U2AF2

Functionⁱ

Plays a role in pre-mRNA splicing and 3'-end processing (PubMed:17024186). By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. Positively regulates pre-mRNA 3'-end processing by recruiting the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).5 Publications

GO - Molecular functionⁱ

C2H2 zinc finger domain binding Source: Ensembl
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19574390
poly-pyrimidine tract binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
pre-mRNA 3'-splice site binding
Source: GO_Central
Inferred from direct assayⁱ
- 2531895
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mRNA 3'-end processing Source: Reactome
mRNA export from nucleus Source: Reactome
mRNA processing
Source: ProtInc
Traceable author statementⁱ
- 1538748
mRNA splicing, via spliceosome
Source: GO_Central
Inferred from direct assayⁱ
- 1824937
negative regulation of mRNA splicing, via spliceosome
Source: UniProtKB
Inferred from direct assayⁱ
- 15009664
negative regulation of protein ubiquitination
Source: BHF-UCL
Inferred from direct assayⁱ
- 24389012
positive regulation of RNA splicing
Source: UniProtKB
Inferred from direct assayⁱ
- 21536736
RNA export from nucleus Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor, RNA-binding
Biological process	mRNA processing, mRNA splicing

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	P26368

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Splicing factor U2AF 65 kDa subunit Alternative name(s): U2 auxiliary factor 65 kDa subunit Short name: hU2AF(65) Short name: hU2AF65 U2 snRNP auxiliary factor large subunit
Gene namesⁱ	Name:U2AF2 Synonyms:U2AF65
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000063244.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23156 U2AF2
MIMⁱ	191318 gene
neXtProtⁱ	NX_P26368

Keywords - Cellular componentⁱ

Nucleus, Spliceosome

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	92	W → A: Decreases affinity for UAF1 by 3 orders of magnitude. 1 Publication	1
Mutagenesisⁱ	96	P → G: Decreases affinity for UAF1 by 2 orders of magnitude. 1 Publication	1
Mutagenesisⁱ	104	P → G: Decreases affinity for UAF1 by 2 orders of magnitude. 1 Publication	1
Mutagenesisⁱ	387 – 388	EE → RR: Reduces interaction with SF1. 1 Publication	2
Mutagenesisⁱ	391 – 394	DDEE → AAAA: Reduces interaction with SF1.	4
Mutagenesisⁱ	391 – 394	DDEE → RRKK: Reduces interaction with SF1.	4
Mutagenesisⁱ	396 – 397	EE → AA: No effect. 1 Publication	2
Mutagenesisⁱ	396 – 397	EE → GA: Reduces interaction with SF1. 1 Publication	2
Mutagenesisⁱ	396 – 397	EE → KK: Reduces interaction with SF1. 1 Publication	2
Mutagenesisⁱ	454	F → A: Reduces interaction with SF1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11338
Open Targets More...OpenTargetsⁱ	ENSG00000063244
PharmGKBⁱ	PA134908683

Polymorphism and mutation databases

BioMutaⁱ	U2AF2
DMDMⁱ	267188

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000081988	2 – 475	Splicing factor U2AF 65 kDa subunitAdd BLAST		474

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources1 Publication	1
Modified residueⁱ	2	PhosphoserineCombined sources	1
Modified residueⁱ	15	5-hydroxylysine; by JMJD6; alternate1 Publication	1
Cross-linkⁱ	15	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	70	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	70	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	79	PhosphoserineCombined sources	1
Modified residueⁱ	276	5-hydroxylysine; by JMJD61 Publication	1
Modified residueⁱ	294	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Keywords - PTMⁱ

Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P26368
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P26368
PaxDbⁱ	P26368
PeptideAtlas More...PeptideAtlasⁱ	P26368
PRIDEⁱ	P26368
ProteomicsDBⁱ	54325 54326 [P26368-2]
TopDownProteomicsⁱ	P26368-1 [P26368-1] P26368-2 [P26368-2]

