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Entry version 131 (13 Feb 2019)
Sequence version 1 (01 Aug 1992)
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Protein

Keratin-associated protein 5-9

Gene

KRTAP5-9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • epidermis development Source: ProtInc
  • keratinization Source: Reactome

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 5-9
Alternative name(s):
Keratin, cuticle, ultrahigh sulfur 1
Keratin, ultra high-sulfur matrix protein A
Keratin-associated protein 5.9
UHS keratin A
Short name:
UHS KerA
Ultrahigh sulfur keratin-associated protein 5.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP5-9
Synonyms:KAP5.9, KRN1, KRTAP5.9, UHSK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000254997.3

Human Gene Nomenclature Database

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HGNCi
HGNC:23604 KRTAP5-9

Online Mendelian Inheritance in Man (OMIM)

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MIMi
148021 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P26371

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3846

Open Targets

More...
OpenTargetsi
ENSG00000254997

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134946701

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRTAP5-9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001841071 – 169Keratin-associated protein 5-9Add BLAST169

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P26371

PRoteomics IDEntifications database

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PRIDEi
P26371

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54327

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P26371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P26371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At a late stage of fiber differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000254997 Expressed in 67 organ(s), highest expression level in hair follicle

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P26371 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q5BKY63EBI-3958099,EBI-10243533
Q9NWL93EBI-3958099,EBI-10315054
ADAMTSL4Q6UY14-39EBI-3958099,EBI-10173507
ALPPP051875EBI-3958099,EBI-1211484
ATG9AQ7Z3C63EBI-3958099,EBI-727146
BEX2Q9BXY83EBI-3958099,EBI-745073
BMP7A8K5713EBI-3958099,EBI-10174327
C10orf62Q5T6813EBI-3958099,EBI-744052
C11orf87Q6NUJ23EBI-3958099,EBI-6660291
CATSPER1Q8NEC57EBI-3958099,EBI-744545
CHIC2Q9UKJ55EBI-3958099,EBI-741528
CHRDQ9H2X05EBI-3958099,EBI-947551
CKS1BP610243EBI-3958099,EBI-456371
CNNM3Q8NE015EBI-3958099,EBI-741032
COMTP21964-23EBI-3958099,EBI-10200977
CRCT1Q9UGL95EBI-3958099,EBI-713677
CTSZQ9UBR26EBI-3958099,EBI-8636823
CYSRT1A8MQ034EBI-3958099,EBI-3867333
DHRS1Q96LJ73EBI-3958099,EBI-746300
DMRT3Q9NQL93EBI-3958099,EBI-9679045
DOCK2Q926085EBI-3958099,EBI-448771
FAHP169303EBI-3958099,EBI-4397076
FAM124BQ9H5Z63EBI-3958099,EBI-741626
FAM161AQ3B8205EBI-3958099,EBI-719941
FAM74A6Q5TZK35EBI-3958099,EBI-10247271
FAM76BQ5HYJ33EBI-3958099,EBI-751192
GLRX3O760037EBI-3958099,EBI-374781
GNEQ9Y2233EBI-3958099,EBI-4291090
HOXA1P496399EBI-3958099,EBI-740785
Hoxa1P090223EBI-3958099,EBI-3957603From Mus musculus.
