Transforming growth factor beta receptor type 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
    Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K.
    Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
• coreceptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling."
    Lewis K.A., Gray P.C., Blount A.L., MacConell L.A., Wiater E., Bilezikjian L.M., Vale W.
    Nature 404:411-414(2000) [PubMed] [Europe PMC] [Abstract]
• fibroblast growth factor binding Source: RGDInferred from direct assayⁱ
  • "Binding of two growth factor families to separate domains of the proteoglycan betaglycan."
    Andres J.L., DeFalcis D., Noda M., Massague J.
    J. Biol. Chem. 267:5927-5930(1992) [PubMed] [Europe PMC] [Abstract]
• glycosaminoglycan binding Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• heparin binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from sequence orthologyⁱ
  • "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."
    Blobe G.C., Liu X., Fang S.J., How T., Lodish H.F.
    J. Biol. Chem. 276:39608-39617(2001) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: RGDInferred from sequence orthologyⁱ
  • "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."
    Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., Knaus P.
    EMBO J. 20:480-490(2001) [PubMed] [Europe PMC] [Abstract]
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev. Dyn. 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta-activated receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling."
    Chen W., Kirkbride K.C., How T., Nelson C.D., Mo J., Frederick J.P., Wang X.-F., Lefkowitz R.J., Blobe G.C.
    Science 301:1394-1397(2003) [PubMed] [Europe PMC] [Abstract]
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J. Biol. Chem. 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
  • "Murine betaglycan primary structure, expression and glycosaminoglycan attachment sites."
    Ponce-Castaneda M.V., Esparza-Lopez J., Vilchis-Landeros M.M., Mendoza V., Lopez-Casillas F.
    Biochim. Biophys. Acta 1384:189-196(1998) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor activity, type III Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• type II transforming growth factor beta receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."
    Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., Knaus P.
    EMBO J. 20:480-490(2001) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• animal organ regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition."
    Nishikawa Y., Wang M., Carr B.I.
    J. Cell. Physiol. 176:612-623(1998) [PubMed] [Europe PMC] [Abstract]
• blastocyst development Source: RGDInferred from sequence orthologyⁱ
  • "Identification of two distinct functions for TGF-beta in early mouse development."
    Roelen B.A., Goumans M.J., Zwijsen A., Mummery C.L.
    Differentiation 64:19-31(1998) [PubMed] [Europe PMC] [Abstract]
• blood vessel development Source: RGDInferred from sequence orthologyⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• blood vessel remodeling Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor."
    Kirkbride K.C., Townsend T.A., Bruinsma M.W., Barnett J.V., Blobe G.C.
    J. Biol. Chem. 283:7628-7637(2008) [PubMed] [Europe PMC] [Abstract]
• cardiac epithelial to mesenchymal transition Source: RGDInferred from sequence orthologyⁱ
  • "Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor."
    Kirkbride K.C., Townsend T.A., Bruinsma M.W., Barnett J.V., Blobe G.C.
    J. Biol. Chem. 283:7628-7637(2008) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• collagen metabolic process Source: RGDInferred from sequence orthologyⁱ
  • "A novel reciprocal loop between microRNA-21 and TGFbetaRIII is involved in cardiac fibrosis."
    Liang H., Zhang C., Ban T., Liu Y., Mei L., Piao X., Zhao D., Lu Y., Chu W., Yang B.
    Int. J. Biochem. Cell Biol. 44:2152-2160(2012) [PubMed] [Europe PMC] [Abstract]
• definitive erythrocyte differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• definitive hemopoiesis Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• epicardium-derived cardiac fibroblast cell development Source: RGDInferred from sequence orthologyⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition Source: RGDInferred from sequence orthologyⁱ
  • "Bone morphogenetic proteins signal through the transforming growth factor-beta type III receptor."
    Kirkbride K.C., Townsend T.A., Bruinsma M.W., Barnett J.V., Blobe G.C.
    J. Biol. Chem. 283:7628-7637(2008) [PubMed] [Europe PMC] [Abstract]
• heart trabecula formation Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• heart trabecula morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• immune response Source: RGDInferred from sequence orthologyⁱ
  • "Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia."
    Adewoye A.H., Nolan V.G., Ma Q., Baldwin C., Wyszynski D.F., Farrell J.J., Farrer L.A., Steinberg M.H.
    Clin. Infect. Dis. 43:593-598(2006) [PubMed] [Europe PMC] [Abstract]
• intracellular signal transduction Source: RGDInferred from sequence orthologyⁱ
  • "Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells."
    Liu J., Kuulasmaa T., Kosma V.M., Butzow R., Vanttinen T., Hyden-Granskog C., Voutilainen R.
