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UniProtKB - P26414 (GUNA_THEBI)
Protein
Endoglucanase A
Gene
celA
Organism
Thermobispora bispora (Microbispora bispora)
Status
Functioni
Catalytic activityi
- Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. EC:3.2.1.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 113 | PROSITE-ProRule annotation | 1 | |
Active sitei | 151 | Proton donorPROSITE-ProRule annotation | 1 | |
Active sitei | 300 | NucleophilePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cellulase activity Source: UniProtKB-EC
- polysaccharide binding Source: InterPro
GO - Biological processi
- cellulose catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation |
Protein family/group databases
CAZyi | CBM2, Carbohydrate-Binding Module Family 2 GH6, Glycoside Hydrolase Family 6 |
Names & Taxonomyi
Protein namesi | Recommended name: Endoglucanase A (EC:3.2.1.4)Alternative name(s): Cellulase A Endo-1,4-beta-glucanase A |
Gene namesi | Name:celA |
Organismi | Thermobispora bispora (Microbispora bispora) |
Taxonomic identifieri | 2006 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Streptosporangiales › Streptosporangiaceae › Thermobispora |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_0000007905 | 31 – 456 | Endoglucanase AAdd BLAST | 426 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 114 ↔ 159 | By similarity | ||
Disulfide bondi | 267 ↔ 302 | By similarity | ||
Disulfide bondi | 360 ↔ 453 | By similarity |
Keywords - PTMi
Disulfide bondFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 353 – 456 | CBM2PROSITE-ProRule annotationAdd BLAST | 104 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 322 | CatalyticAdd BLAST | 292 | |
Regioni | 255 – 280 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 321 – 358 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 323 – 355 | Linker ('hinge') (Pro-Ser box)Add BLAST | 33 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 325 – 354 | Pro residuesSequence analysisAdd BLAST | 30 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 6 (cellulase B) family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.60.40.290, 1 hit 3.20.20.40, 1 hit |
InterProi | View protein in InterPro IPR016288, Beta_cellobiohydrolase IPR036434, Beta_cellobiohydrolase_sf IPR001919, CBD2 IPR008965, CBM2/CBM3_carb-bd_dom_sf IPR012291, CBM2_carb-bd_dom_sf IPR018366, CBM2_CS IPR001524, Glyco_hydro_6_CS |
PANTHERi | PTHR34876, PTHR34876, 1 hit |
Pfami | View protein in Pfam PF00553, CBM_2, 1 hit PF01341, Glyco_hydro_6, 1 hit |
PRINTSi | PR00733, GLHYDRLASE6 |
SMARTi | View protein in SMART SM00637, CBD_II, 1 hit |
SUPFAMi | SSF49384, SSF49384, 1 hit SSF51989, SSF51989, 1 hit |
PROSITEi | View protein in PROSITE PS51173, CBM2, 1 hit PS00561, CBM2_A, 1 hit PS00655, GLYCOSYL_HYDROL_F6_1, 1 hit PS00656, GLYCOSYL_HYDROL_F6_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26414-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSRIRRFLAT ALAAATAGVG AIVTAIASAG PAHAYDSPFY VDPQSNAAKW
60 70 80 90 100
VAANPNDPRT PVIRDRIAAV PTGRWFANYN PSTVRAEVDA YVGAAAAAGK
110 120 130 140 150
IPIMVVYAMP NRDCGGPSAG GAPNHTAYRA WIDEIAAGLR NRPAVIILEP
160 170 180 190 200
DALPIMTNCM SPSEQAEVQA SAVGAGKKFK AASSQAKVYF DAGHDAWVPA
210 220 230 240 250
DEMASRLRGA DIANSADGIA LNVSNYRYTS GLISYAKSVL SAIGASHLRA
260 270 280 290 300
VIDTSRNGNG PLGSEWCDPP GRATGTWSTT DTGDPAIDAF LWIKPPGEAD
310 320 330 340 350
GCIATPGVFV PDRAYELAMN AAPPTYSPSP TPSTPSPSPS QSDPGSPSPS
360 370 380 390 400
PSQPPAGRAC EATYALVNQW PGGFQAEVTV KNTGSSPING WTVQWTLPSG
410 420 430 440 450
QSITQLWNGD LSTSGSNVTV RNVSWNGNVP AGGSTSFGFL GSGTGQLSSS
ITCSAS
Similar proteinsi
Cross-referencesi
3D structure databases
AlphaFoldDBi | P26414 |
SMRi | P26414 |
ModBasei | Search... |
Protein family/group databases
CAZyi | CBM2, Carbohydrate-Binding Module Family 2 GH6, Glycoside Hydrolase Family 6 |
Family and domain databases
Gene3Di | 2.60.40.290, 1 hit 3.20.20.40, 1 hit |
InterProi | View protein in InterPro IPR016288, Beta_cellobiohydrolase IPR036434, Beta_cellobiohydrolase_sf IPR001919, CBD2 IPR008965, CBM2/CBM3_carb-bd_dom_sf IPR012291, CBM2_carb-bd_dom_sf IPR018366, CBM2_CS IPR001524, Glyco_hydro_6_CS |
PANTHERi | PTHR34876, PTHR34876, 1 hit |
Pfami | View protein in Pfam PF00553, CBM_2, 1 hit PF01341, Glyco_hydro_6, 1 hit |
PRINTSi | PR00733, GLHYDRLASE6 |
SMARTi | View protein in SMART SM00637, CBD_II, 1 hit |
SUPFAMi | SSF49384, SSF49384, 1 hit SSF51989, SSF51989, 1 hit |
PROSITEi | View protein in PROSITE PS51173, CBM2, 1 hit PS00561, CBM2_A, 1 hit PS00655, GLYCOSYL_HYDROL_F6_1, 1 hit PS00656, GLYCOSYL_HYDROL_F6_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GUNA_THEBI | |
Accessioni | P26414Primary (citable) accession number: P26414 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families