PTM databases

iPTMnetⁱ	P26368
PhosphoSitePlusⁱ	P26368
SwissPalmⁱ	P26368

Miscellaneous databases

PMAP-CutDBⁱ	P26368

PMAP-CutDBⁱ

P26368

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000063244 Expressed in 222 organ(s), highest expression level in right testis
CleanExⁱ	HS_U2AF2
ExpressionAtlasⁱ	P26368 baseline and differential
Genevisibleⁱ	P26368 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB010910 HPA041943 HPA043562

HPAⁱ

CAB010910
HPA041943
HPA043562

Interactionⁱ

Subunit structureⁱ

Interacts with U2AF1L4 (By similarity). Heterodimer with U2AF1 (PubMed:11551507). Binds unphosphorylated SF1 (PubMed:10449420, PubMed:12718882). Interacts with SCAF11 and SNW1 (PubMed:9447963, PubMed:21460037). Interacts with ZRSR2/U2AF1-RS2. Interacts with RBM17 (PubMed:17589525). Interacts with PRPF19; the interaction is direct. Interacts with POLR2A (via the C-terminal domain); recruits PRPF19 and the Prp19 complex to the pre-mRNA (PubMed:21536736). Interacts with KHDC4 (Isoform 2) (PubMed:19641227). Interacts with ZRSR2 (PubMed:9237760). Interacts with the SF3B complex composed of SF3B1, SF3B2, SF3B3, SF3B4, SF3B5, SF3B6 and PHF5A (PubMed:27720643). Interacts (via N-terminus) with CPSF7 (via C-terminus); this interaction stimulates pre-mRNA 3'-end processing by promoting the recruitment of the CFIm complex to cleavage and polyadenylation signals (PubMed:17024186).By similarity12 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AES	Q08117	3	EBI-742339,EBI-717810
ATXN1	P54253	4	EBI-742339,EBI-930964
CHERP	Q8IWX8	2	EBI-742339,EBI-2555370
CPSF7	Q8N684	2	EBI-742339,EBI-746909
DACH1	Q9UI36-2	3	EBI-742339,EBI-10186082
DDX39B	Q13838	4	EBI-11097439,EBI-348622
MUC1	P15941	2	EBI-742339,EBI-2804728
PRPF3	O43395	2	EBI-742339,EBI-744322
PUF60	Q9UHX1	5	EBI-742339,EBI-1053259
RBM10	P98175	2	EBI-742339,EBI-721525
RBM17	Q96I25	2	EBI-742339,EBI-740272
RBM5	P52756	2	EBI-742339,EBI-714003
SARNP	P82979	3	EBI-742339,EBI-347495
SF1	Q15637	19	EBI-742339,EBI-744603
SNRPA	P09012	5	EBI-742339,EBI-607085
SNW1	Q13573	5	EBI-742339,EBI-632715
SRPK2	P78362	4	EBI-742339,EBI-593303
SUGP1	Q8IWZ8	3	EBI-742339,EBI-2691671
THAP1	Q9NVV9	4	EBI-742339,EBI-741515
U2AF1	Q01081	11	EBI-742339,EBI-632461
U2AF1L5	P0DN76	4	EBI-11097439,EBI-14082807

GO - Molecular functionⁱ

C2H2 zinc finger domain binding Source: Ensembl
enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19574390

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116466, 382 interactors
CORUMⁱ	P26368
Database of interacting proteins More...DIPⁱ	DIP-2154N
IntActⁱ	P26368, 77 interactors
Molecular INTeraction database More...MINTⁱ	P26368
STRINGⁱ	9606.ENSP00000307863

