UniProtKB - P26379 (PTFA_BACSU)
Protein
PTS system fructose-specific EIIA component
Gene
levD
Organism
Bacillus subtilis (strain 168)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LevDE PTS system is involved in fructose transport.1 Publication1 Publication
LevD and LevE act as negative regulators of the levanase operon. They may be involved in a PTS-mediated phosphorylation of a regulator.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 9 | Tele-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication | 1 |
GO - Molecular functioni
- kinase activity Source: UniProtKB-KW
- phosphotransferase activity, alcohol group as acceptor Source: InterPro
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | BSUB:BSU27070-MONOMER |
Protein family/group databases
TCDBi | 4.A.6.1.2, the pts mannose-fructose-sorbose (man) family |
Names & Taxonomyi
Protein namesi | Recommended name: PTS system fructose-specific EIIA component1 PublicationAlternative name(s): EIIA-Fru1 Publication Fructose-specific phosphotransferase enzyme IIA component1 Publication lev-PTS1 Publication p161 Publication |
Gene namesi | Name:levD1 Publication Synonyms:sacL Ordered Locus Names:BSU27070 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Other locations
- cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: InterPro
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 9 | H → A: Phosphorylation is only slightly increased. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186523 | 1 – 146 | PTS system fructose-specific EIIA componentAdd BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 9 | Phosphohistidine; by HPr1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P26379 |
PRIDEi | P26379 |
PTM databases
iPTMneti | P26379 |
Expressioni
Inductioni
By fructose and LevR.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 124 | PTS EIIA type-4PROSITE-ProRule annotationAdd BLAST | 124 |
Domaini
The EIIA type-4 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB type-4 domain.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | COG2893, Bacteria |
InParanoidi | P26379 |
OMAi | LAISVMD |
PhylomeDBi | P26379 |
Family and domain databases
CDDi | cd00006, PTS_IIA_man, 1 hit |
Gene3Di | 3.40.50.510, 1 hit |
InterProi | View protein in InterPro IPR013789, PTS_EIIA_man IPR004701, PTS_EIIA_man-typ IPR036662, PTS_EIIA_man-typ_sf IPR033887, PTS_IIA_man |
Pfami | View protein in Pfam PF03610, EIIA-man, 1 hit |
SUPFAMi | SSF53062, SSF53062, 1 hit |
TIGRFAMsi | TIGR00824, EIIA-man, 1 hit |
PROSITEi | View protein in PROSITE PS51096, PTS_EIIA_TYPE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
P26379-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISVIISGHG DFPIALKESS GMIFGEENNL IAVPFFKGEG IQTLQEKYHQ
60 70 80 90 100
ALKDIPEEHE VLFLVDIFGG TPYNAAASFI AEDQRMDMAA GVNLPILLEV
110 120 130 140
LSLREHLALK DLLNNLKAMS QQSFQVCSEH LEKVKTANQD TREDEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56098 Genomic DNA Translation: CAA39577.1 X92868 Genomic DNA Translation: CAA63461.1 AL009126 Genomic DNA Translation: CAB14649.1 |
PIRi | S11398 |
RefSeqi | NP_390585.1, NC_000964.3 WP_003246144.1, NZ_JNCM01000036.1 |
Genome annotation databases
EnsemblBacteriai | CAB14649; CAB14649; BSU_27070 |
GeneIDi | 936536 |
KEGGi | bsu:BSU27070 |
PATRICi | fig|224308.179.peg.2940 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56098 Genomic DNA Translation: CAA39577.1 X92868 Genomic DNA Translation: CAA63461.1 AL009126 Genomic DNA Translation: CAB14649.1 |
PIRi | S11398 |
RefSeqi | NP_390585.1, NC_000964.3 WP_003246144.1, NZ_JNCM01000036.1 |
3D structure databases
SMRi | P26379 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU27070 |
Protein family/group databases
TCDBi | 4.A.6.1.2, the pts mannose-fructose-sorbose (man) family |
PTM databases
iPTMneti | P26379 |
Proteomic databases
PaxDbi | P26379 |
PRIDEi | P26379 |
Genome annotation databases
EnsemblBacteriai | CAB14649; CAB14649; BSU_27070 |
GeneIDi | 936536 |
KEGGi | bsu:BSU27070 |
PATRICi | fig|224308.179.peg.2940 |
Phylogenomic databases
eggNOGi | COG2893, Bacteria |
InParanoidi | P26379 |
OMAi | LAISVMD |
PhylomeDBi | P26379 |
Enzyme and pathway databases
BioCyci | BSUB:BSU27070-MONOMER |
Family and domain databases
CDDi | cd00006, PTS_IIA_man, 1 hit |
Gene3Di | 3.40.50.510, 1 hit |
InterProi | View protein in InterPro IPR013789, PTS_EIIA_man IPR004701, PTS_EIIA_man-typ IPR036662, PTS_EIIA_man-typ_sf IPR033887, PTS_IIA_man |
Pfami | View protein in Pfam PF03610, EIIA-man, 1 hit |
SUPFAMi | SSF53062, SSF53062, 1 hit |
TIGRFAMsi | TIGR00824, EIIA-man, 1 hit |
PROSITEi | View protein in PROSITE PS51096, PTS_EIIA_TYPE_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTFA_BACSU | |
Accessioni | P26379Primary (citable) accession number: P26379 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |