The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - P26371 (KRA59_HUMAN)
Protein
Keratin-associated protein 5-9
Gene
KRTAP5-9
Organism
Homo sapiens (Human)
Status
Functioni
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- epidermis development Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | P26371 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | P26371 |
Names & Taxonomyi
Protein namesi | Recommended name: Keratin-associated protein 5-9Alternative name(s): Keratin, cuticle, ultrahigh sulfur 1 Keratin, ultra high-sulfur matrix protein A Keratin-associated protein 5.9 UHS keratin A Short name: UHS KerA Ultrahigh sulfur keratin-associated protein 5.9 |
Gene namesi | Name:KRTAP5-9 Synonyms:KAP5.9, KRN1, KRTAP5.9, UHSK1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23604, KRTAP5-9 |
MIMi | 148021, gene |
neXtProti | NX_P26371 |
VEuPathDBi | HostDB:ENSG00000254997 |
Subcellular locationi
Cytoskeleton
- keratin filament Source: InterPro
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
KeratinPathology & Biotechi
Organism-specific databases
DisGeNETi | 3846 |
OpenTargetsi | ENSG00000254997 |
PharmGKBi | PA134946701 |
Miscellaneous databases
Pharosi | P26371, Tdark |
Genetic variation databases
BioMutai | KRTAP5-9 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184107 | 1 – 169 | Keratin-associated protein 5-9Add BLAST | 169 |
Proteomic databases
MassIVEi | P26371 |
PaxDbi | P26371 |
PeptideAtlasi | P26371 |
PRIDEi | P26371 |
PTM databases
iPTMneti | P26371 |
PhosphoSitePlusi | P26371 |
Expressioni
Tissue specificityi
Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.1 Publication
Developmental stagei
At a late stage of fiber differentiation.
Gene expression databases
Bgeei | ENSG00000254997, Expressed in hair follicle and 88 other tissues |
Genevisiblei | P26371, HS |
Organism-specific databases
HPAi | ENSG00000254997, Tissue enhanced (testis) |
Interactioni
Subunit structurei
Interacts with hair keratins.
Binary interactionsi
P26371
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 110044, 199 interactors |
IntActi | P26371, 195 interactors |
MINTi | P26371 |
Miscellaneous databases
RNActi | P26371, protein |
Structurei
3D structure databases
AlphaFoldDBi | P26371 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 35 – 38 | 1 | 4 | |
Repeati | 41 – 44 | 2 | 4 | |
Repeati | 47 – 50 | 3 | 4 | |
Repeati | 82 – 85 | 4 | 4 | |
Repeati | 101 – 104 | 5 | 4 | |
Repeati | 130 – 134 | 6 | 5 | |
Repeati | 149 – 152 | 7 | 4 | |
Repeati | 159 – 162 | 8 | 4 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 35 – 162 | 8 X 4 AA repeats of C-C-X-PAdd BLAST | 128 |
Sequence similaritiesi
Belongs to the KRTAP type 5 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00950000186550 |
HOGENOMi | CLU_097966_0_0_1 |
OMAi | CGPSCCA |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 1 hit |
i Sequence
Sequence statusi: Complete.
P26371-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP
60 70 80 90 100
ACSCSSCGKR GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS
110 120 130 140 150
CCKPYCSQCS CCKPCCSSSG RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC
160
KPCCSQSRCC VPVCYQCKI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053731 | 8 | G → R. Corresponds to variant dbSNP:rs34213141Ensembl. | 1 | |
Natural variantiVAR_053732 | 40 | Y → C1 PublicationCorresponds to variant dbSNP:rs10792769Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55293 Genomic DNA Translation: CAA39005.1 AJ006693 Genomic DNA Translation: CAA07189.1 X63755 mRNA Translation: CAA45283.1 AB126078 mRNA Translation: BAD20205.1 BC069531 mRNA Translation: AAH69531.1 BC101744 mRNA Translation: AAI01745.2 |
CCDSi | CCDS53677.1 |
PIRi | S18946 |
RefSeqi | NP_005544.4, NM_005553.3 |
Genome annotation databases
Ensembli | ENST00000528743.4; ENSP00000431443.3; ENSG00000254997.4 |
GeneIDi | 3846 |
KEGGi | hsa:3846 |
MANE-Selecti | ENST00000528743.4; ENSP00000431443.3; NM_005553.4; NP_005544.4 |
UCSCi | uc001oqs.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X55293 Genomic DNA Translation: CAA39005.1 AJ006693 Genomic DNA Translation: CAA07189.1 X63755 mRNA Translation: CAA45283.1 AB126078 mRNA Translation: BAD20205.1 BC069531 mRNA Translation: AAH69531.1 BC101744 mRNA Translation: AAI01745.2 |
CCDSi | CCDS53677.1 |
PIRi | S18946 |
RefSeqi | NP_005544.4, NM_005553.3 |
3D structure databases
AlphaFoldDBi | P26371 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 110044, 199 interactors |
IntActi | P26371, 195 interactors |
MINTi | P26371 |
PTM databases
iPTMneti | P26371 |
PhosphoSitePlusi | P26371 |
Genetic variation databases
BioMutai | KRTAP5-9 |
Proteomic databases
MassIVEi | P26371 |
PaxDbi | P26371 |
PeptideAtlasi | P26371 |
PRIDEi | P26371 |
Protocols and materials databases
DNASUi | 3846 |
Genome annotation databases
Ensembli | ENST00000528743.4; ENSP00000431443.3; ENSG00000254997.4 |
GeneIDi | 3846 |
KEGGi | hsa:3846 |
MANE-Selecti | ENST00000528743.4; ENSP00000431443.3; NM_005553.4; NP_005544.4 |
UCSCi | uc001oqs.2, human |
Organism-specific databases
CTDi | 3846 |
DisGeNETi | 3846 |
GeneCardsi | KRTAP5-9 |
HGNCi | HGNC:23604, KRTAP5-9 |
HPAi | ENSG00000254997, Tissue enhanced (testis) |
MIMi | 148021, gene |
neXtProti | NX_P26371 |
OpenTargetsi | ENSG00000254997 |
PharmGKBi | PA134946701 |
VEuPathDBi | HostDB:ENSG00000254997 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00950000186550 |
HOGENOMi | CLU_097966_0_0_1 |
OMAi | CGPSCCA |
Enzyme and pathway databases
PathwayCommonsi | P26371 |
Reactomei | R-HSA-6805567, Keratinization |
SignaLinki | P26371 |
Miscellaneous databases
BioGRID-ORCSi | 3846, 72 hits in 1053 CRISPR screens |
GenomeRNAii | 3846 |
Pharosi | P26371, Tdark |
PROi | PR:P26371 |
RNActi | P26371, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000254997, Expressed in hair follicle and 88 other tissues |
Genevisiblei | P26371, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002494, KAP |
PANTHERi | PTHR23262, PTHR23262, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | KRA59_HUMAN | |
Accessioni | P26371Primary (citable) accession number: P26371 Secondary accession number(s): Q14564, Q3MIP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1992 |
Last sequence update: | August 1, 1992 | |
Last modified: | May 25, 2022 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families