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	104 – 109	Combined sources	6
Helixⁱ	147 – 149	Combined sources	3
Beta strandⁱ	150 – 155	Combined sources	6
Helixⁱ	162 – 175	Combined sources	14
Beta strandⁱ	180 – 183	Combined sources	4
Beta strandⁱ	185 – 191	Combined sources	7
Turnⁱ	193 – 196	Combined sources	4
Beta strandⁱ	197 – 203	Combined sources	7
Helixⁱ	205 – 211	Combined sources	7
Helixⁱ	212 – 214	Combined sources	3
Beta strandⁱ	219 – 222	Combined sources	4
Beta strandⁱ	225 – 227	Combined sources	3
Beta strandⁱ	238 – 240	Combined sources	3
Beta strandⁱ	244 – 246	Combined sources	3
Beta strandⁱ	260 – 264	Combined sources	5
Helixⁱ	272 – 280	Combined sources	9
Beta strandⁱ	281 – 283	Combined sources	3
Beta strandⁱ	285 – 292	Combined sources	8
Turnⁱ	294 – 296	Combined sources	3
Beta strandⁱ	299 – 308	Combined sources	10
Helixⁱ	310 – 320	Combined sources	11
Beta strandⁱ	326 – 328	Combined sources	3
Beta strandⁱ	331 – 334	Combined sources	4
Helixⁱ	335 – 338	Combined sources	4
Beta strandⁱ	376 – 383	Combined sources	8
Helixⁱ	386 – 389	Combined sources	4
Helixⁱ	392 – 406	Combined sources	15
Turnⁱ	407 – 409	Combined sources	3
Beta strandⁱ	414 – 416	Combined sources	3
Turnⁱ	422 – 424	Combined sources	3
Turnⁱ	427 – 430	Combined sources	4
Beta strandⁱ	431 – 435	Combined sources	5
Helixⁱ	439 – 449	Combined sources	11
Beta strandⁱ	454 – 457	Combined sources	4
Beta strandⁱ	460 – 463	Combined sources	4
Helixⁱ	466 – 470	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	P26368
SMRⁱ	P26368
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P26368

EvolutionaryTraceⁱ

P26368

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	149 – 231	RRM 1PROSITE-ProRule annotationAdd BLAST	83
Domainⁱ	259 – 337	RRM 2PROSITE-ProRule annotationAdd BLAST	79
Domainⁱ	385 – 466	RRM 3PROSITE-ProRule annotationAdd BLAST	82

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	2 – 93	Required for interaction with PRPF191 PublicationAdd BLAST		92
Regionⁱ	17 – 47	Necessary and sufficient to stimulate pre-mRNAs 3'-end cleavage in a CFIm complex-dependent manner1 PublicationAdd BLAST		31

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	27 – 62	Arg/Ser-rich (RS domain)Add BLAST		36

Sequence similaritiesⁱ

Belongs to the splicing factor SR family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0120 Eukaryota ENOG410XP92 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00790000123065
HOGENOMⁱ	HOG000180745
HOVERGENⁱ	HBG062169
InParanoidⁱ	P26368
KEGG Orthology (KO) More...KOⁱ	K12837
OMAⁱ	MQAKQTG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08BA
PhylomeDBⁱ	P26368
TreeFamⁱ	TF314111

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR006529 U2AF_lg
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 3 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
TIGRFAMsⁱ	TIGR01642 U2AF_lg, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P26368-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDFDEFERQ LNENKQERDK ENRHRKRSHS RSRSRDRKRR SRSRDRRNRD 
        60         70         80         90        100
QRSASRDRRR RSKPLTRGAK EEHGGLIRSP RHEKKKKVRK YWDVPPPGFE 
       110        120        130        140        150
HITPMQYKAM QAAGQIPATA LLPTMTPDGL AVTPTPVPVV GSQMTRQARR 
       160        170        180        190        200
LYVGNIPFGI TEEAMMDFFN AQMRLGGLTQ APGNPVLAVQ INQDKNFAFL 
       210        220        230        240        250
EFRSVDETTQ AMAFDGIIFQ GQSLKIRRPH DYQPLPGMSE NPSVYVPGVV 
       260        270        280        290        300
STVVPDSAHK LFIGGLPNYL NDDQVKELLT SFGPLKAFNL VKDSATGLSK 
       310        320        330        340        350
GYAFCEYVDI NVTDQAIAGL NGMQLGDKKL LVQRASVGAK NATLVSPPST 
       360        370        380        390        400
INQTPVTLQV PGLMSSQVQM GGHPTEVLCL MNMVLPEELL DDEEYEEIVE 
       410        420        430        440        450
DVRDECSKYG LVKSIEIPRP VDGVEVPGCG KIFVEFTSVF DCQKAMQGLT 
       460        470 
GRKFANRVVV TKYCDPDSYH RRDFW