    J. Clin. Endocrinol. Metab. 88:5002-5008(2003) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: RGDInferred from sequence orthologyⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• liver development Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• muscular septum morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process involved in morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cellular component movement Source: RGDInferred from sequence orthologyⁱ
  • "Loss of type III transforming growth factor beta receptor expression increases motility and invasiveness associated with epithelial to mesenchymal transition during pancreatic cancer progression."
    Gordon K.J., Dong M., Chislock E.M., Fields T.A., Blobe G.C.
    Carcinogenesis 29:252-262(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell migration Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J. Biol. Chem. 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev. Dyn. 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial to mesenchymal transition Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J. Biol. Chem. 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: RGDInferred from sequence orthologyⁱ
  • "A novel reciprocal loop between microRNA-21 and TGFbetaRIII is involved in cardiac fibrosis."
    Liang H., Zhang C., Ban T., Liu Y., Mei L., Piao X., Zhao D., Lu Y., Chu W., Yang B.
    Int. J. Biochem. Cell Biol. 44:2152-2160(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transforming growth factor beta receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling."
    Lewis K.A., Gray P.C., Blount A.L., MacConell L.A., Wiater E., Bilezikjian L.M., Vale W.
    Nature 404:411-414(2000) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• outflow tract morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• pathway-restricted SMAD protein phosphorylation Source: RGDInferred from sequence orthologyⁱ
  • "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."
    Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., Knaus P.
    EMBO J. 20:480-490(2001) [PubMed] [Europe PMC] [Abstract]
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev. Dyn. 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of BMP signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cardiac muscle cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NF-kappaB transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "Modulation of NFkappaB activity and E-cadherin by the type III transforming growth factor beta receptor regulates cell growth and motility."
    Criswell T.L., Arteaga C.L.
    J. Biol. Chem. 282:32491-32500(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transforming growth factor beta receptor signaling pathway Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex assembly Source: RGDInferred from direct assayⁱ
  • "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
    Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K.
    Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of protein binding Source: RGDInferred from direct assayⁱ
  • "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
    Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K.
    Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
• response to follicle-stimulating hormone Source: RGDInferred from sequence orthologyⁱ
  • "Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells."
    Liu J., Kuulasmaa T., Kosma V.M., Butzow R., Vanttinen T., Hyden-Granskog C., Voutilainen R.
    J. Clin. Endocrinol. Metab. 88:5002-5008(2003) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: RGDInferred from expression patternⁱ
  • "Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia."
    Vicencio A.G., Eickelberg O., Stankewich M.C., Kashgarian M., Haddad G.G.
    J. Appl. Physiol. 93:1123-1130(2002) [PubMed] [Europe PMC] [Abstract]
• response to luteinizing hormone Source: RGDInferred from sequence orthologyⁱ
  • "Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells."
    Liu J., Kuulasmaa T., Kosma V.M., Butzow R., Vanttinen T., Hyden-Granskog C., Voutilainen R.
    J. Clin. Endocrinol. Metab. 88:5002-5008(2003) [PubMed] [Europe PMC] [Abstract]
• response to prostaglandin E Source: RGDInferred from sequence orthologyⁱ
  • "Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells."
    Liu J., Kuulasmaa T., Kosma V.M., Butzow R., Vanttinen T., Hyden-Granskog C., Voutilainen R.
    J. Clin. Endocrinol. Metab. 88:5002-5008(2003) [PubMed] [Europe PMC] [Abstract]
• roof of mouth development Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• secondary palate development Source: RGDInferred from sequence orthologyⁱ
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev. Dyn. 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
    Moren A., Ichijo H., Miyazono K.
    Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor complex assembly Source: RGDInferred from mutant phenotypeⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."
    Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., Knaus P.
    EMBO J. 20:480-490(2001) [PubMed] [Europe PMC] [Abstract]
  • "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."
    Blobe G.C., Liu X., Fang S.J., How T., Lodish H.F.
    J. Biol. Chem. 276:39608-39617(2001) [PubMed] [Europe PMC] [Abstract]
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
  • "Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling."
    Chen W., Kirkbride K.C., How T., Nelson C.D., Mo J., Frederick J.P., Wang X.-F., Lefkowitz R.J., Blobe G.C.
    Science 301:1394-1397(2003) [PubMed] [Europe PMC] [Abstract]
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev. Dyn. 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• vasculogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis."
    Hill C.R., Jacobs B.H., Brown C.B., Barnett J.V., Goudy S.L.
