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Entry version 154 (29 Sep 2021)
Sequence version 1 (01 Aug 1992)
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Protein

Sodium/hydrogen exchanger 3

Gene

Slc9a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

By similarity

Caution

The number, localization and denomination of hydrophobic domains in the Na+/H+ exchangers vary among authors.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-425986, Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.2, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 3
Alternative name(s):
Na(+)/H(+) exchanger 3
Short name:
NHE-3
Solute carrier family 9 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc9a3
Synonyms:Nhe3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
3720, Slc9a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei12 – 25Name=A/M1Sequence analysisAdd BLAST14
Topological domaini26 – 51CytoplasmicSequence analysisAdd BLAST26
Intramembranei52 – 70Name=B/M2Sequence analysisAdd BLAST19
Topological domaini71 – 76CytoplasmicSequence analysis6
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei77 – 96Helical; Name=C/M3Sequence analysisAdd BLAST20
Topological domaini97 – 109ExtracellularSequence analysisAdd BLAST13
Transmembranei110 – 130Helical; Name=D/M4Sequence analysisAdd BLAST21
Topological domaini131 – 136CytoplasmicSequence analysis6
Transmembranei137 – 157Helical; Name=E/M5Sequence analysisAdd BLAST21
Topological domaini158 – 177ExtracellularSequence analysisAdd BLAST20
Transmembranei178 – 199Helical; Name=F/M5ASequence analysisAdd BLAST22
Topological domaini200 – 207CytoplasmicSequence analysis8
Transmembranei208 – 229Helical; Name=G/M5BSequence analysisAdd BLAST22
Topological domaini230 – 249ExtracellularSequence analysisAdd BLAST20
Transmembranei250 – 271Helical; Name=H/M6Sequence analysisAdd BLAST22
Topological domaini272 – 287CytoplasmicSequence analysisAdd BLAST16
Transmembranei288 – 306Helical; Name=I/M7Sequence analysisAdd BLAST19
Topological domaini307 – 337ExtracellularSequence analysisAdd BLAST31
Transmembranei338 – 359Helical; Name=J/M8Sequence analysisAdd BLAST22
Topological domaini360 – 366CytoplasmicSequence analysis7
Transmembranei367 – 387Helical; Name=K/M9Sequence analysisAdd BLAST21
Topological domaini388 – 402ExtracellularSequence analysisAdd BLAST15
Intramembranei403 – 423Name=LSequence analysisAdd BLAST21
Topological domaini424 – 432ExtracellularSequence analysis9
Transmembranei433 – 453Helical; Name=M/M10Sequence analysisAdd BLAST21
Topological domaini454 – 831CytoplasmicSequence analysisAdd BLAST378

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879842

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
950

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523581 – 831Sodium/hydrogen exchanger 3Add BLAST831

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei552PhosphoserineCombined sources1 Publication1
Modified residuei560PhosphoserineCombined sources1
Modified residuei590PhosphoserineBy similarity1
Modified residuei605Phosphoserine1 Publication1
Modified residuei661Phosphoserine; by SGK1By similarity1
Modified residuei807PhosphoserineCombined sources1
Modified residuei810PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PKA, which inhibits activity (PubMed:9933588). Phosphorylation at Ser-661 by SGK1 is associated with increased abundance at the cell membrane (By similarity).By similarity1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26433

PRoteomics IDEntifications database

More...
PRIDEi
P26433

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P26433, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26433

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26433

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Most abundant in colon and small intestine, followed by kidney and stomach. In kidney, expressed in proximal tubules and outer medulla (at protein level) (PubMed:20584908).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds SLC9A3R1 and SLC9A3R2.

Interacts with PDZD3 and interactions decrease in response to elevated calcium ion levels.

Interacts with PDZK1 (via C-terminal PDZ domain) (By similarity).

Interacts with CHP1, CHP2 and SHANK2 (PubMed:12576672, PubMed:16293618).