Length:475

Mass (Da):53,501

Last modified:January 23, 2007 - v4

Checksum:ⁱ26AD271CD8FC6211

GO

Isoform 2 (identifier: P26368-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
345-348: Missing.

« Hide

        10         20         30         40         50
MSDFDEFERQ LNENKQERDK ENRHRKRSHS RSRSRDRKRR SRSRDRRNRD 
        60         70         80         90        100
QRSASRDRRR RSKPLTRGAK EEHGGLIRSP RHEKKKKVRK YWDVPPPGFE 
       110        120        130        140        150
HITPMQYKAM QAAGQIPATA LLPTMTPDGL AVTPTPVPVV GSQMTRQARR 
       160        170        180        190        200
LYVGNIPFGI TEEAMMDFFN AQMRLGGLTQ APGNPVLAVQ INQDKNFAFL 
       210        220        230        240        250
EFRSVDETTQ AMAFDGIIFQ GQSLKIRRPH DYQPLPGMSE NPSVYVPGVV 
       260        270        280        290        300
STVVPDSAHK LFIGGLPNYL NDDQVKELLT SFGPLKAFNL VKDSATGLSK 
       310        320        330        340        350
GYAFCEYVDI NVTDQAIAGL NGMQLGDKKL LVQRASVGAK NATLSTINQT 
       360        370        380        390        400
PVTLQVPGLM SSQVQMGGHP TEVLCLMNMV LPEELLDDEE YEEIVEDVRD 
       410        420        430        440        450
ECSKYGLVKS IEIPRPVDGV EVPGCGKIFV EFTSVFDCQK AMQGLTGRKF 
       460        470 
ANRVVVTKYC DPDSYHRRDF W

Show »

Length:471

Mass (Da):53,121

Checksum:ⁱ3F59A02CD2B03F46

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ENG2	K7ENG2_HUMAN	U2 snRNP auxiliary factor large sub... U2 snRNP auxiliary factor large subunit	U2AF2	307	Annotation score:
K7ELP8	K7ELP8_HUMAN	Splicing factor U2AF 65 kDa subunit Splicing factor U2AF 65 kDa subunit	U2AF2	86	Annotation score:
M0QYQ9	M0QYQ9_HUMAN	Splicing factor U2AF 65 kDa subunit Splicing factor U2AF 65 kDa subunit	U2AF2	51	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035414	345 – 348	Missing in isoform 2. 1 Publication		4

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64044 mRNA Translation: CAA45409.1 CH471135 Genomic DNA Translation: EAW72404.1 BC008740 mRNA Translation: AAH08740.1 BC030574 mRNA Translation: AAH30574.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12933.1 [P26368-1] CCDS46197.1 [P26368-2]
PIRⁱ	S20250
NCBI Reference Sequences More...RefSeqⁱ	NP_001012496.1, NM_001012478.1 [P26368-2] NP_009210.1, NM_007279.2 [P26368-1]
UniGeneⁱ	Hs.528007

