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Protein

Prothymosin alpha

Gene

Ptma

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Molecular functioni

  • activating transcription factor binding Source: Ensembl
  • histone binding Source: MGI

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:Ptma
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97803 Ptma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232561 – 111Prothymosin alphaAdd BLAST111
Initiator methionineiRemoved; alternateCombined sources1 Publication
ChainiPRO_00002992512 – 111Prothymosin alpha, N-terminally processedAdd BLAST110
PeptideiPRO_00000298662 – 29Thymosin alphaAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylserine; in Prothymosin alpha, N-terminally processedCombined sources1
Modified residuei2PhosphoserineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei9PhosphoserineBy similarity1
Modified residuei10PhosphoserineBy similarity1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15N6-acetyllysine; alternateCombined sources1
Modified residuei15N6-succinyllysine; alternateCombined sources1
Modified residuei102PhosphothreonineBy similarity1
Modified residuei103N6-acetyllysine; alternateCombined sources1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei107PhosphothreonineBy similarity1

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP26350
PaxDbiP26350
PeptideAtlasiP26350
PRIDEiP26350
TopDownProteomicsiP26350

PTM databases

iPTMnetiP26350
PhosphoSitePlusiP26350

Miscellaneous databases

PMAP-CutDBiP26350

Expressioni

Gene expression databases

BgeeiENSMUSG00000026238 Expressed in 81 organ(s), highest expression level in thymus
CleanExiMM_PTMA
ExpressionAtlasiP26350 baseline and differential
GenevisibleiP26350 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202469, 4 interactors
ELMiP26350
STRINGi10090.ENSMUSP00000044188

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP26350
SMRiP26350
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP26350

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 101Asp/Glu-rich (acidic)Add BLAST60

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563 Eukaryota
ENOG410ZA5I LUCA
GeneTreeiENSGT00730000111051
HOVERGENiHBG078507
InParanoidiP26350
KOiK13784
OMAiANWNDNE
TreeFamiTF350357

Family and domain databases

InterProiView protein in InterPro
IPR004931 Pro/parathymosin
PANTHERiPTHR22745 PTHR22745, 1 hit
PfamiView protein in Pfam
PF03247 Prothymosin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P26350-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV
110
DTKKQKTEED D
Length:111
Mass (Da):12,254
Last modified:January 23, 2007 - v2
Checksum:i345FACE953A3E8FA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WPN6A0A087WPN6_MOUSE
Prothymosin alpha
Ptma
98Annotation score:
A0A087WQN2A0A087WQN2_MOUSE
Prothymosin alpha
Ptma
145Annotation score:
A0A087WP98A0A087WP98_MOUSE
Prothymosin alpha
Ptma mCG_133549
58Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106K → KK AA sequence (PubMed:2226839).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56135 mRNA Translation: CAA39601.1
AK037980 mRNA Translation: BAC29913.1
AK084218 mRNA Translation: BAC39141.1
AK132003 mRNA Translation: BAE20932.1
AK142076 mRNA Translation: BAE24932.1
AK145650 mRNA Translation: BAE26566.1
AK153953 mRNA Translation: BAE32276.1
BC081453 mRNA Translation: AAH81453.1
BC083135 mRNA Translation: AAH83135.1
CCDSiCCDS35649.1
PIRiS15073
RefSeqiNP_032998.1, NM_008972.2
UniGeneiMm.19187

Genome annotation databases

EnsembliENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238
GeneIDi19231
KEGGimmu:19231
UCSCiuc007bvp.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56135 mRNA Translation: CAA39601.1
AK037980 mRNA Translation: BAC29913.1
AK084218 mRNA Translation: BAC39141.1
AK132003 mRNA Translation: BAE20932.1
AK142076 mRNA Translation: BAE24932.1
AK145650 mRNA Translation: BAE26566.1
AK153953 mRNA Translation: BAE32276.1
BC081453 mRNA Translation: AAH81453.1
BC083135 mRNA Translation: AAH83135.1
CCDSiCCDS35649.1
PIRiS15073
RefSeqiNP_032998.1, NM_008972.2
UniGeneiMm.19187

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Z32X-ray2.00B39-54[»]
ProteinModelPortaliP26350
SMRiP26350
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202469, 4 interactors
ELMiP26350
STRINGi10090.ENSMUSP00000044188

PTM databases

iPTMnetiP26350
PhosphoSitePlusiP26350

Proteomic databases

EPDiP26350
PaxDbiP26350
PeptideAtlasiP26350
PRIDEiP26350
TopDownProteomicsiP26350

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238
GeneIDi19231
KEGGimmu:19231
UCSCiuc007bvp.1 mouse

Organism-specific databases

CTDi5757
MGIiMGI:97803 Ptma

Phylogenomic databases

eggNOGiENOG410J563 Eukaryota
ENOG410ZA5I LUCA
GeneTreeiENSGT00730000111051
HOVERGENiHBG078507
InParanoidiP26350
KOiK13784
OMAiANWNDNE
TreeFamiTF350357

Miscellaneous databases

ChiTaRSiPtma mouse
EvolutionaryTraceiP26350
PMAP-CutDBiP26350
PROiPR:P26350
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026238 Expressed in 81 organ(s), highest expression level in thymus
CleanExiMM_PTMA
ExpressionAtlasiP26350 baseline and differential
GenevisibleiP26350 MM

Family and domain databases

InterProiView protein in InterPro
IPR004931 Pro/parathymosin
PANTHERiPTHR22745 PTHR22745, 1 hit
PfamiView protein in Pfam
PF03247 Prothymosin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTMA_MOUSE
AccessioniPrimary (citable) accession number: P26350
Secondary accession number(s): Q3UQV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 1992
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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