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UniProtKB - P26306 (RAD9_SCHPO)
Protein
DNA repair protein rad9
Gene
rad9
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. Repressor of entry into mitosis that is activated by chromosome breaks.
GO - Molecular functioni
- protein kinase activator activity Source: PomBase
- signaling adaptor activity Source: PomBase
GO - Biological processi
- cellular response to ionizing radiation Source: GO_Central
- DNA repair Source: GO_Central
- DNA replication checkpoint signaling Source: GO_Central
- mitotic DNA damage checkpoint signaling Source: PomBase
- mitotic DNA replication checkpoint signaling Source: PomBase
- mitotic intra-S DNA damage checkpoint signaling Source: PomBase
- negative regulation of double-strand break repair via homologous recombination Source: PomBase
- telomere maintenance Source: PomBase
Keywordsi
Biological process | DNA damage |
Enzyme and pathway databases
Reactomei | R-SPO-176187, Activation of ATR in response to replication stress |
Names & Taxonomyi
Protein namesi | Recommended name: DNA repair protein rad9 |
Gene namesi | Name:rad9 ORF Names:SPAC664.07c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC664.07c, rad9 |
VEuPathDBi | FungiDB:SPAC664.07c |
Subcellular locationi
Cytosol
- cytosol Source: PomBase
Nucleus
- checkpoint clamp complex Source: PomBase
- nucleus Source: PomBase
Other locations
- chromatin Source: PomBase
- chromosome, telomeric repeat region Source: PomBase
- cytoplasm Source: PomBase
- site of double-strand break Source: PomBase
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 196 | L → P in rad9-192; sensitive to ionizing radiation. | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097157 | 1 – 426 | DNA repair protein rad9Add BLAST | 426 |
Proteomic databases
PaxDbi | P26306 |
PTM databases
iPTMneti | P26306 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 279961, 78 interactors |
IntActi | P26306, 1 interactor |
STRINGi | 4896.SPAC664.07c.1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 147 | Required for DNA repair functionAdd BLAST | 147 | |
Regioni | 402 – 426 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 406 – 426 | Polar residuesSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the rad9 family.Curated
Phylogenomic databases
eggNOGi | KOG2810, Eukaryota |
HOGENOMi | CLU_030657_1_0_1 |
InParanoidi | P26306 |
OMAi | ERMWVRN |
PhylomeDBi | P26306 |
Family and domain databases
InterProi | View protein in InterPro IPR026584, Rad9 IPR007268, Rad9/Ddc1 |
PANTHERi | PTHR15237, PTHR15237, 1 hit |
Pfami | View protein in Pfam PF04139, Rad9, 1 hit |
PIRSFi | PIRSF009303, Cell_cycle_RAD9, 1 hit |
i Sequence
Sequence statusi: Complete.
P26306-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFTVSNVNL RDLARIFTNL SRIDDAVNWE INKNQIEITC LNSSRSGFSM
60 70 80 90 100
VTLKKAFFDK YIFQPDSVLL TGLMTPTIRI RTQVKPILSV FRNKIFDFIP
110 120 130 140 150
TVVTTNSKNG YGSESASRKD VIVENVQISI STGSECRIIF KFLCKHGVIK
160 170 180 190 200
TYKISYEQTQ TLHAVFDKSL SHNNFQINSK ILKDLTEHFG QRTEELTIQP
210 220 230 240 250
LQERVLLTSF TEEVVHNRDI LKQPTQTTVS IDGKEFERVA LNEGVSVTLS
260 270 280 290 300
LREFRAAVIL AEALGSSICA YYGVPGKPIL LTFAKGKNSE IEAQFILATV
310 320 330 340 350
VGSDEQEVSS MMGNRWQHSS TPASLFNSVE RNNSLTAVAH NPPGSIGWQT
360 370 380 390 400
DQSDSSRMFN SALDRSDETN GIKEPSTTND AGQSLFLDGI PNESELAAFN
410 420
NDVNDDAEFG PTQAEQSYHG IFSQED
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58231 Genomic DNA Translation: CAA41189.1 X64648 Genomic DNA Translation: CAA45919.1 X65864 Genomic DNA Translation: CAA46693.1 X77276 mRNA Translation: CAA54491.1 CU329670 Genomic DNA Translation: CAB65808.1 |
PIRi | S26143 T52475 |
RefSeqi | NP_593455.1, NM_001018888.2 |
Genome annotation databases
EnsemblFungii | SPAC664.07c.1; SPAC664.07c.1:pep; SPAC664.07c |
GeneIDi | 2543544 |
KEGGi | spo:SPAC664.07c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X58231 Genomic DNA Translation: CAA41189.1 X64648 Genomic DNA Translation: CAA45919.1 X65864 Genomic DNA Translation: CAA46693.1 X77276 mRNA Translation: CAA54491.1 CU329670 Genomic DNA Translation: CAB65808.1 |
PIRi | S26143 T52475 |
RefSeqi | NP_593455.1, NM_001018888.2 |
3D structure databases
SMRi | P26306 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 279961, 78 interactors |
IntActi | P26306, 1 interactor |
STRINGi | 4896.SPAC664.07c.1 |
PTM databases
iPTMneti | P26306 |
Proteomic databases
PaxDbi | P26306 |
Genome annotation databases
EnsemblFungii | SPAC664.07c.1; SPAC664.07c.1:pep; SPAC664.07c |
GeneIDi | 2543544 |
KEGGi | spo:SPAC664.07c |
Organism-specific databases
PomBasei | SPAC664.07c, rad9 |
VEuPathDBi | FungiDB:SPAC664.07c |
Phylogenomic databases
eggNOGi | KOG2810, Eukaryota |
HOGENOMi | CLU_030657_1_0_1 |
InParanoidi | P26306 |
OMAi | ERMWVRN |
PhylomeDBi | P26306 |
Enzyme and pathway databases
Reactomei | R-SPO-176187, Activation of ATR in response to replication stress |
Miscellaneous databases
PROi | PR:P26306 |
Family and domain databases
InterProi | View protein in InterPro IPR026584, Rad9 IPR007268, Rad9/Ddc1 |
PANTHERi | PTHR15237, PTHR15237, 1 hit |
Pfami | View protein in Pfam PF04139, Rad9, 1 hit |
PIRSFi | PIRSF009303, Cell_cycle_RAD9, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RAD9_SCHPO | |
Accessioni | P26306Primary (citable) accession number: P26306 Secondary accession number(s): Q10455 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 1992 |
Last sequence update: | May 1, 1992 | |
Last modified: | February 23, 2022 | |
This is version 136 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families