Genome annotation databases

Ensemblⁱ	ENST00000308924; ENSP00000307863; ENSG00000063244 [P26368-1] ENST00000450554; ENSP00000388475; ENSG00000063244 [P26368-2]
GeneIDⁱ	11338
KEGGⁱ	hsa:11338
UCSC genome browser More...UCSCⁱ	uc002qlt.4 human [P26368-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P26368	U2 snRNP auxiliary factor large subunit		CALJA		475	UniRef100_P26368
U2 snRNP auxiliary factor large subunit		PANTR		475
U2 snRNP auxiliary factor large subunit		PROCO		475
U2 snRNP auxiliary factor large subunit		MACMU		475
U2 snRNP auxiliary factor large subunit		Cebus capucinus imitator		475
+16
P26368-2	U2 snRNP auxiliary factor large subunit		MOUSE		471	UniRef100_Q80XR5
U2 snRNP auxiliary factor large subunit		CALJA		471
U2 snRNP auxiliary factor large subunit		PANTR		471
U2 snRNP auxiliary factor large subunit		PIG		471
U2 snRNP auxiliary factor large subunit		SAIBB		471
+22

Protein	Similar proteins		Species	Score	Length	Source
P26368	Splicing factor U2AF 65 kDa subunit	)	MOUSE		475	UniRef90_P26368
U2 snRNP auxiliary factor large subunit		CALJA		475
U2 snRNP auxiliary factor large subunit		PANTR		475
U2 snRNP auxiliary factor large subunit		PROCO		475
U2 snRNP auxiliary factor large subunit		MACMU		475
+148

Protein	Similar proteins		Species	Score	Length	Source
P26368	Splicing factor U2AF 65 kDa subunit	)	MOUSE		475	UniRef50_P26368
U2 snRNP auxiliary factor large subunit		CALJA		475
U2 snRNP auxiliary factor large subunit		PANTR		475
U2 snRNP auxiliary factor large subunit		PROCO		475
U2 snRNP auxiliary factor large subunit		MACMU		475
+304

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X64044 mRNA Translation: CAA45409.1 CH471135 Genomic DNA Translation: EAW72404.1 BC008740 mRNA Translation: AAH08740.1 BC030574 mRNA Translation: AAH30574.1
CCDSⁱ	CCDS12933.1 [P26368-1] CCDS46197.1 [P26368-2]
PIRⁱ	S20250
RefSeqⁱ	NP_001012496.1, NM_001012478.1 [P26368-2] NP_009210.1, NM_007279.2 [P26368-1]
UniGeneⁱ	Hs.528007

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1JMT	X-ray	2.20	B	85-112	[»]
	1O0P	NMR	-	A	372-475	[»]
	1OPI	NMR	-	A	372-475	[»]
	1U2F	NMR	-	A	148-237	[»]
	2G4B	X-ray	2.50	A	148-336	[»]
	2HZC	X-ray	1.47	A	148-229	[»]
	2M0G	NMR	-	B	372-475	[»]
	2U2F	NMR	-	A	258-342	[»]
	2YH0	NMR	-	A	148-342	[»]
	2YH1	NMR	-	A	148-342	[»]
	3VAF	X-ray	2.49	A/B	148-336	[»]
	3VAG	X-ray	2.19	A/B	148-336	[»]
	3VAH	X-ray	2.50	A/B	148-336	[»]
	3VAI	X-ray	2.20	A/B	148-336	[»]
	3VAJ	X-ray	1.90	A/B	148-336	[»]
	3VAK	X-ray	2.17	A/B	148-336	[»]
	3VAL	X-ray	2.50	A/B/D/I	148-336	[»]
	3VAM	X-ray	2.40	A/B	148-336	[»]
	4FXW	X-ray	2.29	A/C	375-475	[»]
	4TU7	X-ray	2.09	A/B	148-336	[»]
	4TU8	X-ray	1.92	A/B	148-336	[»]
	4TU9	X-ray	1.99	A/B	148-336	[»]
	5EV1	X-ray	2.04	A	141-341	[»]
	5EV2	X-ray	1.86	A	141-341	[»]
	5EV3	X-ray	1.50	A	141-341	[»]
	5EV4	X-ray	1.57	A	141-341	[»]
	5W0G	X-ray	1.07	A	148-229	[»]
	5W0H	X-ray	1.11	A	258-336	[»]
ProteinModelPortalⁱ	P26368
SMRⁱ	P26368
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116466, 382 interactors
CORUMⁱ	P26368
DIPⁱ	DIP-2154N
IntActⁱ	P26368, 77 interactors
MINTⁱ	P26368
STRINGⁱ	9606.ENSP00000307863

