Transforming growth factor beta receptor type 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• activin binding Source: RGD <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
    Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K.
    Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
• coreceptor activity Source: RGD
• fibroblast growth factor binding Source: RGDInferred from direct assayⁱ
  • "Binding of two growth factor families to separate domains of the proteoglycan betaglycan."
    Andres J.L., DeFalcis D., Noda M., Massague J.
    J Biol Chem 267:5927-5930(1992) [PubMed] [Europe PMC] [Abstract]
• glycosaminoglycan binding Source: RGD
• heparin binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGD
• SMAD binding Source: RGD
• transforming growth factor beta-activated receptor activity Source: RGD
• transforming growth factor beta binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor activity, type III Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• type II transforming growth factor beta receptor binding Source: RGD

GO - Biological processⁱ

• angiogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• animal organ regeneration Source: RGD <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Changes in TGF-beta receptors of rat hepatocytes during primary culture and liver regeneration: increased expression of TGF-beta receptors associated with increased sensitivity to TGF-beta-mediated growth inhibition."
    Nishikawa Y., Wang M., Carr B.I.
    J Cell Physiol 176:612-623(1998) [PubMed] [Europe PMC] [Abstract]
• blastocyst development Source: RGD
• blood vessel development Source: RGD
• blood vessel remodeling Source: RGD
• BMP signaling pathway Source: RGD
• cardiac epithelial to mesenchymal transition Source: RGD
• cardiac muscle cell proliferation Source: RGD
• cell migration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• collagen metabolic process Source: RGD
• definitive erythrocyte differentiation Source: RGD
• definitive hemopoiesis Source: RGD
• epicardium-derived cardiac fibroblast cell development Source: RGD
• epithelial to mesenchymal transition Source: RGD
• heart trabecula formation Source: RGD
• heart trabecula morphogenesis Source: RGD
• immune response Source: RGD
• intracellular signal transduction Source: RGD
• in utero embryonic development Source: RGD
• liver development Source: RGD
• muscular septum morphogenesis Source: RGD
• negative regulation of apoptotic process involved in morphogenesis Source: RGD
• negative regulation of cellular component movement Source: RGD
• negative regulation of epithelial cell migration Source: RGD
• negative regulation of epithelial cell proliferation Source: RGD
• negative regulation of epithelial to mesenchymal transition Source: RGD
• negative regulation of gene expression Source: RGD
• negative regulation of transforming growth factor beta receptor signaling pathway Source: RGDInferred from direct assayⁱ
  • "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling."
    Lewis K.A., Gray P.C., Blount A.L., MacConell L.A., Wiater E., Bilezikjian L.M., Vale W.
    Nature 404:411-414(2000) [PubMed] [Europe PMC] [Abstract]
• osteoblast differentiation Source: RGD
• outflow tract morphogenesis Source: RGD
• pathway-restricted SMAD protein phosphorylation Source: RGD
• positive regulation of BMP signaling pathway Source: RGD
• positive regulation of cardiac muscle cell proliferation Source: RGD
• positive regulation of cell population proliferation Source: RGD
• positive regulation of NF-kappaB transcription factor activity Source: RGD
• positive regulation of transforming growth factor beta receptor signaling pathway Source: RGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• protein-containing complex assembly Source: RGDInferred from direct assayⁱ
  • "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
    Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K.
    Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of protein binding Source: RGDInferred from direct assayⁱ
  • "Properties of inhibin binding to betaglycan, InhBP/p120 and the activin type II receptors."
    Chapman S.C., Bernard D.J., Jelen J., Woodruff T.K.
    Mol. Cell. Endocrinol. 196:79-93(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of transforming growth factor beta receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to follicle-stimulating hormone Source: RGD
• response to hypoxia Source: RGDInferred from expression patternⁱ
  • "Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia."
    Vicencio A.G., Eickelberg O., Stankewich M.C., Kashgarian M., Haddad G.G.
    J Appl Physiol (1985) 93:1123-1130(2002) [PubMed] [Europe PMC] [Abstract]
• response to luteinizing hormone Source: RGD
• response to prostaglandin E Source: RGD
• roof of mouth development Source: RGD
• secondary palate development Source: RGD
• signal transduction Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Molecular cloning and characterization of the human and porcine transforming growth factor-beta type III receptors."
    Moren A., Ichijo H., Miyazono K.
    Biochem. Biophys. Res. Commun. 189:356-362(1992) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor complex assembly Source: RGDInferred from mutant phenotypeⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor signaling pathway Source: RGD
• vasculogenesis Source: RGD
• vasculogenesis involved in coronary vascular morphogenesis Source: RGD
• ventricular cardiac muscle tissue morphogenesis Source: RGD
• ventricular compact myocardium morphogenesis Source: RGD
• ventricular septum morphogenesis Source: RGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• fibroblast growth factor binding Source: RGDInferred from direct assayⁱ
  • "Binding of two growth factor families to separate domains of the proteoglycan betaglycan."
    Andres J.L., DeFalcis D., Noda M., Massague J.
    J Biol Chem 267:5927-5930(1992) [PubMed] [Europe PMC] [Abstract]
• PDZ domain binding Source: RGD
• SMAD binding Source: RGD
• transforming growth factor beta binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• transforming growth factor beta receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites."
    Lopez-Casillas F., Payne H.M., Andres J.L., Massague J.
    J Cell Biol 124:557-568(1994) [PubMed] [Europe PMC] [Abstract]
• type II transforming growth factor beta receptor binding Source: RGD

