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UniProtKB - P26371 (KRA59_HUMAN)

Entry version 141 (22 Apr 2020)
Sequence version 1 (01 Aug 1992)
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Protein

Keratin-associated protein 5-9

Gene

KRTAP5-9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • epidermis development Source: ProtInc
  • keratinization Source: Reactome
Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6805567 Keratinization

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin-associated protein 5-9
Alternative name(s):
Keratin, cuticle, ultrahigh sulfur 1
Keratin, ultra high-sulfur matrix protein A
Keratin-associated protein 5.9
UHS keratin A
Short name:
UHS KerA
Ultrahigh sulfur keratin-associated protein 5.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRTAP5-9
Synonyms:KAP5.9, KRN1, KRTAP5.9, UHSK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23604 KRTAP5-9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		148021 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P26371

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3846

Open Targets

More...OpenTargetsi		ENSG00000254997

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134946701

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P26371 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KRTAP5-9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001841071 – 169Keratin-associated protein 5-9Add BLAST169

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P26371

PRoteomics IDEntifications database

More...PRIDEi		P26371

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54327

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P26371

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P26371

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At a late stage of fiber differentiation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000254997 Expressed in hair follicle and 66 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P26371 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000254997 Tissue enhanced (epididymis, testis, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hair keratins.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

P26371
With#Exp.IntAct
itself3EBI-3958099,EBI-3958099
Q5BKY63EBI-3958099,EBI-10243533
Q9NWL93EBI-3958099,EBI-10315054
ADAM12 - isoform 4 [O43184-4]3EBI-3958099,EBI-12006944
ADAMTSL4 - isoform 3 [Q6UY14-3]8EBI-3958099,EBI-10173507
ADAMTSL5 [Q6ZMM2]3EBI-3958099,EBI-9075891
ALDH3B1 [P43353]3EBI-3958099,EBI-2558314
ALPP [P05187]6EBI-3958099,EBI-1211484
ATG9A [Q7Z3C6]3EBI-3958099,EBI-727146
