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Entry version 178 (29 Sep 2021)
Sequence version 2 (01 Oct 1996)
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Protein

Sodium/hydrogen exchanger 1

Gene

Slc9a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.

Caution

The region between transmembrane regions M4 and M5 and between M6 and M7 (also termed intracellular loops IL2 and IL4, respectively) seem to be localized at least in part in the membrane. The hydrophobic region H10 is proposed to be located within the membrane.Curated
Although PubMed:18321853 show that TESC-binding results in the maturation and accumulation of SLC9A1 at the cell surface, previous studies with human SLC9A1 report that TESC-binding results in a decrease in activity.Curated
The interacting region with TESC is conflicting: It has been reported that SLC9A1 interacts with TESC via the juxtamembrane region of the cytoplasmic C-terminal domain, including residues 505-571 (PubMed:18321853). However, studies with human SLC9A1 report the interaction with TESC via residues 503-545 or via residues 633-815.Curated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei165Channel pore-liningBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding
Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2160916, Hyaluronan uptake and degradation
R-RNO-425986, Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.1.1, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 1
Alternative name(s):
Na(+)/H(+) exchanger 1
Short name:
NHE-1
Solute carrier family 9 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc9a1
Synonyms:Nhe1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
3718, Slc9a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33Helical; Name=M1Sequence analysisAdd BLAST21
Topological domaini34 – 105ExtracellularSequence analysisAdd BLAST72
Transmembranei106 – 131Helical; Name=M2Sequence analysisAdd BLAST26
Topological domaini132 – 133CytoplasmicSequence analysis2
Transmembranei134 – 153Helical; Name=M3Sequence analysisAdd BLAST20
Topological domaini154 – 158ExtracellularSequence analysis5
Transmembranei159 – 178Helical; Name=M4Sequence analysisAdd BLAST20
Topological domaini179 – 195CytoplasmicSequence analysisAdd BLAST17
Transmembranei196 – 215Helical; Name=M5Sequence analysisAdd BLAST20
Topological domaini216 – 231ExtracellularSequence analysisAdd BLAST16
Transmembranei232 – 251Helical; Name=M6Sequence analysisAdd BLAST20
Topological domaini252 – 260CytoplasmicSequence analysis9
Transmembranei261 – 280Helical; Name=M7Sequence analysisAdd BLAST20
Topological domaini281 – 298ExtracellularSequence analysisAdd BLAST18
Transmembranei299 – 319Helical; Name=M8Sequence analysisAdd BLAST21
Topological domaini320 – 342CytoplasmicSequence analysisAdd BLAST23
Transmembranei343 – 362Helical; Name=M9Sequence analysisAdd BLAST20
Topological domaini363 – 385ExtracellularSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei386 – 406Name=H10By similarityAdd BLAST21
Topological domaini407 – 414ExtracellularSequence analysis8
Transmembranei415 – 434Helical; Name=M10Sequence analysisAdd BLAST20
Topological domaini435 – 452CytoplasmicSequence analysisAdd BLAST18
Transmembranei453 – 474Helical; Name=M11Sequence analysisAdd BLAST22
Topological domaini475 – 483ExtracellularSequence analysis9
Transmembranei484 – 503Helical; Name=M12Sequence analysisAdd BLAST20
Topological domaini504 – 820CytoplasmicSequence analysisAdd BLAST317

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi522 – 538INEEI…LLTGI → QNEEQHTQQLDHQQTGQ: Abolishes interaction with TESC and markedly reduces transporter activity. Does not alter its cell membrane localization. 1 PublicationAdd BLAST17
Mutagenesisi530 – 535FLDHLL → AADHAA: Abolishes interaction with TESC and markedly reduces transporter activity. Does not alter its cell membrane localization. 1 Publication6
Mutagenesisi530 – 535FLDHLL → QQDHQQ: Abolishes interaction with TESC and markedly reduces transporter activity. Does not alter its cell membrane localization. 1 Publication6
Mutagenesisi530 – 535FLDHLL → RRDHRR: Abolishes interaction with TESC and markedly reduces transporter activity. Does not alter its cell membrane localization. 1 Publication6