Interacts with AHCYL1; the interaction is required for SLC9A3 activity (PubMed:20584908).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
246908, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P26433, 5 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000020711

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P26433

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26433

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni588 – 665Interaction with PDZD3By similarityAdd BLAST78
Regioni808 – 831DisorderedSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26433

Database of Orthologous Groups

More...
OrthoDBi
389547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26433

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR018410, Na/H_exchanger_3/5
IPR004709, NaH_exchanger

The PANTHER Classification System

More...
PANTHERi
PTHR10110, PTHR10110, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084, NAHEXCHNGR
PR01087, NAHEXCHNGR3

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P26433-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWHPALGPGW KPLLALAVAV TSLRGVRGIE EEPNSGGSFQ IVTFKWHHVQ
60 70 80 90 100
DPYIIALWIL VASLAKIVFH LSHKVTSVVP ESALLIVLGL VLGGIVWAAD
110 120 130 140 150
HIASFTLTPT LFFFYLLPPI VLDAGYFMPN RLFFGNLGTI LLYAVIGTIW
160 170 180 190 200
NAATTGLSLY GVFLSGLMGE LKIGLLDFLL FGSLIAAVDP VAVLAVFEEV
210 220 230 240 250
HVNEVLFIIV FGESLLNDAV TVVLYNVFES FVTLGGDAVT GVDCVKGIVS
260 270 280 290 300
FFVVSLGGTL VGVIFAFLLS LVTRFTKHVR IIEPGFVFVI SYLSYLTSEM
310 320 330 340 350
LSLSAILAIT FCGICCQKYV KANISEQSAT TVRYTMKMLA SGAETIIFMF
360 370 380 390 400
LGISAVDPVI WTWNTAFVLL TLVFISVYRA IGVVLQTWIL NRYRMVQLET
410 420 430 440 450
IDQVVMSYGG LRGAVAYALV VLLDEKKVKE KNLFVSTTLI VVFFTVIFQG
460 470 480 490 500
LTIKPLVQWL KVKRSEQREP KLNEKLHGRA FDHILSAIED ISGQIGHNYL
510 520 530 540 550
RDKWSNFDRK FLSKVLMRRS AQKSRDRILN VFHELNLKDA ISYVAEGERR
560 570 580 590 600
GSLAFIRSPS TDNMVNVDFS TPRPSTVEAS VSYFLRENVS AVCLDMQSLE
610 620 630 640 650
QRRRSIRDTE DMVTHHTLQQ YLYKPRQEYK HLYSRHELTP NEDEKQDKEI
660 670 680 690 700
FHRTMRKRLE SFKSAKLGIN QNKKAAKLYK RERAQKRRNS SIPNGKLPME
710 720 730 740 750
NLAHNFTIKE KDLELSEPEE ATNYEEISGG IEFLASVTKD VASDSGAGID
760 770 780 790 800
NPVFSPDEDL DPSILSRVPP WLSPGETVVP SQRARVQIPN SPSNFRRLTP
810 820 830
FRLSNKSVDS FLQADGPEEQ LQPASPESTH M
Length:831
Mass (Da):93,105
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i77A4BF10DFF99E3F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7Y7G3V7Y7_RAT
Sodium/hydrogen exchanger
Slc9a3 rCG_42024
831Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M85300 mRNA Translation: AAA41702.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B40204

NCBI Reference Sequences

More...
RefSeqi
NP_036786.1, NM_012654.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24784

UCSC genome browser

More...
UCSCi
RGD:3720, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85300 mRNA Translation: AAA41702.1
PIRiB40204
RefSeqiNP_036786.1, NM_012654.1

3D structure databases

SMRiP26433
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi246908, 1 interactor
IntActiP26433, 5 interactors
STRINGi10116.ENSRNOP00000020711

Chemistry databases

BindingDBiP26433
ChEMBLiCHEMBL3879842
GuidetoPHARMACOLOGYi950

Protein family/group databases

TCDBi2.A.36.1.2, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

GlyGeniP26433, 1 site
iPTMnetiP26433
PhosphoSitePlusiP26433

Proteomic databases

PaxDbiP26433
PRIDEiP26433

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
24784

Genome annotation databases

GeneIDi24784
KEGGirno:24784
UCSCiRGD:3720, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6550
RGDi3720, Slc9a3

Phylogenomic databases

eggNOGiKOG1966, Eukaryota
InParanoidiP26433
OrthoDBi389547at2759
PhylomeDBiP26433

Enzyme and pathway databases

ReactomeiR-RNO-425986, Sodium/Proton exchangers

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P26433

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR018410, Na/H_exchanger_3/5
IPR004709, NaH_exchanger
PANTHERiPTHR10110, PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PRINTSiPR01084, NAHEXCHNGR
PR01087, NAHEXCHNGR3
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26433
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: September 29, 2021
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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