BEX2 [Q9BXY8]3EBI-3958099,EBI-745073
BMP7 [A8K571]3EBI-3958099,EBI-10174327
BMP7 [P18075]3EBI-3958099,EBI-1035195
C10orf62 [Q5T681]3EBI-3958099,EBI-744052
C11orf87 [Q6NUJ2]3EBI-3958099,EBI-6660291
CATSPER1 [Q8NEC5]6EBI-3958099,EBI-744545
CHIC2 [Q9UKJ5]6EBI-3958099,EBI-741528
CHRD [Q9H2X0]6EBI-3958099,EBI-947551
CHRNG - isoform 2 [P07510-2]3EBI-3958099,EBI-11979451
CKS1B [P61024]3EBI-3958099,EBI-456371
CNNM3 [Q8NE01]6EBI-3958099,EBI-741032
COL8A1 [P27658]3EBI-3958099,EBI-747133
COMT - isoform Soluble [P21964-2]3EBI-3958099,EBI-10200977
CRCT1 [Q9UGL9]6EBI-3958099,EBI-713677
CREB5 - isoform 3 [Q02930-3]3EBI-3958099,EBI-10192698
CRH [P06850]3EBI-3958099,EBI-3870390
CRY2 [Q49AN0]3EBI-3958099,EBI-2212355
CTNNBIP1 [Q9NSA3]3EBI-3958099,EBI-747082
CTSZ [Q9UBR2]8EBI-3958099,EBI-8636823
CYSRT1 [A8MQ03]3EBI-3958099,EBI-3867333
DCDC2 [Q9UHG0]3EBI-3958099,EBI-10303987
DHRS1 [Q96LJ7]3EBI-3958099,EBI-746300
DMRT3 [Q9NQL9]3EBI-3958099,EBI-9679045
DNASE1L3 [Q13609]3EBI-3958099,EBI-9512718
DOCK2 [Q92608]6EBI-3958099,EBI-448771
EMC7 [Q9NPA0]3EBI-3958099,EBI-6309137
ENKD1 [Q9H0I2]3EBI-3958099,EBI-744099
ENPP7 [Q6UWV6]3EBI-3958099,EBI-12047821
FAH [P16930]3EBI-3958099,EBI-4397076
FAM124B [Q9H5Z6]3EBI-3958099,EBI-741626
FAM161A [Q3B820]6EBI-3958099,EBI-719941
FAM74A6 [Q5TZK3]3EBI-3958099,EBI-10247271
FAM76B [Q5HYJ3]3EBI-3958099,EBI-751192
FAM76B - isoform 3 [Q5HYJ3-3]3EBI-3958099,EBI-11956087
FLT3LG [P49771]3EBI-3958099,EBI-724977
GGN [Q86UU5]3EBI-3958099,EBI-10259069
GLP1R [P43220]3EBI-3958099,EBI-7466542
GLRX3 [O76003]8EBI-3958099,EBI-374781
GNE [Q9Y223]3EBI-3958099,EBI-4291090
GNE - isoform 2 [Q9Y223-2]3EBI-3958099,EBI-11975289
GRN [P28799]3EBI-3958099,EBI-747754
GSC2 [O15499]3EBI-3958099,EBI-19954058
HEY2 [Q9UBP5]3EBI-3958099,EBI-750630
HHEX [Q03014]3EBI-3958099,EBI-747421
HLCS [P50747]3EBI-3958099,EBI-3915568
HOXA1 [P49639]12EBI-3958099,EBI-740785
Hoxa1 [P09022] from Mus musculus.3EBI-3958099,EBI-3957603
HOXB9 [P17482]3EBI-3958099,EBI-745290
HPCAL1 [P37235]3EBI-3958099,EBI-749311
HSD3B7 [Q9H2F3]3EBI-3958099,EBI-3918847
HSPD1 [P10809]3EBI-3958099,EBI-352528
IGFBP6 [P24592]3EBI-3958099,EBI-947015
JOSD1 [Q15040]3EBI-3958099,EBI-2510602
KLHL38 [Q2WGJ6]6EBI-3958099,EBI-6426443
KLK8 [O60259]3EBI-3958099,EBI-3915857
KPRP [Q5T749]3EBI-3958099,EBI-10981970
KRTAP10-10 [P60014]3EBI-3958099,EBI-11955579
KRTAP10-11 [P60412]6EBI-3958099,EBI-10217483
KRTAP10-5 [P60370]8EBI-3958099,EBI-10172150
KRTAP10-6 [P60371]3EBI-3958099,EBI-12012928
KRTAP10-7 [P60409]5EBI-3958099,EBI-10172290
KRTAP10-8 [P60410]6EBI-3958099,EBI-10171774
KRTAP10-9 [P60411]6EBI-3958099,EBI-10172052
KRTAP11-1 [Q8IUC1]4EBI-3958099,EBI-1052037