PTM databases

iPTMnetⁱ	P26368
PhosphoSitePlusⁱ	P26368
SwissPalmⁱ	P26368

Polymorphism and mutation databases

BioMutaⁱ	U2AF2
DMDMⁱ	267188

Proteomic databases

EPDⁱ	P26368
MaxQBⁱ	P26368
PaxDbⁱ	P26368
PeptideAtlasⁱ	P26368
PRIDEⁱ	P26368
ProteomicsDBⁱ	54325 54326 [P26368-2]
TopDownProteomicsⁱ	P26368-1 [P26368-1] P26368-2 [P26368-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11338
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308924; ENSP00000307863; ENSG00000063244 [P26368-1] ENST00000450554; ENSP00000388475; ENSG00000063244 [P26368-2]
GeneIDⁱ	11338
KEGGⁱ	hsa:11338
UCSCⁱ	uc002qlt.4 human [P26368-1]

Organism-specific databases

CTDⁱ	11338
DisGeNETⁱ	11338
EuPathDBⁱ	HostDB:ENSG00000063244.12
GeneCardsⁱ	U2AF2
HGNCⁱ	HGNC:23156 U2AF2
HPAⁱ	CAB010910 HPA041943 HPA043562
MIMⁱ	191318 gene
neXtProtⁱ	NX_P26368
OpenTargetsⁱ	ENSG00000063244
PharmGKBⁱ	PA134908683
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0120 Eukaryota ENOG410XP92 LUCA
GeneTreeⁱ	ENSGT00790000123065
HOGENOMⁱ	HOG000180745
HOVERGENⁱ	HBG062169
InParanoidⁱ	P26368
KOⁱ	K12837
OMAⁱ	MQAKQTG
OrthoDBⁱ	EOG091G08BA
PhylomeDBⁱ	P26368
TreeFamⁱ	TF314111

Enzyme and pathway databases

Reactomeⁱ	R-HSA-109688 Cleavage of Growing Transcript in the Termination Region R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript R-HSA-72163 mRNA Splicing - Major Pathway R-HSA-72187 mRNA 3'-end processing
SIGNORⁱ	P26368

Miscellaneous databases

ChiTaRSⁱ	U2AF2 human
EvolutionaryTraceⁱ	P26368
GeneWikiⁱ	U2AF2
GenomeRNAiⁱ	11338
PMAP-CutDBⁱ	P26368
Protein Ontology More...PROⁱ	PR:P26368
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000063244 Expressed in 222 organ(s), highest expression level in right testis
CleanExⁱ	HS_U2AF2
ExpressionAtlasⁱ	P26368 baseline and differential
Genevisibleⁱ	P26368 HS

Family and domain databases

Gene3Dⁱ	3.30.70.330, 3 hits
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR035979 RBD_domain_sf IPR000504 RRM_dom IPR006529 U2AF_lg
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 3 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 3 hits
SUPFAMⁱ	SSF54928 SSF54928, 3 hits
TIGRFAMsⁱ	TIGR01642 U2AF_lg, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	U2AF2_HUMAN
Accessionⁱ	P26368Primary (citable) accession number: P26368 Secondary accession number(s): Q96HC5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1992
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 210 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - P26368 (U2AF2_HUMAN)

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Splicing factor U2AF 65 kDa subunit

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