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MAVTSHHMIP VMVVLMSACL ATAGPEPSTR CELSPINASH PVQALMESFT 
        60         70         80         90        100
VLSGCASRGT TGLPREVHVL NLRSTDQGPG QRQREVTLHL NPIASVHTHH 
       110        120        130        140        150
KPIVFLLNSP QPLVWHLKTE RLAAGVPRLF LVSEGSVVQF PSGNFSLTAE 
       160        170        180        190        200
TEERNFPQEN EHLLRWAQKE YGAVTSFTEL KIARNIYIKV GEDQVFPPTC 
       210        220        230        240        250
NIGKNFLSLN YLAEYLQPKA AEGCVLPSQP HEKEVHIIEL ITPSSNPYSA 
       260        270        280        290        300
FQVDIIVDIR PAQEDPEVVK NLVLILKCKK SVNWVIKSFD VKGNLKVIAP 
       310        320        330        340        350
NSIGFGKESE RSMTMTKLVR DDIPSTQENL MKWALDNGYR PVTSYTMAPV 
       360        370        380        390        400
ANRFHLRLEN NEEMRDEEVH TIPPELRILL DPDHPPALDN PLFPGEGSPN 
       410        420        430        440        450
GGLPFPFPDI PRRGWKEGED RIPRPKQPIV PSVQLLPDHR EPEEVQGGVD 
       460        470        480        490        500
IALSVKCDHE KMVVAVDKDS FQTNGYSGME LTLLDPSCKA KMNGTHFVLE 
       510        520        530        540        550
SPLNGCGTRH RRSTPDGVVY YNSIVVQAPS PGDSSGWPDG YEDLESGDNG 
       560        570        580        590        600
FPGDGDEGET APLSRAGVVV FNCSLRQLRN PSGFQGQLDG NATFNMELYN 
       610        620        630        640        650
TDLFLVPSPG VFSVAENEHV YVEVSVTKAD QDLGFAIQTC FLSPYSNPDR 
       660        670        680        690        700
MSDYTIIENI CPKDDSVKFY SSKRVHFPIP HAEVDKKRFS FLFKSVFNTS 
       710        720        730        740        750
LLFLHCELTL CSRKKGSLKL PRCVTPDDAC TSLDATMIWT MMQNKKTFTK 
       760        770        780        790        800
PLAVVLQVDY KENVPSTKDS SPIPPPPPQI FHGLDTLTVM GIAFAAFVIG 
       810        820        830        840        850
ALLTGALWYI YSHTGETARR QQVPTSPPAS ENSSAAHSIG STQSTPCSSS 

STA                                                    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references