KRTAP12-1 [P59990]6EBI-3958099,EBI-10210845
KRTAP12-2 [P59991]6EBI-3958099,EBI-10176379
KRTAP12-3 [P60328]3EBI-3958099,EBI-11953334
KRTAP2-4 [Q9BYR9]3EBI-3958099,EBI-14065470
KRTAP4-11 [Q9BYQ6]6EBI-3958099,EBI-10302392
KRTAP4-12 [Q9BQ66]8EBI-3958099,EBI-739863
KRTAP4-2 [Q9BYR5]8EBI-3958099,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-3958099,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-3958099,EBI-11993254
KRTAP5-11 [Q6L8G4]3EBI-3958099,EBI-11993296
KRTAP5-2 [Q701N4]3EBI-3958099,EBI-11958178
KRTAP5-3 [Q6L8H2]3EBI-3958099,EBI-11974251
KRTAP5-4 [Q6L8H1]6EBI-3958099,EBI-11963072
KRTAP5-6 [Q6L8G9]9EBI-3958099,EBI-10250562
KRTAP9-2 [Q9BYQ4]6EBI-3958099,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-3958099,EBI-1043191
KRTAP9-4 [Q9BYQ2]3EBI-3958099,EBI-10185730
KRTAP9-8 [Q9BYQ0]6EBI-3958099,EBI-11958364
LCE1A [Q5T7P2]3EBI-3958099,EBI-11962058
LCE1B [Q5T7P3]10EBI-3958099,EBI-10245913
LCE1C [Q5T751]3EBI-3958099,EBI-12224199
LCE1D [Q5T752]3EBI-3958099,EBI-11741311
LCE1E [Q5T753]6EBI-3958099,EBI-11955335
LCE1F [Q5T754]6EBI-3958099,EBI-11958008
LCE2A [Q5TA79]9EBI-3958099,EBI-10246607
LCE2B [O14633]6EBI-3958099,EBI-11478468
LCE2C [Q5TA81]3EBI-3958099,EBI-11973993
LCE2D [Q5TA82]3EBI-3958099,EBI-10246750
LCE3A [Q5TA76]6EBI-3958099,EBI-9394625
LCE3B [Q5TA77]4EBI-3958099,EBI-11974495
LCE3C [Q5T5A8]10EBI-3958099,EBI-10245291
LCE3D [Q9BYE3]3EBI-3958099,EBI-6658837
LCE3E [Q5T5B0]9EBI-3958099,EBI-10245456
LCE4A [Q5TA78]6EBI-3958099,EBI-10246358
LCE5A [Q5TCM9]6EBI-3958099,EBI-11955689
LELP1 [Q5T871]3EBI-3958099,EBI-18115868
LINGO1 [Q96FE5]3EBI-3958099,EBI-719955
LNX1 [Q8TBB1]3EBI-3958099,EBI-739832
LY6H [O94772]3EBI-3958099,EBI-724687
MAPKBP1 [O60336]6EBI-3958099,EBI-947402
MEOX2 [P50222]3EBI-3958099,EBI-748397
MEOX2 [Q6FHY5]3EBI-3958099,EBI-16439278
MOBP - isoform 3 [Q13875-3]3EBI-3958099,EBI-12013470
MST065 [Q549C5]3EBI-3958099,EBI-10243297
MT1M [Q8N339]3EBI-3958099,EBI-3911571
NAXD [Q8IW45]3EBI-3958099,EBI-8650724
NCLN - isoform 2 [Q969V3-2]3EBI-3958099,EBI-10281480
NECTIN2 [Q92692]3EBI-3958099,EBI-718419
NECTIN3 - isoform 2 [Q9NQS3-2]3EBI-3958099,EBI-12106440
NKD1 [Q969G9]3EBI-3958099,EBI-1538217
NLK [Q9UBE8]3EBI-3958099,EBI-366978
NMU [P48645]6EBI-3958099,EBI-10210351
NOTCH2NLA [Q7Z3S9]3EBI-3958099,EBI-945833
NOTCH2NLC [P0DPK4]3EBI-3958099,EBI-22310682
NPBWR2 [P48146]3EBI-3958099,EBI-10210114
NPDC1 [Q9NQX5]6EBI-3958099,EBI-748927
NR4A3 [Q92570]3EBI-3958099,EBI-13644623
NTM [Q9P121]3EBI-3958099,EBI-4315078
NTN4 [Q9HB63]4EBI-3958099,EBI-743459
NTN4 - isoform 3 [Q9HB63-3]3EBI-3958099,EBI-10310092
NUFIP2 [Q7Z417]5EBI-3958099,EBI-1210753
OTX1 [P32242]8EBI-3958099,EBI-740446
