UniProtKB - P26342 (TGBR3_RAT)
Protein
Transforming growth factor beta receptor type 3
Gene
Tgfbr3
Organism
Rattus norvegicus (Rat)
Status
Functioni
Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors.
GO - Molecular functioni
- activin binding Source: RGD
- coreceptor activity Source: RGD
- fibroblast growth factor binding Source: RGD
- glycosaminoglycan binding Source: RGD
- heparin binding Source: BHF-UCL
- PDZ domain binding Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta-activated receptor activity Source: RGD
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor activity, type III Source: BHF-UCL
- transforming growth factor beta receptor binding Source: BHF-UCL
- type II transforming growth factor beta receptor binding Source: RGD
GO - Biological processi
- angiogenesis Source: GO_Central
- animal organ regeneration Source: RGD
- blastocyst development Source: RGD
- blood vessel development Source: RGD
- blood vessel remodeling Source: RGD
- BMP signaling pathway Source: RGD
- cardiac epithelial to mesenchymal transition Source: RGD
- cardiac muscle cell proliferation Source: RGD
- cell migration Source: GO_Central
- collagen metabolic process Source: RGD
- definitive erythrocyte differentiation Source: RGD
- definitive hemopoiesis Source: RGD
- epicardium-derived cardiac fibroblast cell development Source: RGD
- epithelial to mesenchymal transition Source: RGD
- heart trabecula formation Source: RGD
- heart trabecula morphogenesis Source: RGD
- immune response Source: RGD
- intracellular signal transduction Source: RGD
- in utero embryonic development Source: RGD
- liver development Source: RGD
- muscular septum morphogenesis Source: RGD
- negative regulation of apoptotic process involved in morphogenesis Source: RGD
- negative regulation of cellular component movement Source: RGD
- negative regulation of epithelial cell migration Source: RGD
- negative regulation of epithelial cell proliferation Source: RGD
- negative regulation of epithelial to mesenchymal transition Source: RGD
- negative regulation of gene expression Source: RGD
- negative regulation of transforming growth factor beta receptor signaling pathway Source: RGD
- osteoblast differentiation Source: RGD
- outflow tract morphogenesis Source: RGD
- pathway-restricted SMAD protein phosphorylation Source: RGD
- positive regulation of BMP signaling pathway Source: RGD
- positive regulation of cardiac muscle cell proliferation Source: RGD
- positive regulation of cell population proliferation Source: RGD
- positive regulation of NF-kappaB transcription factor activity Source: RGD
- positive regulation of transforming growth factor beta receptor signaling pathway Source: RGD
- protein-containing complex assembly Source: RGD
- regulation of protein binding Source: RGD
- regulation of transforming growth factor beta receptor signaling pathway Source: GO_Central
- response to follicle-stimulating hormone Source: RGD
- response to hypoxia Source: RGD
- response to luteinizing hormone Source: RGD
- response to prostaglandin E Source: RGD
- roof of mouth development Source: RGD
- secondary palate development Source: RGD
- signal transduction Source: BHF-UCL
- transforming growth factor beta receptor complex assembly Source: RGD
- transforming growth factor beta receptor signaling pathway Source: RGD
- vasculogenesis Source: RGD
- vasculogenesis involved in coronary vascular morphogenesis Source: RGD
- ventricular cardiac muscle tissue morphogenesis Source: RGD
- ventricular compact myocardium morphogenesis Source: RGD
- ventricular septum morphogenesis Source: RGD
Keywordsi
Molecular function | Receptor |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta receptor type 3Short name: TGF-beta receptor type 3 Short name: TGFR-3 Alternative name(s): Betaglycan Transforming growth factor beta receptor III Short name: TGF-beta receptor type III |
Gene namesi | Name:Tgfbr3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 61821, Tgfbr3 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
Note: Exists both as a membrane-bound form and as soluble form in serum and in the extracellular matrix.
Endoplasmic reticulum
- endoplasmic reticulum Source: RGD
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular matrix Source: RGD
- extracellular space Source: RGD
Plasma Membrane
- external side of plasma membrane Source: RGD
- inhibin-betaglycan-ActRII complex Source: RGD
- integral component of plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- cytoplasm Source: RGD
- integral component of membrane Source: BHF-UCL
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 789 | ExtracellularSequence analysisAdd BLAST | 766 | |
Transmembranei | 790 – 811 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 812 – 853 | CytoplasmicSequence analysisAdd BLAST | 42 |
Keywords - Cellular componenti
Cell membrane, Extracellular matrix, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000041666 | 24 – 853 | Transforming growth factor beta receptor type 3Add BLAST | 830 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 37 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 144 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 493 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 535 | O-linked (Xyl...) (glycosaminoglycan) serineBy similarity | 1 | |
Glycosylationi | 546 | O-linked (Xyl...) (glycosaminoglycan) serineBy similarity | 1 | |
Glycosylationi | 572 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 591 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 640 ↔ 706 | 1 Publication | ||
Disulfide bondi | 661 ↔ 730 | 1 Publication | ||
Glycosylationi | 698 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 711 ↔ 723 | By similarity |
Post-translational modificationi
Extensively modified by glycosaminoglycan groups (GAG).
Keywords - PTMi
Disulfide bond, Glycoprotein, ProteoglycanProteomic databases
PaxDbi | P26342 |
PRIDEi | P26342 |
PTM databases
GlyGeni | P26342, 8 sites |
iPTMneti | P26342 |
PhosphoSitePlusi | P26342 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000002093, Expressed in lung and 20 other tissues |
Genevisiblei | P26342, RN |
Interactioni
Subunit structurei
Interacts with TCTEX1D4.