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2577

DrugCentral

More...
DrugCentrali
P26431

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
948

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523511 – 820Sodium/hydrogen exchanger 1Add BLAST820

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei603PhosphoserineCombined sources1
Modified residuei606PhosphoserineBy similarity1
Modified residuei607PhosphothreonineBy similarity1
Modified residuei609PhosphoserineCombined sources1
Modified residuei697PhosphoserineCombined sources1
Modified residuei701PhosphoserineCombined sources1
Modified residuei707PhosphoserineCombined sources1
Modified residuei727PhosphoserineCombined sources1
Modified residuei730PhosphoserineCombined sources1
Modified residuei733PhosphoserineCombined sources1
Modified residuei755PhosphothreonineBy similarity1
Modified residuei790PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated and O-glycosylated in the N-terminal region.2 Publications
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P26431

PRoteomics IDEntifications database

More...
PRIDEi
P26431

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P26431, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26431

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26431

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Not tissue specific.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000007982, Expressed in stomach and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P26431, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomer (PubMed:21543739).

Interacts with CALM1 in a calcium-dependent manner (By similarity).

Interacts with TESC (PubMed:18321853).

Interacts (via residues 504-563; the juxtamembrane region of the cytoplasmic C-terminal domain) with CHP1 (PubMed:12576672). The interaction with CHP1 occurs at the plasma membrane in a calcium-dependent manner (By similarity).

Interacts with CHP2 (PubMed:12576672). The interaction with CHP2 occurs in a calcium-dependent manner (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
246906, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P26431, 3 interactors

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000011049

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P26431

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P26431

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P26431

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 71DisorderedSequence analysisAdd BLAST28
Regioni505 – 571Interaction with TESC1 PublicationAdd BLAST67
Regioni519 – 549Interaction with CHP2By similarityAdd BLAST31
Regioni637 – 820Interaction with CALM1By similarityAdd BLAST184
Regioni637 – 820Interaction with TESCBy similarityAdd BLAST184
Regioni747 – 820DisorderedSequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi777 – 797Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1966, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156338

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005912_4_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P26431

Identification of Orthologs from Complete Genome Data

More...
OMAi
MMRTKEP

Database of Orthologous Groups

More...
OrthoDBi
389547at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P26431

TreeFam database of animal gene trees

More...
TreeFami
TF317212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR001970, Na/H_exchanger_1
IPR004709, NaH_exchanger
IPR032103, NHE_CaM-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10110, PTHR10110, 1 hit
PTHR10110:SF59, PTHR10110:SF59, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF16644, NEXCaM_BD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01084, NAHEXCHNGR
PR01085, NAHEXCHNGR1

