UniProtKB - P26323 (FLI1_MOUSE)
Protein
Friend leukemia integration 1 transcription factor
Gene
Fli1
Organism
Mus musculus (Mouse)
Status
Functioni
Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 281 – 361 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- animal organ morphogenesis Source: MGI
- blood circulation Source: MGI
- cell differentiation Source: GO_Central
- cellular process Source: MGI
- megakaryocyte development Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Friend leukemia integration 1 transcription factorAlternative name(s): Retroviral integration site protein Fli-1 |
Gene namesi | Name:Fli1 Synonyms:Fli-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95554, Fli1 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear body Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Involved in erythroleukemia induction by Friend murine leukemia virus (F-MULV).1 Publication
Keywords - Diseasei
Proto-oncogenePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204125 | 1 – 452 | Friend leukemia integration 1 transcription factorAdd BLAST | 452 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 39 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P26323 |
jPOSTi | P26323 |
PaxDbi | P26323 |
PeptideAtlasi | P26323 |
PRIDEi | P26323 |
ProteomicsDBi | 267594 |
PTM databases
iPTMneti | P26323 |
PhosphoSitePlusi | P26323 |
Expressioni
Tissue specificityi
Expressed in both hematopoietic and nonhematopoietic tissues.
Inductioni
Specifically up-regulated in leukemic clones with F-MuLV insertions up-stream of the FLI-1 locus.
Gene expression databases
Bgeei | ENSMUSG00000016087, Expressed in pineal body and 278 other tissues |
ExpressionAtlasi | P26323, baseline and differential |
Genevisiblei | P26323, MM |
Interactioni
Subunit structurei
Can form homodimers or heterodimers with ETV6/TEL1.
By similarityProtein-protein interaction databases
BioGRIDi | 199702, 2 interactors |
IntActi | P26323, 2 interactors |
STRINGi | 10090.ENSMUSP00000016231 |
Miscellaneous databases
RNActi | P26323, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 198 | PNTPROSITE-ProRule annotationAdd BLAST | 87 |
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000158261 |
HOGENOMi | CLU_045216_0_1_1 |
InParanoidi | P26323 |
OMAi | TAFFQNM |
OrthoDBi | 1113327at2759 |
PhylomeDBi | P26323 |
TreeFami | TF350537 |
Family and domain databases
CDDi | cd08541, SAM_PNT-FLI-1, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR035575, Fli-1 IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR035573, SAM_PNT-FLI-1 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF161, PTHR11849:SF161, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P26323-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGTIKEALS VVSDDQSLFD SAYGAAAHLP KADMTASGSP DYGQPHKINP
60 70 80 90 100
LPPQQEWINQ PVRVNVKREY DHMNGSRESP VDCSVSKCNK LVGGGEANPM
110 120 130 140 150
NYNSYMDEKN GPPPPNMTTN ERRVIVPADP TLWTQEHVRQ WLEWAIKEYG
160 170 180 190 200
LMEIDTSFFQ NMDGKELCKM NKEDFLRATS AYNTEVLLSH LSYLRESSLL
210 220 230 240 250
AYNTTSHTDQ SSRLNVKEDP SYDSVRRGAW NNNMNSGLNK SPLLGGSQTM
260 270 280 290 300
GKNTEQRPQP DPYQILGPTS SRLANPGSGQ IQLWQFLLEL LSDSANASCI
310 320 330 340 350
TWEGTNGEFK MTDPDEVARR WGERKSKPNM NYDKLSRALR YYYDKNIMTK
360 370 380 390 400
VHGKRYAYKF DFHGIAQALQ PHPTETSMYK YPSDISYMPS YHAHQQKVNF
410 420 430 440 450
VPSHPSSMPV TSSSFFGAAS QYWTSPTAGI YPNPSVPRHP NTHVPSHLGS
YY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketV9GX50 | V9GX50_MOUSE | Friend leukemia integration 1 trans... | Fli1 | 209 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59421 mRNA Translation: CAA42055.1 |
CCDSi | CCDS40571.1 |
PIRi | S17403 |
RefSeqi | NP_032052.1, NM_008026.5 |
Genome annotation databases
Ensembli | ENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087 |
GeneIDi | 14247 |
KEGGi | mmu:14247 |
UCSCi | uc009orz.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X59421 mRNA Translation: CAA42055.1 |
CCDSi | CCDS40571.1 |
PIRi | S17403 |
RefSeqi | NP_032052.1, NM_008026.5 |
3D structure databases
BMRBi | P26323 |
SMRi | P26323 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199702, 2 interactors |
IntActi | P26323, 2 interactors |
STRINGi | 10090.ENSMUSP00000016231 |
PTM databases
iPTMneti | P26323 |
PhosphoSitePlusi | P26323 |
Proteomic databases
EPDi | P26323 |
jPOSTi | P26323 |
PaxDbi | P26323 |
PeptideAtlasi | P26323 |
PRIDEi | P26323 |
ProteomicsDBi | 267594 |
Protocols and materials databases
ABCDi | P26323, 85 sequenced antibodies |
Antibodypediai | 9350, 668 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000016231; ENSMUSP00000016231; ENSMUSG00000016087 |
GeneIDi | 14247 |
KEGGi | mmu:14247 |
UCSCi | uc009orz.2, mouse |
Organism-specific databases
CTDi | 2313 |
MGIi | MGI:95554, Fli1 |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000158261 |
HOGENOMi | CLU_045216_0_1_1 |
InParanoidi | P26323 |
OMAi | TAFFQNM |
OrthoDBi | 1113327at2759 |
PhylomeDBi | P26323 |
TreeFami | TF350537 |
Miscellaneous databases
BioGRID-ORCSi | 14247, 6 hits in 54 CRISPR screens |
ChiTaRSi | Fli1, mouse |
PROi | PR:P26323 |
RNActi | P26323, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000016087, Expressed in pineal body and 278 other tissues |
ExpressionAtlasi | P26323, baseline and differential |
Genevisiblei | P26323, MM |
Family and domain databases
CDDi | cd08541, SAM_PNT-FLI-1, 1 hit |
Gene3Di | 1.10.10.10, 1 hit 1.10.150.50, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR035575, Fli-1 IPR003118, Pointed_dom IPR013761, SAM/pointed_sf IPR035573, SAM_PNT-FLI-1 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR11849:SF161, PTHR11849:SF161, 1 hit |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF02198, SAM_PNT, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit SM00251, SAM_PNT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit SSF47769, SSF47769, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit PS51433, PNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FLI1_MOUSE | |
Accessioni | P26323Primary (citable) accession number: P26323 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families