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UniProtKB - P26350 (PTMA_MOUSE)
Protein
Prothymosin alpha
Gene
Ptma
Organism
Mus musculus (Mouse)
Status
Functioni
Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.
GO - Molecular functioni
- DNA-binding transcription factor binding Source: MGI
- histone binding Source: MGI
GO - Biological processi
- histone exchange Source: MGI
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: MGI
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: Prothymosin alphaCleaved into the following 2 chains: |
Gene namesi | Name:Ptma |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97803, Ptma |
VEuPathDBi | HostDB:ENSMUSG00000026238 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000423256 | 1 – 111 | Prothymosin alphaAdd BLAST | 111 | |
Initiator methioninei | Removed; alternateCombined sources1 Publication | |||
ChainiPRO_0000299251 | 2 – 111 | Prothymosin alpha, N-terminally processedAdd BLAST | 110 | |
PeptideiPRO_0000029866 | 2 – 29 | Thymosin alphaAdd BLAST | 28 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylserine; in Prothymosin alpha, N-terminally processedCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineBy similarity | 1 | |
Modified residuei | 8 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 9 | PhosphoserineBy similarity | 1 | |
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Modified residuei | 13 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 14 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 15 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 15 | N6-succinyllysine; alternateCombined sources | 1 | |
Modified residuei | 102 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 103 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 103 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 107 | PhosphothreonineBy similarity | 1 |
Post-translational modificationi
Covalently linked to a small RNA of about 20 nucleotides.
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P26350 |
jPOSTi | P26350 |
PaxDbi | P26350 |
PeptideAtlasi | P26350 |
PRIDEi | P26350 |
ProteomicsDBi | 301957 |
TopDownProteomicsi | P26350 |
PTM databases
iPTMneti | P26350 |
PhosphoSitePlusi | P26350 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026238, Expressed in forelimb bud and 124 other tissues |
Genevisiblei | P26350, MM |
Interactioni
Subunit structurei
Interacts with NUPR1; regulates apoptotic process.
By similarityGO - Molecular functioni
- DNA-binding transcription factor binding Source: MGI
- histone binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 202469, 19 interactors |
ELMi | P26350 |
IntActi | P26350, 1 interactor |
STRINGi | 10090.ENSMUSP00000044188 |
Miscellaneous databases
RNActi | P26350, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P26350 |
BMRBi | P26350 |
SMRi | P26350 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P26350 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 111 | DisorderedSequence analysisAdd BLAST | 111 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 29 | Basic and acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 45 – 82 | Acidic residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 83 – 111 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the pro/parathymosin family.Curated
Phylogenomic databases
eggNOGi | ENOG502S55T, Eukaryota |
GeneTreei | ENSGT01020000232226 |
InParanoidi | P26350 |
OMAi | RTPPMND |
TreeFami | TF350357 |
Family and domain databases
IDEALi | IID50035 |
InterProi | View protein in InterPro IPR004931, Pro/parathymosin |
PANTHERi | PTHR22745, PTHR22745, 1 hit |
Pfami | View protein in Pfam PF03247, Prothymosin, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P26350-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAQ NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAEAPTGKR VAEDDEDDDV
110
DTKKQKTEED D
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WP98 | A0A087WP98_MOUSE | Prothymosin alpha | Ptma | 58 | Annotation score: | ||
A0A087WPN6 | A0A087WPN6_MOUSE | Prothymosin alpha | Ptma | 98 | Annotation score: | ||
A0A087WQN2 | A0A087WQN2_MOUSE | Prothymosin alpha | Ptma | 145 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 106 | K → KK AA sequence (PubMed:2226839).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56135 mRNA Translation: CAA39601.1 AK037980 mRNA Translation: BAC29913.1 AK084218 mRNA Translation: BAC39141.1 AK132003 mRNA Translation: BAE20932.1 AK142076 mRNA Translation: BAE24932.1 AK145650 mRNA Translation: BAE26566.1 AK153953 mRNA Translation: BAE32276.1 BC081453 mRNA Translation: AAH81453.1 BC083135 mRNA Translation: AAH83135.1 |
CCDSi | CCDS35649.1 |
PIRi | S15073 |
RefSeqi | NP_032998.1, NM_008972.2 |
Genome annotation databases
Ensembli | ENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238 |
GeneIDi | 19231 |
KEGGi | mmu:19231 |
UCSCi | uc007bvp.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X56135 mRNA Translation: CAA39601.1 AK037980 mRNA Translation: BAC29913.1 AK084218 mRNA Translation: BAC39141.1 AK132003 mRNA Translation: BAE20932.1 AK142076 mRNA Translation: BAE24932.1 AK145650 mRNA Translation: BAE26566.1 AK153953 mRNA Translation: BAE32276.1 BC081453 mRNA Translation: AAH81453.1 BC083135 mRNA Translation: AAH83135.1 |
CCDSi | CCDS35649.1 |
PIRi | S15073 |
RefSeqi | NP_032998.1, NM_008972.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2Z32 | X-ray | 2.00 | B | 39-54 | [»] | |
AlphaFoldDBi | P26350 | |||||
BMRBi | P26350 | |||||
SMRi | P26350 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 202469, 19 interactors |
ELMi | P26350 |
IntActi | P26350, 1 interactor |
STRINGi | 10090.ENSMUSP00000044188 |
PTM databases
iPTMneti | P26350 |
PhosphoSitePlusi | P26350 |
Proteomic databases
EPDi | P26350 |
jPOSTi | P26350 |
PaxDbi | P26350 |
PeptideAtlasi | P26350 |
PRIDEi | P26350 |
ProteomicsDBi | 301957 |
TopDownProteomicsi | P26350 |
Protocols and materials databases
DNASUi | 19231 |
Genome annotation databases
Ensembli | ENSMUST00000045897; ENSMUSP00000044188; ENSMUSG00000026238 |
GeneIDi | 19231 |
KEGGi | mmu:19231 |
UCSCi | uc007bvp.1, mouse |
Organism-specific databases
CTDi | 5757 |
MGIi | MGI:97803, Ptma |
VEuPathDBi | HostDB:ENSMUSG00000026238 |
Phylogenomic databases
eggNOGi | ENOG502S55T, Eukaryota |
GeneTreei | ENSGT01020000232226 |
InParanoidi | P26350 |
OMAi | RTPPMND |
TreeFami | TF350357 |
Miscellaneous databases
BioGRID-ORCSi | 19231, 17 hits in 72 CRISPR screens |
ChiTaRSi | Ptma, mouse |
EvolutionaryTracei | P26350 |
PROi | PR:P26350 |
RNActi | P26350, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026238, Expressed in forelimb bud and 124 other tissues |
Genevisiblei | P26350, MM |
Family and domain databases
IDEALi | IID50035 |
InterProi | View protein in InterPro IPR004931, Pro/parathymosin |
PANTHERi | PTHR22745, PTHR22745, 1 hit |
Pfami | View protein in Pfam PF03247, Prothymosin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PTMA_MOUSE | |
Accessioni | P26350Primary (citable) accession number: P26350 Secondary accession number(s): Q3UQV6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 156 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families