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Protein

60S ribosomal protein L13

Gene

RPL13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L13
Alternative name(s):
Breast basic conserved protein 1
Large ribosomal subunit protein eL131 Publication
Gene namesi
Name:RPL13
Synonyms:BBC1
ORF Names:OK/SW-cl.46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000167526.13
HGNCiHGNC:10303 RPL13
MIMi113703 gene
neXtProtiNX_P26373

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6137
OpenTargetsiENSG00000167526
PharmGKBiPA34670

Polymorphism and mutation databases

BioMutaiRPL13
DMDMi21903462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001929191 – 21160S ribosomal protein L13Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16N6-acetyllysineCombined sources1
Modified residuei52PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Cross-linki123Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei177N6-acetyllysine; alternateCombined sources1
Cross-linki177Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP26373
MaxQBiP26373
PaxDbiP26373
PeptideAtlasiP26373
PRIDEiP26373
ProteomicsDBi54328
TopDownProteomicsiP26373-1 [P26373-1]
P26373-2 [P26373-2]

PTM databases

iPTMnetiP26373
PhosphoSitePlusiP26373
SwissPalmiP26373

Miscellaneous databases

PMAP-CutDBiP26373

Expressioni

Tissue specificityi

Higher levels of expression in benign breast lesions than in carcinomas.

Gene expression databases

BgeeiENSG00000167526 Expressed in 234 organ(s), highest expression level in right ovary
CleanExiHS_RPL13
ExpressionAtlasiP26373 baseline and differential
GenevisibleiP26373 HS

Organism-specific databases

HPAiHPA051702

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi112057, 234 interactors
CORUMiP26373
IntActiP26373, 53 interactors
MINTiP26373
STRINGi9606.ENSP00000307889

Structurei

3D structure databases

ProteinModelPortaliP26373
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3295 Eukaryota
COG4352 LUCA
GeneTreeiENSGT00390000007818
HOGENOMiHOG000170452
HOVERGENiHBG001156
InParanoidiP26373
KOiK02873
OMAiIVVDHRR
OrthoDBiEOG091G0KGO
PhylomeDBiP26373
TreeFamiTF300073

Family and domain databases

HAMAPiMF_00499 Ribosomal_L13e, 1 hit
InterProiView protein in InterPro
IPR001380 Ribosomal_L13e
IPR018256 Ribosomal_L13e_CS
PANTHERiPTHR11722 PTHR11722, 1 hit
PfamiView protein in Pfam
PF01294 Ribosomal_L13e, 1 hit
PROSITEiView protein in PROSITE
PS01104 RIBOSOMAL_L13E, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P26373-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPSRNGMVL KPHFHKDWQR RVATWFNQPA RKIRRRKARQ AKARRIAPRP
60 70 80 90 100
ASGPIRPIVR CPTVRYHTKV RAGRGFSLEE LRVAGIHKKV ARTIGISVDP
110 120 130 140 150
RRRNKSTESL QANVQRLKEY RSKLILFPRK PSAPKKGDSS AEELKLATQL
160 170 180 190 200
TGPVMPVRNV YKKEKARVIT EEEKNFKAFA SLRMARANAR LFGIRAKRAK
210
EAAEQDVEKK K
Length:211
Mass (Da):24,261
Last modified:January 23, 2007 - v4
Checksum:iDB9FC57768E6BEDE
GO
Isoform 2 (identifier: P26373-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     88-134: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):18,845
Checksum:iF631C531204EEFAC
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QSB4J3QSB4_HUMAN
60S ribosomal protein L13
RPL13
126Annotation score:
H3BTH3H3BTH3_HUMAN
60S ribosomal protein L13
RPL13
63Annotation score:
J3KS98J3KS98_HUMAN
60S ribosomal protein L13
RPL13
78Annotation score:
H3BUK8H3BUK8_HUMAN
60S ribosomal protein L13
RPL13
54Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → A in BAG59685 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051801112A → T2 PublicationsCorresponds to variant dbSNP:rs9930567Ensembl.1
Natural variantiVAR_051802170T → P. Corresponds to variant dbSNP:rs1062450Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04602888 – 134Missing in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64707 mRNA Translation: CAA45963.1
AB062392 mRNA Translation: BAB93479.1
AK297198 mRNA Translation: BAG59685.1
AC092123 Genomic DNA No translation available.
BC004954 mRNA Translation: AAH04954.1
BC007345 mRNA Translation: AAH07345.1
BC007563 mRNA Translation: AAH07563.1
BC007805 mRNA Translation: AAH07805.1
BC010994 mRNA Translation: AAH10994.1
BC013078 mRNA Translation: AAH13078.1
BC014167 mRNA Translation: AAH14167.1
BC020804 mRNA Translation: AAH20804.1
BC027463 mRNA Translation: AAH27463.1
BC063378 mRNA Translation: AAH63378.1
BC093063 mRNA Translation: AAH93063.1
BC106058 mRNA Translation: AAI06059.1
CCDSiCCDS10979.1 [P26373-1]
CCDS58492.1 [P26373-2]
PIRiS23753
RefSeqiNP_000968.2, NM_000977.3 [P26373-1]
NP_001230059.1, NM_001243130.1
NP_001230060.1, NM_001243131.1 [P26373-2]
NP_150254.1, NM_033251.2 [P26373-1]
UniGeneiHs.410817

