symporter (bass) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/bile acid cotransporterAlternative name(s): Na(+)/bile acid cotransporter Na(+)/taurocholate transport protein Sodium/taurocholate cotransporting polypeptide Solute carrier family 10 member 1 |
Gene namesi | Name:Slc10a1 Synonyms:Ntcp |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3681, Slc10a1 |
Subcellular locationi
Other locations
Plasma Membrane
- basolateral plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 24 – 45 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 82 – 98 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 158 – 178 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 190 – 211 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 228 – 244 | HelicalSequence analysisAdd BLAST | 17 | |
Transmembranei | 285 – 306 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052337 | 1 – 362 | Sodium/bile acid cotransporterAdd BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 5 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 117 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 271 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 330 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P26435 |
PRIDEi | P26435 |
PTM databases
GlyGeni | P26435, 5 sites |
iPTMneti | P26435 |
PhosphoSitePlusi | P26435 |
Expressioni
Tissue specificityi
Liver and kidney.
Gene expression databases
Bgeei | ENSRNOG00000005794, Expressed in liver and 19 other tissues |
Genevisiblei | P26435, RN |
Interactioni
Protein-protein interaction databases
IntActi | P26435, 2 interactors |
STRINGi | 10116.ENSRNOP00000007825 |
Chemistry databases
BindingDBi | P26435 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | P26435 |
OMAi | KSIMFVM |
OrthoDBi | 1148347at2759 |
PhylomeDBi | P26435 |
TreeFami | TF315811 |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030208, SLC10A1 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF40, PTHR10361:SF40, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
i Sequence
Sequence statusi: Complete.
P26435-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVHNVSAPF NFSLPPGFGH RATDKALSII LVLMLLLIML SLGCTMEFSK
60 70 80 90 100
IKAHLWKPKG VIVALVAQFG IMPLAAFLLG KIFHLSNIEA LAILICGCSP
110 120 130 140 150
GGNLSNLFTL AMKGDMNLSI VMTTCSSFSA LGMMPLLLYV YSKGIYDGDL
160 170 180 190 200
KDKVPYKGIM ISLVIVLIPC TIGIVLKSKR PHYVPYILKG GMIITFLLSV
210 220 230 240 250
AVTALSVINV GNSIMFVMTP HLLATSSLMP FSGFLMGYIL SALFQLNPSC
260 270 280 290 300
RRTISMETGF QNIQLCSTIL NVTFPPEVIG PLFFFPLLYM IFQLAEGLLI
310 320 330 340 350
IIIFRCYEKI KPPKDQTKIT YKAAATEDAT PAALEKGTHN GNIPPLQPGP
360
SPNGLNSGQM AN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77479 mRNA Translation: AAA42112.1 BC091152 mRNA Translation: AAH91152.1 |
PIRi | A41601 |
RefSeqi | NP_058743.1, NM_017047.1 |
Genome annotation databases
Ensembli | ENSRNOT00000007825; ENSRNOP00000007825; ENSRNOG00000005794 |
GeneIDi | 24777 |
KEGGi | rno:24777 |
UCSCi | RGD:3681, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77479 mRNA Translation: AAA42112.1 BC091152 mRNA Translation: AAH91152.1 |
PIRi | A41601 |
RefSeqi | NP_058743.1, NM_017047.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | P26435, 2 interactors |
STRINGi | 10116.ENSRNOP00000007825 |
Chemistry databases
BindingDBi | P26435 |
ChEMBLi | CHEMBL4847 |
Protein family/group databases
TCDBi | 2.A.28.1.1, the bile acid:na(+) symporter (bass) family |
PTM databases
GlyGeni | P26435, 5 sites |
iPTMneti | P26435 |
PhosphoSitePlusi | P26435 |
Proteomic databases
PaxDbi | P26435 |
PRIDEi | P26435 |
Genome annotation databases
Ensembli | ENSRNOT00000007825; ENSRNOP00000007825; ENSRNOG00000005794 |
GeneIDi | 24777 |
KEGGi | rno:24777 |
UCSCi | RGD:3681, rat |
Organism-specific databases
CTDi | 6554 |
RGDi | 3681, Slc10a1 |
Phylogenomic databases
eggNOGi | KOG2718, Eukaryota |
GeneTreei | ENSGT00950000182808 |
HOGENOMi | CLU_034788_7_5_1 |
InParanoidi | P26435 |
OMAi | KSIMFVM |
OrthoDBi | 1148347at2759 |
PhylomeDBi | P26435 |
TreeFami | TF315811 |
Enzyme and pathway databases
Reactomei | R-RNO-159418, Recycling of bile acids and salts |
Miscellaneous databases
PROi | PR:P26435 |
Gene expression databases
Bgeei | ENSRNOG00000005794, Expressed in liver and 19 other tissues |
Genevisiblei | P26435, RN |
Family and domain databases
Gene3Di | 1.20.1530.20, 1 hit |
InterProi | View protein in InterPro IPR002657, BilAc:Na_symport/Acr3 IPR004710, Bilac:Na_transpt IPR038770, Na+/solute_symporter_sf IPR030208, SLC10A1 |
PANTHERi | PTHR10361, PTHR10361, 1 hit PTHR10361:SF40, PTHR10361:SF40, 1 hit |
Pfami | View protein in Pfam PF01758, SBF, 1 hit |
TIGRFAMsi | TIGR00841, bass, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NTCP_RAT | |
Accessioni | P26435Primary (citable) accession number: P26435 Secondary accession number(s): Q5BK99 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families