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P26431-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMLRWSGIWG LYPPRIFPSL LVVVALVGLL PVLRSHGLQL NPTASTIRGS
60 70 80 90 100
EPPRERSIGD VTTAPSEPLH HPDDRNLTNL YIEHGAKPVR KAFPVLDIDY
110 120 130 140 150
LHVRTPFEIS LWILLACLMK IGFHVIPTIS SIVPESCLLI VVGLLVGGLI
160 170 180 190 200
KGVGETPPFL QSDVFFLFLL PPIILDAGYF LPLRQFTENL GTILIFAVVG
210 220 230 240 250
TLWNAFFLGG LLYAVCLVGG EQINNIGLLD TLLFGSIISA VDPVAVLAVF
260 270 280 290 300
EEIHINELLH ILVFGESLLN DAVTVVLYHL FEEFASYEYV GISDIFLGFL
310 320 330 340 350
SFFVVSLGGV FVGVVYGVIA AFTSRFTSHI RVIEPLFVFL YSYMAYLSAE
360 370 380 390 400
LFHLSGIMAL IASGVVMRPY VEANISHKSH TTIKYFLKMW SSVSETLIFI
410 420 430 440 450
FLGVSTVAGS HQWNWTFVIS TLLFCLIARV LGVLVLTWFI NKFRIVKLTP
460 470 480 490 500
KDQFIIAYGG LRGAIAFSLG YLLDKKHFPM CDLFLTAIIT VIFFTVFVQG
510 520 530 540 550
MTIRPLVDLL AVKKKQETKR SINEEIHTQF LDHLLTGIED ICGHYGHHHW
560 570 580 590 600
KDKLNRFNKK YVKKCLIAGE RSKEPQLIAF YHKMEMKQAI ELVESGGMGK
610 620 630 640 650
IPSAVSTVSM QNIHPKSAAS ERILPALSKD KEEEIRKILR SNLQKTRQRL
660 670 680 690 700
RSYNRHTLVA DPYEEAWNQM LLRRQKARQL EQKITNYLTV PAHKLDSPTM
710 720 730 740 750
SRARIGSDPL AYEPKADLPV ITIDPASPQS PESVDLVNEE LKGKVLGLKR
760 770 780 790 800
GPRTTPEEEE EDEDGVIMIR SKEPSSPGTD DVFTPGPSDS PGSQRIQRCL
810 820
SDPGPHPEPG EGEPFIPKGQ
Length:820
Mass (Da):91,647
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58398DE74A9642FB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M85299 mRNA Translation: AAA98479.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40204

NCBI Reference Sequences

More...
RefSeqi
NP_036784.1, NM_012652.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000011049; ENSRNOP00000011049; ENSRNOG00000007982

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
24782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:24782

UCSC genome browser

More...
UCSCi
RGD:3718, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M85299 mRNA Translation: AAA98479.1
PIRiA40204
RefSeqiNP_036784.1, NM_012652.1

3D structure databases

BMRBiP26431
SMRiP26431
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi246906, 1 interactor
IntActiP26431, 3 interactors
STRINGi10116.ENSRNOP00000011049

Chemistry databases

BindingDBiP26431
ChEMBLiCHEMBL2577
DrugCentraliP26431
GuidetoPHARMACOLOGYi948

Protein family/group databases

TCDBi2.A.36.1.1, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

GlyGeniP26431, 1 site
iPTMnetiP26431
PhosphoSitePlusiP26431

Proteomic databases

PaxDbiP26431
PRIDEiP26431

Genome annotation databases

EnsembliENSRNOT00000011049; ENSRNOP00000011049; ENSRNOG00000007982
GeneIDi24782
KEGGirno:24782
UCSCiRGD:3718, rat

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6548
RGDi3718, Slc9a1

Phylogenomic databases

eggNOGiKOG1966, Eukaryota
GeneTreeiENSGT00940000156338
HOGENOMiCLU_005912_4_1_1
InParanoidiP26431
OMAiMMRTKEP
OrthoDBi389547at2759
PhylomeDBiP26431
TreeFamiTF317212

Enzyme and pathway databases

ReactomeiR-RNO-2160916, Hyaluronan uptake and degradation
R-RNO-425986, Sodium/Proton exchangers

Miscellaneous databases

Protein Ontology

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PROi
PR:P26431

Gene expression databases

BgeeiENSRNOG00000007982, Expressed in stomach and 21 other tissues
GenevisibleiP26431, RN

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR001970, Na/H_exchanger_1
IPR004709, NaH_exchanger
IPR032103, NHE_CaM-bd
PANTHERiPTHR10110, PTHR10110, 1 hit
PTHR10110:SF59, PTHR10110:SF59, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF16644, NEXCaM_BD, 1 hit
PRINTSiPR01084, NAHEXCHNGR
PR01085, NAHEXCHNGR1
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26431
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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