HOXB9P174823EBI-3958099,EBI-745290
HPCAL1P372353EBI-3958099,EBI-749311
HSPD1P108093EBI-3958099,EBI-352528
JOSD1Q150403EBI-3958099,EBI-2510602
KLHL38Q2WGJ65EBI-3958099,EBI-6426443
KRTAP10-11P604125EBI-3958099,EBI-10217483
KRTAP10-5P603709EBI-3958099,EBI-10172150
KRTAP10-7P604095EBI-3958099,EBI-10172290
KRTAP10-8P604107EBI-3958099,EBI-10171774
KRTAP10-9P604115EBI-3958099,EBI-10172052
KRTAP12-1P599905EBI-3958099,EBI-10210845
KRTAP12-2P599915EBI-3958099,EBI-10176379
KRTAP4-11Q9BYQ65EBI-3958099,EBI-10302392
KRTAP4-12Q9BQ667EBI-3958099,EBI-739863
KRTAP4-2Q9BYR57EBI-3958099,EBI-10172511
KRTAP5-4Q6L8H14EBI-3958099,EBI-11963072
KRTAP5-6Q6L8G97EBI-3958099,EBI-10250562
KRTAP9-2Q9BYQ45EBI-3958099,EBI-1044640
KRTAP9-3Q9BYQ34EBI-3958099,EBI-1043191
KRTAP9-4Q9BYQ23EBI-3958099,EBI-10185730
KRTAP9-8Q9BYQ04EBI-3958099,EBI-11958364
LCE1BQ5T7P35EBI-3958099,EBI-10245913
LCE1DQ5T7524EBI-3958099,EBI-11741311
LCE1EQ5T7534EBI-3958099,EBI-11955335
LCE1FQ5T7544EBI-3958099,EBI-11958008
LCE2AQ5TA797EBI-3958099,EBI-10246607
LCE2BO146334EBI-3958099,EBI-11478468
LCE2CQ5TA814EBI-3958099,EBI-11973993
LCE3AQ5TA764EBI-3958099,EBI-9394625
LCE3BQ5TA774EBI-3958099,EBI-11974495
LCE3CQ5T5A87EBI-3958099,EBI-10245291
LCE3EQ5T5B07EBI-3958099,EBI-10245456
LCE4AQ5TA785EBI-3958099,EBI-10246358
LCE5AQ5TCM94EBI-3958099,EBI-11955689
LY6HO947723EBI-3958099,EBI-724687
MAPKBP1O603365EBI-3958099,EBI-947402
MEOX2P502223EBI-3958099,EBI-748397
MST065Q549C53EBI-3958099,EBI-10243297
NAXDQ8IW453EBI-3958099,EBI-8650724
NCLNQ969V3-23EBI-3958099,EBI-10281480
NECTIN2Q926923EBI-3958099,EBI-718419
NLKQ9UBE83EBI-3958099,EBI-366978
NMUP486455EBI-3958099,EBI-10210351
NOTCH2NLAQ7Z3S95EBI-3958099,EBI-945833
NPBWR2P481463EBI-3958099,EBI-10210114
NPDC1Q9NQX55EBI-3958099,EBI-748927
NTMQ9P1213EBI-3958099,EBI-4315078
NTN4Q9HB633EBI-3958099,EBI-743459
NTN4Q9HB63-33EBI-3958099,EBI-10310092
NUFIP2Q7Z4175EBI-3958099,EBI-1210753
OTX1P322429EBI-3958099,EBI-740446
P2RX4Q995713EBI-3958099,EBI-2828248
PCSK5Q928243EBI-3958099,EBI-751290
PFKLP178583EBI-3958099,EBI-487243
PRKAB2O437415EBI-3958099,EBI-1053424
PSMA1P257865EBI-3958099,EBI-359352
PTPMT1Q8WUK05EBI-3958099,EBI-7199479
RAMP3O608963EBI-3958099,EBI-720447
RGS20O760813EBI-3958099,EBI-1052678
RGS20O76081-65EBI-3958099,EBI-10178530
RNF111Q6ZNA44EBI-3958099,EBI-2129175
RYDENQ9NUL53EBI-3958099,EBI-10313866
SCARB1Q8WTV03EBI-3958099,EBI-78657
SDC3A0A0S2Z4U39EBI-3958099,EBI-10204280
SDCBPO005605EBI-3958099,EBI-727004
SLC22A23A1A5C73EBI-3958099,EBI-10171756
SLC25A10Q9UBX33EBI-3958099,EBI-750394
SLC25A10Q9UBX3-23EBI-3958099,EBI-12056597
SMCPP499019EBI-3958099,EBI-750494
SPINK2P201553EBI-3958099,EBI-10200479
SPRY2O435973EBI-3958099,EBI-742487
TBC1D10CQ8IV043EBI-3958099,EBI-10261452
TCEA2Q155603EBI-3958099,EBI-710310
TCEANCQ8N8B73EBI-3958099,EBI-954696
TYRO3Q064184EBI-3958099,EBI-3951628
WDYHV1Q96HA85EBI-3958099,EBI-741158
YIPF3Q9GZM53EBI-3958099,EBI-743787
ZBTB24O431673EBI-3958099,EBI-744471
ZFYVE21Q9BQ243EBI-3958099,EBI-2849569
ZNF124Q159735EBI-3958099,EBI-2555767
ZNF266Q145843EBI-3958099,EBI-7115319
ZNF417Q8TAU35EBI-3958099,EBI-740727
ZNF439Q8NDP45EBI-3958099,EBI-747580
ZNF581Q9P0T43EBI-3958099,EBI-745520
ZNF587Q96SQ55EBI-3958099,EBI-6427977