By similarityGO - Molecular functioni
- fibroblast growth factor binding Source: RGD
- PDZ domain binding Source: RGD
- SMAD binding Source: RGD
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor binding Source: BHF-UCL
- type II transforming growth factor beta receptor binding Source: RGD
Protein-protein interaction databases
DIPi | DIP-6248N |
STRINGi | 10116.ENSRNOP00000002867 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P26342 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P26342 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 456 – 730 | ZPPROSITE-ProRule annotationAdd BLAST | 275 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 737 – 751 | Interaction with TGF-beta ligandBy similarityAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 772 – 778 | Poly-Pro | 7 |
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QWNZ, Eukaryota |
GeneTreei | ENSGT00530000063861 |
HOGENOMi | CLU_018613_0_0_1 |
InParanoidi | P26342 |
OMAi | FRSPCEL |
OrthoDBi | 1263397at2759 |
PhylomeDBi | P26342 |
TreeFami | TF337375 |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P26342-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVTSHHMIP VMVVLMSACL ATAGPEPSTR CELSPINASH PVQALMESFT
60 70 80 90 100
VLSGCASRGT TGLPREVHVL NLRSTDQGPG QRQREVTLHL NPIASVHTHH
110 120 130 140 150
KPIVFLLNSP QPLVWHLKTE RLAAGVPRLF LVSEGSVVQF PSGNFSLTAE
160 170 180 190 200
TEERNFPQEN EHLLRWAQKE YGAVTSFTEL KIARNIYIKV GEDQVFPPTC
210 220 230 240 250
NIGKNFLSLN YLAEYLQPKA AEGCVLPSQP HEKEVHIIEL ITPSSNPYSA
260 270 280 290 300
FQVDIIVDIR PAQEDPEVVK NLVLILKCKK SVNWVIKSFD VKGNLKVIAP
310 320 330 340 350
NSIGFGKESE RSMTMTKLVR DDIPSTQENL MKWALDNGYR PVTSYTMAPV
360 370 380 390 400
ANRFHLRLEN NEEMRDEEVH TIPPELRILL DPDHPPALDN PLFPGEGSPN
410 420 430 440 450
GGLPFPFPDI PRRGWKEGED RIPRPKQPIV PSVQLLPDHR EPEEVQGGVD
460 470 480 490 500
IALSVKCDHE KMVVAVDKDS FQTNGYSGME LTLLDPSCKA KMNGTHFVLE
510 520 530 540 550
SPLNGCGTRH RRSTPDGVVY YNSIVVQAPS PGDSSGWPDG YEDLESGDNG
560 570 580 590 600
FPGDGDEGET APLSRAGVVV FNCSLRQLRN PSGFQGQLDG NATFNMELYN
610 620 630 640 650
TDLFLVPSPG VFSVAENEHV YVEVSVTKAD QDLGFAIQTC FLSPYSNPDR
660 670 680 690 700
MSDYTIIENI CPKDDSVKFY SSKRVHFPIP HAEVDKKRFS FLFKSVFNTS
710 720 730 740 750
LLFLHCELTL CSRKKGSLKL PRCVTPDDAC TSLDATMIWT MMQNKKTFTK
760 770 780 790 800
PLAVVLQVDY KENVPSTKDS SPIPPPPPQI FHGLDTLTVM GIAFAAFVIG
810 820 830 840 850
ALLTGALWYI YSHTGETARR QQVPTSPPAS ENSSAAHSIG STQSTPCSSS
STA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 164 | L → V in AAA42236 (PubMed:1657407).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77809 mRNA Translation: AAA40813.1 M80784 mRNA Translation: AAA42236.1 |
PIRi | A41220 |
RefSeqi | NP_058952.1, NM_017256.1 |
Genome annotation databases
Ensembli | ENSRNOT00000002867; ENSRNOP00000002867; ENSRNOG00000002093 |
GeneIDi | 29610 |
KEGGi | rno:29610 |
UCSCi | RGD:61821, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M77809 mRNA Translation: AAA40813.1 M80784 mRNA Translation: AAA42236.1 |
PIRi | A41220 |
RefSeqi | NP_058952.1, NM_017256.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3QW9 | X-ray | 2.00 | A/B | 591-763 | [»] | |
SMRi | P26342 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-6248N |
STRINGi | 10116.ENSRNOP00000002867 |
PTM databases
GlyGeni | P26342, 8 sites |
iPTMneti | P26342 |
PhosphoSitePlusi | P26342 |
Proteomic databases
PaxDbi | P26342 |
PRIDEi | P26342 |
Genome annotation databases
Ensembli | ENSRNOT00000002867; ENSRNOP00000002867; ENSRNOG00000002093 |
GeneIDi | 29610 |
KEGGi | rno:29610 |
UCSCi | RGD:61821, rat |
Organism-specific databases
CTDi | 7049 |
RGDi | 61821, Tgfbr3 |
Phylogenomic databases
eggNOGi | ENOG502QWNZ, Eukaryota |
GeneTreei | ENSGT00530000063861 |
HOGENOMi | CLU_018613_0_0_1 |
InParanoidi | P26342 |
OMAi | FRSPCEL |
OrthoDBi | 1263397at2759 |
PhylomeDBi | P26342 |
TreeFami | TF337375 |
Miscellaneous databases
EvolutionaryTracei | P26342 |
PROi | PR:P26342 |
Gene expression databases
Bgeei | ENSRNOG00000002093, Expressed in lung and 20 other tissues |
Genevisiblei | P26342, RN |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGBR3_RAT | |
Accessioni | P26342Primary (citable) accession number: P26342 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references