P2RX4 [Q99571]3EBI-3958099,EBI-2828248
P2RY6 [Q15077]3EBI-3958099,EBI-10235794
P4HB [P07237]3EBI-3958099,EBI-395883
PCSK5 [Q92824]3EBI-3958099,EBI-751290
PCSK5 - isoform PC6A [Q92824-2]3EBI-3958099,EBI-11956269
PDE9A - isoform PDE9A2 [O76083-2]3EBI-3958099,EBI-11524542
PFKL [P17858]3EBI-3958099,EBI-487243
PHLDA1 [A2BDE7]3EBI-3958099,EBI-14084211
PIN1 [Q13526]3EBI-3958099,EBI-714158
POTEB3 [A0JP26]3EBI-3958099,EBI-18165900
POU4F2 [Q12837]3EBI-3958099,EBI-17236143
PRKAB2 [O43741]6EBI-3958099,EBI-1053424
PSMA1 [P25786]6EBI-3958099,EBI-359352
PTPMT1 [Q8WUK0]6EBI-3958099,EBI-7199479
RAMP3 [O60896]3EBI-3958099,EBI-720447
RASD1 [Q9Y272]3EBI-3958099,EBI-740818
RGS20 [O76081]3EBI-3958099,EBI-1052678
RGS20 - isoform 5 [O76081-6]6EBI-3958099,EBI-10178530
RNF111 [Q6ZNA4]5EBI-3958099,EBI-2129175
SCARB1 [Q8WTV0]3EBI-3958099,EBI-78657
SCNM1 [Q9BWG6]3EBI-3958099,EBI-748391
SDC3 [A0A0S2Z4U3]9EBI-3958099,EBI-10204280
SDCBP [O00560]6EBI-3958099,EBI-727004
SEMA3B - isoform 2 [Q13214-2]3EBI-3958099,EBI-11017428
SHFL [Q9NUL5]3EBI-3958099,EBI-10313866
SHFL - isoform 4 [Q9NUL5-4]3EBI-3958099,EBI-11955083
SLC13A5 [Q86YT5]3EBI-3958099,EBI-12002412
SLC15A3 [Q8IY34]3EBI-3958099,EBI-12179023
SLC22A23 [A1A5C7]3EBI-3958099,EBI-10171756
SLC25A10 [Q9UBX3]3EBI-3958099,EBI-750394
SLC25A10 - isoform 2 [Q9UBX3-2]3EBI-3958099,EBI-12056597
SMCP [P49901]8EBI-3958099,EBI-750494
SPATA3 [A0A024R4B0]3EBI-3958099,EBI-14123856
SPINK2 [P20155]3EBI-3958099,EBI-10200479
SPRY1 [O43609]3EBI-3958099,EBI-3866665
SPRY2 [O43597]3EBI-3958099,EBI-742487
TBC1D10C [Q8IV04]3EBI-3958099,EBI-10261452
TCEA2 [Q15560]3EBI-3958099,EBI-710310
TCEANC [Q8N8B7]3EBI-3958099,EBI-954696
TCEANC - isoform 2 [Q8N8B7-2]3EBI-3958099,EBI-11955057
TGM1 [P22735]3EBI-3958099,EBI-2562368
TMEM8A [Q9HCN3]3EBI-3958099,EBI-10310808
TUSC5 [A5PKU2]3EBI-3958099,EBI-11988865
TYRO3 [Q06418]5EBI-3958099,EBI-3951628
UBE2I [Q7KZS0]3EBI-3958099,EBI-10180829
UXT [Q9UBK9]3EBI-3958099,EBI-357355
VWC2 [Q2TAL6]3EBI-3958099,EBI-11957238
WDYHV1 [Q96HA8]6EBI-3958099,EBI-741158
WNT11 [O96014]3EBI-3958099,EBI-8058160
YIPF3 [Q9GZM5]3EBI-3958099,EBI-743787
ZBTB24 [O43167]3EBI-3958099,EBI-744471
ZFYVE21 [Q9BQ24]3EBI-3958099,EBI-2849569
ZNF124 [Q15973]6EBI-3958099,EBI-2555767
ZNF266 [Q14584]3EBI-3958099,EBI-7115319
ZNF408 [Q9H9D4]3EBI-3958099,EBI-347633
ZNF414 [Q96IQ9]3EBI-3958099,EBI-744257
ZNF417 [Q8TAU3]6EBI-3958099,EBI-740727
ZNF439 [Q8NDP4]6EBI-3958099,EBI-747580
ZNF440 [Q8IYI8]3EBI-3958099,EBI-726439
ZNF581 [Q9P0T4]3EBI-3958099,EBI-745520
ZNF587 [Q96SQ5]6EBI-3958099,EBI-6427977
ZNF655 [Q8N720]3EBI-3958099,EBI-625509
ZNF696 [Q9H7X3]3EBI-3958099,EBI-11090299
ZNF837 [Q96EG3]3EBI-3958099,EBI-11962574