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110044, 108 interactors

Protein interaction database and analysis system

More...
IntActi
P26371, 191 interactors

Molecular INTeraction database

More...
MINTi
P26371

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000431443

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P26371

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati35 – 3814
Repeati41 – 4424
Repeati47 – 5034
Repeati82 – 8544
Repeati101 – 10454
Repeati130 – 13465
Repeati149 – 15274
Repeati159 – 16284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 1628 X 4 AA repeats of C-C-X-PAdd BLAST128

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
GDSCKCG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

More...
PANTHERi
PTHR23262 PTHR23262, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P26371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP
60 70 80 90 100
ACSCSSCGKR GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS
110 120 130 140 150
CCKPYCSQCS CCKPCCSSSG RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC
160
KPCCSQSRCC VPVCYQCKI
Length:169
Mass (Da):16,276
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i219B14FEEB49D4AB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0537318G → R. Corresponds to variant dbSNP:rs34213141Ensembl.1
Natural variantiVAR_05373240Y → C1 PublicationCorresponds to variant dbSNP:rs10792769Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X55293 Genomic DNA Translation: CAA39005.1
AJ006693 Genomic DNA Translation: CAA07189.1
X63755 mRNA Translation: CAA45283.1
AB126078 mRNA Translation: BAD20205.1
BC069531 mRNA Translation: AAH69531.1
BC101744 mRNA Translation: AAI01745.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53677.1

Protein sequence database of the Protein Information Resource

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PIRi
S18946

NCBI Reference Sequences

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RefSeqi
NP_005544.4, NM_005553.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.709220

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000528743; ENSP00000431443; ENSG00000254997

Database of genes from NCBI RefSeq genomes

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GeneIDi
3846

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3846

UCSC genome browser

More...
UCSCi
uc001oqs.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55293 Genomic DNA Translation: CAA39005.1
AJ006693 Genomic DNA Translation: CAA07189.1
X63755 mRNA Translation: CAA45283.1
AB126078 mRNA Translation: BAD20205.1
BC069531 mRNA Translation: AAH69531.1
BC101744 mRNA Translation: AAI01745.2
CCDSiCCDS53677.1
PIRiS18946
RefSeqiNP_005544.4, NM_005553.3
UniGeneiHs.709220

3D structure databases

ProteinModelPortaliP26371
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110044, 108 interactors
IntActiP26371, 191 interactors
MINTiP26371
STRINGi9606.ENSP00000431443

PTM databases

iPTMnetiP26371
PhosphoSitePlusiP26371

Polymorphism and mutation databases

BioMutaiKRTAP5-9

Proteomic databases

PaxDbiP26371
PRIDEiP26371
ProteomicsDBi54327

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3846
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000528743; ENSP00000431443; ENSG00000254997
GeneIDi3846
KEGGihsa:3846
UCSCiuc001oqs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3846
DisGeNETi3846
EuPathDBiHostDB:ENSG00000254997.3

GeneCards: human genes, protein and diseases

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GeneCardsi
KRTAP5-9
HGNCiHGNC:23604 KRTAP5-9
MIMi148021 gene
neXtProtiNX_P26371
OpenTargetsiENSG00000254997
PharmGKBiPA134946701

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

OMAiGDSCKCG

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3846

Protein Ontology

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PROi
PR:P26371

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000254997 Expressed in 67 organ(s), highest expression level in hair follicle
GenevisibleiP26371 HS

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA59_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26371
Secondary accession number(s): Q14564, Q3MIP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: February 13, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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