Genome annotation databases

EnsembliENST00000311528; ENSP00000307889; ENSG00000167526 [P26373-1]
ENST00000393099; ENSP00000376811; ENSG00000167526 [P26373-1]
ENST00000452368; ENSP00000438959; ENSG00000167526 [P26373-2]
ENST00000567815; ENSP00000455009; ENSG00000167526 [P26373-1]
GeneIDi6137
KEGGihsa:6137
UCSCiuc002fnm.3 human [P26373-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64707 mRNA Translation: CAA45963.1
AB062392 mRNA Translation: BAB93479.1
AK297198 mRNA Translation: BAG59685.1
AC092123 Genomic DNA No translation available.
BC004954 mRNA Translation: AAH04954.1
BC007345 mRNA Translation: AAH07345.1
BC007563 mRNA Translation: AAH07563.1
BC007805 mRNA Translation: AAH07805.1
BC010994 mRNA Translation: AAH10994.1
BC013078 mRNA Translation: AAH13078.1
BC014167 mRNA Translation: AAH14167.1
BC020804 mRNA Translation: AAH20804.1
BC027463 mRNA Translation: AAH27463.1
BC063378 mRNA Translation: AAH63378.1
BC093063 mRNA Translation: AAH93063.1
BC106058 mRNA Translation: AAI06059.1
CCDSiCCDS10979.1 [P26373-1]
CCDS58492.1 [P26373-2]
PIRiS23753
RefSeqiNP_000968.2, NM_000977.3 [P26373-1]
NP_001230059.1, NM_001243130.1
NP_001230060.1, NM_001243131.1 [P26373-2]
NP_150254.1, NM_033251.2 [P26373-1]
UniGeneiHs.410817

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-LL1-211[»]
4V6Xelectron microscopy5.00CL1-211[»]
5AJ0electron microscopy3.50AL1-211[»]
5LKSelectron microscopy3.60LL1-211[»]
5T2Celectron microscopy3.60r1-211[»]
6EK0electron microscopy2.90LL1-211[»]
ProteinModelPortaliP26373
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112057, 234 interactors
CORUMiP26373
IntActiP26373, 53 interactors
MINTiP26373
STRINGi9606.ENSP00000307889

PTM databases

iPTMnetiP26373
PhosphoSitePlusiP26373
SwissPalmiP26373

Polymorphism and mutation databases

BioMutaiRPL13
DMDMi21903462

Proteomic databases

EPDiP26373
MaxQBiP26373
PaxDbiP26373
PeptideAtlasiP26373
PRIDEiP26373
ProteomicsDBi54328
TopDownProteomicsiP26373-1 [P26373-1]
P26373-2 [P26373-2]

Protocols and materials databases

DNASUi6137
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311528; ENSP00000307889; ENSG00000167526 [P26373-1]
ENST00000393099; ENSP00000376811; ENSG00000167526 [P26373-1]
ENST00000452368; ENSP00000438959; ENSG00000167526 [P26373-2]
ENST00000567815; ENSP00000455009; ENSG00000167526 [P26373-1]
GeneIDi6137
KEGGihsa:6137
UCSCiuc002fnm.3 human [P26373-1]

Organism-specific databases

CTDi6137
DisGeNETi6137
EuPathDBiHostDB:ENSG00000167526.13
GeneCardsiRPL13
HGNCiHGNC:10303 RPL13
HPAiHPA051702
MIMi113703 gene
neXtProtiNX_P26373
OpenTargetsiENSG00000167526
PharmGKBiPA34670
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3295 Eukaryota
COG4352 LUCA
GeneTreeiENSGT00390000007818
HOGENOMiHOG000170452
HOVERGENiHBG001156
InParanoidiP26373
KOiK02873
OMAiIVVDHRR
OrthoDBiEOG091G0KGO
PhylomeDBiP26373
TreeFamiTF300073

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRPL13 human
GeneWikiiRPL13
GenomeRNAii6137
PMAP-CutDBiP26373
PROiPR:P26373
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167526 Expressed in 234 organ(s), highest expression level in right ovary
CleanExiHS_RPL13
ExpressionAtlasiP26373 baseline and differential
GenevisibleiP26373 HS

Family and domain databases

HAMAPiMF_00499 Ribosomal_L13e, 1 hit
InterProiView protein in InterPro
IPR001380 Ribosomal_L13e
IPR018256 Ribosomal_L13e_CS
PANTHERiPTHR11722 PTHR11722, 1 hit
PfamiView protein in Pfam
PF01294 Ribosomal_L13e, 1 hit
PROSITEiView protein in PROSITE
PS01104 RIBOSOMAL_L13E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL13_HUMAN
AccessioniPrimary (citable) accession number: P26373
Secondary accession number(s): B4DLX3
, F5H1S2, Q3KQT8, Q567Q8, Q9BPX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 184 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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