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		110044, 109 interactors

Protein interaction database and analysis system

More...IntActi		P26371, 194 interactors

Molecular INTeraction database

More...MINTi		P26371

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000431443

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P26371 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati35 – 3814
Repeati41 – 4424
Repeati47 – 5034
Repeati82 – 8544
Repeati101 – 10454
Repeati130 – 13465
Repeati149 – 15274
Repeati159 – 16284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 1628 X 4 AA repeats of C-C-X-PAdd BLAST128

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the KRTAP type 5 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00950000186550

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_097966_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		DVCCNES

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002494 KAP

The PANTHER Classification System

More...PANTHERi		PTHR23262 PTHR23262, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P26371-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP 
        60         70         80         90        100
ACSCSSCGKR GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS 
       110        120        130        140        150
CCKPYCSQCS CCKPCCSSSG RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC 
       160 
KPCCSQSRCC VPVCYQCKI
Length:169
Mass (Da):16,276
Last modified:August 1, 1992 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i219B14FEEB49D4AB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0537318G → R. Corresponds to variant dbSNP:rs34213141Ensembl.1
Natural variantiVAR_05373240Y → C1 PublicationCorresponds to variant dbSNP:rs10792769Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X55293 Genomic DNA Translation: CAA39005.1
AJ006693 Genomic DNA Translation: CAA07189.1
X63755 mRNA Translation: CAA45283.1
AB126078 mRNA Translation: BAD20205.1
BC069531 mRNA Translation: AAH69531.1
BC101744 mRNA Translation: AAI01745.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53677.1

Protein sequence database of the Protein Information Resource

More...PIRi		S18946

NCBI Reference Sequences

More...RefSeqi		NP_005544.4, NM_005553.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000528743; ENSP00000431443; ENSG00000254997

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3846

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3846

UCSC genome browser

More...UCSCi		uc001oqs.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55293 Genomic DNA Translation: CAA39005.1
AJ006693 Genomic DNA Translation: CAA07189.1
X63755 mRNA Translation: CAA45283.1
AB126078 mRNA Translation: BAD20205.1
BC069531 mRNA Translation: AAH69531.1
BC101744 mRNA Translation: AAI01745.2
CCDSiCCDS53677.1
PIRiS18946
RefSeqiNP_005544.4, NM_005553.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi110044, 109 interactors
IntActiP26371, 194 interactors
MINTiP26371
STRINGi9606.ENSP00000431443

PTM databases

iPTMnetiP26371
PhosphoSitePlusiP26371

Polymorphism and mutation databases

BioMutaiKRTAP5-9

Proteomic databases

PaxDbiP26371
PRIDEiP26371
ProteomicsDBi54327

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3846

Genome annotation databases

EnsembliENST00000528743; ENSP00000431443; ENSG00000254997
GeneIDi3846
KEGGihsa:3846
UCSCiuc001oqs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3846
DisGeNETi3846

GeneCards: human genes, protein and diseases

More...GeneCardsi		KRTAP5-9
HGNCiHGNC:23604 KRTAP5-9
HPAiENSG00000254997 Tissue enhanced (epididymis, testis, urinary bladder)
MIMi148021 gene
neXtProtiNX_P26371
OpenTargetsiENSG00000254997
PharmGKBiPA134946701

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00950000186550
HOGENOMiCLU_097966_0_0_1
OMAiDVCCNES

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3846
PharosiP26371 Tbio

Protein Ontology

More...PROi		PR:P26371
RNActiP26371 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000254997 Expressed in hair follicle and 66 other tissues
GenevisibleiP26371 HS

Family and domain databases

InterProiView protein in InterPro
IPR002494 KAP
PANTHERiPTHR23262 PTHR23262, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKRA59_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P26371
Secondary accession number(s): Q14564, Q3MIP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1992
Last sequence update: August 1, 1992
Last modified: April 22, 2020
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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