    Dev. Dyn. 244:122-133(2015) [PubMed] [Europe PMC] [Abstract]
• vasculogenesis involved in coronary vascular morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• ventricular cardiac muscle tissue morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
• ventricular compact myocardium morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos."
    Stenvers K.L., Tursky M.L., Harder K.W., Kountouri N., Amatayakul-Chantler S., Grail D., Small C., Weinberg R.A., Sizeland A.M., Zhu H.J.
    Mol. Cell. Biol. 23:4371-4385(2003) [PubMed] [Europe PMC] [Abstract]
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]
• ventricular septum morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Coronary vessel development is dependent on the type III transforming growth factor beta receptor."
    Compton L.A., Potash D.A., Brown C.B., Barnett J.V.
    Circ. Res. 101:784-791(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• fibroblast growth factor binding Source: RGDInferred from direct assayⁱ
  • "Binding of two growth factor families to separate domains of the proteoglycan betaglycan."
    Andres J.L., DeFalcis D., Noda M., Massague J.
    J. Biol. Chem. 267:5927-5930(1992) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGDInferred from sequence orthologyⁱ
  • "A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC."
    Blobe G.C., Liu X., Fang S.J., How T., Lodish H.F.
    J. Biol. Chem. 276:39608-39617(2001) [PubMed] [Europe PMC] [Abstract]
• SMAD binding Source: RGDInferred from sequence orthologyⁱ
  • "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."
    Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., Knaus P.
    EMBO J. 20:480-490(2001) [PubMed] [Europe PMC] [Abstract]
  • "Functional role of transforming growth factor-beta type III receptor during palatal fusion."
    Nakajima A., Ito Y., Asano M., Maeno M., Iwata K., Mitsui N., Shimizu N., Cui X.M., Shuler C.F.
    Dev. Dyn. 236:791-801(2007) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J. Cell Biol. 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• type II transforming growth factor beta receptor binding Source: RGDInferred from sequence orthologyⁱ
  • "Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor."
    Rotzer D., Roth M., Lutz M., Lindemann D., Sebald W., Knaus P.
    EMBO J. 20:480-490(2001) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MAVTSHHMIP VMVVLMSACL ATAGPEPSTR CELSPINASH PVQALMESFT 
        60         70         80         90        100
VLSGCASRGT TGLPREVHVL NLRSTDQGPG QRQREVTLHL NPIASVHTHH 
       110        120        130        140        150
KPIVFLLNSP QPLVWHLKTE RLAAGVPRLF LVSEGSVVQF PSGNFSLTAE 
       160        170        180        190        200
TEERNFPQEN EHLLRWAQKE YGAVTSFTEL KIARNIYIKV GEDQVFPPTC 
       210        220        230        240        250
NIGKNFLSLN YLAEYLQPKA AEGCVLPSQP HEKEVHIIEL ITPSSNPYSA 
       260        270        280        290        300
FQVDIIVDIR PAQEDPEVVK NLVLILKCKK SVNWVIKSFD VKGNLKVIAP 
       310        320        330        340        350
NSIGFGKESE RSMTMTKLVR DDIPSTQENL MKWALDNGYR PVTSYTMAPV 
       360        370        380        390        400
ANRFHLRLEN NEEMRDEEVH TIPPELRILL DPDHPPALDN PLFPGEGSPN 
       410        420        430        440        450
GGLPFPFPDI PRRGWKEGED RIPRPKQPIV PSVQLLPDHR EPEEVQGGVD 
       460        470        480        490        500
IALSVKCDHE KMVVAVDKDS FQTNGYSGME LTLLDPSCKA KMNGTHFVLE 
       510        520        530        540        550
SPLNGCGTRH RRSTPDGVVY YNSIVVQAPS PGDSSGWPDG YEDLESGDNG 
       560        570        580        590        600
FPGDGDEGET APLSRAGVVV FNCSLRQLRN PSGFQGQLDG NATFNMELYN 
       610        620        630        640        650
TDLFLVPSPG VFSVAENEHV YVEVSVTKAD QDLGFAIQTC FLSPYSNPDR 
       660        670        680        690        700
MSDYTIIENI CPKDDSVKFY SSKRVHFPIP HAEVDKKRFS FLFKSVFNTS 
       710        720        730        740        750
LLFLHCELTL CSRKKGSLKL PRCVTPDDAC TSLDATMIWT MMQNKKTFTK 
       760        770        780        790        800
PLAVVLQVDY KENVPSTKDS SPIPPPPPQI FHGLDTLTVM GIAFAAFVIG 
       810        820        830        840        850
ALLTGALWYI YSHTGETARR QQVPTSPPAS ENSSAAHSIG STQSTPCSSS 

STA                                                    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references